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Conserved domains on  [gi|25150435|ref|NP_499784|]
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BTB domain-containing protein [Caenorhabditis elegans]

Protein Classification

kelch-like protein( domain architecture ID 1003721)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-149 1.26e-57

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18247:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 116  Bit Score: 188.64  E-value: 1.26e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  32 EMYKKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFA 111
Cdd:cd18247   1 DLPSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQ--GIEPSALEALINFA 78

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25150435 112 YTGELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTR 149
Cdd:cd18247  79 YSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
PHA03098 super family cl33709
kelch-like protein; Provisional
 51-568 3.40e-57

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 200.76  E-value: 3.40e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435   51 CDVALLVENRKLS--AHKVILAATIPYFRGMFTLDLMEanmKEINIEDsdmNYETVDALLSFAYTGELRITTSNVQSIML 128
Cdd:PHA03098  10 CDESIIIVNGGGIikVHKIILSSSSEYFKKMFKNNFKE---NEINLNI---DYDSFNEVIKYIYTGKINITSNNVKDILS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  129 GANFFQMLEVVQHCGNFLLTRLHPSNALSIREF-----CKmmcveeKITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIEL 203
Cdd:PHA03098  84 IANYLIIDFLINLCINYIIKIIDDNNCIDIYRFsffygCK------KLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  204 LRNDHLYVDSEEQVYVAAMEWLNC-DVIRHEQAAKILPCVRLPLLSP-------TYLSSIVASNPIIKKDIPCrdlidea 275
Cdd:PHA03098 158 LSDDKLNVSSEDVVLEIIIKWLTSkKNNKYKDICLILKVLRITFLSEegikklkRWKLRIKKKKIVFNKRCIK------- 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  276 kdyHLLPDRRSLIKSFKCTPRLCQIVPGLIVAIGGLMhqsqskSSVEIYDPTSKKWSPIDgmVTLRTRVGVAVNQRQVYA 355
Cdd:PHA03098 231 ---IIYSKKYNLNKILPRSSTFGSIIYIHITMSIFTY------NYITNYSPLSEINTIID--IHYVYCFGSVVLNNVIYF 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  356 IGGFNGQ-DRLDLVEKFDYDTLKWTTLSPLTRKRSALAAAFVTNRLYVCGGYDGLHSLSSIEIYDINRNVWEAGPPMENM 434
Cdd:PHA03098 300 IGGMNKNnLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFP 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  435 RSAAGVTVIDKHIYICGG-HDGMQIFASVERLDTENQQWERIPSMIQQRCRFGAATFKGKIYVAGGY---DGTSFLKSVE 510
Cdd:PHA03098 380 RYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVE 459

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 25150435  511 VYDPVEKKWSPVSPMNMRRSRVSLVSTNEGLFAVAGFDGENNLCSMEQYDDVTDSWTI 568
Cdd:PHA03098 460 SYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTL 517
 
Name Accession Description Interval E-value
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-149 1.26e-57

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 188.64  E-value: 1.26e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  32 EMYKKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFA 111
Cdd:cd18247   1 DLPSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQ--GIEPSALEALINFA 78

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25150435 112 YTGELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTR 149
Cdd:cd18247  79 YSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
PHA03098 PHA03098
kelch-like protein; Provisional
 51-568 3.40e-57

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 200.76  E-value: 3.40e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435   51 CDVALLVENRKLS--AHKVILAATIPYFRGMFTLDLMEanmKEINIEDsdmNYETVDALLSFAYTGELRITTSNVQSIML 128
Cdd:PHA03098  10 CDESIIIVNGGGIikVHKIILSSSSEYFKKMFKNNFKE---NEINLNI---DYDSFNEVIKYIYTGKINITSNNVKDILS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  129 GANFFQMLEVVQHCGNFLLTRLHPSNALSIREF-----CKmmcveeKITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIEL 203
Cdd:PHA03098  84 IANYLIIDFLINLCINYIIKIIDDNNCIDIYRFsffygCK------KLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  204 LRNDHLYVDSEEQVYVAAMEWLNC-DVIRHEQAAKILPCVRLPLLSP-------TYLSSIVASNPIIKKDIPCrdlidea 275
Cdd:PHA03098 158 LSDDKLNVSSEDVVLEIIIKWLTSkKNNKYKDICLILKVLRITFLSEegikklkRWKLRIKKKKIVFNKRCIK------- 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  276 kdyHLLPDRRSLIKSFKCTPRLCQIVPGLIVAIGGLMhqsqskSSVEIYDPTSKKWSPIDgmVTLRTRVGVAVNQRQVYA 355
Cdd:PHA03098 231 ---IIYSKKYNLNKILPRSSTFGSIIYIHITMSIFTY------NYITNYSPLSEINTIID--IHYVYCFGSVVLNNVIYF 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  356 IGGFNGQ-DRLDLVEKFDYDTLKWTTLSPLTRKRSALAAAFVTNRLYVCGGYDGLHSLSSIEIYDINRNVWEAGPPMENM 434
Cdd:PHA03098 300 IGGMNKNnLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFP 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  435 RSAAGVTVIDKHIYICGG-HDGMQIFASVERLDTENQQWERIPSMIQQRCRFGAATFKGKIYVAGGY---DGTSFLKSVE 510
Cdd:PHA03098 380 RYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVE 459

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 25150435  511 VYDPVEKKWSPVSPMNMRRSRVSLVSTNEGLFAVAGFDGENNLCSMEQYDDVTDSWTI 568
Cdd:PHA03098 460 SYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTL 517
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
303-560 9.24e-50

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 173.80  E-value: 9.24e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 303 GLIVAIGGLMHQSQSKSsVEIYDPTSKKWSPIDGMVTLRT--RVGVAVNQRqVYAIGGFNGQDR----LDLVEKFDYDTL 376
Cdd:COG3055  23 GKVYVAGGLSGGSASNS-FEVYDPATNTWSELAPLPGPPRhhAAAVAQDGK-LYVFGGFTGANPsstpLNDVYVYDPATN 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 377 KWTTLSPLTRKRSALAAAFVTNRLYVCGGYDGLHSLSSIEIYDINRNVWEAGPPMENMR-SAAGVTVIDKHIYICGGHDG 455
Cdd:COG3055 101 TWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRdHLAAAVLPDGKILVIGGRNG 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 456 mqifasverlDTENQQWERIPSMIQQRCRFGAATFKGKIYVAGGYDGtsFLKSVEVYDPVEKKWSPVSPMNMRRSRVSLV 535
Cdd:COG3055 181 ----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGELPTPRHGHAAV 248

                       250       260
                ....*....|....*....|....*....
gi 25150435 536 STNEGLFAVAGFD----GENNLCSMEQYD 560
Cdd:COG3055 249 LTDGKVYVIGGETkpgvRTPLVTSAEVYD 277
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 155-257 2.88e-33

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 122.65  E-value: 2.88e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435   155 ALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDV-IRHE 233
Cdd:pfam07707   1 CLGIYRFADAYGCTE-LAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVeRRKK 79

                          90       100
                  ....*....|....*....|....
gi 25150435   234 QAAKILPCVRLPLLSPTYLSSIVA 257
Cdd:pfam07707  80 HLPELLSAVRLPLLSPQYLLNLVE 103
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 150-285 4.54e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 123.28  E-value: 4.54e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCD- 228
Cdd:cd18452   1 LDPSNCLGIRDFAETHNCVD-LMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDk 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 25150435 229 VIRHEQAAKILPCVRLPLLSPTYLSSIVASNPIIKKDIPCRDLIDEAKDYHLLPDRR 285
Cdd:cd18452  80 EEREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRPELR 136
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 41-150 5.26e-33

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 121.98  E-value: 5.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435    41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFAYTGELrITT 120
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLD--DVSPEDFEALLEFMYTGKL-ISE 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 25150435   121 SNVQSIMLGANFFQMLEVVQHCGNFLLTRL 150
Cdd:pfam00651  78 ENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 155-252 8.87e-26

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 101.65  E-value: 8.87e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435    155 ALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDV-IRHE 233
Cdd:smart00875   1 CLGIRRFADAHGLEE-LAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPeKRRE 79

                           90
                   ....*....|....*....
gi 25150435    234 QAAKILPCVRLPLLSPTYL 252
Cdd:smart00875  80 HLPELLEHVRLPLLSPDYL 98
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 52-150 1.14e-25

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 101.23  E-value: 1.14e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435     52 DVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDsdMNYETVDALLSFAYTGELRITTSNVQSIMLGAN 131
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*....
gi 25150435    132 FFQMLEVVQHCGNFLLTRL 150
Cdd:smart00225  79 YLQIPGLVELCEEFLLKLL 97
 
Name Accession Description Interval E-value
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-149 1.26e-57

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 188.64  E-value: 1.26e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  32 EMYKKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFA 111
Cdd:cd18247   1 DLPSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQ--GIEPSALEALINFA 78

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25150435 112 YTGELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTR 149
Cdd:cd18247  79 YSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
PHA03098 PHA03098
kelch-like protein; Provisional
 51-568 3.40e-57

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 200.76  E-value: 3.40e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435   51 CDVALLVENRKLS--AHKVILAATIPYFRGMFTLDLMEanmKEINIEDsdmNYETVDALLSFAYTGELRITTSNVQSIML 128
Cdd:PHA03098  10 CDESIIIVNGGGIikVHKIILSSSSEYFKKMFKNNFKE---NEINLNI---DYDSFNEVIKYIYTGKINITSNNVKDILS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  129 GANFFQMLEVVQHCGNFLLTRLHPSNALSIREF-----CKmmcveeKITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIEL 203
Cdd:PHA03098  84 IANYLIIDFLINLCINYIIKIIDDNNCIDIYRFsffygCK------KLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  204 LRNDHLYVDSEEQVYVAAMEWLNC-DVIRHEQAAKILPCVRLPLLSP-------TYLSSIVASNPIIKKDIPCrdlidea 275
Cdd:PHA03098 158 LSDDKLNVSSEDVVLEIIIKWLTSkKNNKYKDICLILKVLRITFLSEegikklkRWKLRIKKKKIVFNKRCIK------- 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  276 kdyHLLPDRRSLIKSFKCTPRLCQIVPGLIVAIGGLMhqsqskSSVEIYDPTSKKWSPIDgmVTLRTRVGVAVNQRQVYA 355
Cdd:PHA03098 231 ---IIYSKKYNLNKILPRSSTFGSIIYIHITMSIFTY------NYITNYSPLSEINTIID--IHYVYCFGSVVLNNVIYF 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  356 IGGFNGQ-DRLDLVEKFDYDTLKWTTLSPLTRKRSALAAAFVTNRLYVCGGYDGLHSLSSIEIYDINRNVWEAGPPMENM 434
Cdd:PHA03098 300 IGGMNKNnLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFP 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  435 RSAAGVTVIDKHIYICGG-HDGMQIFASVERLDTENQQWERIPSMIQQRCRFGAATFKGKIYVAGGY---DGTSFLKSVE 510
Cdd:PHA03098 380 RYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVE 459

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 25150435  511 VYDPVEKKWSPVSPMNMRRSRVSLVSTNEGLFAVAGFDGENNLCSMEQYDDVTDSWTI 568
Cdd:PHA03098 460 SYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTL 517
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
303-560 9.24e-50

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 173.80  E-value: 9.24e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 303 GLIVAIGGLMHQSQSKSsVEIYDPTSKKWSPIDGMVTLRT--RVGVAVNQRqVYAIGGFNGQDR----LDLVEKFDYDTL 376
Cdd:COG3055  23 GKVYVAGGLSGGSASNS-FEVYDPATNTWSELAPLPGPPRhhAAAVAQDGK-LYVFGGFTGANPsstpLNDVYVYDPATN 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 377 KWTTLSPLTRKRSALAAAFVTNRLYVCGGYDGLHSLSSIEIYDINRNVWEAGPPMENMR-SAAGVTVIDKHIYICGGHDG 455
Cdd:COG3055 101 TWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRdHLAAAVLPDGKILVIGGRNG 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 456 mqifasverlDTENQQWERIPSMIQQRCRFGAATFKGKIYVAGGYDGtsFLKSVEVYDPVEKKWSPVSPMNMRRSRVSLV 535
Cdd:COG3055 181 ----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGELPTPRHGHAAV 248

