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    Susd1 sushi domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 634731, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Susd1provided by MGI
    Official Full Name
    sushi domain containing 1provided by MGI
    Primary source
    MGI:MGI:3651543
    See related
    Ensembl:ENSMUSG00000038578 AllianceGenome:MGI:3651543
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm12528; A530080P10
    Summary
    Orthologous to human SUSD1 (sushi domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 9.1), liver E14.5 (RPKM 6.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Susd1 in Genome Data Viewer
    Location:
    4 B3; 4 32.5 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (59314190..59438738, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (59314202..59439869, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9084 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:59274266-59274419 Neighboring gene STARR-seq mESC enhancer starr_10371 Neighboring gene STARR-positive B cell enhancer mm9_chr4:59288450-59288750 Neighboring gene predicted gene 12596 Neighboring gene STARR-positive B cell enhancer mm9_chr4:59300165-59300466 Neighboring gene predicted gene, 35578 Neighboring gene STARR-positive B cell enhancer mm9_chr4:59344609-59344910 Neighboring gene STARR-positive B cell enhancer ABC_E9588 Neighboring gene STARR-positive B cell enhancer ABC_E9589 Neighboring gene STARR-seq mESC enhancer starr_10373 Neighboring gene zinc finger, MYND domain containing 19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10375 Neighboring gene STARR-positive B cell enhancer ABC_E4630 Neighboring gene STARR-seq mESC enhancer starr_10376 Neighboring gene polypyrimidine tract binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_10379 Neighboring gene STARR-positive B cell enhancer ABC_E4631 Neighboring gene STARR-positive B cell enhancer ABC_E6183 Neighboring gene STARR-positive B cell enhancer ABC_E835 Neighboring gene STARR-seq mESC enhancer starr_10381 Neighboring gene hydroxysteroid dehydrogenase like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32142

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    sushi domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163288.3 → NP_001156760.2  sushi domain-containing protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL808112, AL824704
      Consensus CDS
      CCDS51184.1
      UniProtKB/TrEMBL
      B2RY76, E9Q3H4
      Related
      ENSMUSP00000048201.7, ENSMUST00000040166.14
      Conserved Domains (3) summary
      cd00033
      Location:184 → 240
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00179
      Location:130 → 161
      EGF_CA; Calcium-binding EGF-like domain
      pfam12947
      Location:47 → 74
      EGF_3; EGF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      59314190..59438738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164287.1 → XP_036020180.1  sushi domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      B2RY76
      Conserved Domains (3) summary
      cd00033
      Location:94 → 150
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00179
      Location:40 → 71
      EGF_CA; Calcium-binding EGF-like domain
      pfam18861
      Location:526 → 657
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

    2. XM_006538143.5 → XP_006538206.1  sushi domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B2RY76
      Conserved Domains (2) summary
      cd00033
      Location:146 → 202
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00179
      Location:92 → 123
      EGF_CA; Calcium-binding EGF-like domain

    3. XM_006538141.5 → XP_006538204.1  sushi domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      B2RY76
      Conserved Domains (3) summary
      cd00033
      Location:184 → 240
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00179
      Location:130 → 161
      EGF_CA; Calcium-binding EGF-like domain
      pfam12947
      Location:47 → 74
      EGF_3; EGF domain

    4. XM_006538142.5 → XP_006538205.1  sushi domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RXU0
      Conserved Domains (3) summary
      cd00033
      Location:184 → 240
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00179
      Location:130 → 161
      EGF_CA; Calcium-binding EGF-like domain
      pfam12947
      Location:47 → 74
      EGF_3; EGF domain

    5. XM_036164288.1 → XP_036020181.1  sushi domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      A2AN91
      Conserved Domains (2) summary
      cd00033
      Location:27 → 83
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam18861
      Location:459 → 590
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

    6. XM_006538144.5 → XP_006538207.1  sushi domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      B2RY76
      Conserved Domains (3) summary
      cd00033
      Location:184 → 240
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00179
      Location:130 → 161
      EGF_CA; Calcium-binding EGF-like domain
      pfam12947
      Location:47 → 74
      EGF_3; EGF domain

    7. XM_006538146.5 → XP_006538209.1  sushi domain-containing protein 1 isoform X8

      Conserved Domains (3) summary
      cd00033
      Location:184 → 240
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00179
      Location:130 → 161
      EGF_CA; Calcium-binding EGF-like domain
      pfam12947
      Location:47 → 74
      EGF_3; EGF domain

    8. XM_006538145.5 → XP_006538208.1  sushi domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      B2RXU0
      Conserved Domains (3) summary
      cd00033
      Location:184 → 240
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00179
      Location:130 → 161
      EGF_CA; Calcium-binding EGF-like domain
      pfam12947
      Location:47 → 74
      EGF_3; EGF domain

    RNA

    1. XR_001784175.3 RNA Sequence

    2. XR_003954993.2 RNA Sequence

    3. XR_390338.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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