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    SUGP2 SURP and G-patch domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 10147, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SUGP2provided by HGNC
    Official Full Name
    SURP and G-patch domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:18641
    See related
    Ensembl:ENSG00000064607 MIM:607993; AllianceGenome:HGNC:18641
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SFRS14; SRFS14
    Summary
    This gene encodes a member of the arginine/serine-rich family of splicing factors. The encoded protein functions in mRNA processing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
    Expression
    Broad expression in testis (RPKM 45.5), brain (RPKM 19.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SUGP2 in Genome Data Viewer
    Location:
    19p13.11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (18990887..19033844, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (19126690..19169638, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19101696..19144653, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10426 Neighboring gene homer scaffold protein 3 Neighboring gene HOMER3 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 70, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19088899-19089543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19100696-19101196 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:19136044-19137243 Neighboring gene NANOG hESC enhancer GRCh37_chr19:19143058-19143559 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19162565-19163065 Neighboring gene armadillo repeat containing 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14335 Neighboring gene uncharacterized LOC124904655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10429 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10430 Neighboring gene solute carrier family 25 member 42 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:19198769-19199269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19205587-19206086 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:19207400-19208599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10431 Neighboring gene Sharpr-MPRA regulatory region 5014

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. Sampson ND, et al. Gene, 2003 Feb 13. PMID 12594045
    2. The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28. Kim WJ, et al. J Biol Chem, 2015 Jun 5. PMID 25882849, Free PMC Article
    3. Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation. Chen Z, et al. Cell Death Differ, 2022 Oct. PMID 35379950, Free PMC Article
    4. EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis. Béguelin W, et al. Cancer Cell, 2016 Aug 8. PMID 27505670, Free PMC Article
    5. FBXO22 degrades nuclear PTEN to promote tumorigenesis. Ge MK, et al. Nat Commun, 2020 Apr 6. PMID 32249768, Free PMC Article

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21855, DKFZp686M2322, DKFZp779L2418

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    SURP and G-patch domain-containing protein 2
    Names
    arginine/serine-rich-splicing factor 14
    splicing factor, arginine/serine-rich 14

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017392.5 → NP_001017392.2  SURP and G-patch domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001017392.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1-4 encode the same isoform (1).
      Source sequence(s)
      AC004447, AL832488, BG166266, BX647813, DC335817
      Consensus CDS
      CCDS12392.1
      UniProtKB/Swiss-Prot
      C9JI71, O15071, O60369, Q5JPH7, Q8IX01, Q8WUF7
      UniProtKB/TrEMBL
      A8K5G0
      Related
      ENSP00000389380.1, ENST00000452918.7
      Conserved Domains (3) summary
      smart00443
      Location:1009 → 1054
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:785 → 838
      SWAP; Suppressor-of-White-APricot splicing regulator
      cl02715
      Location:589 → 639
      Surp; Surp module

    2. NM_001321697.2 → NP_001308626.1  SURP and G-patch domain-containing protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC004447, BG166266, DA770920
      Consensus CDS
      CCDS12392.1
      UniProtKB/Swiss-Prot
      C9JI71, O15071, O60369, Q5JPH7, Q8IX01, Q8WUF7
      UniProtKB/TrEMBL
      A8K5G0
      Related
      ENSP00000470915.1, ENST00000594773.5
      Conserved Domains (3) summary
      smart00443
      Location:1009 → 1054
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:785 → 838
      SWAP; Suppressor-of-White-APricot splicing regulator
      cl02715
      Location:589 → 639
      Surp; Surp module

    3. NM_001321698.1 → NP_001308627.1  SURP and G-patch domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC004447, BG166266
      Consensus CDS
      CCDS82322.1
      UniProtKB/TrEMBL
      A8K5G0, M0R2Z9
      Conserved Domains (3) summary
      smart00443
      Location:1023 → 1068
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:799 → 852
      SWAP; Suppressor-of-White-APricot splicing regulator
      cl02715
      Location:603 → 653
      Surp; Surp module

    4. NM_001321699.1 → NP_001308628.1  SURP and G-patch domain-containing protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC004447, BG166266, DC402794
      Consensus CDS
      CCDS82322.1
      UniProtKB/TrEMBL
      A8K5G0, M0R2Z9
      Conserved Domains (3) summary
      smart00443
      Location:1023 → 1068
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:799 → 852
      SWAP; Suppressor-of-White-APricot splicing regulator
      cl02715
      Location:603 → 653
      Surp; Surp module

    5. NM_001352071.2 → NP_001339000.1  SURP and G-patch domain-containing protein 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (1).
      Source sequence(s)
      AC004447, AL832488, BG166266, BX647813, DA240141
      Consensus CDS
      CCDS12392.1
      UniProtKB/Swiss-Prot
      C9JI71, O15071, O60369, Q5JPH7, Q8IX01, Q8WUF7
      UniProtKB/TrEMBL
      A8K5G0
      Related
      ENSP00000472286.1, ENST00000601879.5
      Conserved Domains (3) summary
      smart00443
      Location:1009 → 1054
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:785 → 838
      SWAP; Suppressor-of-White-APricot splicing regulator
      cl02715
      Location:589 → 639
      Surp; Surp module