                       250       260
                ....*....|....*....|....*....
gi 25150435 536 STNEGLFAVAGFD----GENNLCSMEQYD 560
Cdd:COG3055 249 LTDGKVYVIGGETkpgvRTPLVTSAEVYD 277
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
331-573 2.22e-44

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 159.17  E-value: 2.22e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 331 WSPIDGMVTLRTRVGVAVNQRQVYAIGGFNGQDRLDLVEKFDYDTLKWTTLSPLTRKRSALAAAFVTN-RLYVCGGYDGL 409
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDgKLYVFGGFTGA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 410 HS----LSSIEIYDINRNVWEAGPPMENMRSAAGVTVIDKHIYICGGHDGMQIFASVERLDTENQQWERIPSMIQQRCRF 485
Cdd:COG3055  83 NPsstpLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 486 GAATF-KGKIYVAGGYDGTSFLksvevydpveKKWSPVSPMNMRRSRVSLVSTNEGLFAVAGFDGENNlcSMEQYDDVTD 564
Cdd:COG3055 163 AAAVLpDGKILVIGGRNGSGFS----------NTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD--EVEAYDPATN 230


                ....*....
gi 25150435 565 SWTIATALT 573
Cdd:COG3055 231 TWTALGELP 239
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-157 5.81e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 127.79  E-value: 5.81e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  36 KSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMnyETVDALLSFAYTGE 115
Cdd:cd18238   1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDE--EAVELLVDFAYTGK 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 25150435 116 LRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALS 157
Cdd:cd18238  79 LTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 155-257 2.88e-33

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 122.65  E-value: 2.88e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435   155 ALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDV-IRHE 233
Cdd:pfam07707   1 CLGIYRFADAYGCTE-LAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVeRRKK 79

                          90       100
                  ....*....|....*....|....
gi 25150435   234 QAAKILPCVRLPLLSPTYLSSIVA 257
Cdd:pfam07707  80 HLPELLSAVRLPLLSPQYLLNLVE 103
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 150-285 4.54e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 123.28  E-value: 4.54e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCD- 228
Cdd:cd18452   1 LDPSNCLGIRDFAETHNCVD-LMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDk 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 25150435 229 VIRHEQAAKILPCVRLPLLSPTYLSSIVASNPIIKKDIPCRDLIDEAKDYHLLPDRR 285
Cdd:cd18452  80 EEREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLRPELR 136
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 41-150 5.26e-33

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 121.98  E-value: 5.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435    41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFAYTGELrITT 120
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLD--DVSPEDFEALLEFMYTGKL-ISE 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 25150435   121 SNVQSIMLGANFFQMLEVVQHCGNFLLTRL 150
Cdd:pfam00651  78 ENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-152 1.09e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 119.06  E-value: 1.09e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  35 KKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMnyETVDALLSFAYTG 114
Cdd:cd18339   6 KKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDG--QTLSKLIDYIYTA 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25150435 115 ELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHP 152
Cdd:cd18339  84 EIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-152 6.19e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 116.76  E-value: 6.19e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  35 KKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMnyETVDALLSFAYTG 114
Cdd:cd18235   6 QKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDG--KALLLLIDYVYTA 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25150435 115 ELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHP 152
Cdd:cd18235  84 EIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-156 1.51e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 116.05  E-value: 1.51e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMnyETVDALLSFAYTGELRITTS 121
Cdd:cd18237  13 NNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEP--DIIELLVEFAYTARISVNSN 90

                        90       100       110
                ....*....|....*....|....*....|....*
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNAL 156
Cdd:cd18237  91 NVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
425-585 4.66e-30

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 119.49  E-value: 4.66e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 425 WEAGPPMENMRSAAGVTVIDKHIYICGGHDGMQIFASVERLDTENQQWERIPSMIQQRcRFGAATF--KGKIYVAGGYDG 502
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPP-RHHAAAVaqDGKLYVFGGFTG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 503 ----TSFLKSVEVYDPVEKKWSPVSPMNMRRSRVSLVSTNEGLFAVAGFDGENNLCSMEQYDDVTDSWTIATALTCHEGG 578
Cdd:COG3055  82 anpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDH 161


                ....*..
gi 25150435 579 VGVGVIP 585
Cdd:COG3055 162 LAAAVLP 168
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-156 1.47e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 112.46  E-value: 1.47e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNyeTVDALLSFAYTGELRITTSNVQSIMLG 129
Cdd:cd18234   1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPD--ALWTLVQYCYTGRLELKEDNVESLLAT 78

                        90       100
                ....*....|....*....|....*..
gi 25150435 130 ANFFQMLEVVQHCGNFLLTRLHPSNAL 156
Cdd:cd18234  79 ACLLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-156 1.88e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 112.88  E-value: 1.88e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNyeTVDALLSFAYTGELRITTS 121
Cdd:cd18256  12 NKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPD--IFHILLDFIYTGVVEVTVS 89

                        90       100       110
                ....*....|....*....|....*....|....*
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNAL 156
Cdd:cd18256  90 NVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 150-263 3.11e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 111.56  E-value: 3.11e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREFCKM-MCVEEKITemTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCD 228
Cdd:cd18445   1 LHPSNCLGIRAFADLhSCTDLLKY--AQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHD 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 25150435 229 V-IRHEQAAKILPCVRLPLLSPTYLSSIVASNPIIK 263
Cdd:cd18445  79 PeNRKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-150 1.85e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 109.78  E-value: 1.85e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  30 LDEMYKKSYSIFNELRSKCQLCDVALLVENR----KLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVD 105
Cdd:cd18248   1 LEDHTKEAFQIMNELRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIE--GVHPCVMS 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 25150435 106 ALLSFAYTGELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRL 150
Cdd:cd18248  79 RLIEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-152 2.69e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 109.39  E-value: 2.69e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  35 KKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMnyETVDALLSFAYTG 114
Cdd:cd18338   6 KKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDG--WTLKMLIDYVYTA 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25150435 115 ELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHP 152
Cdd:cd18338  84 EIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-158 1.22e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 104.65  E-value: 1.22e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDsdMNYETVDALLSFAYTGELRITTS 121
Cdd:cd18306  10 NALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDG--LDPDAVEVLVNYAYTSRLEVPAD 87

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18306  88 LVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-159 1.47e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 104.74  E-value: 1.47e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKcQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMnyETVDALLSFAYTGELRITTS 121
Cdd:cd18336  12 NYLQHK-QLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDP--DALKALVHYAYTGVLELKED 88

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALSIR 159
Cdd:cd18336  89 TIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIR 126
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 150-256 2.85e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 103.16  E-value: 2.85e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREFCK-MMCveEKITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCD 228
Cdd:cd18457   1 LHPNNCLGIRQFAEtMMC--SSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYD 78

                        90       100
                ....*....|....*....|....*....
gi 25150435 229 V-IRHEQAAKILPCVRLPLLSPTYLSSIV 256
Cdd:cd18457  79 ReNREEYLPELLSKVRLPLLRPQFLTDRV 107
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-152 3.87e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 103.39  E-value: 3.87e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDmnyET-VDALLSFAYTGELRITT 120
Cdd:cd18257  10 NLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCID---ETaLQAIVEYAYTGTVFISQ 86

                        90       100       110
                ....*....|....*....|....*....|..
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHCGNFLLTRLHP 152
Cdd:cd18257  87 ATVESLLPAANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-154 5.64e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 102.90  E-value: 5.64e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFAYTGELRITTS 121
Cdd:cd18242  13 NSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQ--GLTASTMEILLDFVYTETVHVTVE 90

                        90       100       110
                ....*....|....*....|....*....|...
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSN 154
Cdd:cd18242  91 NVQELLPAACLLQLKGVKQACCEFLESQLDPSN 123
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 155-252 8.87e-26

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 101.65  E-value: 8.87e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435    155 ALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDV-IRHE 233
Cdd:smart00875   1 CLGIRRFADAHGLEE-LAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPeKRRE 79

                           90
                   ....*....|....*....
gi 25150435    234 QAAKILPCVRLPLLSPTYL 252
Cdd:smart00875  80 HLPELLEHVRLPLLSPDYL 98
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 52-150 1.14e-25

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 101.23  E-value: 1.14e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435     52 DVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDsdMNYETVDALLSFAYTGELRITTSNVQSIMLGAN 131
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD--VSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*....
gi 25150435    132 FFQMLEVVQHCGNFLLTRL 150
Cdd:smart00225  79 YLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-156 1.14e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 102.14  E-value: 1.14e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  35 KKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNyeTVDALLSFAYTG 114
Cdd:cd18249   8 RQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDER--AMELLIDFAYTS 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 25150435 115 ELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNAL 156
Cdd:cd18249  86 QITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-154 1.16e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 102.02  E-value: 1.16e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  39 SIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIedSDMNYETVDALLSFAYTGELRI 118
Cdd:cd18240   6 NVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKI--PGVSPEMMELIIEYAYTRTVPI 83

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 25150435 119 TTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSN 154
Cdd:cd18240  84 TAENVEELLPAADQFNIMGIVKACCDFLEDQLCPEN 119
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-150 1.13e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 99.01  E-value: 1.13e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEinIEDSDMNYETVDALLSFAYTGELRITTS 121
Cdd:cd18255  10 NALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDE--IELKGVSAKGLKHILDFAYTSELTLDLD 87

                        90       100
                ....*....|....*....|....*....
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFLLTRL 150
Cdd:cd18255  88 CIQDVLGAAVHLQMLPVVELCEEFLKSAM 116
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-133 1.17e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 97.62  E-value: 1.17e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFAYTGELRITTSNVQSIMLG 129
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELD--DVSPEAFEALLDYIYTGELELSEENVEELLAA 78


                ....
gi 25150435 130 ANFF 133
Cdd:cd18186  79 ADKL 82
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 150-279 3.81e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 97.83  E-value: 3.81e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREFCKMMCVEEKITEmTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDV 229
Cdd:cd18513   1 LHPTNCLGIRAFADVHTCTELLQQ-ANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDK 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 25150435 230 -IRHEQAAKILPCVRLPLLSPTYLSSIVASNPIIKKDIPCRDLIDEAKDYH 279
Cdd:cd18513  80 eARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-158 1.01e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 96.80  E-value: 1.01e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFAYTGELRITTS 121
Cdd:cd18276  13 NRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLH--DITAESVSIILNYMYSSDLHLTNS 90

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18276  91 NVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 150-279 1.73e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 96.25  E-value: 1.73e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREFCKM-MCVEekITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCD 228
Cdd:cd18512   1 LHPTNCLGIRAFADMhACTE--LLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHD 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 25150435 229 V-IRHEQAAKILPCVRLPLLSPTYLSSIVASNPIIKKDIPCRDLIDEAKDYH 279
Cdd:cd18512  79 KeVRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-154 3.60e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 95.30  E-value: 3.60e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  44 LRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMnyETVDALLSFAYTGELRITTSNV 123
Cdd:cd18236  18 LRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDA--ETMQILLDYTYTSKVLITKQNV 95

                        90       100       110
                ....*....|....*....|....*....|.
gi 25150435 124 QSIMLGANFFQMLEVVQHCGNFLLTRLHPSN 154
Cdd:cd18236  96 QRVLEAASLFQFLRMVDACASFLTEALHPEN 126
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-154 8.24e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 93.75  E-value: 8.24e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  40 IFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEAnmKEINIEDSDMNYETVDALLSFAYTGELRIT 119
Cdd:cd18253   8 VFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRES--REMLVEINGILAEAMDCFLQYVYTGKVKIT 85

                        90       100       110
                ....*....|....*....|....*....|....*
gi 25150435 120 TSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSN 154
Cdd:cd18253  86 TENVQYLFETSSLFQISPLRDACAKFLEEQLDPCN 120
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-155 1.57e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 93.29  E-value: 1.57e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFAYTGELRITTS 121
Cdd:cd18250  13 SELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLH--GVSAEILGLLLDFSYTGRVTVTQD 90

