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Conserved domains on  [gi|334185014|ref|NP_001189789|]
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SIN3-like 1 [Arabidopsis thaliana]

Protein Classification

Sin3 family protein( domain architecture ID 13432989)

Sin3 family protein similar to Homo sapiens paired amphipathic helix proteins Sin3a and Sin3b, which act as transcriptional repressors

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sin3 super family cl35027
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
13-660 4.82e-89

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


The actual alignment was detected with superfamily member COG5602:

Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 314.93  E-value: 4.82e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014   13 SQFRRPLGSSRGQLCGQSPVHGSGDTEEEEEGGSRRVS-QKLTTNDALSYLREVKEMFQDQREKYDRFLEVMKDFKAQRT 91
Cdd:COG5602    85 EDVEQILSSLAGDNPDPSTDHGSASNQNMERSPPPRIPyRPLDVSDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKSQAI 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014   92 DTGGVIARVKELFKGHNNLIYGFNTFLPKGYEITLIEED----------------------------------------- 130
Cdd:COG5602   165 DTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLPQpngsrlhvttpqgplssppvqssyyvapcnhdqrtshptlp 244
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  131 ---------------DALPKKTVEFEQAINFVNKIKMRFKHDEHVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDL 195
Cdd:COG5602   245 sdsqpepsapshmpsDARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDL 324
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  196 LEQFTRFLPASlpSHSAAQhSRSQAQQYSDRGSDPPLLHQMQVEKERRRERavalrgdysverydlnddktmvkiQREQR 275
Cdd:COG5602   325 LEEFKEFLPDS--SVSAEQ-STANAQKPSKRLPPIGSFSLPTAAPEQNRPS------------------------LLWES 377
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  276 KRLDKENRARRGRDLDDREagqdnLHHFPEKRKSSrraealeaYSGMYKQAFVFCEKVKDRLCSQDDYQTFLKCLNIFSN 355
Cdd:COG5602   378 PRSISNISRYRADLLTSFS-----RNFVPIRIHMP--------ISHLSNESEDFFERIKQYLKDKNLYHEFLKLLNLYSQ 444
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  356 GIIQRKDLQNLVSDLLGKFPDLMDEFNQFFERCESItdgfqrlagvmskklfssEEQLSRPMKveekesehkpeleavke 435
Cdd:COG5602   445 KIIDKNDLVERLFAFLGSNEELIRWFKAFINYSEPE------------------KEPLRETRK----------------- 489
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  436 teqckkeymgksiqelDLSDCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSV-TSGSEDYSFKHMRRNQYEESL 514
Cdd:COG5602   490 ----------------DLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHpTWASEDSGFIAHRKNQYEEAL 553
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  515 FRCEDDRFELDMLLESVSSAARSAESLLNIITEKKISFSGSFRIEDHFTALNLRCIER----LYG-DHGLDVIDILNKNP 589
Cdd:COG5602   554 FKIEEERYEYDRHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKvikkVYDkEHAPEILEALLKKP 633
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185014  590 ATALPVILTRLKQKQGEWKKCRDDFDKVWANVYAKNHYKSLDHRSFYFKQQDSKNLSAKSLLAEIKELKEK 660
Cdd:COG5602   634 HVTIPIVLKRLKMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEIDDRSQA 704
Sin3a_C pfam16879
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at ...
1088-1331 4.85e-52

C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at the C-terminus of the co-repressor Sin3a, and downstream of family Sin3_corepress, pfam08295.


:

