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Conserved domains on  [gi|665393809|ref|NP_001287284|]
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importin 9, isoform D [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CSE1 super family cl35039
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
17-424 9.69e-20

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5657:

Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 95.26  E-value: 9.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809   17 IIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYVENHWtddddVKRKANGCMA 96
Cdd:COG5657     6 VVKQLDLAQSPDPPSVKCAEERLRQWEKQHGFALKLLSINLSAFNSMSLRWAALIQFKNYIDKHW-----REENGNSILP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809   97 SEQAkrTIRNILPNGLYDPNSKIRSSVAHTISTIAATDYPHCWAELF-DIIVKCLGGNEDS-------IHGAMQVLQDFS 168
Cdd:COG5657    81 DENV--LIRDELFSLIISSSNQLQIQNALAVSRIARLDFPDEWPTLVpDLLSLLSEKDMVTnenslrvLHHIFKRLRRLF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  169 YDVEQIKELGPVVIPEVYR-IFDSEQNYSIKTRVSAiRILKpLFASIAALI-----TNKEEQSTMMSSILTNFMDKLMHY 242
Cdd:COG5657   159 RSDALFLEIAPVLLSILCPfLFSSAYFWSMSENLDE-SLLS-LFQVCLKLIrryydLGFQDIPEFFEDNLDKFMEHFCKL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  243 LSMNS--------GAVSSFLLRTEIIKVFTHLVNEMPKYINPFMDRVLPIVWQLLTQIAETYVKVSVNQTETSPLASGDS 314
Cdd:COG5657   237 LSYSNpvlqkdclEDCVYFKLKGSICEIFNLYTTKYPEVITYLIYDFVEIVWNLLTTITRPYIRDYLVSKSLTVLINVIK 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  315 EEDDEqtnfqslIIQILEFinciltcnklrgSIKNVLADLIYITIV-YIQLSEEQLEDWHDDPEKFVDDEDDGGVELTVR 393
Cdd:COG5657   317 YPIRK-------TAEVLSN------------VSENLINNLVDLLILpNLILREEDLEEWEDDPLEYIREQSKTDYEVNVR 377
                         410       420       430
                  ....*....|....*....|....*....|.
gi 665393809  394 MCGRDVLLAINDEFGANAIQPLQEALGRHFS 424
Cdd:COG5657   378 PCIENELKDLFDVFGRIAVGHELTVIESEAT 408
SXM1 super family cl35038
Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, ...
14-891 8.20e-11

Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG5656:

Pssm-ID: 227943 [Multi-domain]  Cd Length: 970  Bit Score: 66.41  E-value: 8.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809   14 KQAIIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYVENHWTDDDDVKRKANg 93
Cdd:COG5656     2 REELLQCFLQTLDADAGKRTIAEAMLKDLEKQPGFVMALLHICSKDEGDLNVKLSAAIYFKNKIIRSWSSKRDDGIKAD- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809   94 cMASEQAKRTIRNILPNGLYDPNSkIRSSVAHTISTIAATDYPHCWAELFDIIVKCLGGNEDS-IHGAMQVLQD------ 166
Cdd:COG5656    81 -EKSEAKKYLIENILDVFLYSPEV-TRTALNAILVNIFSEDKPSDLWGLFPKAANLLRSSEANhVYTGLLCLEElfkayr 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  167 FSYDVEQ------IKELGPVVIpEVYRIFDSEQNYSIktrVSAIRILKPLFASIAAL-ITNKEEQSTMMSSILtnfmdKL 239
Cdd:COG5656   159 WKYNDEQvdilmlITALFPILE-KVGGNLESQGNYGS---VETLMLILKSFKSVCYYsLPDFLSAIETFSSWF-----QL 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  240 MHYLSMNSGAVSSFLLRTEI------IKV----FTHLVNEMPKYINPFMDRVLPIVWQL----LTQIAETYVKvsvnQTE 305
Cdd:COG5656   230 SLRILQKPLPNEVLSLDPEVrslskwVKCkkwaAYNLYRSFQRYIKKSYKKSYLSFYITfmtrVPMILATFFK----QIE 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  306 tsplasgdseeddEQTNFQSLIIQI-LEFINC-ILTCNKLRGSIKNVLADLIYITIVYI----QLSEEQLEDWHDDPEKF 379
Cdd:COG5656   306 -------------EWGQGQLWLSDIeLYFIDFfVELCVDADQTWRLMEPHLQYIISGVIfpllCLSEEEEELFENDPDEY 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  380 VDDEDD-GGVELTVRMCGRDVLLAINDEFGANAIQPLQEALGRHFSvadaEKAANNPNWWKI--QEACMDAVHAFRDVIL 456
Cdd:COG5656   373 IRRYYDfFDNGLSPDLAALFFLIISKSKRKEETFQGILSFLLSILG----QSAATPSNIDNArqAEGALRLLASIKSFIT 448
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  457 AGDSTFDLLNYLtIVRNLLVHQESPP--LVGRALWTLSIYSKsDLYNPQMLTEILDVTLCSLspEKSHI-LRISAVRTLN 533
Cdd:COG5656   449 KMSPAANVMEYF-IVNHVIPAFRSNYgfLKSRACEFISTIEE-DFKDNGILLEAYENTHNCL--KNNHLpVMIEAALALQ 524
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  534 GFLQANETidGEKRTLLVsklPGFLDGIMALVPGSKAAVLALLMEAltFMVKFDAE---FA--FASQAKITPLAIAVFLK 608
Cdd:COG5656   525 FFIFNEQS--HEKFSAHV---PETMEKLLSLSNTFEIDPLSMVMES--FVEYFSEElspFApeLAGSLVRQFLKIAQSLL 597
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  609 YTEDPY-------------VLETVQDLIKALCQRKECLGPLQEKFIPTIVSILgltgaaSTEKQDI---ALDVLNTIVry 672
Cdd:COG5656   598 ENSSDTssvvddkqmaasgILRTIESMILSLENRPLVLKYLEVSLYPVISFIL------KNEISDFyqeALDILDGYT-- 669
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  673 teppLNNSLLETAFPAIINCVlhtddhavmvagGECLRSFINV------SP--EQICSY------KNGEGINCIMQVVAT 738
Cdd:COG5656   670 ----FMSKEIEPIMWGIFELL------------LNLLIDEITAvyseevADalDNFITYgktefmDAGIYGSICSEISKL 733
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  739 VLLNPMNSEMTAAGqIGRLVITIITKMG-SMLGQNVDMLLKAVIS--KMQNLECLKVIMNLVLIFAHLFltqmdavLNFL 815
Cdd:COG5656   734 CLCSEENFLEDFIG-VCRIIESLILNIRdELLSQYLPLFISVAGSglKMIDELGPASVYALELIINNLI-------LRPK 805
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  816 STVPGPNGEPAMQFVLTNWLSRQNSFFGNYERKVTTMAL---CKLFEYGVATQD--NRLTTITFKELVDDPTDTRRRTRS 890
Cdd:COG5656   806 ETLQILEEQGYLQSFFEKWFSQIPKFKRVHDKKLSVLAIltiIRLQEVGALPELlvHNLGEVLVALVTSLPEAIRLRAKE 885

                  .
gi 665393809  891 V 891
Cdd:COG5656   886 K 886
 
Name Accession Description Interval E-value
CSE1 COG5657
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
17-424 9.69e-20