                        90       100       110
                ....*....|....*....|....*....|....
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNA 155
Cdd:cd18250  91 NVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-159 4.65e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 92.05  E-value: 4.65e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKcQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNyeTVDALLSFAYTGELRITTS 121
Cdd:cd18337  16 NYLRHK-QLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPN--ALWALVQYAYTGRLELKED 92

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALSIR 159
Cdd:cd18337  93 NIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 130
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-159 1.01e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 90.87  E-value: 1.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  49 QLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNyeTVDALLSFAYTGELRITTSNVQSIML 128
Cdd:cd18335  18 QLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPN--ALWDLVQFAYTGCLELKEDTIENLLA 95

                        90       100       110
                ....*....|....*....|....*....|.
gi 25150435 129 GANFFQMLEVVQHCGNFLLTRLHPSNALSIR 159
Cdd:cd18335  96 AACLLQLSQVVEVCCHFLMKLLHPSNCLGIR 126
PHA02713 PHA02713
hypothetical protein; Provisional
 50-496 3.54e-21

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 97.39  E-value: 3.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435   50 LCDVALLV-ENRKLSAHKVILAATIPYFRGMFTLDLMEANM-KEINIEDSDMnyETVDALLSFAYTGElrITTSNVQSIM 127
Cdd:PHA02713  25 LCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLvTRVNLQMFDK--DAVKNIVQYLYNRH--ISSMNVIDVL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  128 LGANFFQMLEVVQHCGNFLltrlhpsNALSIREFCkmMCVEEKITEMTD----DYIQKHFMA----VSKDEDFKRLSLED 199
Cdd:PHA02713 101 KCADYLLIDDLVTDCESYI-------KDYTNHDTC--IYMYHRLYEMSHipivKYIKRMLMSniptLITTDAFKKTVFEI 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  200 AIELLR-NDHLYVDSEEQVYVAAMEWLNCDVIRHEQAAKILPCVRLPLLSPTYlSSIVASNPIIKKDIPC-RDLIDEAKD 277
Cdd:PHA02713 172 LFDIIStNDNVYLYREGYKVTILLKWLEYNYITEEQLLCILSCIDIQNLDKKS-RLLLYSNKTINMYPSCiQFLLDNKQN 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  278 YHLLPDRRSLI----KSFKCTPrlCQIVpglivaigglmhqsqskssveiYDPTSKKWSPIDGMVTLRTRVGVAVNQRQV 353
Cdd:PHA02713 251 RNIIPRQLCLVchdtKYNVCNP--CILV----------------------YNINTMEYSVISTIPNHIINYASAIVDNEI 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  354 YAIGGFNGQD-RLDLVEKFDYDTLKWTTLSPLTRKRSALAAAFVTNRLYVCGGYDGLHSLSSIEIYDINRNVWEAGPPME 432
Cdd:PHA02713 307 IIAGGYNFNNpSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMP 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  433 NMRSAAGVTVIDKHIYICGGHDGMQIFASVE------------------RLDTENQQWERIPSMIQQRCRFGAATFKGKI 494
Cdd:PHA02713 387 IALSSYGMCVLDQYIYIIGGRTEHIDYTSVHhmnsidmeedthssnkviRYDTVNNIWETLPNFWTGTIRPGVVSHKDDI 466


                 ..
gi 25150435  495 YV 496
Cdd:PHA02713 467 YV 468
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-158 5.96e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 88.89  E-value: 5.96e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  39 SIFNELRS---KCQLCDVALLVENRK-LSAHKVILAATIPYFRGMFTLDLMEANMKEINIedSDMNYETVDALLSFAYTG 114
Cdd:cd18274   8 SILQQLKAmydEGQLTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRI--VGVEAESMHLVLDYAYTS 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 25150435 115 ELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18274  86 RVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-152 7.82e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 88.93  E-value: 7.82e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  34 YKKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMnyETVDALLSFAYT 113
Cdd:cd18246  23 YHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDP--QALEQLVQYAYT 100

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 25150435 114 GELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHP 152
Cdd:cd18246 101 AEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 149-253 2.55e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 83.53  E-value: 2.55e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 149 RLHPSNALSIREFCKMM-CVEekITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNC 227
Cdd:cd18444   1 QLHPSNCLGIRSFADAQgCTD--LLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKH 78

                        90       100
                ....*....|....*....|....*..
gi 25150435 228 DVI-RHEQAAKILPCVRLPLLSPTYLS 253
Cdd:cd18444  79 DLPeRKKHLAKLLALIRLPLLTPQFLA 105
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-158 4.02e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 83.61  E-value: 4.02e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  52 DVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNyeTVDALLSFAYTGELRITTSNVQSIMLGAN 131
Cdd:cd18269  29 DCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPD--VMGMILKYLYTSEIDLNDQNVQDIFALAS 106

                        90       100
                ....*....|....*....|....*..
gi 25150435 132 FFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18269 107 RFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-146 1.67e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 81.83  E-value: 1.67e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDS--DMNYETVDA---LLSFAYTGEL 116
Cdd:cd18228  11 NSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSPAGKCvlDLHHVTVTGfapLLEYAYTSTL 90

                        90       100       110
                ....*....|....*....|....*....|
gi 25150435 117 RITTSNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18228  91 SINTENIIDVLAAASYMQMFNVANTCSEFM 120
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-148 1.76e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 81.79  E-value: 1.76e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  44 LRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFAYTGELRITTSNV 123
Cdd:cd18251  17 LRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIH--GVSYNAMCKILDFIYTSELELSLDNV 94

                        90       100
                ....*....|....*....|....*
gi 25150435 124 QSIMLGANFFQMLEVVQHCGNFLLT 148
Cdd:cd18251  95 QETLTAACQLQIPEVIGFCCDFLMS 119
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-156 1.87e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 81.60  E-value: 1.87e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSdMNYETVDALLSFAYTGELRITT 120
Cdd:cd18254  13 LNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDS-LHPEVLELLLDFAYSSRIIINE 91

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNAL 156
Cdd:cd18254  92 ENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-156 2.04e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 81.80  E-value: 2.04e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  20 DDLDFI----KVDILDEMYKksysifneLRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIE 95
Cdd:cd18259   6 DDLDFClpshPQSILDGLQT--------LRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIK 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 25150435  96 DSDMNyeTVDALLSFAYTGELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNAL 156
Cdd:cd18259  78 DVDPA--VMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-158 3.11e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 81.42  E-value: 3.11e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  52 DVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMnyETVDALLSFAYTGELRITTSNVQSIMLGAN 131
Cdd:cd18340  29 DCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDP--DVMGKILHYIYTSEIEITEQNVQDIFAAAN 106

                        90       100
                ....*....|....*....|....*..
gi 25150435 132 FFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18340 107 MFQIPSIFTVCVSFLQKRLCLSNCLAI 133
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-156 5.24e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 80.40  E-value: 5.24e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  39 SIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFAYTGELRI 118
Cdd:cd18261  17 AALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLH--GVTSLGLKQALDFAYTGQILL 94

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25150435 119 TTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNAL 156
Cdd:cd18261  95 EPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-161 7.49e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 80.32  E-value: 7.49e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSdmNYETVDALLSFAYTGELRITT 120
Cdd:cd18266  16 LNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGA--SYIGLKAVIDFLYSSELPLDG 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALSIREF 161
Cdd:cd18266  94 GNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQEL 134
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-158 7.50e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 79.83  E-value: 7.50e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNyeTVDALLSFAYTGELRITTS 121
Cdd:cd18268  15 NSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSD--VLDQIVDYVYTGEILITRD 92

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18268  93 NVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-158 9.93e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 80.42  E-value: 9.93e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSdMNYETVDALLSFAYTGELRITT 120
Cdd:cd18267  31 LNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDS-IHPEVLELLLDYAYSSRVIINE 109

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18267 110 ENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-158 1.32e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 79.87  E-value: 1.32e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  44 LRSKCQLCDVALLVE--------NRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMnyETVDALLSFAYTGE 115
Cdd:cd18273  20 FYDARLLTDVTIEVNgpgsgpgsGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDS--ESMALIIDYCYTGR 97

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 25150435 116 LRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18273  98 VTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
471-572 2.26e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 82.51  E-value: 2.26e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 471 QWERIPSMIQQRCRFGAATFKGKIYVAGGYDGTSFLKSVEVYDPVEKKWSPVSPMNM-RRSRVSLVSTNEGLFAVAGFDG 549
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFTG 81

                        90       100
                ....*....|....*....|....*..
gi 25150435 550 ENN----LCSMEQYDDVTDSWTIATAL 572
Cdd:COG3055  82 ANPsstpLNDVYVYDPATNTWTKLAPM 108
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 151-252 3.55e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 77.07  E-value: 3.55e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 151 HPSNALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDVI 230
Cdd:cd18468   1 TPSNCLGIWALAEALQCTE-LHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPK 79

                        90       100
                ....*....|....*....|...
gi 25150435 231 -RHEQAAKILPCVRLPLLSPTYL 252
Cdd:cd18468  80 nRKQHIAELLAVVRLPFIHPSYL 102
Kelch smart00612
Kelch domain;
493-539 4.18e-17

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 74.90  E-value: 4.18e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 25150435    493 KIYVAGGYDGTSFLKSVEVYDPVEKKWSPVSPMNMRRSRVSLVSTNE 539
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 149-245 8.57e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 75.81  E-value: 8.57e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 149 RLHPSNALSIREFCKMM-CVEekITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNC 227
Cdd:cd18448   1 HLHPSNCLGVRTFAEQHnRVD--LMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKH 78

                        90
                ....*....|....*....
gi 25150435 228 DVIRHEQ-AAKILPCVRLP 245
Cdd:cd18448  79 DPQHRKRhLDDLLSQVRLP 97
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-158 1.38e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 76.42  E-value: 1.38e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  43 ELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNyeTVDALLSFAYTGELRITTSN 122
Cdd:cd18341  20 ELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPN--IMDMILKYLYSAEIDLNDGN 97

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 25150435 123 VQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18341  98 VQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 152-252 1.77e-16

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 75.21  E-value: 1.77e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 152 PSNALSIREFCKMM-CVEekITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDVI 230
Cdd:cd18466   3 PANCIGIFQFSEQIaCHD--LLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVG 80

                        90       100
                ....*....|....*....|...
gi 25150435 231 -RHEQAAKILPCVRLPLLSPTYL 252
Cdd:cd18466  81 kRKKHVVEVLEPVRFPLLPPQRL 103
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 149-253 4.84e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 73.95  E-value: 4.84e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 149 RLHPSNALSIREFCKMM-CVEekITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNC 227
Cdd:cd18511   1 QLHPSNCLGIRSFADAQgCTD--LHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRH 78

                        90       100
                ....*....|....*....|....*..
gi 25150435 228 DV-IRHEQAAKILPCVRLPLLSPTYLS 253
Cdd:cd18511  79 DVeQRRKDLSKLLAYIRLPLLAPQFLA 105
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 482-526 6.99e-16

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 71.49  E-value: 6.99e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 25150435   482 RCRFGAATFKGKIYVAGGYDGTSFLKSVEVYDPVEKKWSPVSPMN 526
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-145 9.90e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 72.91  E-value: 9.90e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  51 CDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEA-NMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSIMLG 129
Cdd:cd18307   2 CDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKAtDELSITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKG 81

                        90
                ....*....|....*.
gi 25150435 130 ANFFQMLEVVQHCGNF 145
Cdd:cd18307  82 AKYFNIPRLKDHCVDF 97
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-146 1.01e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 73.14  E-value: 1.01e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITTS 121
Cdd:cd18245   6 NSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSED 85

                        90       100
                ....*....|....*....|....*
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18245  86 NIQDIVQAADLLLMTDLKDLCCEFL 110
PHA02790 PHA02790
Kelch-like protein; Provisional
 65-568 1.67e-15

