Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568927153 146 CGIPPEVPEGYVVGSYSS-TLGGQAHYSCKEGFlSVSGDRISRCTALGVWEPPKLHCQ 202
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGY-TLVGSSTITCTENGGWSPPPPTCE 57

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568927153 206 CGSPPEIQNAILVGNHSS-RQGSVAHYDCQEGFEsPGGKITSVCTEKGAWSEITYAC 261
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYT-LVGSSTITCTENGGWSPPPPTC 56

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 568927153  92 DIDECEDSGLCRHGGRCVNTPGSFACYCMEGYVAKN 127
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568927153    40 DKDECQFGAtvICGNHTSCHNTPGGFYCICHEGYRATNN 78
Cdd:smart00179   1 DIDECASGN--PCQNGGTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 568927153  40 DKDECQFGAtvICGNHTSCHNTPGGFYCICHEGYRATN 77
Cdd:cd00054    1 DIDECASGN--PCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Sushi repeat (SCR repeat);

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568927153  146 CGIPPEVPEGYVVGSYSSTL-GGQAHYSCKEGFlSVSGDRISRCTALGVWEPPKLHC 201
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNyGASVSYECDPGY-RLVGSPTITCQEDGTWSPPFPEC 56

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568927153   206 CGSPPEIQNA-ILVGNHSSRQGSVAHYDCQEGFESPGGKiTSVCTEKGAWSEITYAC 261
Cdd:smart00032   1 CPPPPDIENGtVTSSSGTYSYGDTVTYSCDPGYTLIGSS-TITCLENGTWSPPPPTC 56

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|...
gi 568927153   40 DKDECQFGATViCGNHTSCHNTPGGFYCICHEG 72
Cdd:pfam07645   1 DVDECATGTHN-CPANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 568927153  92 DIDECEDSGLCRHGGRCVNTPGSFACYCMEGYVAKN 127
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568927153    40 DKDECQFGAtvICGNHTSCHNTPGGFYCICHEGYRATNN 78
Cdd:smart00179   1 DIDECASGN--PCQNGGTCVNTVGSYRCECPPGYTDGRN 37

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 568927153  40 DKDECQFGAtvICGNHTSCHNTPGGFYCICHEGYRATN 77
Cdd:cd00054    1 DIDECASGN--PCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                         10        20
                 ....*....|....*....|....*....
gi 568927153  95 ECEDSGLCRHGGRCVNTPGSFACYCMEGY 123
Cdd:cd00053    1 ECAASNPCSNGGTCVNTPGSYRCVCPPGY 29

secreted complement-binding protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927153 119 CMEGYvAKNGPEPFHPRTDAT------SCTEIDCGIPPEVPEGYV-VGSysSTLGGQAHYSCKEGFLSVsGDRISRC--- 188
Cdd:PHA02927  54 CLPGY-RKQKMGPIYAKCTGTgwtlfnQCIKRRCPSPRDIDNGQLdIGG--VDFGSSITYSCNSGYQLI-GESKSYCelg 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568927153 189 -TALGVWEPPKLHCQEISCGSPPEIQNailvGNHSSRQ-----GSVAHYDCQEGFESPGGkiTSVCTEKGAWSE 256
Cdd:PHA02927 130 sTGSMVWNPEAPICESVKCQSPPSISN----GRHNGYEdfytdGSVVTYSCNSGYSLIGN--SGVLCSGGEWSD 197

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|..
gi 568927153   92 DIDECEDSG-LCRHGGRCVNTPGSFACYCMEG 122
Cdd:pfam07645   1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32

Epidermal growth factor-like domain;

                           10        20
                   ....*....|....*....|....*....
gi 568927153    95 ECEDSGLCRHGgRCVNTPGSFACYCMEGY 123
Cdd:smart00181   1 ECASGGPCSNG-TCINTPGSYTCSCPPGY 28

EEV Host range protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927153 139 TSCTEIDCGIPPEVPEGYVVGSYSS-TLGGQAHYSCKEGFLSVS----GDRISRCTALGVWEPPKLHCQEISCgSPPEIQ 213
Cdd:PHA02817  17 SLCDLNKCCYPPSIKNGYIYNKKTEyNIGSNVTFFCGNNTRGVRytlvGEKNIICEKDGKWNKEFPVCKIIRC-RFPALQ 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568927153 214 NAILVGNHSSRQ---GSVAHYDCQEGFESPGGKItSVCTEKGAW 254
Cdd:PHA02817  96 NGFVNGIPDSKKfyyESEVSFSCKPGFVLIGTKY-SVCGINSSW 138

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568927153   52 CGNHTSCHNTPGGFYCICHEGYRAtnnnetfipnDGTFC 90
Cdd:pfam12947   8 CHPNATCTNTGGSFTCTCNDGYTG----------DGVTC 36

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.

                          10        20
                  ....*....|....*....|..
gi 568927153  102 CRHGGRCVNTPGSFACYCMEGY 123
Cdd:pfam00008   6 CSNGGTCVDTPGGYTCICPEGY 27

EEV host range protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927153 138 ATSCTEIDCGIPPEVPEGYVVGSYSS-TLGGQAHYSCKEGF---LSVSGDRISRCTALGVWEPPKLHCQEISCgSPPEIQ 213
Cdd:PHA02639  77 APFCMLKECNDPPSIINGKIYNKREMyKVGDEIYYVCNEHKgvqYSLVGNEKITCIQDKSWKPDPPICKMINC-RFPALQ 155

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568927153 214 NAILVGNHSSRQ---GSVAHYDCQEGFESPGGKItSVCTEKGAW 254
Cdd:PHA02639 156 NGYINGIPSNKKfyyKTRVGFSCKSGFDLVGEKY-STCNINATW 198