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    DCTN3 dynactin subunit 3 [ Homo sapiens (human) ]

    Gene ID: 11258, updated on 10-Dec-2024

    Summary

    Official Symbol
    DCTN3provided by HGNC
    Official Full Name
    dynactin subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:2713
    See related
    Ensembl:ENSG00000137100 MIM:607387; AllianceGenome:HGNC:2713
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCTN22; DCTN-22
    Summary
    This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Ubiquitous expression in brain (RPKM 30.6), bone marrow (RPKM 26.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DCTN3 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (34613546..34620495, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (34632092..34639042, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34613543..34620492, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ciliary neurotrophic factor receptor Neighboring gene uncharacterized LOC105376023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34570922-34571422 Neighboring gene CNTFR antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34578559-34579533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34611012-34611565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28312 Neighboring gene ribonuclease P/MRP subunit p25 like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34624191-34624739 Neighboring gene AT-rich interaction domain 3C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19853 Neighboring gene sigma non-opioid intracellular receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC111190

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in centrosome PubMed 
    located_in cleavage furrow  
    located_in cytosol  
    located_in cytosol  
    part_of dynactin complex  
    part_of dynactin complex PubMed 
    located_in kinetochore  
    located_in midbody  
    located_in nucleolus  
    located_in perinuclear region of cytoplasm PubMed 
    located_in spindle  

    General protein information

    Preferred Names
    dynactin subunit 3
    Names
    dynactin 3 (p22)
    dynactin complex subunit 22 kDa subunit
    dynactin light chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281425.2NP_001268354.1  dynactin subunit 3 isoform 3

      See identical proteins and their annotated locations for NP_001268354.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      BI837796, CN257020, DA212054
      Consensus CDS
      CCDS65028.1
      UniProtKB/TrEMBL
      X6RCK5
      Related
      ENSP00000368196.4, ENST00000378916.8
      Conserved Domains (1) summary
      pfam07426
      Location:10142
      Dynactin_p22; Dynactin subunit p22
    2. NM_001281426.2NP_001268355.1  dynactin subunit 3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a translational frameshift, compared to variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC107697, BI596981, CN257020, DA212054
      UniProtKB/TrEMBL
      X6RA56
      Related
      ENSP00000368193.2, ENST00000378913.6
      Conserved Domains (1) summary
      pfam07426
      Location:10137
      Dynactin_p22; Dynactin subunit p22
    3. NM_001281427.2NP_001268356.1  dynactin subunit 3 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (5) is shorter and contains a distinct internal segment, compared to isoform 1.
      Source sequence(s)
      AW953496, CN257020, DA212054
      Consensus CDS
      CCDS65029.1
      UniProtKB/TrEMBL
      X6RCK5, X6RLR1
      Related
      ENSP00000432915.2, ENST00000477738.6
      Conserved Domains (1) summary
      pfam07426
      Location:10160
      Dynactin_p22; Dynactin subunit p22
    4. NM_007234.5NP_009165.1  dynactin subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_009165.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC107697, CN257020, DA212054
      Consensus CDS
      CCDS6560.1
      UniProtKB/Swiss-Prot
      A6NII7, B2RBM5, O75935, Q5T1I5, Q5T1I7, Q5T8G3, Q9BPU8
      UniProtKB/TrEMBL
      X6RCK5
      Related
      ENSP00000259632.7, ENST00000259632.12
      Conserved Domains (1) summary
      pfam07426
      Location:10170
      Dynactin_p22; Dynactin subunit p22
    5. NM_024348.4NP_077324.1  dynactin subunit 3 isoform 2

      See identical proteins and their annotated locations for NP_077324.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a translational frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC000319, CN257020, DA212054
      Consensus CDS
      CCDS6561.1
      UniProtKB/Swiss-Prot
      O75935
      Related
      ENSP00000343986.2, ENST00000341694.6
      Conserved Domains (1) summary
      pfam07426
      Location:10155
      Dynactin_p22; Dynactin subunit p22

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      34613546..34620495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      34632092..34639042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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