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    coq-2 4-hydroxybenzoate polyprenyltransferase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 175969, updated on 9-Dec-2024

    Summary

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    Official Symbol
    coq-2
    Official Full Name
    4-hydroxybenzoate polyprenyltransferase, mitochondrial
    Primary source
    WormBase:WBGene00000762
    Locus tag
    CELE_F57B9.4
    See related
    AllianceGenome:WB:WBGene00000762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 4-hydroxybenzoate polyprenyltransferase activity. Involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 1. Orthologous to human COQ2 (coenzyme Q2, polyprenyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See coq-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (6935967..6939457)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Eukaryotic initiation factor 4A Neighboring gene Cell adhesion protein byn-1 Neighboring gene Tyrosine-protein kinase Neighboring gene RNA helicase Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing of coq-2 controls the levels of rhodoquinone in animals. Tan JH, et al. Elife, 2020 Aug 3. PMID 32744503, Free PMC Article
    2. Rhodoquinone in bacteria and animals: Two distinct pathways for biosynthesis of this key electron transporter used in anaerobic bioenergetics. Salinas G, et al. Biochim Biophys Acta Bioenerg, 2020 Nov 1. PMID 32735860
    3. C. elegans knockouts in ubiquinone biosynthesis genes result in different phenotypes during larval development. Gavilán A, et al. Biofactors, 2005. PMID 16873927
    4. Caenorhabditis elegans ubiquinone biosynthesis genes. Rodríguez-Aguilera JC, et al. Biofactors, 2003. PMID 14695939
    5. Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans. Asencio C, et al. FASEB J, 2003 Jun. PMID 12709403

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alternative splicing of coq-2 controls the levels of rhodoquinone in animals.
      Title: Alternative splicing of coq-2 controls the levels of rhodoquinone in animals.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 4-hydroxybenzoate polyprenyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-hydroxybenzoate polyprenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyprenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    4-hydroxybenzoate polyprenyltransferase, mitochondrial
    NP_498513.2
    • Confirmed by transcript evidence
    NP_871684.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6935967..6939457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_181955.5 → NP_871684.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871684.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5DX46, Q8I7J4
      Conserved Domains (1) summary
      cl00337
      Location:59 → 343
      PT_UbiA; UbiA family of prenyltransferases (PTases)

    2. NM_066112.7 → NP_498513.2  4-hydroxybenzoate polyprenyltransferase, mitochondrial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5DX46, Q8I7J4
      Conserved Domains (1) summary
      cl00337
      Location:59 → 343
      PT_UbiA; UbiA family of prenyltransferases (PTases)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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