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 79.32  E-value: 1.67e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435   65 HKVILAATIPYFRGMFTLDLMEaNMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSIMLGANFFQMLEVVQHCGN 144
Cdd:PHA02790  36 NSTILKKLSPYFRTHLRQKYTK-NKDPVTRVCLDLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCIN 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  145 FLLTRLHPSNALSirefCKMMCVEEKITEM---TDDYIQKHFMAVSKD--EDFKRLSLEdaiELLRNDHLYVDSEEQVYV 219
Cdd:PHA02790 115 FILRDFRKEYCVE----CYMMGIEYGLSNLlchTKDFIAKHFLELEDDiiDNFDYLSMK---LILESDELNVPDEDYVVD 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  220 AAMEWLncdVIRHEQAAKILPCVRlPLLSPTYLSSIVASNpiikkdipCRDLIDEAKDYHLlpDRRsliksfkctPRLCQ 299
Cdd:PHA02790 188 FVIKWY---MKRRNRLGNLLLLIK-NVIRSNYLSPRGINN--------VKWILDCTKIFHC--DKQ---------PRKSY 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  300 IVPglivAIGGLMHQSQSkssVEIYDptskkwspidgMVTlRTRVGvavnqRQVYAIGGFNGQDRLDLVEKFDYDTLKWT 379
Cdd:PHA02790 245 KYP----FIEYPMNMDQI---IDIFH-----------MCT-STHVG-----EVVYLIGGWMNNEIHNNAIAVNYISNNWI 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  380 TLSPLTRKRSALAAAFVTNRLYVCGGydgLHSLSSIEIYDINRNVWEAGPPMENMRSAAGVTVIDKHIYICGGHDgmQIF 459
Cdd:PHA02790 301 PIPPMNSPRLYASGVPANNKLYVVGG---LPNPTSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGHS--ETD 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  460 ASVERLDTENQQWERIPSMIQQRCRFGAATFKGKIYVAGgydgtsflKSVEVYDPVEKKWSPVSPMNMRRSRVSLVSTNE 539
Cdd:PHA02790 376 TTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG--------RNAEFYCESSNTWTLIDDPIYPRDNPELIIVDN 447

                        490       500
                 ....*....|....*....|....*....
gi 25150435  540 GLFAVAGFDGENNLCSMEQYDDVTDSWTI 568
Cdd:PHA02790 448 KLLLIGGFYRGSYIDTIEVYNNRTYSWNI 476
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-156 2.05e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 72.94  E-value: 2.05e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  65 HKVILAATIPYFRGMFTLDLMEANMKEINIedSDMNYETVDALLSFAYTGELRITTSNVQSIMLGANFFQMLEVVQHCGN 144
Cdd:cd18252  37 HKAALAACSSYFKVMFTADMKEKSNNVIKL--SGIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQ 114

                        90
                ....*....|..
gi 25150435 145 FLLTRLHPSNAL 156
Cdd:cd18252 115 FLVRHLDIDNCL 126
Kelch smart00612
Kelch domain;
446-492 2.59e-15

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 69.89  E-value: 2.59e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 25150435    446 HIYICGGHDGMQIFASVERLDTENQQWERIPSMIQQRCRFGAATFKG 492
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-146 3.80e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 71.92  E-value: 3.80e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIedSDMNYETVDALLSFAYTG---ELRITTSNVQSI 126
Cdd:cd18297  12 MSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEI--PDIRYDIFQLMMQYLYTGgveSLDVAQDDALEL 89

                        90       100
                ....*....|....*....|
gi 25150435 127 MLGANFFQMLEVVQHCGNFL 146
Cdd:cd18297  90 LRAASFFQLDGLKRHCEILL 109
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-146 4.06e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 71.89  E-value: 4.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  39 SIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLM--EANMKEINIedsdMNYETVDALLSFAYTGEL 116
Cdd:cd18326  14 SSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVvdQQNVYEIDF----VSAEALTALLDFAYTATL 89

                        90       100       110
                ....*....|....*....|....*....|
gi 25150435 117 RITTSNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18326  90 TVSTSNVGDILSAARLLEIPAVSHVCADLL 119
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 150-253 5.06e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 71.21  E-value: 5.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREFCKMM-CVEekITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCD 228
Cdd:cd18509   2 LHPSNCLGIRAFADAQgCIE--LMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYD 79

                        90       100
                ....*....|....*....|....*.
gi 25150435 229 VI-RHEQAAKILPCVRLPLLSPTYLS 253
Cdd:cd18509  80 MQrRCSDLSMLLAYIRLPLLPPQLLA 105
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-156 5.76e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 71.73  E-value: 5.76e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDsdMNYETVDALLSFAYTGELRITTS 121
Cdd:cd18265  15 NAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQK--VSAAAMEVLLDYMYGGGLRIQED 92

                        90       100       110
                ....*....|....*....|....*....|....*
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNAL 156
Cdd:cd18265  93 NVESVLEASDLLQVSKLREACVRFLEGQLHPCNCL 127
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-146 8.18e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 71.04  E-value: 8.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTlDLMEANMKEINIeDSDMNYETVDALLSFAYTGELRITT 120
Cdd:cd18331  15 LNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFT-DQLKCNLSVINL-DPEINPEGFNILLDFMYTSRLNLRE 92

                        90       100
                ....*....|....*....|....*.
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18331  93 GNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-158 8.38e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 71.57  E-value: 8.38e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMnyETVDALLSFAYTGELRITTSNVQSIMLG 129
Cdd:cd18270  26 LTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDA--ATLQIIITYAYTGNLAINDSTVEQLYET 103

                        90       100
                ....*....|....*....|....*....
gi 25150435 130 ANFFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18270 104 ACFLQVEDVLQRCREYLIKKINAENCVRL 132
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-146 8.69e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 71.23  E-value: 8.69e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  39 SIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEAnmkeinIEDSDMNYETV-DALLSFAYTGELR 117
Cdd:cd18222  14 SHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMST------VSISVIKNPTVfEQLLSFCYTGRIC 87

                        90       100
                ....*....|....*....|....*....
gi 25150435 118 ITTSNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18222  88 LQLADIISYLTAASFLQMQHIIDKCTQIL 116
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 150-248 1.21e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 70.03  E-value: 1.21e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDV 229
Cdd:cd18456   1 LDPSNCLGIRGFADTHSCSD-LLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDV 79

                        90       100
                ....*....|....*....|
gi 25150435 230 -IRHEQAAKILPCVRLPLLS 248
Cdd:cd18456  80 dGRRQHVPRLMKCVRLPLLS 99
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-158 1.52e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 70.76  E-value: 1.52e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFAYTGELRITT 120
Cdd:cd18244  21 FRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLK--GLTATGFSHVLQFMYYGTIELSM 98

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18244  99 LTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEI 136
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-152 1.55e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 70.46  E-value: 1.55e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  34 YKKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNYETVDALLSFAYT 113
Cdd:cd18196   5 FEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSEVVTAEAFAALIDMMYT 84

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 25150435 114 GELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHP 152
Cdd:cd18196  85 STLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLP 123
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-154 2.47e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 70.27  E-value: 2.47e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLV---ENRKLSAHKVILAATIPYFRGMFTLDLMEA-----NMKEiNIEDSDMNYETVDALLSFAYT 113
Cdd:cd18241  15 NEQRKQGLFCDITLAFggaGGREFRAHRSVLAAATEYFTPLLSGQFSESrsgrvEMRK-WSSEPGPDPDTVEAVIQYMYT 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 25150435 114 GELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSN 154
Cdd:cd18241  94 GRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-158 3.77e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 69.48  E-value: 3.77e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  35 KKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIedSDMNYETVDALLSFAYTG 114
Cdd:cd18271   9 QQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTI--SNLSPKAVKAFLDYAYTG 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 25150435 115 ELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18271  87 KAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
Kelch smart00612
Kelch domain;
399-445 5.49e-14

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 66.04  E-value: 5.49e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 25150435    399 RLYVCGGYDGLHSLSSIEIYDINRNVWEAGPPMENMRSAAGVTVIDK 445
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 149-253 6.06e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 68.02  E-value: 6.06e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 149 RLHPSNALSIREFCKMM-CVEekITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNC 227
Cdd:cd18510   1 QLHPSNCLGIRSFGDAQgCTE--LLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRH 78

                        90       100
                ....*....|....*....|....*..
gi 25150435 228 DVI-RHEQAAKILPCVRLPLLSPTYLS 253
Cdd:cd18510  79 DLQnRQKDLGMLLSYIRLPLLPPQLLA 105
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 150-228 7.09e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 67.32  E-value: 7.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREFCKMM-CVE--EKITEmtddYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLN 226
Cdd:cd18458   2 LDPSNCIGIANFAEQHgCTElhKKARE----YIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVK 77


                ..
gi 25150435 227 CD 228
Cdd:cd18458  78 YD 79
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-145 1.20e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 67.51  E-value: 1.20e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTlDLMEANMKEINIEdsDMNYETVDALLSFAYTGELRITT 120
Cdd:cd18212  14 FEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFA-DEGEVGQSIYMLE--GMVAETFGALLEFIYTGCLQVGE 90

                        90       100
                ....*....|....*....|....*
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHCGNF 145
Cdd:cd18212  91 KSLEQILATAQFLKVNDLVKAYSDY 115
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 49-142 2.70e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 65.83  E-value: 2.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  49 QLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMnyETVDALLSFAYTGELRITTSNVQSIML 128
Cdd:cd18314   5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEP--EIFETVLKYMYTGQVTLSEENVLDLLM 82

                        90
                ....*....|....
gi 25150435 129 GANFFQMLEVVQHC 142
Cdd:cd18314  83 LASKYQVPDLEKLC 96
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-146 2.81e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 66.52  E-value: 2.81e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEaNMKEINIEDSDM-NYETVDALLSFAYTGELRIT 119
Cdd:cd18201  12 LNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKE-SCDQTTVTHLDVvAVQGFSVILDFMYSGNLVLT 90

                        90       100
                ....*....|....*....|....*..
gi 25150435 120 TSNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18201  91 SQNAIEVMSVASYLQMTEVVQSCRNFI 117
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 149-248 2.94e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 65.91  E-value: 2.94e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 149 RLHPSNALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCD 228
Cdd:cd18459   1 QLDPSNCLGIRAFADTHACRE-LLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYN 79

                        90       100
                ....*....|....*....|.
gi 25150435 229 VI-RHEQAAKILPCVRLPLLS 248
Cdd:cd18459  80 IQeRRPHLPQVLQHVRLPLLS 100
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-145 3.63e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 66.05  E-value: 3.63e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  38 YSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTlDLMEANMKEINIeDSDMNYETVDALLSFAYTGELR 117
Cdd:cd18215   7 LLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFT-DQLKNNVSVINL-DPEIEPEGFRILLDFMYTSRLN 84

                        90       100
                ....*....|....*....|....*...
gi 25150435 118 ITTSNVQSIMLGANFFQMLEVVQHCGNF 145
Cdd:cd18215  85 LREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-146 3.73e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 66.43  E-value: 3.73e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  39 SIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLM--EANMKEINIedsdMNYETVDALLSFAYTGEL 116
Cdd:cd18198  14 SGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVvdQQNVYEIDF----VSPEALTALLEFAYTATL 89

                        90       100       110
                ....*....|....*....|....*....|
gi 25150435 117 RITTSNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18198  90 TVSTANVGDILSAARLLEIPCVSHVCAEIL 119
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 153-228 4.61e-13

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 64.74  E-value: 4.61e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25150435 153 SNALSIREFCKMM-CVEekITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCD 228
Cdd:cd18508   3 TNCLGIHEFADAHsCVE--LEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-154 4.68e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 66.37  E-value: 4.68e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVEN--RKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDsdMNYETVDALLSFAYTGELRI 118
Cdd:cd18239  14 FDQLRGEGLLCDVTLVPGDgdETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHG--VSKIGLKNIIDFIYTAKLSL 91

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 25150435 119 TTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSN 154
Cdd:cd18239  92 NMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLEN 127
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 434-478 7.72e-13

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 63.01  E-value: 7.72e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 25150435   434 MRSAAGVTVIDKHIYICGGHDGMQIFASVERLDTENQQWERIPSM 478
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-146 7.93e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 65.43  E-value: 7.93e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEA-NMKEINiedsdmNYETVDALLSFAYTGELRIT 119
Cdd:cd18220  16 LNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGlSISVIK------NPNVFEQLLSFCYTGRMSLQ 89