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 95.26  E-value: 9.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809   17 IIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYVENHWtddddVKRKANGCMA 96
Cdd:COG5657     6 VVKQLDLAQSPDPPSVKCAEERLRQWEKQHGFALKLLSINLSAFNSMSLRWAALIQFKNYIDKHW-----REENGNSILP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809   97 SEQAkrTIRNILPNGLYDPNSKIRSSVAHTISTIAATDYPHCWAELF-DIIVKCLGGNEDS-------IHGAMQVLQDFS 168
Cdd:COG5657    81 DENV--LIRDELFSLIISSSNQLQIQNALAVSRIARLDFPDEWPTLVpDLLSLLSEKDMVTnenslrvLHHIFKRLRRLF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  169 YDVEQIKELGPVVIPEVYR-IFDSEQNYSIKTRVSAiRILKpLFASIAALI-----TNKEEQSTMMSSILTNFMDKLMHY 242
Cdd:COG5657   159 RSDALFLEIAPVLLSILCPfLFSSAYFWSMSENLDE-SLLS-LFQVCLKLIrryydLGFQDIPEFFEDNLDKFMEHFCKL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  243 LSMNS--------GAVSSFLLRTEIIKVFTHLVNEMPKYINPFMDRVLPIVWQLLTQIAETYVKVSVNQTETSPLASGDS 314
Cdd:COG5657   237 LSYSNpvlqkdclEDCVYFKLKGSICEIFNLYTTKYPEVITYLIYDFVEIVWNLLTTITRPYIRDYLVSKSLTVLINVIK 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  315 EEDDEqtnfqslIIQILEFinciltcnklrgSIKNVLADLIYITIV-YIQLSEEQLEDWHDDPEKFVDDEDDGGVELTVR 393
Cdd:COG5657   317 YPIRK-------TAEVLSN------------VSENLINNLVDLLILpNLILREEDLEEWEDDPLEYIREQSKTDYEVNVR 377
                         410       420       430
                  ....*....|....*....|....*....|.
gi 665393809  394 MCGRDVLLAINDEFGANAIQPLQEALGRHFS 424
Cdd:COG5657   378 PCIENELKDLFDVFGRIAVGHELTVIESEAT 408
SXM1 COG5656
Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, ...
14-891 8.20e-11

Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227943 [Multi-domain]  Cd Length: 970  Bit Score: 66.41  E-value: 8.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809   14 KQAIIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYVENHWTDDDDVKRKANg 93
Cdd:COG5656     2 REELLQCFLQTLDADAGKRTIAEAMLKDLEKQPGFVMALLHICSKDEGDLNVKLSAAIYFKNKIIRSWSSKRDDGIKAD- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809   94 cMASEQAKRTIRNILPNGLYDPNSkIRSSVAHTISTIAATDYPHCWAELFDIIVKCLGGNEDS-IHGAMQVLQD------ 166
Cdd:COG5656    81 -EKSEAKKYLIENILDVFLYSPEV-TRTALNAILVNIFSEDKPSDLWGLFPKAANLLRSSEANhVYTGLLCLEElfkayr 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  167 FSYDVEQ------IKELGPVVIpEVYRIFDSEQNYSIktrVSAIRILKPLFASIAAL-ITNKEEQSTMMSSILtnfmdKL 239
Cdd:COG5656   159 WKYNDEQvdilmlITALFPILE-KVGGNLESQGNYGS---VETLMLILKSFKSVCYYsLPDFLSAIETFSSWF-----QL 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  240 MHYLSMNSGAVSSFLLRTEI------IKV----FTHLVNEMPKYINPFMDRVLPIVWQL----LTQIAETYVKvsvnQTE 305
Cdd:COG5656   230 SLRILQKPLPNEVLSLDPEVrslskwVKCkkwaAYNLYRSFQRYIKKSYKKSYLSFYITfmtrVPMILATFFK----QIE 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  306 tsplasgdseeddEQTNFQSLIIQI-LEFINC-ILTCNKLRGSIKNVLADLIYITIVYI----QLSEEQLEDWHDDPEKF 379
Cdd:COG5656   306 -------------EWGQGQLWLSDIeLYFIDFfVELCVDADQTWRLMEPHLQYIISGVIfpllCLSEEEEELFENDPDEY 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  380 VDDEDD-GGVELTVRMCGRDVLLAINDEFGANAIQPLQEALGRHFSvadaEKAANNPNWWKI--QEACMDAVHAFRDVIL 456
Cdd:COG5656   373 IRRYYDfFDNGLSPDLAALFFLIISKSKRKEETFQGILSFLLSILG----QSAATPSNIDNArqAEGALRLLASIKSFIT 448
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  457 AGDSTFDLLNYLtIVRNLLVHQESPP--LVGRALWTLSIYSKsDLYNPQMLTEILDVTLCSLspEKSHI-LRISAVRTLN 533
Cdd:COG5656   449 KMSPAANVMEYF-IVNHVIPAFRSNYgfLKSRACEFISTIEE-DFKDNGILLEAYENTHNCL--KNNHLpVMIEAALALQ 524
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  534 GFLQANETidGEKRTLLVsklPGFLDGIMALVPGSKAAVLALLMEAltFMVKFDAE---FA--FASQAKITPLAIAVFLK 608
Cdd:COG5656   525 FFIFNEQS--HEKFSAHV---PETMEKLLSLSNTFEIDPLSMVMES--FVEYFSEElspFApeLAGSLVRQFLKIAQSLL 597
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  609 YTEDPY-------------VLETVQDLIKALCQRKECLGPLQEKFIPTIVSILgltgaaSTEKQDI---ALDVLNTIVry 672
Cdd:COG5656   598 ENSSDTssvvddkqmaasgILRTIESMILSLENRPLVLKYLEVSLYPVISFIL------KNEISDFyqeALDILDGYT-- 669
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  673 teppLNNSLLETAFPAIINCVlhtddhavmvagGECLRSFINV------SP--EQICSY------KNGEGINCIMQVVAT 738
Cdd:COG5656   670 ----FMSKEIEPIMWGIFELL------------LNLLIDEITAvyseevADalDNFITYgktefmDAGIYGSICSEISKL 733
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  739 VLLNPMNSEMTAAGqIGRLVITIITKMG-SMLGQNVDMLLKAVIS--KMQNLECLKVIMNLVLIFAHLFltqmdavLNFL 815
Cdd:COG5656   734 CLCSEENFLEDFIG-VCRIIESLILNIRdELLSQYLPLFISVAGSglKMIDELGPASVYALELIINNLI-------LRPK 805
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  816 STVPGPNGEPAMQFVLTNWLSRQNSFFGNYERKVTTMAL---CKLFEYGVATQD--NRLTTITFKELVDDPTDTRRRTRS 890
Cdd:COG5656   806 ETLQILEEQGYLQSFFEKWFSQIPKFKRVHDKKLSVLAIltiIRLQEVGALPELlvHNLGEVLVALVTSLPEAIRLRAKE 885