Pssm-ID: 465294  Cd Length: 281  Bit Score: 184.73  E-value: 4.85e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  1088 FYGNDDFYVLFRLHQILYERILYAKRNCS--GGELKSKN-------------------LKDTNAGDPYARFMRVLYGLLD 1146
Cdd:pfam16879    1 FFANTTIYVFFRLFQILYERLLKIKQAEEevAEEIKRRKankpakdlgliskeledfgLDLSDPEDYYPQLLELCERLID 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  1147 GSAENTKFEDECRAIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYY-ENVRVLV-H 1224
Cdd:pfam16879   81 GEIDQSQFEDSLRQMYGNKAYKLYTIDKLIQALVKQLQTIVSDSKSQELLELFEKERSKEETTAQDEILYrKQAEKLLgK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  1225 EENIYRLECSSLPSRLSIQLMDNIIEKPEAYAVSMDPTFASYMQ-------TELLSVSSGKKeeghdIVLQRNLTGL--- 1294
Cdd:pfam16879  161 DENLFRIEWNPQSKTVTIQLLDKDDLTFDDDELTAEERWQYYVSsyvlshpTEGVPRSKLRK-----PFLKRNLKAEree 235
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 334185014  1295 ---------YDLCKAMEGVEVVNGLECKMSCSSYKIAYVLDTEDYF 1331
Cdd:pfam16879  236 eedeeeepkADAEEPEGPLEFESGLEIRICLNSYKLFYVPGTEDYF 281
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
919-1060 2.16e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 42.68  E-value: 2.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014   919 LANGLRSDS-SKGTRNSDDPEGPSRNEKEEGELS-----PNGDFEDNFGVYKDHGVKSTSKPEN-SAEAEVEADAEVENE 991
Cdd:TIGR00927  630 LSKGDVAEAeHTGERTGEEGERPTEAEGENGEESggeaeQEGETETKGENESEGEIPAERKGEQeGEGEIEAKEADHKGE 709
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334185014   992 DDADDVDSENASEASGTESGGDVCSQDEDREEENGEHDEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1060
Cdd:TIGR00927  710 TEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDE 778
 
Name Accession Description Interval E-value
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
13-660 4.82e-89

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 314.93  E-value: 4.82e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014   13 SQFRRPLGSSRGQLCGQSPVHGSGDTEEEEEGGSRRVS-QKLTTNDALSYLREVKEMFQDQREKYDRFLEVMKDFKAQRT 91
Cdd:COG5602    85 EDVEQILSSLAGDNPDPSTDHGSASNQNMERSPPPRIPyRPLDVSDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKSQAI 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014   92 DTGGVIARVKELFKGHNNLIYGFNTFLPKGYEITLIEED----------------------------------------- 130
Cdd:COG5602   165 DTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLPQpngsrlhvttpqgplssppvqssyyvapcnhdqrtshptlp 244
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  131 ---------------DALPKKTVEFEQAINFVNKIKMRFKHDEHVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDL 195
Cdd:COG5602   245 sdsqpepsapshmpsDARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDL 324
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  196 LEQFTRFLPASlpSHSAAQhSRSQAQQYSDRGSDPPLLHQMQVEKERRRERavalrgdysverydlnddktmvkiQREQR 275
Cdd:COG5602   325 LEEFKEFLPDS--SVSAEQ-STANAQKPSKRLPPIGSFSLPTAAPEQNRPS------------------------LLWES 377
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  276 KRLDKENRARRGRDLDDREagqdnLHHFPEKRKSSrraealeaYSGMYKQAFVFCEKVKDRLCSQDDYQTFLKCLNIFSN 355
Cdd:COG5602   378 PRSISNISRYRADLLTSFS-----RNFVPIRIHMP--------ISHLSNESEDFFERIKQYLKDKNLYHEFLKLLNLYSQ 444
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  356 GIIQRKDLQNLVSDLLGKFPDLMDEFNQFFERCESItdgfqrlagvmskklfssEEQLSRPMKveekesehkpeleavke 435
Cdd:COG5602   445 KIIDKNDLVERLFAFLGSNEELIRWFKAFINYSEPE------------------KEPLRETRK----------------- 489
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  436 teqckkeymgksiqelDLSDCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSV-TSGSEDYSFKHMRRNQYEESL 514
Cdd:COG5602   490 ----------------DLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHpTWASEDSGFIAHRKNQYEEAL 553
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  515 FRCEDDRFELDMLLESVSSAARSAESLLNIITEKKISFSGSFRIEDHFTALNLRCIER----LYG-DHGLDVIDILNKNP 589
Cdd:COG5602   554 FKIEEERYEYDRHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKvikkVYDkEHAPEILEALLKKP 633
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185014  590 ATALPVILTRLKQKQGEWKKCRDDFDKVWANVYAKNHYKSLDHRSFYFKQQDSKNLSAKSLLAEIKELKEK 660
Cdd:COG5602   634 HVTIPIVLKRLKMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEIDDRSQA 704
Sin3a_C pfam16879
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at ...
1088-1331 4.85e-52

C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at the C-terminus of the co-repressor Sin3a, and downstream of family Sin3_corepress, pfam08295.