    6. NM_014884.5 → NP_055699.2  SURP and G-patch domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_055699.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1-4 encode the same isoform (1).
      Source sequence(s)
      AF518874, AK291275
      Consensus CDS
      CCDS12392.1
      UniProtKB/Swiss-Prot
      C9JI71, O15071, O60369, Q5JPH7, Q8IX01, Q8WUF7
      UniProtKB/TrEMBL
      A8K5G0
      Related
      ENSP00000337926.5, ENST00000337018.10
      Conserved Domains (3) summary
      smart00443
      Location:1009 → 1054
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:785 → 838
      SWAP; Suppressor-of-White-APricot splicing regulator
      cl02715
      Location:589 → 639
      Surp; Surp module

    RNA

    1. NR_147913.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004447, AF518874, AK291275, BE166620, BG166266, CA422995, CB160925

    2. NR_147914.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AF518874, AK291275, BU730975

    3. NR_147915.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AA505711, AC004447, AF518874, AK291275, BE622050, BG166266, CA422995, DA240141

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      18990887..19033844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438023.1 → XP_047293979.1  SURP and G-patch domain-containing protein 2 isoform X3

    2. XM_024451308.2 → XP_024307076.1  SURP and G-patch domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A8K5G0, M0R2Z9
      Related
      ENSP00000472914.1, ENST00000600377.1
      Conserved Domains (3) summary
      smart00443
      Location:1023 → 1068
      G_patch; glycine rich nucleic binding domain
      smart00648
      Location:799 → 852
      SWAP; Suppressor-of-White-APricot splicing regulator
      cl02715
      Location:603 → 653
      Surp; Surp module

    3. XM_024451307.2 → XP_024307075.1  SURP and G-patch domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A8K5G0
      Conserved Domains (3) summary
      smart00648
      Location:799 → 852
      SWAP; Suppressor-of-White-APricot splicing regulator
      pfam01585
      Location:1026 → 1057
      G-patch; G-patch domain
      cl02715
      Location:603 → 653
      Surp; Surp module

    4. XM_047438022.1 → XP_047293978.1  SURP and G-patch domain-containing protein 2 isoform X3

    5. XM_047438027.1 → XP_047293983.1  SURP and G-patch domain-containing protein 2 isoform X3

    6. XM_047438025.1 → XP_047293981.1  SURP and G-patch domain-containing protein 2 isoform X4

    7. XM_047438026.1 → XP_047293982.1  SURP and G-patch domain-containing protein 2 isoform X5

    RNA

    1. XR_430124.5 RNA Sequence

    2. XR_001753576.3 RNA Sequence

    3. XR_007066515.1 RNA Sequence

    4. XR_430122.5 RNA Sequence

    5. XR_002958236.2 RNA Sequence

    6. XR_007066514.1 RNA Sequence

    7. XR_007066517.1 RNA Sequence

    8. XR_007066519.1 RNA Sequence

    9. XR_007066518.1 RNA Sequence

    10. XR_007066512.1 RNA Sequence

    11. XR_007066530.1 RNA Sequence

    12. XR_007066523.1 RNA Sequence

    13. XR_007066526.1 RNA Sequence

    14. XR_007066525.1 RNA Sequence

    15. XR_007066527.1 RNA Sequence

    16. XR_007066524.1 RNA Sequence

    17. XR_007066520.1 RNA Sequence

    18. XR_007066528.1 RNA Sequence

    19. XR_007066529.1 RNA Sequence

    20. XR_007066521.1 RNA Sequence

    21. XR_007066531.1 RNA Sequence

    22. XR_007066513.1 RNA Sequence

    23. XR_007066516.1 RNA Sequence

    24. XR_007066522.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      19126690..19169638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319490.1 → XP_054175465.1  SURP and G-patch domain-containing protein 2 isoform X3

    2. XM_054319488.1 → XP_054175463.1  SURP and G-patch domain-containing protein 2 isoform X2

    3. XM_054319487.1 → XP_054175462.1  SURP and G-patch domain-containing protein 2 isoform X1

    4. XM_054319489.1 → XP_054175464.1  SURP and G-patch domain-containing protein 2 isoform X3

    5. XM_054319493.1 → XP_054175468.1  SURP and G-patch domain-containing protein 2 isoform X3

    6. XM_054319491.1 → XP_054175466.1  SURP and G-patch domain-containing protein 2 isoform X4

    7. XM_054319492.1 → XP_054175467.1  SURP and G-patch domain-containing protein 2 isoform X5

    RNA

    1. XR_008485044.1 RNA Sequence

    2. XR_008485047.1 RNA Sequence

    3. XR_008485042.1 RNA Sequence

    4. XR_008485043.1 RNA Sequence

    5. XR_008485046.1 RNA Sequence

    6. XR_008485041.1 RNA Sequence

    7. XR_008485048.1 RNA Sequence

    8. XR_008485050.1 RNA Sequence

    9. XR_008485049.1 RNA Sequence

    10. XR_008485039.1 RNA Sequence

    11. XR_008485061.1 RNA Sequence

    12. XR_008485054.1 RNA Sequence

    13. XR_008485057.1 RNA Sequence

    14. XR_008485056.1 RNA Sequence

    15. XR_008485058.1 RNA Sequence

    16. XR_008485055.1 RNA Sequence

    17. XR_008485051.1 RNA Sequence

    18. XR_008485059.1 RNA Sequence

    19. XR_008485060.1 RNA Sequence

    20. XR_008485052.1 RNA Sequence

    21. XR_008485062.1 RNA Sequence

    22. XR_008485040.1 RNA Sequence

    23. XR_008485045.1 RNA Sequence

    24. XR_008485053.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IX01.2 GenPept UniProtKB/Swiss-Prot:Q8IX01

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