SNL1 SIN3-like 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SNL1
Official Full Name: SIN3-like 1
Primary source: TAIR:AT3G01320
Locus tag: AT3G01320
See related: Araport:AT3G01320
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: SIN3-like 1; T22N4.5; T22N4_5
Summary: Encodes SIN3-like 1, a homolog of the transcriptional repressor SIN3 (AT1G24190).
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Genomic context

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See SNL1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 22

Sequence:: Chromosome: 3; NC_003074.8 (106294..113679)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNL1 and SNL2 regulate seed dormancy by mediating the abscisic acid (ABA)-ethylene antagonism in Arabidopsis. SNL1 and SNL2 could represent a cross-link point of the ABA and ethylene pathways in the regulation of seed dormancy.
Title: Arabidopsis paired amphipathic helix proteins SNL1 and SNL2 redundantly regulate primary seed dormancy via abscisic acid-ethylene antagonism mediated by histone deacetylation.
full-length SNL1 was shown to repress transcription in a histone-deacetylase-dependent manner, demonstrating the conserved nature of SIN3 function
Title: PAH-domain-specific interactions of the Arabidopsis transcription coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS EARLY2 Myb-DNA binding factors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001202860.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Sin3-type complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: SIN3-like 1

NP_001189789.1

SIN3-like 1 (SNL1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Histone deacetylase interacting (InterPro:IPR013194), Paired amphipathic helix (InterPro:IPR003822); BEST Arabidopsis thaliana protein match is: SIN3-like 2 (TAIR:AT5G15020.2).

NP_186781.4

SIN3-like 1 (SNL1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Histone deacetylase interacting (InterPro:IPR013194), Paired amphipathic helix (InterPro:IPR003822); BEST Arabidopsis thaliana protein match is: SIN3-like 2 (TAIR:AT5G15020.2); Has 8924 Blast hits to 4656 proteins in 481 species: Archae - 44; Bacteria - 2736; Metazoa - 2712; Fungi - 1300; Plants - 581; Viruses - 181; Other Eukaryotes - 1370 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

106294..113679

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_110998.5 → NP_186781.4 SIN3-like 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_186781.4

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SRH9

UniProtKB/TrEMBL

A0A178VAF5, A0A654FDK6

Conserved Domains (5) summary

smart00761
Location:467 → 563

HDAC_interact; Histone deacetylase (HDAC) interacting

COG5602
Location:13 → 672

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

pfam02671
Location:74 → 118

PAH; Paired amphipathic helix repeat

pfam16879
Location:1100 → 1343

Sin3a_C; C-terminal domain of Sin3a protein

cl11968
Location:46 → 144

harmonin_N_like; N-terminal protein-binding module of harmonin and similar domains, also known as HHD (harmonin homology domain)
NM_001202860.2 → NP_001189789.1 SIN3-like 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189789.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VAF5, A0A654FDK6, F4JAQ8

Conserved Domains (5) summary

smart00761
Location:455 → 551

HDAC_interact; Histone deacetylase (HDAC) interacting

COG5602
Location:13 → 660

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

pfam02671
Location:74 → 118

PAH; Paired amphipathic helix repeat

pfam16879
Location:1088 → 1331

Sin3a_C; C-terminal domain of Sin3a protein

cl11968
Location:46 → 144

harmonin_N_like; N-terminal protein-binding module of harmonin and similar domains, also known as HHD (harmonin homology domain)