Pssm-ID: 465294  Cd Length: 281  Bit Score: 184.73  E-value: 4.85e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  1088 FYGNDDFYVLFRLHQILYERILYAKRNCS--GGELKSKN-------------------LKDTNAGDPYARFMRVLYGLLD 1146
Cdd:pfam16879    1 FFANTTIYVFFRLFQILYERLLKIKQAEEevAEEIKRRKankpakdlgliskeledfgLDLSDPEDYYPQLLELCERLID 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  1147 GSAENTKFEDECRAIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYY-ENVRVLV-H 1224
Cdd:pfam16879   81 GEIDQSQFEDSLRQMYGNKAYKLYTIDKLIQALVKQLQTIVSDSKSQELLELFEKERSKEETTAQDEILYrKQAEKLLgK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  1225 EENIYRLECSSLPSRLSIQLMDNIIEKPEAYAVSMDPTFASYMQ-------TELLSVSSGKKeeghdIVLQRNLTGL--- 1294
Cdd:pfam16879  161 DENLFRIEWNPQSKTVTIQLLDKDDLTFDDDELTAEERWQYYVSsyvlshpTEGVPRSKLRK-----PFLKRNLKAEree 235
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 334185014  1295 ---------YDLCKAMEGVEVVNGLECKMSCSSYKIAYVLDTEDYF 1331
Cdd:pfam16879  236 eedeeeepkADAEEPEGPLEFESGLEIRICLNSYKLFYVPGTEDYF 281
HDAC_interact smart00761
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It ...
455-551 5.38e-45

Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.


Pssm-ID: 214808 [Multi-domain]  Cd Length: 102  Bit Score: 157.47  E-value: 5.38e-45
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014    455 DCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSG-SEDYSFKHMRRNQYEESLFRCEDDRFELDMLLESVSS 533
Cdd:smart00761    1 NCERCGPSYRLLPKSEKQPKCSGRDELCKEVLNDTWVSHPTWaSEDSGFVAHRKNQYEEALFRCEDERFELDMVIESNSS 80
                            90
                    ....*....|....*...
gi 334185014    534 AARSAESLLNIITEKKIS 551
Cdd:smart00761   81 TIKLLEEILNKIEDMSDE 98
Sin3_corepress pfam08295
Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms ...
457-550 1.61e-39

Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.


Pssm-ID: 462418  Cd Length: 97  Bit Score: 141.60  E-value: 1.61e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014   457 ECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSG-SEDY-SFKHMRRNQYEESLFRCEDDRFELDMLLESVSSA 534
Cdd:pfam08295    1 KRCGPSYRLLPKSEPQLPCSGRDELCWEVLNDEWVSHPTWaSEDSgSFVAHRKNQYEEALFRCEDERYEYDMHIESNLRT 80
                           90
                   ....*....|....*.
gi 334185014   535 ARSAESLLNIITEKKI 550
Cdd:pfam08295   81 IKLLEPIAEKINNMSP 96
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
1080-1329 5.09e-13

