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Conserved domains on  [gi|2169419196|ref|NP_001385687|]
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arginyl-tRNA--protein transferase 1 isoform 2 [Rattus norvegicus]

Protein Classification

arginyl-tRNA--protein transferase( domain architecture ID 10516211)

arginyl-tRNA--protein transferase (arginyltransferase) is involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATE_C pfam04377
Arginine-tRNA-protein transferase, C terminus; This family represents the C terminal region of ...
 296-431 9.80e-64

Arginine-tRNA-protein transferase, C terminus; This family represents the C terminal region of the enzyme arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyzes the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a destabilising amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis. N terminal cysteine is sometimes modified.


:

Pssm-ID: 461282  Cd Length: 122  Bit Score: 203.42  E-value: 9.80e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196 296 LYTKYQVAIHQDEPDICDKSEFTRFLCNSPleaehpangpecgYGSFHQQYWLDGKIIAVGVIDILPYCVSSVYLYYDPD 375
Cdd:pfam04377   5 LYRRYQRARHGDMPDDSSEQGYKRFLCDSP-------------VGTYHQEYRLDGKLIAVGVIDILPDGLSSVYFFYDPD 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2169419196 376 YSFLSLGVYSALREIAFTRQLhektsQLSYYYMGFYIHSCPKMRYKGQYRPSDLLC 431
Cdd:pfam04377  72 YAKRSLGTYSILREIELAREL-----GLPYYYLGYYIHDCPKMRYKARFRPLELLC 122
ATE_N pfam04376
Arginine-tRNA-protein transferase, N terminus; This family represents the N terminal region of ...
 23-92 6.99e-29

Arginine-tRNA-protein transferase, N terminus; This family represents the N terminal region of the enzyme arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyzes the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a de-stabilising amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis. N terminal cysteine is sometimes modified. In S cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important for activity. Of these, only Cys 94 appears to be completely conserved in this family.


:

Pssm-ID: 461281 [Multi-domain]  Cd Length: 71  Bit Score: 108.80  E-value: 6.99e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196  23 CGYCKSNFGSRSHGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMnQTCCPQYTIRCHPLQFQPSKSHKK 92
Cdd:pfam04376   3 CGYCPGRKARKLFADPSGLISPELYQELLDRGFRRSGNYLYRPDC-RTCCACYTIRLDVAEFKPSRSQRR 71
 
Name Accession Description Interval E-value
ATE_C pfam04377
Arginine-tRNA-protein transferase, C terminus; This family represents the C terminal region of ...
 296-431 9.80e-64

Arginine-tRNA-protein transferase, C terminus; This family represents the C terminal region of the enzyme arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyzes the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a destabilising amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis. N terminal cysteine is sometimes modified.


Pssm-ID: 461282  Cd Length: 122  Bit Score: 203.42  E-value: 9.80e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196 296 LYTKYQVAIHQDEPDICDKSEFTRFLCNSPleaehpangpecgYGSFHQQYWLDGKIIAVGVIDILPYCVSSVYLYYDPD 375
Cdd:pfam04377   5 LYRRYQRARHGDMPDDSSEQGYKRFLCDSP-------------VGTYHQEYRLDGKLIAVGVIDILPDGLSSVYFFYDPD 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2169419196 376 YSFLSLGVYSALREIAFTRQLhektsQLSYYYMGFYIHSCPKMRYKGQYRPSDLLC 431
Cdd:pfam04377  72 YAKRSLGTYSILREIELAREL-----GLPYYYLGYYIHDCPKMRYKARFRPLELLC 122
Ate1 COG2935
Arginyl-tRNA--protein-N-Asp/Glu arginylyltransferase [Posttranslational modification, protein ...
 272-441 1.40e-31

Arginyl-tRNA--protein-N-Asp/Glu arginylyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442178 [Multi-domain]  Cd Length: 240  Bit Score: 121.80  E-value: 1.40e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196 272 LEVRLVPASFeDPEFkssfnqsLSLYTKYQVAIHQD---EPDicDKSEFTRFLCNSPLEaehpangpecgygSFHQQYWL 348
Cdd:COG2935    95 LTVRVLPPEF-TEEH-------YALYRRYLAARHADggmDPM--SREQYAAFLEDSWVD-------------TRLVEFRL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196 349 DGKIIAVGVIDILPYCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLhektsQLSYYYMGFYIHSCPKMRYKGQYRPSD 428
Cdd:COG2935   152 DGRLVAVALTDVLPDGLSAVYTFFDPDLARRSLGTYAILWQIELARRL-----GLPYLYLGYWIEGSRKMAYKARFRPLE 226

                         170
                  ....*....|...
gi 2169419196 429 LLCPEtyVWVPIE 441
Cdd:COG2935   227 RLIGG--GWQRLD 237
PRK01305 PRK01305
arginyl-tRNA-protein transferase; Provisional
 272-441 1.50e-30

arginyl-tRNA-protein transferase; Provisional


Pssm-ID: 234939 [Multi-domain]  Cd Length: 240  Bit Score: 119.16  E-value: 1.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196 272 LEVRLVPASFEDpefkssfnQSLSLYTKYQVAIHQD---EPDicDKSEFTRFLCNSPLEaehpangpecgygSFHQQYWL 348
Cdd:PRK01305   95 LVVRVLPPEFTE--------EHYALYRRYLRARHADggmDPP--SRDQYAQFLEDSWVN-------------TRFIEFRG 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196 349 DGKIIAVGVIDILPYCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLhektsQLSYYYMGFYIHSCPKMRYKGQYRPSD 428
Cdd:PRK01305  152 DGKLVAVAVTDVLDDGLSAVYTFYDPDEEHRSLGTFAILWQIELAKRL-----GLPYVYLGYWIKGSRKMNYKARFRPLE 226

                         170
                  ....*....|...
gi 2169419196 429 LLCPetYVWVPIE 441
Cdd:PRK01305  227 ILID--GGWQRLE 237
ATE_N pfam04376
Arginine-tRNA-protein transferase, N terminus; This family represents the N terminal region of ...
 23-92 6.99e-29

Arginine-tRNA-protein transferase, N terminus; This family represents the N terminal region of the enzyme arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyzes the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a de-stabilising amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis. N terminal cysteine is sometimes modified. In S cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important for activity. Of these, only Cys 94 appears to be completely conserved in this family.