                  .
gi 665393809  891 V 891
Cdd:COG5656   886 K 886
IBN_N pfam03810
Importin-beta N-terminal domain;
36-114 6.33e-10

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 56.09  E-value: 6.33e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665393809    36 EKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYVENHWtddddvkRKANGCMASEQaKRTIRNILPNGLYD 114
Cdd:pfam03810    2 EKQLEQFEKSPGFWSKLLQILSNSENPLEVRQLAALYLKNLITRHW-------EEEKNSLPPEE-KEQIKNNLLNLLGS 72
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
36-114 1.23e-04

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 41.07  E-value: 1.23e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665393809     36 EKRIKQLEYTEGYGVYLSEIIMNqAHELPLRQIAIVMLTRYVENHWTDdddvkrkangcmASEQAKRTIRNILPNGLYD 114
Cdd:smart00913    2 EKQLEQFQKSPGFWLLLLEILAN-SEDQYVRQLAAITLKNKITRRWSS------------LPEEEKEEIKNSLLELLLS 67
 
Name Accession Description Interval E-value
CSE1 COG5657
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
17-424 9.69e-20

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 95.26  E-value: 9.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809   17 IIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYVENHWtddddVKRKANGCMA 96
Cdd:COG5657     6 VVKQLDLAQSPDPPSVKCAEERLRQWEKQHGFALKLLSINLSAFNSMSLRWAALIQFKNYIDKHW-----REENGNSILP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809   97 SEQAkrTIRNILPNGLYDPNSKIRSSVAHTISTIAATDYPHCWAELF-DIIVKCLGGNEDS-------IHGAMQVLQDFS 168
Cdd:COG5657    81 DENV--LIRDELFSLIISSSNQLQIQNALAVSRIARLDFPDEWPTLVpDLLSLLSEKDMVTnenslrvLHHIFKRLRRLF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  169 YDVEQIKELGPVVIPEVYR-IFDSEQNYSIKTRVSAiRILKpLFASIAALI-----TNKEEQSTMMSSILTNFMDKLMHY 242
Cdd:COG5657   159 RSDALFLEIAPVLLSILCPfLFSSAYFWSMSENLDE-SLLS-LFQVCLKLIrryydLGFQDIPEFFEDNLDKFMEHFCKL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  243 LSMNS--------GAVSSFLLRTEIIKVFTHLVNEMPKYINPFMDRVLPIVWQLLTQIAETYVKVSVNQTETSPLASGDS 314
Cdd:COG5657   237 LSYSNpvlqkdclEDCVYFKLKGSICEIFNLYTTKYPEVITYLIYDFVEIVWNLLTTITRPYIRDYLVSKSLTVLINVIK 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  315 EEDDEqtnfqslIIQILEFinciltcnklrgSIKNVLADLIYITIV-YIQLSEEQLEDWHDDPEKFVDDEDDGGVELTVR 393
Cdd:COG5657   317 YPIRK-------TAEVLSN------------VSENLINNLVDLLILpNLILREEDLEEWEDDPLEYIREQSKTDYEVNVR 377
                         410       420       430
                  ....*....|....*....|....*....|.
gi 665393809  394 MCGRDVLLAINDEFGANAIQPLQEALGRHFS 424
Cdd:COG5657   378 PCIENELKDLFDVFGRIAVGHELTVIESEAT 408
SXM1 COG5656
Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, ...
14-891 8.20e-11

Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227943 [Multi-domain]  Cd Length: 970  Bit Score: 66.41  E-value: 8.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809   14 KQAIIEELQNLLSSDTGVLQQTEKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYVENHWTDDDDVKRKANg 93
Cdd:COG5656     2 REELLQCFLQTLDADAGKRTIAEAMLKDLEKQPGFVMALLHICSKDEGDLNVKLSAAIYFKNKIIRSWSSKRDDGIKAD- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809   94 cMASEQAKRTIRNILPNGLYDPNSkIRSSVAHTISTIAATDYPHCWAELFDIIVKCLGGNEDS-IHGAMQVLQD------ 166
Cdd:COG5656    81 -EKSEAKKYLIENILDVFLYSPEV-TRTALNAILVNIFSEDKPSDLWGLFPKAANLLRSSEANhVYTGLLCLEElfkayr 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  167 FSYDVEQ------IKELGPVVIpEVYRIFDSEQNYSIktrVSAIRILKPLFASIAAL-ITNKEEQSTMMSSILtnfmdKL 239
Cdd:COG5656   159 WKYNDEQvdilmlITALFPILE-KVGGNLESQGNYGS---VETLMLILKSFKSVCYYsLPDFLSAIETFSSWF-----QL 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  240 MHYLSMNSGAVSSFLLRTEI------IKV----FTHLVNEMPKYINPFMDRVLPIVWQL----LTQIAETYVKvsvnQTE 305
Cdd:COG5656   230 SLRILQKPLPNEVLSLDPEVrslskwVKCkkwaAYNLYRSFQRYIKKSYKKSYLSFYITfmtrVPMILATFFK----QIE 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  306 tsplasgdseeddEQTNFQSLIIQI-LEFINC-ILTCNKLRGSIKNVLADLIYITIVYI----QLSEEQLEDWHDDPEKF 379
Cdd:COG5656   306 -------------EWGQGQLWLSDIeLYFIDFfVELCVDADQTWRLMEPHLQYIISGVIfpllCLSEEEEELFENDPDEY 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  380 VDDEDD-GGVELTVRMCGRDVLLAINDEFGANAIQPLQEALGRHFSvadaEKAANNPNWWKI--QEACMDAVHAFRDVIL 456
Cdd:COG5656   373 IRRYYDfFDNGLSPDLAALFFLIISKSKRKEETFQGILSFLLSILG----QSAATPSNIDNArqAEGALRLLASIKSFIT 448
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  457 AGDSTFDLLNYLtIVRNLLVHQESPP--LVGRALWTLSIYSKsDLYNPQMLTEILDVTLCSLspEKSHI-LRISAVRTLN 533
Cdd:COG5656   449 KMSPAANVMEYF-IVNHVIPAFRSNYgfLKSRACEFISTIEE-DFKDNGILLEAYENTHNCL--KNNHLpVMIEAALALQ 524
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  534 GFLQANETidGEKRTLLVsklPGFLDGIMALVPGSKAAVLALLMEAltFMVKFDAE---FA--FASQAKITPLAIAVFLK 608
Cdd:COG5656   525 FFIFNEQS--HEKFSAHV---PETMEKLLSLSNTFEIDPLSMVMES--FVEYFSEElspFApeLAGSLVRQFLKIAQSLL 597
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  609 YTEDPY-------------VLETVQDLIKALCQRKECLGPLQEKFIPTIVSILgltgaaSTEKQDI---ALDVLNTIVry 672
Cdd:COG5656   598 ENSSDTssvvddkqmaasgILRTIESMILSLENRPLVLKYLEVSLYPVISFIL------KNEISDFyqeALDILDGYT-- 669
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  673 teppLNNSLLETAFPAIINCVlhtddhavmvagGECLRSFINV------SP--EQICSY------KNGEGINCIMQVVAT 738
Cdd:COG5656   670 ----FMSKEIEPIMWGIFELL------------LNLLIDEITAvyseevADalDNFITYgktefmDAGIYGSICSEISKL 733
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  739 VLLNPMNSEMTAAGqIGRLVITIITKMG-SMLGQNVDMLLKAVIS--KMQNLECLKVIMNLVLIFAHLFltqmdavLNFL 815
Cdd:COG5656   734 CLCSEENFLEDFIG-VCRIIESLILNIRdELLSQYLPLFISVAGSglKMIDELGPASVYALELIINNLI-------LRPK 805
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809  816 STVPGPNGEPAMQFVLTNWLSRQNSFFGNYERKVTTMAL---CKLFEYGVATQD--NRLTTITFKELVDDPTDTRRRTRS 890
Cdd:COG5656   806 ETLQILEEQGYLQSFFEKWFSQIPKFKRVHDKKLSVLAIltiIRLQEVGALPELlvHNLGEVLVALVTSLPEAIRLRAKE 885

