Tspy1 testis specific protein, Y-linked 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tspy1provided by RGD
Official Full Name: testis specific protein, Y-linked 1provided by RGD
Primary source: RGD:3912
See related: EnsemblRapid:ENSRNOG00000054648 AllianceGenome:RGD:3912
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tspy
Summary: Enables histone binding activity. Involved in spermatogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including TSPY1 (testis specific protein Y-linked 1); TSPY4 (testis specific protein Y-linked 4); and TSPY9 (testis specific protein Y-linked 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 16.6), Testes (RPKM 13.5) and 8 other tissues See more
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Genomic context

Location:: Yq11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	Y	NC_086040.1 (213710..218718, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	Y Unlocalized Scaffold	NW_023637718.1 (200860..206429)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	Y	NC_024475.1 (151941..156587)

Chromosome Y - NC_086040.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

rat Tspy may play critical roles as a histone chaperone during maturation of the elongating spermatids in the rat testis
Title: The rat Tspy is preferentially expressed in elongated spermatids and interacts with the core histones.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in gonadal mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: testis-specific Y-encoded protein 1

Names: Testis specific protein on Y; rTSPY; testis-specific protein TSPY

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022923.2 → NP_075212.2 testis-specific Y-encoded protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000022

UniProtKB/Swiss-Prot

O70602, Q9R1M3, Q9R1M4

UniProtKB/TrEMBL

A0A8L2R474

Related

ENSRNOP00000075045.1, ENSRNOT00000083382.4

Conserved Domains (1) summary

cl08298
Location:173 → 328

NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086040.1 Reference GRCr8

Range

213710..218718 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039100721.2 → XP_038956649.1 testis-specific Y-encoded protein 1 isoform X2

Conserved Domains (1) summary

cl08298
Location:36 → 110

NAP; Nucleosome assembly protein (NAP)
XM_008773672.4 → XP_008771894.1 testis-specific Y-encoded protein 1 isoform X1

See identical proteins and their annotated locations for XP_008771894.1

UniProtKB/Swiss-Prot

O70602, Q9R1M3, Q9R1M4

UniProtKB/TrEMBL

A0A8L2R474

Conserved Domains (1) summary

cl08298
Location:173 → 328

NAP; Nucleosome assembly protein (NAP)