Pssm-ID: 461281 [Multi-domain]  Cd Length: 71  Bit Score: 108.80  E-value: 6.99e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196  23 CGYCKSNFGSRSHGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMnQTCCPQYTIRCHPLQFQPSKSHKK 92
Cdd:pfam04376   3 CGYCPGRKARKLFADPSGLISPELYQELLDRGFRRSGNYLYRPDC-RTCCACYTIRLDVAEFKPSRSQRR 71
 
Name Accession Description Interval E-value
ATE_C pfam04377
Arginine-tRNA-protein transferase, C terminus; This family represents the C terminal region of ...
 296-431 9.80e-64

Arginine-tRNA-protein transferase, C terminus; This family represents the C terminal region of the enzyme arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyzes the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a destabilising amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis. N terminal cysteine is sometimes modified.


Pssm-ID: 461282  Cd Length: 122  Bit Score: 203.42  E-value: 9.80e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196 296 LYTKYQVAIHQDEPDICDKSEFTRFLCNSPleaehpangpecgYGSFHQQYWLDGKIIAVGVIDILPYCVSSVYLYYDPD 375
Cdd:pfam04377   5 LYRRYQRARHGDMPDDSSEQGYKRFLCDSP-------------VGTYHQEYRLDGKLIAVGVIDILPDGLSSVYFFYDPD 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2169419196 376 YSFLSLGVYSALREIAFTRQLhektsQLSYYYMGFYIHSCPKMRYKGQYRPSDLLC 431
Cdd:pfam04377  72 YAKRSLGTYSILREIELAREL-----GLPYYYLGYYIHDCPKMRYKARFRPLELLC 122
Ate1 COG2935
Arginyl-tRNA--protein-N-Asp/Glu arginylyltransferase [Posttranslational modification, protein ...
 272-441 1.40e-31

Arginyl-tRNA--protein-N-Asp/Glu arginylyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442178 [Multi-domain]  Cd Length: 240  Bit Score: 121.80  E-value: 1.40e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196 272 LEVRLVPASFeDPEFkssfnqsLSLYTKYQVAIHQD---EPDicDKSEFTRFLCNSPLEaehpangpecgygSFHQQYWL 348
Cdd:COG2935    95 LTVRVLPPEF-TEEH-------YALYRRYLAARHADggmDPM--SREQYAAFLEDSWVD-------------TRLVEFRL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196 349 DGKIIAVGVIDILPYCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLhektsQLSYYYMGFYIHSCPKMRYKGQYRPSD 428
Cdd:COG2935   152 DGRLVAVALTDVLPDGLSAVYTFFDPDLARRSLGTYAILWQIELARRL-----GLPYLYLGYWIEGSRKMAYKARFRPLE 226

                         170
                  ....*....|...
gi 2169419196 429 LLCPEtyVWVPIE 441
Cdd:COG2935   227 RLIGG--GWQRLD 237
PRK01305 PRK01305
arginyl-tRNA-protein transferase; Provisional
 272-441 1.50e-30

arginyl-tRNA-protein transferase; Provisional


Pssm-ID: 234939 [Multi-domain]  Cd Length: 240  Bit Score: 119.16  E-value: 1.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196 272 LEVRLVPASFEDpefkssfnQSLSLYTKYQVAIHQD---EPDicDKSEFTRFLCNSPLEaehpangpecgygSFHQQYWL 348
Cdd:PRK01305   95 LVVRVLPPEFTE--------EHYALYRRYLRARHADggmDPP--SRDQYAQFLEDSWVN-------------TRFIEFRG 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196 349 DGKIIAVGVIDILPYCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLhektsQLSYYYMGFYIHSCPKMRYKGQYRPSD 428
Cdd:PRK01305  152 DGKLVAVAVTDVLDDGLSAVYTFYDPDEEHRSLGTFAILWQIELAKRL-----GLPYVYLGYWIKGSRKMNYKARFRPLE 226

                         170
                  ....*....|...
gi 2169419196 429 LLCPetYVWVPIE 441
Cdd:PRK01305  227 ILID--GGWQRLE 237
ATE_N pfam04376
Arginine-tRNA-protein transferase, N terminus; This family represents the N terminal region of ...
 23-92 6.99e-29

Arginine-tRNA-protein transferase, N terminus; This family represents the N terminal region of the enzyme arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyzes the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a de-stabilising amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis. N terminal cysteine is sometimes modified. In S cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important for activity. Of these, only Cys 94 appears to be completely conserved in this family.


Pssm-ID: 461281 [Multi-domain]  Cd Length: 71  Bit Score: 108.80  E-value: 6.99e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2169419196  23 CGYCKSNFGSRSHGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMnQTCCPQYTIRCHPLQFQPSKSHKK 92
Cdd:pfam04376   3 CGYCPGRKARKLFADPSGLISPELYQELLDRGFRRSGNYLYRPDC-RTCCACYTIRLDVAEFKPSRSQRR 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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