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 74.18  E-value: 5.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1080 ERTKDLQVFYGNDDFYVLFRLHQILYERILYAKRncsggeLKSKNLKDTNAGDPYARFMRVLYGLLDGSAENTKFEDECR 1159
Cdd:COG5602   852 EKQVIALTEFGNSLMYVFFRLRFDSYERLYEIKK------IKEAVTIGMMEPGHYENELWDSYRLIFGALTPCEFEKYLR 925
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1160 AIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYYEN-VR-VLVHEENIYRLECSSLP 1237
Cdd:COG5602   926 PFYNNTCYKIYTIDRLRQSLKKQLHPITYDIKYIAKSELFEMNSAASSKRKQDQTKYRLeVEsLLNPDEILFRFCWINKF 1005
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1238 SRLSIQLM---DNIIEKPEA-----------YAVSMDPTFASYMQTEL----LSVSSGKKEEGHDIVLQRNLTGLYdlck 1299
Cdd:COG5602  1006 KSFGIQIMkraDLTVDQSLDtqrvwkyyvqsYAIQHLTEGISYKNYKCpflcRNIEKERTVEQLVSRLQTKLLRSH---- 1081
                         250       260       270
                  ....*....|....*....|....*....|
gi 334185014 1300 amegvEVVNGLECKMSCSSYKIAYVLDTED 1329
Cdd:COG5602  1082 -----ELVSGLQAFLCLDTFKLLYLPNTED 1106
HN_RTEL1 cd13932
harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL); ...
46-144 4.54e-04

harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL); Mouse Rtel is an essential protein required for the maintenance of both telomeric and genomic stability. RTEL1 appears to maintain genome stability by suppressing homologous recombination (HR). In vitro, purified human and insect RTEL1 have been shown to promote the disassembly of D loop recombination intermediates, in a reaction dependent upon ATP hydrolysis. Human RTEL1 is implicated in the etiology of Dyskeratosis congenital (DC, is an inherited bone marrow failure and cancer predisposition syndrome). Point mutations in its helicase domains, and truncations which result in loss of its C-terminus have been discovered in DC families. RTEL1 is also a candidate gene influencing glioma susceptibility. The C-terminal domain of RTEL1, represented here, appears similar to the N-terminal domain of the scaffolding protein harmonin.


Pssm-ID: 259826 [Multi-domain]  Cd Length: 99  Bit Score: 40.72  E-value: 4.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014   46 SRRVSQKLTTNDALSYLREVKEMFqdQREKYDRFLEVMKDFKaQRTDTGGVIARVKELFKGHN--NLIYGFNTFLPkgye 123
Cdd:cd13932     8 SSSSGAKPAPESASAFLREVKQKL--SAAEYRQFSAALQAYK-TGDDFEQLLAVLAELFAEPErhPLLRGFRRFVR---- 80
                          90       100
                  ....*....|....*....|.
gi 334185014  124 itlieeddalPKKTVEFEQAI 144
Cdd:cd13932    81 ----------PHHKKEFDERC 91
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
919-1060 2.16e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 42.68  E-value: 2.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014   919 LANGLRSDS-SKGTRNSDDPEGPSRNEKEEGELS-----PNGDFEDNFGVYKDHGVKSTSKPEN-SAEAEVEADAEVENE 991
Cdd:TIGR00927  630 LSKGDVAEAeHTGERTGEEGERPTEAEGENGEESggeaeQEGETETKGENESEGEIPAERKGEQeGEGEIEAKEADHKGE 709
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334185014   992 DDADDVDSENASEASGTESGGDVCSQDEDREEENGEHDEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1060
Cdd:TIGR00927  710 TEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDE 778
PHA03169 PHA03169
hypothetical protein; Provisional
874-1060 4.78e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 41.11  E-value: 4.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  874 GKEVLPGAHEIQAKPSDTLTDIHHDVDSIETVHSTQGGDVGNSIVLANG---LRSDSSKGTRNSDDPEGPSRNEKEEGEL 950
Cdd:PHA03169   34 GRRRGTAARAAKPAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESRHGekeERGQGGPSGSGSESVGSPTPSPSGSAEE 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  951 SPNGDFEDNFGVYKDHGVKSTSKPEnsaeaeveadaevenEDDADDVDSENASEASGTESGGDVCSQ--DEDREEENGEH 1028
Cdd:PHA03169  114 LASGLSPENTSGSSPESPASHSPPP---------------SPPSHPGPHEPAPPESHNPSPNQQPSSflQPSHEDSPEEP 178
                         170       180       190
                  ....*....|....*....|....*....|..
gi 334185014 1029 DEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1060
Cdd:PHA03169  179 EPPTSEPEPDSPGPPQSETPTSSPPPQSPPDE 210
 