                        90       100
                ....*....|....*....|....*..
gi 25150435 120 TSNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18220  90 LKDVVSFLTAASFLQMQCVIDKCTQIL 116
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-145 8.43e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 64.78  E-value: 8.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  35 KKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFtldlmeANMKEINIEDSDMNYETVDALLSFAYTG 114
Cdd:cd18232   3 VKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLY------GDGTSGSVVLPESFAEVFGLLLDFFYTG 76

                        90       100       110
                ....*....|....*....|....*....|.
gi 25150435 115 ELRITTSNVQSIMLGANFFQMLEVVQHCGNF 145
Cdd:cd18232  77 ELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-146 1.16e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 64.96  E-value: 1.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDlmeaNMKEINIEDSdMNYETVDALLSFAYTGELRITT 120
Cdd:cd18227  16 LNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLK----NSRRIVLPDV-MNPRVFENILLSCYTGRLVLPA 90

                        90       100
                ....*....|....*....|....*.
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18227  91 PEIVSYLTAASFLQMWHVVDKCTELL 116
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-146 1.56e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 64.70  E-value: 1.56e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  34 YKKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLdlMEANMKEINIEDSDM-NYETVDALLSFAY 112
Cdd:cd18230   5 YRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQ--VQKTSDQATVTHLDIvTAQGFKAIIDFMY 82

                        90       100       110
                ....*....|....*....|....*....|....
gi 25150435 113 TGELRITTSNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18230  83 SAHLALTSKNVIEVMSAASYLQMTDIVQACHNFI 116
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 153-246 1.59e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 63.92  E-value: 1.59e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 153 SNALSIREFCKMM-CVEEKITemTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDVI- 230
Cdd:cd18447   5 SNCLGISVLAECLdCPELKAT--ADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPn 82

                        90
                ....*....|....*.
gi 25150435 231 RHEQAAKILPCVRLPL 246
Cdd:cd18447  83 RQPYMVDILAKVRFPL 98
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-138 2.18e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 64.13  E-value: 2.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLM--EANMKEINIedsdMNYETVDALLSFAYTGELRI 118
Cdd:cd18328  16 LNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLadQPYVYEIDF----VTPEALSAILEFAYTSTLTI 91

                        90       100
                ....*....|....*....|
gi 25150435 119 TTSNVQSIMLGAnffQMLEV 138
Cdd:cd18328  92 TTSNVKHILNAA---QMLEI 108
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-120 3.02e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 63.79  E-value: 3.02e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25150435  52 DVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSdmNYETVDALLSFAYTGELRITT 120
Cdd:cd18287  24 DVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDT--NAEAFKALLKYIYTGRLTLTD 90
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-146 3.21e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 63.31  E-value: 3.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANmKEINIEDSDMNYETVDALLSFAYTGELRITTS 121
Cdd:cd18329  13 DEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETG-QPTVATFDVFSPDTFTIILDFVYSGKLSLTSQ 91

                        90       100
                ....*....|....*....|....*
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18329  92 NVIEVMSAASYLQMTDVISVCKTFI 116
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-146 4.86e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 63.02  E-value: 4.86e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  34 YKKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFtLDLMEANMKEINIEDSDMNYETVDALLSFAYT 113
Cdd:cd18330   2 YTKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALL-IHYIQDSGRHSTASLDIVTSEAFSIILDFLYS 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 25150435 114 GELRITTSNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18330  81 GKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 50-134 5.36e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 61.80  E-value: 5.36e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVALLVENRKLSAHKVILAATIPYFRGMFTlDLMEANMKEINIedSDMNYETVDALLSFAYTGELRITTSNVQSIMLG 129
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLK-ETPPDEHPVIIL--PDVPYSELKALLDFIYTGEVNVSQEQLESLLKL 77


                ....*
gi 25150435 130 ANFFQ 134
Cdd:cd18315  78 AELLQ 82
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 150-248 5.43e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 62.27  E-value: 5.43e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREF-----CKMMCVEekitemTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEW 224
Cdd:cd18467   1 LDPGNCIGISRFaetygCHDLYLA------ANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESW 74

                        90       100
                ....*....|....*....|....*
gi 25150435 225 LNCDVI-RHEQAAKILPCVRLPLLS 248
Cdd:cd18467  75 IKYDVQeRQKYLAQLLHCVRLPLLS 99
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-156 6.49e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 63.07  E-value: 6.49e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  32 EMYKKsysiFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRgmftlDLMEANMKEINIED------SDMNYETVD 105
Cdd:cd18258   3 EMLKE----LNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFK-----DLIKRSSRDSGGGEkleltmSNINADVLE 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 25150435 106 ALLSFAYTGELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNAL 156
Cdd:cd18258  74 LLLEFVYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 150-252 7.21e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 62.10  E-value: 7.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNC-D 228
Cdd:cd18446   1 LHPENCVGILRLADAHSLES-LKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYkE 79

                        90       100
                ....*....|....*....|....
gi 25150435 229 VIRHEQAAKILPCVRLPLLSPTYL 252
Cdd:cd18446  80 SERLPLLPRVLENVRLPLLDPWYF 103
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-152 9.03e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 62.20  E-value: 9.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEanmkeiNIEDSDMNYETV--DALLSfAYTGELRIT 119
Cdd:cd18203  17 NQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSS------ELQVSLMHSSRVvaDLLLS-CYTGALEFS 89

                        90       100       110
                ....*....|....*....|....*....|...
gi 25150435 120 TSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHP 152
Cdd:cd18203  90 VRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-154 1.42e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 62.12  E-value: 1.42e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  33 MYKKSY-----SIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIED-SDMNYETVda 106
Cdd:cd18264   6 AYSKSHgeavlSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVvSAAGLQRV-- 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 25150435 107 lLSFAYTGELRITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSN 154
Cdd:cd18264  84 -LDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPEN 130
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 150-247 1.78e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 60.97  E-value: 1.78e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDV 229
Cdd:cd18460   1 LDVSNCLEMQDFAEAFACRG-LAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADP 79

                        90       100
                ....*....|....*....|
gi 25150435 230 iRHEQA--AKILPCVRLPLL 247
Cdd:cd18460  80 -KHRQHfwPELLQHVRLPFV 98
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-145 1.84e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 61.10  E-value: 1.84e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFtldLMEANMKEINIEdsdmNYETVDALLSFAYTGELRITT 120
Cdd:cd18206  13 LNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLF---VDQKDVVHLDIS----NAAGLGQVLEFMYTAKLSLSP 85

                        90       100
                ....*....|....*....|....*
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHCGNF 145
Cdd:cd18206  86 ENVDDVLAVATFLQMQDIVTACHAL 110
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-116 2.31e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 61.19  E-value: 2.31e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25150435  51 CDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFAYTGEL 116
Cdd:cd18280  15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIE--DVEPPVFKALLHFIYKDEL 78
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-146 2.45e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 61.01  E-value: 2.45e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDlmeaNMKEINIEdSDMNYETVDALLSFAYTGELRITTS 121
Cdd:cd18210  13 NQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQVLLK----NMSSISLP-GVMDPGAFESVLASAYTGKLTMLAD 87

                        90       100
                ....*....|....*....|....*
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18210  88 EIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-146 2.74e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 60.90  E-value: 2.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSdMNYETVDALLSFAYTGELRITTS 121
Cdd:cd18199  10 NEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDV-FSSDAFSIILDFVYSGKLSLTSQ 88

                        90       100
                ....*....|....*....|....*
gi 25150435 122 NVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18199  89 NVIEVMSAASYLQMTDVINVCKTFI 113
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 149-226 3.44e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 59.33  E-value: 3.44e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 25150435 149 RLHPSNALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLN 226
Cdd:cd18463   1 QLDPCNCLGIQKFADTHSLKQ-LFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVY 77
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-142 3.90e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 60.64  E-value: 3.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANmKEINIEDSDMNYETVDALLSFAYTGELRITTS 121
Cdd:cd18202  11 NQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSS-HEAVVDLSGFCKSSFLPLLEFAYTSELTFDFC 89

                        90       100
                ....*....|....*....|.
gi 25150435 122 NVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18202  90 SMAEVAMLARHLFMNEVLEIC 110
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-156 4.54e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 60.21  E-value: 4.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDlmeANMKEINIedSDMNYETVDALLSFAYTGELRITT 120
Cdd:cd18260   9 LNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKD---PSLQRVEL--NDISPLGLATVITYAYTGKLTLSL 83

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHCGNFLLTRLHPSNAL 156
Cdd:cd18260  84 YTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 51-156 9.50e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 59.44  E-value: 9.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  51 CDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEIN---IEDSDMNyetvdALLSFAYTGELRITTSNVQSIM 127
Cdd:cd18263  14 CDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQlptIPAKDLR-----LLISFAYSGILHLSWENLFEAT 88

                        90       100
                ....*....|....*....|....*....
gi 25150435 128 LGANFFQMLEVVQHCGNFLLTRLHPSNAL 156
Cdd:cd18263  89 CTALQLQISGALALCLDFLQREISPARCL 117
Kelch smart00612
Kelch domain;
352-396 1.08e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 56.80  E-value: 1.08e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 25150435    352 QVYAIGGFNGQDRLDLVEKFDYDTLKWTTLSPLTRKRSALAAAFV 396
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-142 1.22e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 59.21  E-value: 1.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMeanmkeINIeDSDMNYETV-DALLSFAYTGELRIT 119
Cdd:cd18334  12 LNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNL------INL-DTDMVNPTVfRQILDFIYTGKLLTS 84

                        90       100
                ....*....|....*....|....*..
gi 25150435 120 TS----NVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18334  85 DQpgeqNFNALLTAASYLQLHDLAALC 111
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-140 1.38e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 59.27  E-value: 1.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRgmftlDLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITT 120
Cdd:cd18289  20 LNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFR-----DLFSGNSKSAFELPATVPPACFQQILSFCYTGKLTMAA 94

                        90       100
                ....*....|....*....|
gi 25150435 121 SNVQSIMLGANFFQMLEVVQ 140
Cdd:cd18289  95 SEQLVVMYTAGFLQIQHIVE 114
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 388-431 1.51e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 56.47  E-value: 1.51e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 25150435   388 RSALAAAFVTNRLYVCGGYDGLHSLSSIEIYDINRNVWEAGPPM 431
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-146 1.95e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 58.70  E-value: 1.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  39 SIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEI----NIEDSD-MNYETVDALLSFAYT 113
Cdd:cd18327  14 SCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAgggqDVCELDfVGPEALGALLEFAYT 93

                        90       100       110
                ....*....|....*....|....*....|...
gi 25150435 114 GELRITTSNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18327  94 ATLTISSSNMREVLRAARLLEIPCVADACADIL 126
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-147 2.01e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 58.51  E-value: 2.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTldlmeaNMKEINIE-DSDMNYETVDALLSFAYTGELRIT 119
Cdd:cd18290  18 LNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFN------SSRSAVVElPAAVQPQSFQQILSFCYTGRLSMN 91

                        90       100
                ....*....|....*....|....*...
gi 25150435 120 TSNVQSIMLGANFFQMLEVVQHCGNFLL 147
Cdd:cd18290  92 VGDQFLLMYTAGFLQIQEIMEKGTEFFL 119
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-146 3.52e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 58.04  E-value: 3.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFtldLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITT 120
Cdd:cd18278  22 LNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQAL---VGQTENDLVVSLPEEVTARGFGPLLQFAYTAKLLLSR 98

                        90       100
                ....*....|....*....|....*.
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18278  99 ENIQEVIRCAEFLRMHNLEDSCFRFL 124
PLN02193 PLN02193
nitrile-specifier protein
 340-537 3.78e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 62.28  E-value: 3.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  340 LRTRVGVAVNQRQVYAIGG-FNGQDRLDL-VEKFDYDTLKWTtLSPLT---RKRSALAAAFVT--NRLYVCGGYDGLHSL 412
Cdd:PLN02193 165 LRCSHGIAQVGNKIYSFGGeFTPNQPIDKhLYVFDLETRTWS-ISPATgdvPHLSCLGVRMVSigSTLYVFGGRDASRQY 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  413 SSIEIYDINRNVWEAGPPME---NMRSAAGVTVIDKHIYICGGHDGMQIFASVERLDTENQQWERIPS---MIQQRCRFG 486
Cdd:PLN02193 244 NGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTpgdSFSIRGGAG 323

