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    Arhgap36 Rho GTPase activating protein 36 [ Mus musculus (house mouse) ]

    Gene ID: 75404, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arhgap36provided by MGI
    Official Full Name
    Rho GTPase activating protein 36provided by MGI
    Primary source
    MGI:MGI:1922654
    See related
    Ensembl:ENSMUSG00000036198 AllianceGenome:MGI:1922654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    rho-gap; 1100001E04Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Is expressed in central nervous system; diaphragm; olfactory epithelium; skeletal musculature; and tongue. Orthologous to human ARHGAP36 (Rho GTPase activating protein 36). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 2.3), cerebellum adult (RPKM 1.5) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgap36 in Genome Data Viewer
    Location:
    X A5; X 25.95 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (48537237..48589121)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (49448360..49500244)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ecto-NOX disulfide-thiol exchanger 2 Neighboring gene STARR-seq mESC enhancer starr_47129 Neighboring gene predicted gene, 35210 Neighboring gene STARR-seq mESC enhancer starr_47130 Neighboring gene STARR-seq mESC enhancer starr_47131 Neighboring gene STARR-positive B cell enhancer mm9_chrX:46641346-46641647 Neighboring gene predicted gene, 39513 Neighboring gene predicted gene 14696 Neighboring gene STARR-seq mESC enhancer starr_47132 Neighboring gene serine/arginine repetitive matrix 1 pseudogene Neighboring gene predicted gene 14719

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Arhgap36-dependent activation of Gli transcription factors. Rack PG, et al. Proc Natl Acad Sci U S A, 2014 Jul 29. PMID 25024229, Free PMC Article
    2. Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification. Nam H, et al. Elife, 2019 Jul 15. PMID 31305241, Free PMC Article
    3. Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle. Davie JK, et al. Dev Biol, 2007 Nov 15. PMID 17904117
    4. Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns. Hanley O, et al. Neuron, 2016 Sep 7. PMID 27568519, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AKT stimulates the Shh activity to induce lateral motor columnar motor neurons through the stabilization of ARHGAP36 proteins.
      Title: Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification.
    2. a new mechanism of Gli transcription factor activation and implicate ARHGAP36 dysregulation in the onset and/or progression of GLI-dependent cancers.
      Title: Arhgap36-dependent activation of Gli transcription factors.
    3. Arhgap36 acts in a Smoothened-independent manner to promote the activation of full-length Gli proteins and induces the accumulation of Gli proteins in the primary cilium. Its ability to induce Gli-dependent transcription requires kinesin family member 3a and intraflagellar transport protein 88, proteins that are essential for ciliogenesis. Arhgap36 functionally and biochemically interacts with Suppressor of Fused.
      Title: Arhgap36-dependent activation of Gli transcription factors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 36
    Names
    RhoGAP domain containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081123.2 → NP_001074592.1  rho GTPase-activating protein 36 isoform 1

      See identical proteins and their annotated locations for NP_001074592.1

      Status: VALIDATED

      Source sequence(s)
      AK048167, AL670305, BC090672
      Consensus CDS
      CCDS40963.1
      UniProtKB/Swiss-Prot
      A5D6Q0, A6H5U8, A8IP50, B1AUC6, B1AUC7, B1AUC8
      UniProtKB/TrEMBL
      Z4YJK0
      Related
      ENSMUSP00000110554.4, ENSMUST00000114904.10
      Conserved Domains (1) summary
      cd04376
      Location:215 → 420
      RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...

    2. NM_001356394.1 → NP_001343323.1  rho GTPase-activating protein 36 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL670305, BC090672
      UniProtKB/TrEMBL
      Z4YJK0
      Conserved Domains (1) summary
      cd04376
      Location:199 → 404
      RhoGAP_ARHGAP6; RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      48537237..48589121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318633.2 → XP_017174122.1  rho GTPase-activating protein 36 isoform X2

      UniProtKB/TrEMBL
      Z4YJK0
      Conserved Domains (1) summary
      cd04376
      Location:181 → 386
      RhoGAP_ARHGAP6; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS) ...

    2. XM_006541554.5 → XP_006541617.1  rho GTPase-activating protein 36 isoform X2

      See identical proteins and their annotated locations for XP_006541617.1

      UniProtKB/TrEMBL
      Z4YJK0
      Conserved Domains (1) summary
      cd04376
      Location:181 → 386
      RhoGAP_ARHGAP6; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS) ...

    3. XM_006541555.4 → XP_006541618.1  rho GTPase-activating protein 36 isoform X2

      See identical proteins and their annotated locations for XP_006541618.1

      UniProtKB/TrEMBL
      Z4YJK0
      Conserved Domains (1) summary
      cd04376
      Location:181 → 386
      RhoGAP_ARHGAP6; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS) ...

    4. XM_017318632.3 → XP_017174121.1  rho GTPase-activating protein 36 isoform X1

      UniProtKB/TrEMBL
      Z4YJK0
      Conserved Domains (1) summary
      cd04376
      Location:227 → 432
      RhoGAP_ARHGAP6; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS) ...

    5. XM_030251515.1 → XP_030107375.1  rho GTPase-activating protein 36 isoform X3

      UniProtKB/TrEMBL
      Z4YJK0
      Conserved Domains (1) summary
      cd04376
      Location:128 → 333
      RhoGAP_ARHGAP6; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS) ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AUC7.1 GenPept UniProtKB/Swiss-Prot:B1AUC7

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