Name Accession Description Interval E-value
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
13-660 4.82e-89

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 314.93  E-value: 4.82e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014   13 SQFRRPLGSSRGQLCGQSPVHGSGDTEEEEEGGSRRVS-QKLTTNDALSYLREVKEMFQDQREKYDRFLEVMKDFKAQRT 91
Cdd:COG5602    85 EDVEQILSSLAGDNPDPSTDHGSASNQNMERSPPPRIPyRPLDVSDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKSQAI 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014   92 DTGGVIARVKELFKGHNNLIYGFNTFLPKGYEITLIEED----------------------------------------- 130
Cdd:COG5602   165 DTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLPQpngsrlhvttpqgplssppvqssyyvapcnhdqrtshptlp 244
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  131 ---------------DALPKKTVEFEQAINFVNKIKMRFKHDEHVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDL 195
Cdd:COG5602   245 sdsqpepsapshmpsDARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDL 324
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  196 LEQFTRFLPASlpSHSAAQhSRSQAQQYSDRGSDPPLLHQMQVEKERRRERavalrgdysverydlnddktmvkiQREQR 275
Cdd:COG5602   325 LEEFKEFLPDS--SVSAEQ-STANAQKPSKRLPPIGSFSLPTAAPEQNRPS------------------------LLWES 377
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  276 KRLDKENRARRGRDLDDREagqdnLHHFPEKRKSSrraealeaYSGMYKQAFVFCEKVKDRLCSQDDYQTFLKCLNIFSN 355
Cdd:COG5602   378 PRSISNISRYRADLLTSFS-----RNFVPIRIHMP--------ISHLSNESEDFFERIKQYLKDKNLYHEFLKLLNLYSQ 444
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  356 GIIQRKDLQNLVSDLLGKFPDLMDEFNQFFERCESItdgfqrlagvmskklfssEEQLSRPMKveekesehkpeleavke 435
Cdd:COG5602   445 KIIDKNDLVERLFAFLGSNEELIRWFKAFINYSEPE------------------KEPLRETRK----------------- 489
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  436 teqckkeymgksiqelDLSDCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSV-TSGSEDYSFKHMRRNQYEESL 514
Cdd:COG5602   490 ----------------DLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHpTWASEDSGFIAHRKNQYEEAL 553
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  515 FRCEDDRFELDMLLESVSSAARSAESLLNIITEKKISFSGSFRIEDHFTALNLRCIER----LYG-DHGLDVIDILNKNP 589
Cdd:COG5602   554 FKIEEERYEYDRHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKvikkVYDkEHAPEILEALLKKP 633
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185014  590 ATALPVILTRLKQKQGEWKKCRDDFDKVWANVYAKNHYKSLDHRSFYFKQQDSKNLSAKSLLAEIKELKEK 660
Cdd:COG5602   634 HVTIPIVLKRLKMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEIDDRSQA 704
Sin3a_C pfam16879
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at ...
1088-1331 4.85e-52

C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at the C-terminus of the co-repressor Sin3a, and downstream of family Sin3_corepress, pfam08295.


Pssm-ID: 465294  Cd Length: 281  Bit Score: 184.73  E-value: 4.85e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  1088 FYGNDDFYVLFRLHQILYERILYAKRNCS--GGELKSKN-------------------LKDTNAGDPYARFMRVLYGLLD 1146
Cdd:pfam16879    1 FFANTTIYVFFRLFQILYERLLKIKQAEEevAEEIKRRKankpakdlgliskeledfgLDLSDPEDYYPQLLELCERLID 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  1147 GSAENTKFEDECRAIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYY-ENVRVLV-H 1224
Cdd:pfam16879   81 GEIDQSQFEDSLRQMYGNKAYKLYTIDKLIQALVKQLQTIVSDSKSQELLELFEKERSKEETTAQDEILYrKQAEKLLgK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  1225 EENIYRLECSSLPSRLSIQLMDNIIEKPEAYAVSMDPTFASYMQ-------TELLSVSSGKKeeghdIVLQRNLTGL--- 1294
Cdd:pfam16879  161 DENLFRIEWNPQSKTVTIQLLDKDDLTFDDDELTAEERWQYYVSsyvlshpTEGVPRSKLRK-----PFLKRNLKAEree 235
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 334185014  1295 ---------YDLCKAMEGVEVVNGLECKMSCSSYKIAYVLDTEDYF 1331
Cdd:pfam16879  236 eedeeeepkADAEEPEGPLEFESGLEIRICLNSYKLFYVPGTEDYF 281
HDAC_interact smart00761
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It ...
455-551 5.38e-45

Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.


