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    kel-3 BTB domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kel-3
    Official Full Name
    BTB domain-containing protein
    Primary source
    WormBase:WBGene00002185
    Locus tag
    CELE_T27E9.4
    See related
    AllianceGenome:WB:WBGene00002185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including intestine; nervous system; pharynx; tail; and vulval muscle. Orthologous to human KLHL18 (kelch like family member 18). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kel-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (13464829..13471347)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Cytochrome b-c1 complex subunit 6 Neighboring gene ADP/ATP translocase Neighboring gene Cyclin-dependent-like kinase 5 Neighboring gene Phosphatidylserine synthase Neighboring gene SET domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selected BTB/POZ-kelch proteins bind ATP. T'Jampens D, et al. FEBS Lett, 2002 Apr 10. PMID 11959095
    2. Loss of the insulator protein CTCF during nematode evolution. Heger P, et al. BMC Mol Biol, 2009 Aug 27. PMID 19712444, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BTB domain-containing protein
    NP_499784.2
    • Confirmed by transcript evidence
    NP_499785.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13464829..13471347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067384.7 → NP_499785.2  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499785.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18147
      Conserved Domains (3) summary
      PHA03098
      Location:51 → 566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:386 → 429
      Kelch; KELCH repeat [structural motif]
      cd18247
      Location:32 → 147
      BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)

    2. NM_067383.7 → NP_499784.2  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499784.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQC4
      Conserved Domains (3) summary
      PHA03098
      Location:51 → 568
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:388 → 431
      Kelch; KELCH repeat [structural motif]
      cl38908
      Location:32 → 149
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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