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 25150435  487 AATFKGKIYVAGGYDGTSfLKSVEVYDPVEKKWSPVSPMNMRRSRVSLVST 537
Cdd:PLN02193 324 LEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWTQVETFGVRPSERSVFAS 373
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-147 4.21e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 57.29  E-value: 4.21e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  40 IFNELRSKCQLCDVALLVENRKLSAHKVILAATiPYFRGMFTLDLMEANMKEINIEDSDMNYeTVDAL-LSFA--YTGEL 116
Cdd:cd18305   5 IYQTLFLNGENSDITICALGREWKLHKIYLCQS-GYFASMFSGSWKESKETVINLEIPDDNI-TVEALnVVFGslYRDEI 82

                        90       100       110
                ....*....|....*....|....*....|.
gi 25150435 117 RITTSNVQSIMLGANFFQMLEVVQHCGNFLL 147
Cdd:cd18305  83 EIKPSRVVSILAAATLLQLDGLIQQCSEVMK 113
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 50-150 7.26e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 56.48  E-value: 7.26e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIedSDMNYETVDALLSFAYTGELRItTSNVQS--IM 127
Cdd:cd18300   9 FSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVEL--PGVSKETFLALLEYLYTDQAPI-LEDGDCvgLI 85

                        90       100
                ....*....|....*....|...
gi 25150435 128 LGANFFQMLEVVQHCGNFLLTRL 150
Cdd:cd18300  86 VLANRLCLPRLVALCEQYIVKEL 108
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 170-247 7.74e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 56.31  E-value: 7.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 170 KITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAM------EWLNCDVIRHEQAAKILPCVR 243
Cdd:cd18461  20 HLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALlyhytpEQVEKDQVSLQEPPKLLEAVR 99


                ....
gi 25150435 244 LPLL 247
Cdd:cd18461 100 FPLM 103
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 53-133 7.81e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 55.37  E-value: 7.81e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  53 VALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIedSDMNYETVDALLSFAYTGELRITTSNVQSIMLGANF 132
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINL--RDISPEDFRALLEFLYGGKRDLDASNLLELLEAANF 78


                .
gi 25150435 133 F 133
Cdd:cd01165  79 L 79
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-146 7.86e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 56.79  E-value: 7.86e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTldlmEANMKEINIED--SDMNYETVDALLSFAYTGELRIT 119
Cdd:cd18332  11 NELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFS----GRVGEGVSVLTlpSGLEARGFQLLLDFMYTSRLPLT 86

                        90       100
                ....*....|....*....|....*..
gi 25150435 120 TSNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18332  87 PRTVPAVLAAATYLQMEHVVETCRRFI 113
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-158 8.98e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 57.21  E-value: 8.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  49 QLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKeiNIEDSDMNYETVDALLSFAYTGELRITTSNVQSIML 128
Cdd:cd18272  31 LFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNR--VIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYE 108

                        90       100       110
                ....*....|....*....|....*....|
gi 25150435 129 GANFFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18272 109 VADMYQLTALFEECSRFLARTVQVRNCLQV 138
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-143 1.17e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 56.34  E-value: 1.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  49 QLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDlMEANMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSIML 128
Cdd:cd18293  14 VFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSE-PPPAGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLA 92

                        90
                ....*....|....*
gi 25150435 129 GANFFQMLEVVQHCG 143
Cdd:cd18293  93 AARRLQISELESLCL 107
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-142 1.40e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 55.84  E-value: 1.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEIniedsdMNYETVDALLSFAYTGELRITT 120
Cdd:cd18208  16 LNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV------VSVQSVQKLIDFMYSGVLRVSQ 89

                        90       100
                ....*....|....*....|..
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18208  90 SEALQILTAASILQIKTVIDEC 111
Kelch smart00612
Kelch domain;
304-350 1.57e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 53.72  E-value: 1.57e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 25150435    304 LIVAIGGLMHqSQSKSSVEIYDPTSKKWSPIDGMVTLRTRVGVAVNQ 350
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-146 1.59e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 55.63  E-value: 1.59e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRgmftlDLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITT 120
Cdd:cd18200   9 LNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFH-----DKLLLNDTNCLVLPSVIEAAAFENLLQLIYSGRLTLCM 83

                        90       100
                ....*....|....*....|....*.
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18200  84 DALPSHLLVASGLQMWQVVDRCSELL 109
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 150-228 1.72e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 54.54  E-value: 1.72e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREFCK-MMCveEKITEMTDDYIQKHFMAVSKD-EDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNC 227
Cdd:cd18450   1 LTPENCIGIRKFARyYFC--PELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDH 78


                .
gi 25150435 228 D 228
Cdd:cd18450  79 D 79
PLN02153 PLN02153
epithiospecifier protein
 341-534 2.24e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 59.23  E-value: 2.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  341 RTRVGVAVNQRQVYAIGGF---NGQDRLDLVeKFDYDTLKWTTLSPL--TRKRSALAAAFVT--NRLYVCGGYDGLHSLS 413
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGElkpNEHIDKDLY-VFDFNTHTWSIAPANgdVPRISCLGVRMVAvgTKLYIFGGRDEKREFS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  414 SIEIYDINRNVW--------EAGPPMENMRSAAGvtvIDKHIYICGG--HDGMQI----FASVERLDTENQQWERIP--- 476
Cdd:PLN02153 102 DFYSYDTVKNEWtfltkldeEGGPEARTFHSMAS---DENHVYVFGGvsKGGLMKtperFRTIEAYNIADGKWVQLPdpg 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25150435  477 SMIQQRCRFGAATFKGKIYVAGGYdGTSFL---------KSVEVYDPVEKKWSPVSPMNMRRSRVSL 534
Cdd:PLN02153 179 ENFEKRGGAGFAVVQGKIWVVYGF-ATSILpggksdyesNAVQFFDPASGKWTEVETTGAKPSARSV 244
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 177-247 2.31e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 54.78  E-value: 2.31e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25150435 177 DYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDVI-RHEQAAKILPCVRLPLL 247
Cdd:cd18517  27 DFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKEnRVKSLGEIFDCIRFRLM 98
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-145 2.57e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 54.98  E-value: 2.57e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  49 QLCDVALLVENRKLSAHKVILAATIPYFRGMFT-LDLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSIM 127
Cdd:cd18292  16 ELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSnDWWSESKQSEIELVEDPECAAVFEKFLRYLYTGQISVNLETALPLL 95

                        90
                ....*....|....*...
gi 25150435 128 LGANFFQMLEVVQHCGNF 145
Cdd:cd18292  96 MLADKYNVTDLKQLCVDF 113
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-142 2.65e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 55.63  E-value: 2.65e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  28 DILDEMYKksysifneLRSKCQLCDVALLVENR----KLSAHKVILAATIPYFRGMFtLDLMEANMKEINIEDSDMNYET 103
Cdd:cd18211  11 NLLNEMHK--------LRLLGHLCDVTVQVEHQgskeEFSAHKAVLAASSKYFKEVF-LNEKISDGKNTNVMLNEIYTAD 81

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 25150435 104 VDALLSFAYTGELRITTSNVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18211  82 FASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETC 120
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 341-385 2.93e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 52.61  E-value: 2.93e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 25150435   341 RTRVGVAVNQRQVYAIGGFNGQDRLDLVEKFDYDTLKWTTLSPLT 385
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-146 3.03e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 55.07  E-value: 3.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFR----GMFTLDLMEANMKEINIEDsdmnyetVDALLSFAYTGEL 116
Cdd:cd18277  18 LNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHsrivGQADAELNITLPEEVTVKG-------FEPLIQFAYTAKL 90

                        90       100       110
                ....*....|....*....|....*....|
gi 25150435 117 RITTSNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18277  91 ILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 151-247 3.22e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 54.43  E-value: 3.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 151 HPSNALSIREFCKMMCVEeKITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDV- 229
Cdd:cd18464   1 HPSNCLGMLLLSDAHQCQ-RLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLp 79

                        90
                ....*....|....*...
gi 25150435 230 IRHEQAAKILPCVRLPLL 247
Cdd:cd18464  80 RRHEVLPELLRSVRLALL 97
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-142 4.25e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 54.83  E-value: 4.25e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  31 DEMYKKsysiFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDlmEANMKEINIEDsdmNYETVDALLSF 110
Cdd:cd18214  10 DSMLQK----MNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFLLN--DSREVQISILQ---NSEVGRQLLLS 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 25150435 111 AYTGELRITTSNVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18214  81 CYTGVLEFPEMELVNYLTAASFLQMSHIVERC 112
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 171-247 4.39e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 54.14  E-value: 4.39e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25150435 171 ITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDVIRHEQAAKILPCVRLPLL 247
Cdd:cd18465  21 LKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPSRRASASHVLCHIRFPLM 97
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 150-247 5.08e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 53.69  E-value: 5.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREF-----CKMMCVEEKitemtdDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEW 224
Cdd:cd18477   1 LCLGNCLAIFRLgllldCPRLAVSAR------DFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKW 74

                        90       100
                ....*....|....*....|....*..
gi 25150435 225 LNCDvirHEQAAKILP----CVRLPLL 247
Cdd:cd18477  75 VREA---KENRQKALPtvfeSIRFRLL 98
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-142 5.37e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 54.11  E-value: 5.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDlmEANMKEINIEDsdmNYETVDALLSFAYTGELRITTS 121
Cdd:cd18197  17 NLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLN--QSKQVRITILQ---SAEVGRKLLLSCYTGALEVKKK 91

                        90       100
                ....*....|....*....|.
gi 25150435 122 NVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18197  92 ELLKYLTAASYLQMVHIVEKC 112
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 151-247 5.65e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 53.83  E-value: 5.65e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 151 HPSNALSirefckMMCVEE-----KITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWL 225
Cdd:cd18515   1 HPTNCLG------MLLLSDahqctKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWV 74

                        90       100
                ....*....|....*....|...
gi 25150435 226 NCDV-IRHEQAAKILPCVRLPLL 247
Cdd:cd18515  75 NYDLkKRHCYLSELLQTVRLALL 97
Kelch smart00612
Kelch domain;
541-584 5.94e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 51.79  E-value: 5.94e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 25150435    541 LFAVAGFDGENNLCSMEQYDDVTDSWTIATALTCHEGGVGVGVI 584
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-158 6.01e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 53.65  E-value: 6.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  52 DVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANmkeiniedsDMNYETVDALLSFAYTGELRITTSNVQSIMLGAN 131
Cdd:cd18275   6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDILKVK---------GLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGAR 76

                        90       100
                ....*....|....*....|....*..
gi 25150435 132 FFQMLEVVQHCGNFLLTRLHPSNALSI 158
Cdd:cd18275  77 FLQMPCAAQCAVDAVRAQLCLGNCYEV 103
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 150-245 6.15e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 53.71  E-value: 6.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDV 229
Cdd:cd18483   1 LDPQNSIGVFIFADHYGHQE-LKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQ 79

                        90
                ....*....|....*...
gi 25150435 230 IRHE-QAAKILP-CVRLP 245
Cdd:cd18483  80 SKREmHLPEIFAkCIRMP 97
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 150-249 6.18e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 53.59  E-value: 6.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALS-IR--EFCKMMCVEEKITEMTddyiQKHFMAVSKDEDFKRLSLEDAIELLRNDHLyVDSEEQVYVAAMEWLN 226
Cdd:cd18476   1 LTPSNCLSmIRlsEILNCETLKKKAKDMA----LQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIR 75

                        90       100
                ....*....|....*....|....*
gi 25150435 227 CDvIRHEQAA--KILPCVRLPLLSP 249
Cdd:cd18476  76 HD-PKARKGYihDLFKKVRLQYVHP 99
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-149 8.15e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 53.77  E-value: 8.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVAL-LVENRK-LSAHKVILAATIPYFRGMFTldlMEANMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSIM 127
Cdd:cd18231  14 LCDVDIvLVRQRStFPAHKGVLAAYSQFFHSLFT---QNKQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVL 90

