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    hum-4 Myosin motor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181335, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hum-4
    Official Full Name
    Myosin motor domain-containing protein
    Primary source
    WormBase:WBGene00002037
    Locus tag
    CELE_F46C3.3
    See related
    AllianceGenome:WB:WBGene00002037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calmodulin binding activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to be located in cytoskeleton. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; actin-based cell projection; and cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (myosin XVA) and MYO16 (myosin XVI). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See hum-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    42
    Sequence:
    Chromosome: X; NC_003284.9 (11420465..11433588, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A family of unconventional myosins from the nematode Caenorhabditis elegans. Baker JP, et al. J Mol Biol, 1997 Oct 3. PMID 9325109
    2. Unconventional Myosins from Caenorhabditis elegans as a Probe to Study Human Orthologues. Johnson CA, et al. Biomolecules, 2022 Dec 16. PMID 36551317, Free PMC Article
    3. The C. elegans ezrin-radixin-moesin protein ERM-1 is necessary for apical junction remodelling and tubulogenesis in the intestine. Van Fürden D, et al. Dev Biol, 2004 Aug 1. PMID 15242805
    4. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Shen X, et al. Cell Calcium, 2008 May. PMID 17854888
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin-based cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Myosin motor domain-containing protein
    NP_001257158.1
    • Confirmed by transcript evidence
    NP_001257159.1
    • Confirmed by transcript evidence
    NP_001257161.1
    • Partially confirmed by transcript evidence
    NP_001294791.1
    • Confirmed by transcript evidence
    NP_001294792.1
    • Confirmed by transcript evidence
    NP_001359540.1
    • Confirmed by transcript evidence
    NP_001360186.1
    • Confirmed by transcript evidence
    NP_001379502.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11420465..11433588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373507.3 → NP_001359540.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20456
      Conserved Domains (7) summary
      smart00015
      Location:680 → 701
      IQ; Calmodulin-binding motif
      smart00139
      Location:2100 → 2255
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:2262 → 2475
      B41; Band 4.1 homologues
      PRK10263
      Location:1162 → 1357
      PRK10263; DNA translocase FtsK; Provisional
      cd14874
      Location:13 → 643
      MYSc_Myo12; class XXXIII myosin, motor domain
      cl17036
      Location:1974 → 2030
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:2489 → 2563
      PH-like; Pleckstrin homology-like domain

    2. NM_001392845.1 → NP_001379502.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6KRJ0
      Conserved Domains (4) summary
      smart00139
      Location:486 → 641
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:648 → 861
      B41; Band 4.1 homologues
      cl17036
      Location:360 → 416
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:875 → 949
      PH-like; Pleckstrin homology-like domain

    3. NM_001270232.4 → NP_001257161.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6VQ62
      Conserved Domains (5) summary
      smart00139
      Location:523 → 678
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:685 → 898
      B41; Band 4.1 homologues
      pfam00373
      Location:776 → 898
      FERM_M; FERM central domain
      cl17036
      Location:397 → 453
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:912 → 986
      PH-like; Pleckstrin homology-like domain

    4. NM_001373506.3 → NP_001360186.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6F568
      Conserved Domains (7) summary
      smart00015
      Location:680 → 701
      IQ; Calmodulin-binding motif
      smart00139
      Location:2063 → 2218
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:2225 → 2438
      B41; Band 4.1 homologues
      PRK10263
      Location:1162 → 1357
      PRK10263; DNA translocase FtsK; Provisional
      cd14874
      Location:13 → 643
      MYSc_Myo12; class XXXIII myosin, motor domain
      cl17036
      Location:1937 → 1993
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:2452 → 2526
      PH-like; Pleckstrin homology-like domain

    5. NM_001307862.4 → NP_001294791.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294791.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FD20
      Conserved Domains (7) summary
      smart00139
      Location:861 → 1016
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1023 → 1236
      B41; Band 4.1 homologues
      pfam00373
      Location:1114 → 1236
      FERM_M; FERM central domain
      pfam15752
      Location:1 → 91
      DUF4688; Domain of unknown function (DUF4688)
      pfam17069
      Location:197 → 380
      RSRP; Arginine/Serine-Rich protein 1
      cl17036
      Location:735 → 791
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:1250 → 1324
      PH-like; Pleckstrin homology-like domain

    6. NM_001270229.4 → NP_001257158.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257158.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT13
      Conserved Domains (6) summary
      smart00139
      Location:898 → 1053
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1060 → 1273
      B41; Band 4.1 homologues
      pfam00373
      Location:1151 → 1273
      FERM_M; FERM central domain
      pfam17069
      Location:197 → 380
      RSRP; Arginine/Serine-Rich protein 1
      cl17036
      Location:772 → 828
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:1287 → 1361
      PH-like; Pleckstrin homology-like domain

    7. NM_001307863.4 → NP_001294792.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294792.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6EZR2
      Conserved Domains (7) summary
      smart00139
      Location:772 → 927
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:934 → 1147
      B41; Band 4.1 homologues
      pfam00373
      Location:1025 → 1147
      FERM_M; FERM central domain
      pfam15512
      Location:237 → 341
      CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal
      pfam17069
      Location:108 → 291
      RSRP; Arginine/Serine-Rich protein 1
      cl17036
      Location:646 → 702
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:1161 → 1235
      PH-like; Pleckstrin homology-like domain

    8. NM_001270230.4 → NP_001257159.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257159.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT14
      Conserved Domains (6) summary
      smart00139
      Location:809 → 964
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:971 → 1184
      B41; Band 4.1 homologues
      pfam00373
      Location:1062 → 1184
      FERM_M; FERM central domain
      pfam17069
      Location:108 → 291
      RSRP; Arginine/Serine-Rich protein 1
      cl17036
      Location:683 → 739
      SH3; Src Homology 3 domain superfamily
      cl17171
      Location:1198 → 1272
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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