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    Ankrd13b ankyrin repeat domain 13b [ Mus musculus (house mouse) ]

    Gene ID: 268445, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ankrd13bprovided by MGI
    Official Full Name
    ankyrin repeat domain 13bprovided by MGI
    Primary source
    MGI:MGI:2144501
    See related
    Ensembl:ENSMUSG00000037907 AllianceGenome:MGI:2144501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B930093C12Rik
    Summary
    Predicted to enable ubiquitin-modified protein reader activity. Predicted to be involved in negative regulation of receptor internalization. Predicted to be located in endosome; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in cochlea. Orthologous to human ANKRD13B (ankyrin repeat domain 13B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 67.5), CNS E14 (RPKM 58.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd13b in Genome Data Viewer
    Location:
    11 B5; 11 46.59 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77361311..77380868, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77470485..77490042, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene slingshot protein phosphatase 2 Neighboring gene 60S ribosomal protein L35-like Neighboring gene VISTA enhancer mm146 Neighboring gene STARR-positive B cell enhancer ABC_E5248 Neighboring gene STARR-seq mESC enhancer starr_30055 Neighboring gene microRNA mir-12181 Neighboring gene coronin 6 Neighboring gene STARR-seq mESC enhancer starr_30056 Neighboring gene transformation related protein 53 inducible protein 13 Neighboring gene GIT ArfGAP 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles. Siletti K, et al. Proc Natl Acad Sci U S A, 2017 Dec 26. PMID 29229865, Free PMC Article
    2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-modified protein reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-modified protein reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 13B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001373882.1 → NP_001360811.1  ankyrin repeat domain-containing protein 13B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL607072
      Consensus CDS
      CCDS88195.1
      UniProtKB/Swiss-Prot
      B9EKW8, Q5F259, Q6IR40
      Related
      ENSMUSP00000073584.7, ENSMUST00000037593.14
      Conserved Domains (3) summary
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 490
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001373883.1 → NP_001360812.1  ankyrin repeat domain-containing protein 13B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL607072
      Conserved Domains (3) summary
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 490
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_172945.2 → NP_766533.2  ankyrin repeat domain-containing protein 13B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL607072, CA315262, CA329030, CD578820, CJ131946
      Consensus CDS
      CCDS36233.1
      UniProtKB/Swiss-Prot
      Q5F259
      Related
      ENSMUSP00000090568.4, ENSMUST00000092892.10
      Conserved Domains (4) summary
      PHA02682
      Location:620 → 675
      PHA02682; ORF080 virion core protein; Provisional
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 490
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      77361311..77380868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533397.4 → XP_006533460.1  ankyrin repeat domain-containing protein 13B isoform X12

      Conserved Domains (3) summary
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 490
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_036156714.1 → XP_036012607.1  ankyrin repeat domain-containing protein 13B isoform X9

      Conserved Domains (3) summary
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 490
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_006533389.4 → XP_006533452.1  ankyrin repeat domain-containing protein 13B isoform X3

      Conserved Domains (3) summary
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 490
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_036156715.1 → XP_036012608.1  ankyrin repeat domain-containing protein 13B isoform X14

      Conserved Domains (1) summary
      pfam11904
      Location:1 → 98
      GPCR_chapero_1; GPCR-chaperone

    5. XM_006533398.5 → XP_006533461.1  ankyrin repeat domain-containing protein 13B isoform X13

      Conserved Domains (3) summary
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 368
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_006533394.4 → XP_006533457.1  ankyrin repeat domain-containing protein 13B isoform X10

      Conserved Domains (4) summary
      PHA02682
      Location:427 → 504
      PHA02682; ORF080 virion core protein; Provisional
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 368
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_006533396.4 → XP_006533459.1  ankyrin repeat domain-containing protein 13B isoform X11

      See identical proteins and their annotated locations for XP_006533459.1

      Conserved Domains (4) summary
      PHA02682
      Location:427 → 504
      PHA02682; ORF080 virion core protein; Provisional
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 368
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_011249039.3 → XP_011247341.1  ankyrin repeat domain-containing protein 13B isoform X5

      Conserved Domains (4) summary
      PHA02682
      Location:427 → 504
      PHA02682; ORF080 virion core protein; Provisional
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 368
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_011249040.3 → XP_011247342.1  ankyrin repeat domain-containing protein 13B isoform X6

      Conserved Domains (4) summary
      PRK07003
      Location:441 → 702
      PRK07003; DNA polymerase III subunit gamma/tau
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 368
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    10. XM_006533390.4 → XP_006533453.1  ankyrin repeat domain-containing protein 13B isoform X4

      Conserved Domains (4) summary
      PHA02682
      Location:713 → 768
      PHA02682; ORF080 virion core protein; Provisional
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 368
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    11. XM_011249041.3 → XP_011247343.1  ankyrin repeat domain-containing protein 13B isoform X7

      Conserved Domains (5) summary
      PHA02682
      Location:427 → 504
      PHA02682; ORF080 virion core protein; Provisional
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam04388
      Location:362 → 667
      Hamartin; Hamartin protein
      pfam11904
      Location:163 → 368
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    12. XM_011249038.3 → XP_011247340.1  ankyrin repeat domain-containing protein 13B isoform X2

      Conserved Domains (4) summary
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam04388
      Location:362 → 675
      Hamartin; Hamartin protein
      pfam11904
      Location:163 → 368
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    13. XM_006533388.4 → XP_006533451.1  ankyrin repeat domain-containing protein 13B isoform X1

      Conserved Domains (4) summary
      PRK07764
      Location:411 → 838
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 368
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    14. XM_006533392.4 → XP_006533455.1  ankyrin repeat domain-containing protein 13B isoform X8

      Conserved Domains (4) summary
      PHA02682
      Location:427 → 504
      PHA02682; ORF080 virion core protein; Provisional
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 368
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    15. XM_011249042.3 → XP_011247344.1  ankyrin repeat domain-containing protein 13B isoform X11

      See identical proteins and their annotated locations for XP_011247344.1

      Conserved Domains (4) summary
      PHA02682
      Location:427 → 504
      PHA02682; ORF080 virion core protein; Provisional
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 368
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    16. XM_011249043.4 → XP_011247345.1  ankyrin repeat domain-containing protein 13B isoform X11

      See identical proteins and their annotated locations for XP_011247345.1

      Conserved Domains (4) summary
      PHA02682
      Location:427 → 504
      PHA02682; ORF080 virion core protein; Provisional
      sd00045
      Location:13 → 45
      ANK; ANK repeat [structural motif]
      pfam11904
      Location:163 → 368
      GPCR_chapero_1; GPCR-chaperone
      pfam12796
      Location:18 → 101
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. XR_001780009.3 RNA Sequence

    2. XR_388467.4 RNA Sequence

    3. XR_388468.4 RNA Sequence

    4. XR_004936971.1 RNA Sequence

    5. XR_004936970.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5F259.1 GenPept UniProtKB/Swiss-Prot:Q5F259

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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