                        90       100
                ....*....|....*....|..
gi 25150435 128 LGANFFQMLEVVQHCGNFLLTR 149
Cdd:cd18231  91 NAAAVLQMNDIAASCQELIDSR 112
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-142 8.56e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 53.69  E-value: 8.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMeanmkeINIeDSDMNYETV-DALLSFAYTGELRITT 120
Cdd:cd18216  12 NNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNL------IHL-DQDMVSPTVfQQILDFIYTGKLLDSL 84

                        90       100
                ....*....|....*....|....*
gi 25150435 121 ---SNVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18216  85 feePNLSEVLAAANYLQLPDLAALC 109
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-133 8.56e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 53.72  E-value: 8.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  39 SIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEAN-MKEINIEDSDmnyeTVDALLSFAYTGELR 117
Cdd:cd18209   7 SALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENESQsVFQLDFCEPD----AFENVLNYIYSSSLF 82

                        90       100
                ....*....|....*....|.
gi 25150435 118 ITTSNVQSIM-----LGANFF 133
Cdd:cd18209  83 VEKSSLAAVQelgysLGISFL 103
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-142 8.65e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 53.60  E-value: 8.65e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEAnmkeINIEDSDMNYETVDALLSFAYTGELRITTS 121
Cdd:cd18217  10 NKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNI----VFLDQSQVSADGFQKLLEFIYTGNLNLDSW 85

                        90       100
                ....*....|....*....|.
gi 25150435 122 NVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18217  86 NVAEIHQAASYLGMEEVVAKC 106
PLN02193 PLN02193
nitrile-specifier protein
 324-475 9.76e-09

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 58.04  E-value: 9.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  324 YDPTSKKW---SPIDGMVTLRTRVGVAVNQRQVYAIGGFNGQDRLDLVEKFDYDTLKWTTLSPLTRKRSALAAA---FVT 397
Cdd:PLN02193 249 FDTTTNEWkllTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSFSIRGGAgleVVQ 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  398 NRLYVCGGYDGLHsLSSIEIYDINRNVW---EAGPPMENMRSAAGVTVIDKHIYICGGHDGMQIFASVE---------RL 465
Cdd:PLN02193 329 GKVWVVYGFNGCE-VDDVHYYDPVQDKWtqvETFGVRPSERSVFASAAVGKHIVIFGGEIAMDPLAHVGpgqltdgtfAL 407

                        170
                 ....*....|
gi 25150435  466 DTENQQWERI 475
Cdd:PLN02193 408 DTETLQWERL 417
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-146 9.94e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 53.40  E-value: 9.94e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  49 QLCDVALLV--ENRKLSAHKVILAATIPYFRGMFTLDLM-EANMKEINIedSDMNYETVDALLSFAYTGELRITTSNVQS 125
Cdd:cd18294  13 EFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQkESTQSPLVL--SDIEPEVFRAVLEFIYTNCVTLSNHTVIE 90

                        90       100
                ....*....|....*....|.
gi 25150435 126 IMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18294  91 VLAAAVEYGLDELRKLCERFI 111
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 50-137 1.26e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 53.25  E-value: 1.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIedSDMNYETVDALLSFAYTGELRITTSNVQSIMLG 129
Cdd:cd18352  13 LSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEI--PNIRWEVFELMMRFIYTGSVDITNDIAKDLLRA 90


                ....*...
gi 25150435 130 ANFFqMLE 137
Cdd:cd18352  91 ADQY-LLE 97
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 151-206 1.47e-08

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 51.12  E-value: 1.47e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 25150435 151 HPSNALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRN 206
Cdd:cd14733   1 DPENCLGILELADLYNLEE-LKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-140 2.01e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 52.49  E-value: 2.01e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSK-CQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDlmeANMKEINIEdsDMNYETVDALLSFAYTGELRITT 120
Cdd:cd18226  13 NDDRQKqSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKN---PNTDAVTLD--HVSYSVFQHLLEFLYTSEFFVYE 87

                        90       100
                ....*....|....*....|
gi 25150435 121 SNVQSIMLGANFFQMLEVVQ 140
Cdd:cd18226  88 NEIPLVLEAAKFLDIIDAVK 107
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 176-245 2.25e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 52.04  E-value: 2.25e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 176 DDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDVIRHEQAAKILPCVRLP 245
Cdd:cd18449  26 NDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHEDDRMQFAAKLMENIRFP 95
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 152-243 2.26e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 51.93  E-value: 2.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 152 PSNALSIREFCKMMC---VEEKITEmtddYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCD 228
Cdd:cd18455   2 AENCIGIRDFAERFScphVHYVATE----YLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHD 77

                        90
                ....*....|....*.
gi 25150435 229 V-IRHEQAAKILPCVR 243
Cdd:cd18455  78 PeERKVHLKDLMSSCW 93
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 150-225 4.51e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 50.46  E-value: 4.51e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25150435 150 LHPSNALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWL 225
Cdd:cd18472   1 LSPANCLELWAFADAATLPR-LAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-115 5.13e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 51.77  E-value: 5.13e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25150435  44 LRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIedSDMNYETVDALLSFAYTGE 115
Cdd:cd18345  12 LFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEI--TDVDHEVMREMLRFIYTGK 81
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-154 9.10e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 50.78  E-value: 9.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  39 SIFNELRSKCQLCDVALLVENRKLSAHKVILAAtipyfRGMFTLDLMEANMKEINIedSDMNYETVDALLSFAYTGELRI 118
Cdd:cd18303   7 KTVASLFDKELYSDITIKLADKSIPAHKFVLAA-----RSEKWSNENLASTNELDL--SDISYEVVLALLRWLYTDELDL 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25150435 119 TTSNVQ--SIMLGANFFQMLEVVQHCGNFLLTRLHPSN 154
Cdd:cd18303  80 TLDDEFllELMKAAKRFQLTDLVERCERALMSSVNVDN 117
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-146 1.08e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 50.59  E-value: 1.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  44 LRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMftLDlmeaNMKEINIEDSDMNYETVDALLSFAYTGELRITTSNV 123
Cdd:cd18225  17 LRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSL--LD----STDTISIDASVVSPEEFALLLEMVYTGKLPPGKHNF 90

                        90       100
                ....*....|....*....|...
gi 25150435 124 QSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18225  91 TKIISVADSLQMFDVAVSCKNLL 113
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-146 1.10e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 49.77  E-value: 1.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVALLVENRKLSAHKVILAATIPYFRGmfTLDLMEANMKEINIEDsDMNYETVDALLSFAYTGELRITTSNVQSIMLG 129
Cdd:cd18955   1 LCDVTIVVEDQRFRAHRAVLAACSDYFLS--RVVGQTDGDLVITLPE-EVTVKGFEPLLQFAYTAKLLLSKENVLEVCRC 77

                        90
                ....*....|....*..
gi 25150435 130 ANFFQMLEVVQHCGNFL 146
Cdd:cd18955  78 AEFLGVHNIEKACFDFL 94
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-136 1.26e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 50.42  E-value: 1.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  40 IFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMF-TLDLMEANMKEINIEDSDMNYEtvdaLLSFAYTGELRI 118
Cdd:cd18204   8 TLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFkKLEVDSSSVIEIDFLRSDIFEE----VLNYMYTAKISV 83

                        90       100
                ....*....|....*....|...
gi 25150435 119 TTSNVQSIM-----LGANFFQML 136
Cdd:cd18204  84 KKEDVNLMMssgqiLGIRFLDKL 106
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 47-146 1.81e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 49.52  E-value: 1.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  47 KCQLC-DVALLVENR-KLSAHKVILAATIPYFRGMFTldlmeaNMKEINIeDSDMNYETVDALLSFAYTGELRITTSNVQ 124
Cdd:cd18299   8 HSPSCaDVVFILQGGvRIFAHRIVLAAASSVFADLFL------MMTVVTL-DSDITPEAFRRVLEFLYTGVLDENEDDLK 80

                        90       100
                ....*....|....*....|..
gi 25150435 125 SIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18299  81 ELKDAAELLELFDLVMMCTNVL 102
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-114 2.16e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 49.84  E-value: 2.16e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25150435  52 DVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEAnmKEINIEDSDMNYETVDALLSFAYTG 114
Cdd:cd18279  20 DCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEES--KKNRVEINDVDPEVFKEMMRFIYTG 80
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-142 3.39e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 49.13  E-value: 3.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMeanmkeINIeDSDMNYETV-DALLSFAYTGEL--- 116
Cdd:cd18333  12 LNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNL------INL-DHEMVSPGIfRLILDYIYTGRLseg 84

                        90       100
                ....*....|....*....|....*..
gi 25150435 117 -RITTSNVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18333  85 dPGSEQNLGAVLAAASYLQIPDLVALC 111
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-80 3.52e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 49.02  E-value: 3.52e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 25150435  39 SIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMF 80
Cdd:cd18223   7 SCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAF 48
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-146 5.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 48.35  E-value: 5.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEAN-MKEINIEdsdmNYETVDALLSFAYTGELRIT 119
Cdd:cd18233   9 LHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNdVFHLDIK----NVGGIGQILDFMYTSHLDLN 84

                        90       100
                ....*....|....*....|....*..
gi 25150435 120 TSNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18233  85 QDNVQVMLDIAQCLQVQNVLNMCYTFL 111
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 150-247 5.83e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 47.92  E-value: 5.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSirefckMMCVEE-----KITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEW 224
Cdd:cd18514   1 LHPSNCLG------MMLLSDahqcrRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQW 74

                        90       100
                ....*....|....*....|....
gi 25150435 225 LNCDV-IRHEQAAKILPCVRLPLL 247
Cdd:cd18514  75 VKYDLeKRKDYLPELLRNVRLALL 98
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-146 8.20e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 47.63  E-value: 8.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  52 DVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANmKEInIEDSDMNYETVDALLSFAYTGELRITTSNVQSIMLGAN 131
Cdd:cd18298  14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDD-KNV-IEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLDLAN 91

                        90
                ....*....|....*
gi 25150435 132 FFQMLEVVQHCGNFL 146
Cdd:cd18298  92 SYCEERLKKLCEDII 106
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-142 8.34e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 48.49  E-value: 8.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRgMFTLDLMEAnmKEINIEDSDM-NYETVDALLSFAYTGELRIT 119
Cdd:cd18325  14 LSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFH-LFYRDQLDK--RDIVHLNSDIvTAPAFSLLLEFMYEGKLEFS 90

                        90       100
                ....*....|....*....|...
gi 25150435 120 TSNVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18325  91 SLPVEDVLAAASYLHMYDIVKVC 113
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 52-126 9.98e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 46.94  E-value: 9.98e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25150435  52 DVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSI 126
Cdd:cd18283   4 DVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNL 78
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-140 1.00e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 47.69  E-value: 1.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  34 YKKSYSIFNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTlDLMEANMKEINiEDSDMNYEtvdALLSFAYT 113
Cdd:cd18221   2 YKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQ-DFTQEPLVEIE-GVSNMAFR---HLIEFTYT 76

                        90       100
                ....*....|....*....|....*...
gi 25150435 114 GELRITT-SNVQSIMLGANFFQMLEVVQ 140
Cdd:cd18221  77 AKLMVQGeEEANDVWKAAEYLQMQEAIK 104
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 150-227 1.01e-06

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 47.23  E-value: 1.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 150 LHPSNALSIREF-CKMMCveEKITEMTDDYIQKHFMAVSKDEDFKRLSLEDaIELLRNDH--LYVDSEEQVYVAAMEWLN 226
Cdd:cd18502   1 LTPENCIGIRSFaGRMND--SELLQKVDSYIQENIEEVAESKEFLKLPRLQ-IEVILESNqeLESINERKLCQLVLEWVQ 77


