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    DCTN3 dynactin subunit 3 [ Homo sapiens (human) ]

    Gene ID: 11258, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DCTN3provided by HGNC
    Official Full Name
    dynactin subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:2713
    See related
    Ensembl:ENSG00000137100 MIM:607387; AllianceGenome:HGNC:2713
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCTN22; DCTN-22
    Summary
    This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Ubiquitous expression in brain (RPKM 30.6), bone marrow (RPKM 26.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DCTN3 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (34613546..34620495, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (34632092..34639042, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34613543..34620492, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ciliary neurotrophic factor receptor Neighboring gene uncharacterized LOC105376023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34570922-34571422 Neighboring gene CNTFR antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34578559-34579533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34611012-34611565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28312 Neighboring gene ribonuclease P/MRP subunit p25 like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34624191-34624739 Neighboring gene AT-rich interaction domain 3C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19853 Neighboring gene sigma non-opioid intracellular receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Assignment of p22 dynactin light chain (DCTN3) to human chromosome region 9p13 by radiation hybrid mapping. Mills DR, et al. Cytogenet Cell Genet, 2001. PMID 11306820
    2. Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells. Karki S, et al. J Cell Biol, 1998 Aug 24. PMID 9722614, Free PMC Article
    3. Study on the Prognostic Values of Dynactin Genes in Low-Grade Glioma. Su X, et al. Technol Cancer Res Treat, 2021 Jan-Dec. PMID 33896271, Free PMC Article
    4. Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis. Kuźma-Kozakiewicz M, et al. Neurodegener Dis, 2016. PMID 26954557
    5. A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. Karki S, et al. J Biol Chem, 2000 Feb 18. PMID 10671518

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study on the Prognostic Values of Dynactin Genes in Low-Grade Glioma.
      Title: Study on the Prognostic Values of Dynactin Genes in Low-Grade Glioma.
    2. Study found that in peripheral blood mononuclear cells the median expression of KIFC3, KIF1B, and KIF5C was much lower than the expression of dynactin subunits DCTN1 and DCTN3, in both sporadic amyotrophic lateral sclerosis and healthy cases
      Title: Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111190

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynactin subunit 3
    Names
    dynactin 3 (p22)
    dynactin complex subunit 22 kDa subunit
    dynactin light chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281425.2 → NP_001268354.1  dynactin subunit 3 isoform 3

      See identical proteins and their annotated locations for NP_001268354.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      BI837796, CN257020, DA212054
      Consensus CDS
      CCDS65028.1
      UniProtKB/TrEMBL
      X6RCK5
      Related
      ENSP00000368196.4, ENST00000378916.8
      Conserved Domains (1) summary
      pfam07426
      Location:10 → 142
      Dynactin_p22; Dynactin subunit p22

    2. NM_001281426.2 → NP_001268355.1  dynactin subunit 3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a translational frameshift, compared to variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC107697, BI596981, CN257020, DA212054
      UniProtKB/TrEMBL
      X6RA56
      Related
      ENSP00000368193.2, ENST00000378913.6
      Conserved Domains (1) summary
      pfam07426
      Location:10 → 137
      Dynactin_p22; Dynactin subunit p22

    3. NM_001281427.2 → NP_001268356.1  dynactin subunit 3 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (5) is shorter and contains a distinct internal segment, compared to isoform 1.
      Source sequence(s)
      AW953496, CN257020, DA212054
      Consensus CDS
      CCDS65029.1
      UniProtKB/TrEMBL
      X6RCK5, X6RLR1
      Related
      ENSP00000432915.2, ENST00000477738.6
      Conserved Domains (1) summary
      pfam07426
      Location:10 → 160
      Dynactin_p22; Dynactin subunit p22

    4. NM_007234.5 → NP_009165.1  dynactin subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_009165.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC107697, CN257020, DA212054
      Consensus CDS
      CCDS6560.1
      UniProtKB/Swiss-Prot
      A6NII7, B2RBM5, O75935, Q5T1I5, Q5T1I7, Q5T8G3, Q9BPU8
      UniProtKB/TrEMBL
      X6RCK5
      Related
      ENSP00000259632.7, ENST00000259632.12
      Conserved Domains (1) summary
      pfam07426
      Location:10 → 170
      Dynactin_p22; Dynactin subunit p22

    5. NM_024348.4 → NP_077324.1  dynactin subunit 3 isoform 2

      See identical proteins and their annotated locations for NP_077324.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a translational frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC000319, CN257020, DA212054
      Consensus CDS
      CCDS6561.1
      UniProtKB/Swiss-Prot
      O75935
      Related
      ENSP00000343986.2, ENST00000341694.6
      Conserved Domains (1) summary
      pfam07426
      Location:10 → 155
      Dynactin_p22; Dynactin subunit p22

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      34613546..34620495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      34632092..34639042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75935.1 GenPept UniProtKB/Swiss-Prot:O75935

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