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    icmt-1 Protein-S-isoprenylcysteine O-methyltransferase [ Caenorhabditis elegans ]

    Gene ID: 172106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    icmt-1
    Official Full Name
    Protein-S-isoprenylcysteine O-methyltransferase
    Primary source
    WormBase:WBGene00017673
    Locus tag
    CELE_F21F3.3
    See related
    AllianceGenome:WB:WBGene00017673
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. Predicted to be involved in C-terminal protein methylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human ICMT (isoprenylcysteine carboxyl methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See icmt-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (4901918..4903264)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene B box-type domain-containing protein Neighboring gene ncRNA Neighboring gene DUF4708 domain-containing protein Neighboring gene Acetylcholine receptor subunit alpha-type unc-38 Neighboring gene Protein kinase domain-containing protein Neighboring gene putative peptidyl-alpha-hydroxyglycine alpha-amidating lyase pgal-1 Neighboring gene DUF4149 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. Li J, et al. PLoS Biol, 2008 Sep 30. PMID 18828672, Free PMC Article
    2. Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans. Ludewig AH, et al. Genes Nutr, 2014 Jan. PMID 24311442, Free PMC Article
    3. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in C-terminal protein methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein-S-isoprenylcysteine O-methyltransferase
    NP_491473.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4901918..4903264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059072.4 → NP_491473.1  Protein-S-isoprenylcysteine O-methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491473.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91266
      Conserved Domains (1) summary
      pfam04140
      Location:179 → 269
      ICMT; Isoprenylcysteine carboxyl methyltransferase (ICMT) family
    Nucleotide Protein
    Heading Accession and Version

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