Pssm-ID: 214808 [Multi-domain]  Cd Length: 102  Bit Score: 157.47  E-value: 5.38e-45
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014    455 DCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSG-SEDYSFKHMRRNQYEESLFRCEDDRFELDMLLESVSS 533
Cdd:smart00761    1 NCERCGPSYRLLPKSEKQPKCSGRDELCKEVLNDTWVSHPTWaSEDSGFVAHRKNQYEEALFRCEDERFELDMVIESNSS 80
                            90
                    ....*....|....*...
gi 334185014    534 AARSAESLLNIITEKKIS 551
Cdd:smart00761   81 TIKLLEEILNKIEDMSDE 98
Sin3_corepress pfam08295
Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms ...
457-550 1.61e-39

Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.


Pssm-ID: 462418  Cd Length: 97  Bit Score: 141.60  E-value: 1.61e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014   457 ECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSG-SEDY-SFKHMRRNQYEESLFRCEDDRFELDMLLESVSSA 534
Cdd:pfam08295    1 KRCGPSYRLLPKSEPQLPCSGRDELCWEVLNDEWVSHPTWaSEDSgSFVAHRKNQYEEALFRCEDERYEYDMHIESNLRT 80
                           90
                   ....*....|....*.
gi 334185014   535 ARSAESLLNIITEKKI 550
Cdd:pfam08295   81 IKLLEPIAEKINNMSP 96
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
159-203 1.86e-15

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 71.30  E-value: 1.86e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 334185014   159 HVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDLLEQFTRFL 203
Cdd:pfam02671    1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
74-118 3.21e-15

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 70.53  E-value: 3.21e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 334185014    74 EKYDRFLEVMKDFKAQRTDTGGVIARVKELFKGHNNLIYGFNTFL 118
Cdd:pfam02671    1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
341-385 2.26e-13

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 65.52  E-value: 2.26e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 334185014   341 DDYQTFLKCLNIFSNGIIQRKDLQNLVSDLLGKFPDLMDEFNQFF 385
Cdd:pfam02671    1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
1080-1329 5.09e-13

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 74.18  E-value: 5.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1080 ERTKDLQVFYGNDDFYVLFRLHQILYERILYAKRncsggeLKSKNLKDTNAGDPYARFMRVLYGLLDGSAENTKFEDECR 1159
Cdd:COG5602   852 EKQVIALTEFGNSLMYVFFRLRFDSYERLYEIKK------IKEAVTIGMMEPGHYENELWDSYRLIFGALTPCEFEKYLR 925
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1160 AIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYYEN-VR-VLVHEENIYRLECSSLP 1237
Cdd:COG5602   926 PFYNNTCYKIYTIDRLRQSLKKQLHPITYDIKYIAKSELFEMNSAASSKRKQDQTKYRLeVEsLLNPDEILFRFCWINKF 1005
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1238 SRLSIQLM---DNIIEKPEA-----------YAVSMDPTFASYMQTEL----LSVSSGKKEEGHDIVLQRNLTGLYdlck 1299
Cdd:COG5602  1006 KSFGIQIMkraDLTVDQSLDtqrvwkyyvqsYAIQHLTEGISYKNYKCpflcRNIEKERTVEQLVSRLQTKLLRSH---- 1081
                         250       260       270
                  ....*....|....*....|....*....|
gi 334185014 1300 amegvEVVNGLECKMSCSSYKIAYVLDTED 1329
Cdd:COG5602  1082 -----ELVSGLQAFLCLDTFKLLYLPNTED 1106
HN_RTEL1 cd13932
harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL); ...
46-144 4.54e-04

harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL); Mouse Rtel is an essential protein required for the maintenance of both telomeric and genomic stability. RTEL1 appears to maintain genome stability by suppressing homologous recombination (HR). In vitro, purified human and insect RTEL1 have been shown to promote the disassembly of D loop recombination intermediates, in a reaction dependent upon ATP hydrolysis. Human RTEL1 is implicated in the etiology of Dyskeratosis congenital (DC, is an inherited bone marrow failure and cancer predisposition syndrome). Point mutations in its helicase domains, and truncations which result in loss of its C-terminus have been discovered in DC families. RTEL1 is also a candidate gene influencing glioma susceptibility. The C-terminal domain of RTEL1, represented here, appears similar to the N-terminal domain of the scaffolding protein harmonin.


Pssm-ID: 259826 [Multi-domain]  Cd Length: 99  Bit Score: 40.72  E-value: 4.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014   46 SRRVSQKLTTNDALSYLREVKEMFqdQREKYDRFLEVMKDFKaQRTDTGGVIARVKELFKGHN--NLIYGFNTFLPkgye 123
Cdd:cd13932     8 SSSSGAKPAPESASAFLREVKQKL--SAAEYRQFSAALQAYK-TGDDFEQLLAVLAELFAEPErhPLLRGFRRFVR---- 80
                          90       100
                  ....*....|....*....|.
gi 334185014  124 itlieeddalPKKTVEFEQAI 144
Cdd:cd13932    81 ----------PHHKKEFDERC 91
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
919-1060 2.16e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 42.68  E-value: 2.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014   919 LANGLRSDS-SKGTRNSDDPEGPSRNEKEEGELS-----PNGDFEDNFGVYKDHGVKSTSKPEN-SAEAEVEADAEVENE 991
Cdd:TIGR00927  630 LSKGDVAEAeHTGERTGEEGERPTEAEGENGEESggeaeQEGETETKGENESEGEIPAERKGEQeGEGEIEAKEADHKGE 709
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334185014   992 DDADDVDSENASEASGTESGGDVCSQDEDREEENGEHDEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1060
Cdd:TIGR00927  710 TEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDE 778
PHA03169 PHA03169
hypothetical protein; Provisional
874-1060 4.78e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 41.11  E-value: 4.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  874 GKEVLPGAHEIQAKPSDTLTDIHHDVDSIETVHSTQGGDVGNSIVLANG---LRSDSSKGTRNSDDPEGPSRNEKEEGEL 950
Cdd:PHA03169   34 GRRRGTAARAAKPAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESRHGekeERGQGGPSGSGSESVGSPTPSPSGSAEE 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  951 SPNGDFEDNFGVYKDHGVKSTSKPEnsaeaeveadaevenEDDADDVDSENASEASGTESGGDVCSQ--DEDREEENGEH 1028
Cdd:PHA03169  114 LASGLSPENTSGSSPESPASHSPPP---------------SPPSHPGPHEPAPPESHNPSPNQQPSSflQPSHEDSPEEP 178
                         170       180       190
                  ....*....|....*....|....*....|..
gi 334185014 1029 DEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1060
Cdd:PHA03169  179 EPPTSEPEPDSPGPPQSETPTSSPPPQSPPDE 210
PHA03169 PHA03169
hypothetical protein; Provisional
903-1043 5.31e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 40.72  E-value: 5.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014  903 ETVHSTQGGDVGNSIVLANGLR-SDSSKGTRNSDDPEGPSRNEKEEGELSPNGDFEDNFGVYKDHGvKSTSKPENSAEAE 981
Cdd:PHA03169   98 ESVGSPTPSPSGSAEELASGLSpENTSGSSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQP-SSFLQPSHEDSPE 176
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334185014  982 VEADAEVENEDDADDV-DSENASEASGTESGGDvcSQDEDREEENGEHDEIDGK--AESEGEAEG 1043
Cdd:PHA03169  177 EPEPPTSEPEPDSPGPpQSETPTSSPPPQSPPD--EPGEPQSPTPQQAPSPNTQqaVEHEDEPTE 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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