sdha-2 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sdha-2
Official Full Name: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Primary source: WormBase:WBGene00016392
Locus tag: CELE_C34B2.7
See related: AllianceGenome:WB:WBGene00016392
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and succinate dehydrogenase (quinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sdha-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (10683270..10685587, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C34B2.7 (e-PCR)
- UniSTS:308707

C34B2.8 (e-PCR)
- UniSTS:317683

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase (quinone) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, succinate to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex II (succinate dehydrogenase)	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

NP_492798.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10683270..10685587 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060397.8 → NP_492798.1 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492798.1

Status: REVIEWED

UniProtKB/TrEMBL

O44954

Conserved Domains (3) summary

PTZ00139
Location:5 → 640

PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional

pfam02910
Location:488 → 640

Succ_DH_flav_C; Fumarate reductase flavoprotein C-term

cl21454
Location:59 → 472

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins