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Conserved domains on  [gi|1012443724|ref|NP_001308628|]
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SURP and G-patch domain-containing protein 2 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 1023-1068 2.13e-14

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


:

Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 68.34  E-value: 2.13e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1012443724  1023 LTDKNLGFQMLQKMGWKEGHGLGSLGKGIREPVSVGTPSEGEGLGA 1068
Cdd:smart00443    1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 800-850 8.33e-13

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


:

Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 63.69  E-value: 8.33e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1012443724  800 ETAEKLARFVAQVGPEIEQFSIENSTDNPDLWFLHDQNSSAFKFYRKKVFE 850
Cdd:pfam01805    1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEE 51
SWAP super family cl46999
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 603-653 2.54e-04

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


The actual alignment was detected with superfamily member smart00648:

Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 39.88  E-value: 2.54e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1012443724   603 TIDQLVKRVIEGSLSpKERTLL---KEDPAYWFLSDENSLeYKYYKLKLAEMQR 653
Cdd:smart00648    3 IIDKTAQFVARNGPE-FEAKLMereRNNPQFDFLKPNDPY-HAYYRKKLAEYRQ 54
 
Name Accession Description Interval E-value
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 1023-1068 2.13e-14

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 68.34  E-value: 2.13e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1012443724  1023 LTDKNLGFQMLQKMGWKEGHGLGSLGKGIREPVSVGTPSEGEGLGA 1068
Cdd:smart00443    1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 1026-1069 4.25e-14

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 67.15  E-value: 4.25e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1012443724 1026 KNLGFQMLQKMGWKEGHGLGSLGKGIREPVSVGTPSEGEGLGAD 1069
Cdd:pfam01585    2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 800-850 8.33e-13

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 63.69  E-value: 8.33e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1012443724  800 ETAEKLARFVAQVGPEIEQFSIENSTDNPDLWFLHDQNSSAFKFYRKKVFE 850
Cdd:pfam01805    1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEE 51
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 799-852 8.52e-13

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 63.76  E-value: 8.52e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1012443724   799 METAEKLARFVAQVGPEIEQFSIENSTDNPDLWFLHDqNSSAFKFYRKKVFELC 852
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKP-NDPYHAYYRKKLAEYR 53
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 603-653 2.54e-04

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 39.88  E-value: 2.54e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1012443724   603 TIDQLVKRVIEGSLSpKERTLL---KEDPAYWFLSDENSLeYKYYKLKLAEMQR 653
Cdd:smart00648    3 IIDKTAQFVARNGPE-FEAKLMereRNNPQFDFLKPNDPY-HAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 602-651 6.33e-04

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 38.65  E-value: 6.33e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1012443724  602 GTIDQLVKRVIEGSLSPKERTLLKE--DPAYWFLSDENSLEYKYYKLKLAEM 651
Cdd:pfam01805    1 DIIKKTAQFVARNGPEFEALLMEREerNPQFDFLFDPDDPLHAYYRWKLEEY 52
 
Name Accession Description Interval E-value
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 1023-1068 2.13e-14

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 68.34  E-value: 2.13e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1012443724  1023 LTDKNLGFQMLQKMGWKEGHGLGSLGKGIREPVSVGTPSEGEGLGA 1068
Cdd:smart00443    1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 1026-1069 4.25e-14

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 67.15  E-value: 4.25e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1012443724 1026 KNLGFQMLQKMGWKEGHGLGSLGKGIREPVSVGTPSEGEGLGAD 1069
Cdd:pfam01585    2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 800-850 8.33e-13

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 63.69  E-value: 8.33e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1012443724  800 ETAEKLARFVAQVGPEIEQFSIENSTDNPDLWFLHDQNSSAFKFYRKKVFE 850
Cdd:pfam01805    1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDPLHAYYRWKLEE 51
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 799-852 8.52e-13

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 63.76  E-value: 8.52e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1012443724   799 METAEKLARFVAQVGPEIEQFSIENSTDNPDLWFLHDqNSSAFKFYRKKVFELC 852
Cdd:smart00648    1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKP-NDPYHAYYRKKLAEYR 53
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 603-653 2.54e-04

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 39.88  E-value: 2.54e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1012443724   603 TIDQLVKRVIEGSLSpKERTLL---KEDPAYWFLSDENSLeYKYYKLKLAEMQR 653
Cdd:smart00648    3 IIDKTAQFVARNGPE-FEAKLMereRNNPQFDFLKPNDPY-HAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 602-651 6.33e-04

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 38.65  E-value: 6.33e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1012443724  602 GTIDQLVKRVIEGSLSPKERTLLKE--DPAYWFLSDENSLEYKYYKLKLAEM 651
Cdd:pfam01805    1 DIIKKTAQFVARNGPEFEALLMEREerNPQFDFLFDPDDPLHAYYRWKLEEY 52
G-patch_2 pfam12656
G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ...
 1029-1072 2.21e-03

G-patch domain; Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2. As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2.


Pssm-ID: 432700 [Multi-domain]  Cd Length: 61  Bit Score: 37.26  E-value: 2.21e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1012443724 1029 GFQMLQKMGWKEGHGLGSLGKGIREPVSVGTPSEGEGLGADGQE 1072
Cdd:pfam12656   18 GAAMLRGMGWKPGQGIGKNKKGDVKPKEYKRRPGGLGLGAKPAE 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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