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    Ate1 arginyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293526, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ate1provided by RGD
    Official Full Name
    arginyltransferase 1provided by RGD
    Primary source
    RGD:1309335
    See related
    EnsemblRapid:ENSRNOG00000024414 AllianceGenome:RGD:1309335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable arginyl-tRNA--protein transferase activity. Predicted to be involved in proteasomal protein catabolic process; response to oxidative stress; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within protein arginylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human ATE1 (arginyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 163.9), Lung (RPKM 162.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ate1 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (194391843..194514284, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (184961548..185081112, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (200958564..201082100, complement) , (200810741..200885593, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100911081 Neighboring gene protein UXT-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene similar to RIKEN cDNA 1700022C21 Neighboring gene uncharacterized LOC134483930 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Arginyltransferase knockdown attenuates cardiac hypertrophy and fibrosis through TAK1-JNK1/2 pathway. Singh K, et al. Sci Rep, 2020 Jan 17. PMID 31953451, Free PMC Article
    2. Identification of mammalian arginyltransferases that modify a specific subset of protein substrates. Rai R, et al. Proc Natl Acad Sci U S A, 2005 Jul 19. PMID 16002466, Free PMC Article
    3. Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. Kwon YT, et al. Mol Cell Biol, 1999 Jan. PMID 9858543, Free PMC Article
    4. FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. Sjögren B, et al. PLoS One, 2015. PMID 25970626, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arginyltransferase knockdown attenuates cardiac hypertrophy and fibrosis through TAK1-JNK1/2 pathway.
      Title: Arginyltransferase knockdown attenuates cardiac hypertrophy and fibrosis through TAK1-JNK1/2 pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables arginyl-tRNA--protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginyl-tRNA--protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein arginylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arginyl-tRNA--protein transferase 1
    Names
    arginine-tRNA-protein transferase 1
    NP_001099770.1
    NP_001385686.1
    NP_001385687.1
    NP_001385688.1
    NP_001385689.1
    XP_038963488.1
    XP_038963491.1
    XP_038963503.1
    XP_063142421.1
    XP_063142431.1
    XP_063142435.1
    XP_063142439.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106300.2 → NP_001099770.1  arginyl-tRNA--protein transferase 1 isoform 3

      See identical proteins and their annotated locations for NP_001099770.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6IA33, A6IA34, D4A2N1
      Related
      ENSRNOP00000059441.1, ENSRNOT00000067315.4
      Conserved Domains (2) summary
      pfam04376
      Location:20 → 92
      ATE_N; Arginine-tRNA-protein transferase, N terminus
      pfam04377
      Location:292 → 422
      ATE_C; Arginine-tRNA-protein transferase, C terminus

    2. NM_001398757.1 → NP_001385686.1  arginyl-tRNA--protein transferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AL43, A0A8I6G6E2
      Related
      ENSRNOP00000100383.1, ENSRNOT00000173542.1
      Conserved Domains (2) summary
      pfam04376
      Location:23 → 92
      ATE_N; Arginine-tRNA-protein transferase, N-terminus
      pfam04377
      Location:292 → 431
      ATE_C; Arginine-tRNA-protein transferase, C-terminus

    3. NM_001398758.1 → NP_001385687.1  arginyl-tRNA--protein transferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6G6E2
      Conserved Domains (2) summary
      pfam04376
      Location:23 → 92
      ATE_N; Arginine-tRNA-protein transferase, N-terminus
      pfam04377
      Location:292 → 431
      ATE_C; Arginine-tRNA-protein transferase, C-terminus

    4. NM_001398759.1 → NP_001385688.1  arginyl-tRNA--protein transferase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6GEE1, A6IA33
      Related
      ENSRNOP00000086773.1, ENSRNOT00000101371.2
      Conserved Domains (2) summary
      pfam04376
      Location:23 → 92
      ATE_N; Arginine-tRNA-protein transferase, N-terminus
      pfam04377
      Location:265 → 388
      ATE_C; Arginine-tRNA-protein transferase, C-terminus

    5. NM_001398760.1 → NP_001385689.1  arginyl-tRNA--protein transferase 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6G6E2
      Conserved Domains (2) summary
      pfam04377
      Location:226 → 365
      ATE_C; Arginine-tRNA-protein transferase, C-terminus
      cl27166
      Location:1 → 26
      ATE_N; Arginine-tRNA-protein transferase, N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      194391843..194514284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286351.1 → XP_063142421.1  arginyl-tRNA--protein transferase 1 isoform X3

      UniProtKB/TrEMBL
      A6IA33

    2. XM_039107563.2 → XP_038963491.1  arginyl-tRNA--protein transferase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G6E2
      Related
      ENSRNOP00000080291.2, ENSRNOT00000106036.2
      Conserved Domains (2) summary
      pfam04376
      Location:16 → 85
      ATE_N; Arginine-tRNA-protein transferase, N-terminus
      pfam04377
      Location:285 → 424
      ATE_C; Arginine-tRNA-protein transferase, C-terminus

    3. XM_039107560.2 → XP_038963488.1  arginyl-tRNA--protein transferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX45, A0A8I6G6E2
      Related
      ENSRNOP00000070130.1, ENSRNOT00000079342.3
      Conserved Domains (2) summary
      pfam04376
      Location:16 → 85
      ATE_N; Arginine-tRNA-protein transferase, N-terminus
      pfam04377
      Location:285 → 424
      ATE_C; Arginine-tRNA-protein transferase, C-terminus

    4. XM_063286369.1 → XP_063142439.1  arginyl-tRNA--protein transferase 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6G6E2

    5. XM_063286365.1 → XP_063142435.1  arginyl-tRNA--protein transferase 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6G6E2
      Related
      ENSRNOP00000096095.2, ENSRNOT00000112918.2

    6. XM_039107575.2 → XP_038963503.1  arginyl-tRNA--protein transferase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6G6E2
      Conserved Domains (2) summary
      pfam04377
      Location:226 → 365
      ATE_C; Arginine-tRNA-protein transferase, C-terminus
      cl27166
      Location:1 → 26
      ATE_N; Arginine-tRNA-protein transferase, N-terminus

    7. XM_063286361.1 → XP_063142431.1  arginyl-tRNA--protein transferase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6G6E2
    Nucleotide Protein Strain
    Heading Accession and Version

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