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    hach-1 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 175766, updated on 9-Dec-2024

    Summary

    Official Symbol
    hach-1
    Official Full Name
    3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
    Primary source
    WormBase:WBGene00017301
    Locus tag
    CELE_F09F7.4
    See related
    AllianceGenome:WB:WBGene00017301
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3-hydroxyisobutyryl-CoA hydrolase activity. Predicted to be involved in valine catabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in 3-hydroxyisobutryl-CoA hydrolase deficiency. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See hach-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5555450..5557318)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ferritin Neighboring gene DNA N6-methyl adenine demethylase Neighboring gene DNA-directed RNA polymerase subunit beta Neighboring gene EF-hand domain-containing protein;Myosin, essential light chain

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3-hydroxyisobutyryl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3-hydroxyisobutyryl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in valine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in valine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
    NP_741143.1
    • Confirmed by transcript evidence
    NP_741144.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5555450..5557318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171126.7NP_741143.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19278
      Conserved Domains (2) summary
      PRK05617
      Location:35377
      PRK05617; 3-hydroxyisobutyryl-CoA hydrolase; Provisional
      pfam16113
      Location:46374
      ECH_2; Enoyl-CoA hydratase/isomerase
    2. NM_171127.5NP_741144.1  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741144.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MNT7
      Conserved Domains (2) summary
      PRK05617
      Location:12354
      PRK05617; 3-hydroxyisobutyryl-CoA hydrolase; Provisional
      pfam16113
      Location:23351
      ECH_2; Enoyl-CoA hydratase/isomerase