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Conserved domains on  [gi|17506725|ref|NP_491473|]
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Protein-S-isoprenylcysteine O-methyltransferase [Caenorhabditis elegans]

Protein Classification

protein-S-isoprenylcysteine O-methyltransferase( domain architecture ID 10514227)

protein-S-isoprenylcysteine O-methyltransferase catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ICMT pfam04140
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
179-269 7.54e-27

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


:

Pssm-ID: 427740 [Multi-domain]  Cd Length: 95  Bit Score: 100.51  E-value: 7.54e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506725   179 CIIGEIVRKVGMVHAGLAFTHLMArtKRSGHTLINTGIYAYMRHPGYFGWFIWAVSTQIVLCNP--ISFVIYTFVTWRFF 256
Cdd:pfam04140   5 FLFGQILRKWAMVTLGRYWNHRVA--ILPDHRLVTSGPYRYLRHPNYFGWFIWEIATQPLLCNAwyTALVFYALNAWLLF 82
                          90
                  ....*....|...
gi 17506725   257 ANRIEIEEKDLIS 269
Cdd:pfam04140  83 SVRIRQEEKALAH 95
 
Name Accession Description Interval E-value
ICMT pfam04140
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
179-269 7.54e-27

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


Pssm-ID: 427740 [Multi-domain]  Cd Length: 95  Bit Score: 100.51  E-value: 7.54e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506725   179 CIIGEIVRKVGMVHAGLAFTHLMArtKRSGHTLINTGIYAYMRHPGYFGWFIWAVSTQIVLCNP--ISFVIYTFVTWRFF 256
Cdd:pfam04140   5 FLFGQILRKWAMVTLGRYWNHRVA--ILPDHRLVTSGPYRYLRHPNYFGWFIWEIATQPLLCNAwyTALVFYALNAWLLF 82
                          90
                  ....*....|...
gi 17506725   257 ANRIEIEEKDLIS 269
Cdd:pfam04140  83 SVRIRQEEKALAH 95
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
175-283 6.52e-16

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 72.12  E-value: 6.52e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506725 175 GTFGCIIGEIVRKVGMVHAGLAFTHLMARTKrsGHTLINTGIYAYMRHPGYFGWFIWAVSTQIVLCNPISFVIYTFVTWr 254
Cdd:COG2020   2 GLVLILLGLLLRLWAVLTLGRSWTTLVPPRK--AHRLVTTGPYRYVRHPMYLGFLLLLLGLALLLGSLLALLLALLLLL- 78
                        90       100
                ....*....|....*....|....*....
gi 17506725 255 FFANRIEIEEKDLISFFGDDYAEYQRKTW 283
Cdd:COG2020  79 LYVLRIRREERRLRARFGEEYRAYAARVP 107
isopcys_mtase NF040696
protein-S-isoprenylcysteine O-methyltransferase;
206-282 4.98e-10

protein-S-isoprenylcysteine O-methyltransferase;


Pssm-ID: 468660  Cd Length: 190  Bit Score: 57.64  E-value: 4.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506725  206 RSGHTLINTGIYAYMRHPGYFGWFIWAVSTQIVLCNPI-------SFVIYTFVtwrffanRIEIEEKDLISFFGDDYAEY 278
Cdd:NF040696 107 REGHTLVTSGVYRYIRHPMYAAFWLWAIAQALLLPNWIaglaglvGFGILYFL-------RVPREEQMMLETFGDEYRAY 179

                 ....
gi 17506725  279 QRKT 282
Cdd:NF040696 180 MQRT 183
 
Name Accession Description Interval E-value
ICMT pfam04140
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
179-269 7.54e-27

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


Pssm-ID: 427740 [Multi-domain]  Cd Length: 95  Bit Score: 100.51  E-value: 7.54e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506725   179 CIIGEIVRKVGMVHAGLAFTHLMArtKRSGHTLINTGIYAYMRHPGYFGWFIWAVSTQIVLCNP--ISFVIYTFVTWRFF 256
Cdd:pfam04140   5 FLFGQILRKWAMVTLGRYWNHRVA--ILPDHRLVTSGPYRYLRHPNYFGWFIWEIATQPLLCNAwyTALVFYALNAWLLF 82
                          90
                  ....*....|...
gi 17506725   257 ANRIEIEEKDLIS 269
Cdd:pfam04140  83 SVRIRQEEKALAH 95
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
175-283 6.52e-16

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 72.12  E-value: 6.52e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506725 175 GTFGCIIGEIVRKVGMVHAGLAFTHLMARTKrsGHTLINTGIYAYMRHPGYFGWFIWAVSTQIVLCNPISFVIYTFVTWr 254
Cdd:COG2020   2 GLVLILLGLLLRLWAVLTLGRSWTTLVPPRK--AHRLVTTGPYRYVRHPMYLGFLLLLLGLALLLGSLLALLLALLLLL- 78
                        90       100
                ....*....|....*....|....*....
gi 17506725 255 FFANRIEIEEKDLISFFGDDYAEYQRKTW 283
Cdd:COG2020  79 LYVLRIRREERRLRARFGEEYRAYAARVP 107
isopcys_mtase NF040696
protein-S-isoprenylcysteine O-methyltransferase;
206-282 4.98e-10

protein-S-isoprenylcysteine O-methyltransferase;


Pssm-ID: 468660  Cd Length: 190  Bit Score: 57.64  E-value: 4.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506725  206 RSGHTLINTGIYAYMRHPGYFGWFIWAVSTQIVLCNPI-------SFVIYTFVtwrffanRIEIEEKDLISFFGDDYAEY 278
Cdd:NF040696 107 REGHTLVTSGVYRYIRHPMYAAFWLWAIAQALLLPNWIaglaglvGFGILYFL-------RVPREEQMMLETFGDEYRAY 179

                 ....
gi 17506725  279 QRKT 282
Cdd:NF040696 180 MQRT 183
PEMT pfam04191
Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) ...
172-274 9.64e-03

Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) has a broad substrate specificity of unsaturated phospholipids.


Pssm-ID: 461218 [Multi-domain]  Cd Length: 105  Bit Score: 35.23  E-value: 9.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506725   172 LWIGTFGCIIGEIVRKVGMVHAGLAFTHLMARTKRSGHTLINTGIYAYMRHPGYFGWFIWAVSTQIVLCNPISFVIYTFV 251
Cdd:pfam04191   3 LILGLLLIALGLWLVLSSYRALGIFGTFYGDFFGILMDKLVTGGPYRYLNNPMYVGGTLGFLGLALITGSPAGLLLALLV 82
                          90       100
                  ....*....|....*....|...
gi 17506725   252 TWRFFANRIEIEEKDLISFFGDD 274
Cdd:pfam04191  83 LLVYFIALKFVEEPHMAKIYGKR 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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