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    ath-1 palmitoyl-protein hydrolase [ Caenorhabditis elegans ]

    Gene ID: 172587, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ath-1
    Official Full Name
    palmitoyl-protein hydrolase
    Primary source
    WormBase:WBGene00010564
    Locus tag
    CELE_K04G2.5
    See related
    AllianceGenome:WB:WBGene00010564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carboxylic ester hydrolase activity and palmitoyl-(protein) hydrolase activity. Predicted to be involved in negative regulation of Golgi to plasma membrane protein transport. Predicted to be active in cytoplasm. Orthologous to several human genes including LYPLA1 (lysophospholipase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ath-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (8036941..8039752, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Alpha/beta hydrolase domain-containing protein aho-3 Neighboring gene ATPase family protein 2 homolog Neighboring gene SHSP domain-containing protein Neighboring gene Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein Neighboring gene Protein VAC14 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A systematic analysis of protein palmitoylation in Caenorhabditis elegans. Edmonds MJ, et al. BMC Genomics, 2014 Oct 2. PMID 25277130, Free PMC Article
    2. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in macromolecule depalmitoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyl-protein hydrolase
    NP_001293296.1
    • Confirmed by transcript evidence
    NP_001379150.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8036941..8039752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392635.1 → NP_001379150.1  palmitoyl-protein hydrolase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED25, Q21224
      Conserved Domains (1) summary
      pfam02230
      Location:6 → 221
      Abhydrolase_2; Phospholipase/Carboxylesterase

    2. NM_001306367.3 → NP_001293296.1  palmitoyl-protein hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293296.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACY0
      Conserved Domains (1) summary
      pfam02230
      Location:87 → 302
      Abhydrolase_2; Phospholipase/Carboxylesterase

    RNA

    1. NR_131389.1 RNA Sequence

      Status: REVIEWED

    2. NR_131388.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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