                  .
gi 665393809  891 V 891
Cdd:COG5656   886 K 886
IBN_N pfam03810
Importin-beta N-terminal domain;
36-114 6.33e-10

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 56.09  E-value: 6.33e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665393809    36 EKRIKQLEYTEGYGVYLSEIIMNQAHELPLRQIAIVMLTRYVENHWtddddvkRKANGCMASEQaKRTIRNILPNGLYD 114
Cdd:pfam03810    2 EKQLEQFEKSPGFWSKLLQILSNSENPLEVRQLAALYLKNLITRHW-------EEEKNSLPPEE-KEQIKNNLLNLLGS 72
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
36-114 1.23e-04

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 41.07  E-value: 1.23e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665393809     36 EKRIKQLEYTEGYGVYLSEIIMNqAHELPLRQIAIVMLTRYVENHWTDdddvkrkangcmASEQAKRTIRNILPNGLYD 114
Cdd:smart00913    2 EKQLEQFQKSPGFWLLLLEILAN-SEDQYVRQLAAITLKNKITRRWSS------------LPEEEKEEIKNSLLELLLS 67
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
23-172 2.17e-04

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 45.31  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393809   23 NLLSSDTGVLQQTEKRIKQLEYT--EGYGVYLSEIIMNQAHELPLRQIAIVMLtryvENHWTDDDDVKRKanGCMA---- 96
Cdd:COG5215    13 HVLSPDPNARLRAEAQLLELQSGdfEQFISLLVQVLCDLNSNDQLRMVAGLIL----KNSLHANDPELQK--GCSQrwlg 86
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665393809   97 -SEQAKRTIRNILPNGLYDPNSKIRSSVAHTISTIAATDYPH-CWAELFDIIVKCLgGNEDSIHGAMQVLQDFSYDVE 172
Cdd:COG5215    87 mRHESKEQVKGMALRALKSPEPRFCTMAAQLLAAIARMELPNsLWPGLMEEMVRNV-GDEQPVSGKCESLGICGYHCE 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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