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    Ipo9 Importin 9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41367, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ipo9provided by FlyBase
    Official Full Name
    Importin 9provided by FlyBase
    Primary source
    FLYBASE:FBgn0037894
    Locus tag
    Dmel_CG5252
    See related
    AllianceGenome:FB:FBgn0037894
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5252; Dmel\CG5252; Ranbp9; RanBP9
    Summary
    Predicted to enable nuclear import signal receptor activity. Involved in proteasome localization and protein import into nucleus. Located in cytosol and nucleoplasm. Colocalizes with nuclear envelope. Is expressed in several structures, including adult head; central brain primordium; embryonic central brain surface glial cell; ganglia; and somatic precursor cell. Orthologous to human IPO9 (importin 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ipo9 in Genome Data Viewer
    Location:
    86E4-86E4; 3-51 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11412522..11416142)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7238244..7241864)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene merry-go-round Neighboring gene ncRNA Neighboring gene Inverted repeat-binding protein Neighboring gene brother of rumpel Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear Actin Is Required for Transcription during Drosophila Oogenesis. Sokolova M, et al. iScience, 2018 Nov 30. PMID 30384134, Free PMC Article
    2. Parallel import mechanisms ensure the robust nuclear localization of actin in Drosophila. Borkúti P, et al. Front Mol Biosci, 2022. PMID 36060241, Free PMC Article
    3. Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells. Palacios V, et al. J Cell Sci, 2021 Apr 1. PMID 33632744, Free PMC Article
    4. Active maintenance of nuclear actin by importin 9 supports transcription. Dopie J, et al. Proc Natl Acad Sci U S A, 2012 Feb 28. PMID 22323606, Free PMC Article
    5. Stepping stone: a cytohesin adaptor for membrane cytoskeleton restraint in the syncytial Drosophila embryo. Liu J, et al. Mol Biol Cell, 2015 Feb 15. PMID 25540427, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    importin 9
    Names
    CG5252-PA
    CG5252-PD
    Importin-9
    Ipo9-PA
    Ipo9-PD
    Ranbp9

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11412522..11416142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141811.2 → NP_650068.1  importin 9, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650068.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGP4
      Related
      FBpp0081862, FBtr0082386
      Conserved Domains (2) summary
      COG5656
      Location:14 → 891
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
      pfam03810
      Location:36 → 114
      IBN_N; Importin-beta N-terminal domain

    2. NM_001300355.1 → NP_001287284.1  importin 9, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287284.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGP4
      Conserved Domains (2) summary
      COG5656
      Location:14 → 891
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
      pfam03810
      Location:36 → 114
      IBN_N; Importin-beta N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGP4.1 Q9VGP4

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