                .
gi 25150435 227 C 227
Cdd:cd18502  78 R 78
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 177-247 1.06e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 47.06  E-value: 1.06e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25150435 177 DYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDvirHEQAAKILP----CVRLPLL 247
Cdd:cd18516  27 DFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKD---QEERTKALPvlleSIRFRLM 98
PLN02193 PLN02193
nitrile-specifier protein
 417-567 1.11e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 51.49  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  417 IYDINRNVWEAGPPMENMR--SAAGVTV--IDKHIYICGGHDGMQIFASVERLDTENQQWERIPSMIQ---QRCRFGAAT 489
Cdd:PLN02193 197 VFDLETRTWSISPATGDVPhlSCLGVRMvsIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEgptPRSFHSMAA 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  490 FKGKIYVAGGYDGTSFLKSVEVYDPVEKKW----SPVSPMNMrRSRVSLVSTNEGLFAVAGFDGennlCSMEQ---YDDV 562
Cdd:PLN02193 277 DEENVYVFGGVSATARLKTLDSYNIVDKKWfhcsTPGDSFSI-RGGAGLEVVQGKVWVVYGFNG----CEVDDvhyYDPV 351


                 ....*
gi 25150435  563 TDSWT 567
Cdd:PLN02193 352 QDKWT 356
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 528-573 1.13e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 45.30  E-value: 1.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 25150435   528 RRSRVSLVSTNEGLFAVAGFDGENNLCSMEQYDDVTDSWTIATALT 573
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-115 1.32e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 47.64  E-value: 1.32e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25150435  43 ELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDlMEANMKEInIEDSDMNYETVDALLSFAYTGE 115
Cdd:cd18344  16 ELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHE-MEERLKNP-IEIHDLDPQVFKEMMGFIYTGK 86
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-142 1.50e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 47.67  E-value: 1.50e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  30 LDEMYKKSYSIFNE--LRSKcQLCDVALLVENRKLSAHKVILAATIPYFRGMFTldlMEANMKEINIEDSDMNYETVDAL 107
Cdd:cd18351   3 LTEIKRKQTSRLDPhfLNNK-EMSDVTFLVEGRPFYAHKVLLFTASPRFKALLS---NKPSAENTCIEISYVKYHIFQLV 78

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 25150435 108 LSFAYTG---ELRITTSNVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18351  79 MQYLYCGgteSLLIKNNEIMELLSAAKFFQLEALQRHC 116
Kelch_6 pfam13964
Kelch motif;
482-529 1.55e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.40  E-value: 1.55e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 25150435   482 RCRFGAATFKGKIYVAGGY-DGTSFLKSVEVYDPVEKKWSPVSPMNMRR 529
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 52-114 1.57e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 47.25  E-value: 1.57e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25150435  52 DVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEdsDMNYETVDALLSFAYTG 114
Cdd:cd18286  19 DITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLT--GVSHAAVSFVLLFIYGG 79
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-142 1.60e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 47.53  E-value: 1.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  49 QLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNYETVDALLSFAYTG---ELRITTSNVQS 125
Cdd:cd18350  23 EMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSEQESQGSKTIEISDIKYHIFQMLMQYLYYGgteSMEIPIADVLE 102

                        90
                ....*....|....*..
gi 25150435 126 IMLGANFFQMLEVVQHC 142
Cdd:cd18350 103 LLSAASLFQLDALQRHC 119
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 169-252 1.65e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 46.84  E-value: 1.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 169 EKITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVdSEEQVYVAAMEWLNCDVIRHEQAAKILPCVRLPLLS 248
Cdd:cd14822  19 DDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCA-PEVDIFNAVRRWCEHNPDSKEDAKEILEAVRLPLMS 97


                ....
gi 25150435 249 PTYL 252
Cdd:cd14822  98 LTEL 101
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-142 1.92e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 47.12  E-value: 1.92e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  43 ELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRgMFTLDlmEANMKEIniedSDMNYETVDA-----LLSFAYTGELR 117
Cdd:cd18194  16 EQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH-LFYRD--RLDKRDL----VRLNSDIVTApafglLLDFMYEGRLA 88

                        90       100
                ....*....|....*....|....*
gi 25150435 118 ITTSNVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18194  89 LRDLPVEDVLAAASYLHMYDIVKVC 113
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 51-115 2.13e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 47.00  E-value: 2.13e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25150435  51 CDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNYETVDALLSFAYTGE 115
Cdd:cd18309  21 CDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSRQAFDSLLRYIYYGD 85
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 154-244 2.17e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 46.20  E-value: 2.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 154 NALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDVI-RH 232
Cdd:cd18479   5 NCVRLLSFADLFSCEE-LKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTEsRS 83

                        90
                ....*....|..
gi 25150435 233 EQAAKILPCVRL 244
Cdd:cd18479  84 QYLSSVLSQIRI 95
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-114 2.52e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 46.92  E-value: 2.52e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25150435  52 DVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIedSDMNYETVDALLSFAYTG 114
Cdd:cd18343  23 DCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEI--NDVDPEVFKEMMRFIYTG 83
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 46-117 2.90e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 47.30  E-value: 2.90e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  46 SKCQLCDVALLVEN-RKLSAHKVILAATIPYFRGMFTLDLMEAN-------MKEInIEDSDMNYETVDALLSFAYTGELR 117
Cdd:cd18310  14 PDLFYSDAEIIVEGgRPVPVHRCILAARSPFFRDIFASAKAEGAntkpkleLREL-IPGGIVGYDAFMLVLSYLYSGRLR 92
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-142 3.04e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 46.88  E-value: 3.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  45 RSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTlDLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQ 124
Cdd:cd18207  22 KSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFS-AQEGDGGTPRELEMHTISSKVFGDILDFAYTSRIVVRLESFP 100

                        90
                ....*....|....*...
gi 25150435 125 SIMLGANFFQMLEVVQHC 142
Cdd:cd18207 101 ELMTAAKFLLMRSVIDIC 118
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 173-248 3.07e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 46.02  E-value: 3.07e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25150435 173 EMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDVIRHEQAAKILPCVRLPLLS 248
Cdd:cd18470  23 EAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQKRVKYAADLLSNIRFGTIS 98
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-142 3.16e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 47.34  E-value: 3.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINiedSDMNYETVDA-LLSFAYTGELRIT 119
Cdd:cd18324  14 LSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLN---SDIVTAPAFAlLLEFMYEGKLQFK 90

                        90       100
                ....*....|....*....|...
gi 25150435 120 TSNVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18324  91 DLPIEDVLAAASYLHMYDIVKVC 113
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-142 3.17e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 46.39  E-value: 3.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEIniedsdMNYETVDALLSFAYTGELRITTS 121
Cdd:cd18229  10 NAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPV------VPAQTVRQLVEFMYSGSLVVAQS 83

                        90       100
                ....*....|....*....|.
gi 25150435 122 NVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18229  84 EALQILTAASILQIKTVIDEC 104
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 52-127 3.47e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 46.47  E-value: 3.47e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25150435  52 DVALLVENRKLSAHKVILAATIPYFRGMFtlDLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSIM 127
Cdd:cd18295  21 DVTFNVHGESFPAHRCILSARSPYFAEMF--ETKWKDKREINLKHPLVNPDAFRALLQYLYTGRLEIHVDDVEDCK 94
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-142 3.61e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 46.36  E-value: 3.61e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTldLMEANMKEINIED--SDMNYETVdalLSFAYTGELRIT 119
Cdd:cd18224  18 NKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFL--STELDVARTYVVDfiTPANFEKV---LSFIYTSELFTD 92

                        90       100
                ....*....|....*....|...
gi 25150435 120 TSNVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18224  93 LINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-101 3.67e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 45.98  E-value: 3.67e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTL--DLMEANMKEINIEDSDMNY 101
Cdd:cd18219  13 NEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVagQVVELNFIRADIFAEILNY 74
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 178-243 3.73e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 45.57  E-value: 3.73e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 25150435 178 YIQKHF-MAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDVI-RHEQAAKILPCVR 243
Cdd:cd18482  28 FIARNFqQLLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKeRAASAAEVLKCVR 95
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-135 5.31e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 45.58  E-value: 5.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVALLVENRKLSAHKVILAATIPYFRGMFTLDlmEANMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSIMLG 129
Cdd:cd18192  21 LCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINH--QHTTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSDFEQLKVA 98


                ....*.
gi 25150435 130 ANFFQM 135
Cdd:cd18192  99 MNYLQL 104
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-149 5.86e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 45.97  E-value: 5.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  43 ELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRgMFTLDlmEANMKEINIedsdMNYETVDA-----LLSFAYTGELR 117
Cdd:cd18323  16 EQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MFYKE--QLDKRDLVC----INNEIVTApafslLLEFMYEGRLS 88

                        90       100       110
                ....*....|....*....|....*....|..
gi 25150435 118 ITTSNVQSIMLGANFFQMLEVVQHCGNFLLTR 149
Cdd:cd18323  89 FNDTPVEDVLAAASYLHMNDIVKVCKKRLQAR 120
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-77 6.69e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 45.65  E-value: 6.69e-06
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFR 77
Cdd:cd18195  10 NEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFR 45
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 177-228 8.99e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 44.03  E-value: 8.99e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 25150435 177 DYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCD 228
Cdd:cd18474  27 RVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 43-130 9.54e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 44.51  E-value: 9.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  43 ELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGmfTLDLMEANMKEINIEDSDMNYEtvdALLSFAYTGELRITTSN 122
Cdd:cd18262  11 RLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRE--RLLGSNGPLPPLSLEVTPVGWE---AVLTFAYTGVLGRNPAT 85


                ....*...
gi 25150435 123 VQSIMLGA 130
Cdd:cd18262  86 VGDILVAA 93
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 482-525 1.04e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 42.71  E-value: 1.04e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 25150435   482 RCRFGAATFKGKIYVAGGYDGT--SFLKSVEVYDPVEKKWSPVSPM 525
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLgdLSSSDVLVYDPETNVWTEVPRL 47
Kelch_6 pfam13964
Kelch motif;
388-435 1.05e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.71  E-value: 1.05e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 25150435   388 RSALAAAFVTNRLYVCGGYDGLHSLSS-IEIYDINRNVWEAGPPMENMR 435
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPALNkLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-154 1.61e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 44.73  E-value: 1.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVALLVEN----RKLSAHKVILAATIPYFRGMFTLDLMEanmKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQS 125
Cdd:cd18281  22 LSDVHFIVGKgdneQRIPAHKFVLSIGSAVFDAMFNGGMAT---TSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMT 98

                        90       100
                ....*....|....*....|....*....
gi 25150435 126 IMLGANFFQMLEVVQHCGNFLLTRLHPSN 154
Cdd:cd18281  99 TLYTAKKYAVPALESACVEFLKKNLSSDN 127
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 300-337 2.81e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.44  E-value: 2.81e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 25150435   300 IVPGLIVAIGGLMHQsQSKSSVEIYDPTSKKWSPIDGM 337
Cdd:pfam01344   9 VVGGKIYVIGGFDGN-QSLNSVEVYDPETNTWSKLPSM 45
Kelch_6 pfam13964
Kelch motif;
434-482 2.89e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.55  E-value: 2.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 25150435   434 MRSAAGVTVIDKHIYICGG-HDGMQIFASVERLDTENQQWERIPSMIQQR 482
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 175-228 4.08e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 42.31  E-value: 4.08e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 25150435 175 TDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCD 228
Cdd:cd18480  25 ALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHD 78
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-142 5.38e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 42.62  E-value: 5.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  43 ELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMftldLMEANMKEINIEDSdMNYETVDALLSFAYTGELRITTSN 122
Cdd:cd18218  11 RLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQ----LTNPNPGQWCLGEG-ISPSTFKQLLDFVYGESVEVQPGE 85

                        90       100
                ....*....|....*....|
gi 25150435 123 VQSIMLGANFFQMLEVVQHC 142
Cdd:cd18218  86 LRPLLEAARALEVESLEEAC 105
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-150 6.45e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 42.28  E-value: 6.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  49 QLCDVALLV----ENRKLSAHKVILAATIPYFRGMFTLDLMEANmKEINIEDSDMNYETVdaLLSFAYTGELRITTSNVQ 124
Cdd:cd18349   7 LMADVHFIVgppgASQRVPAHKYVLAVGSSVFYAMFYGDLAEVK-SEIHIPDVEPAAFLI--LLKYMYSDEIDLEADTVL 83

                        90       100
                ....*....|....*....|....*.
gi 25150435 125 SIMLGANFFQMLEVVQHCGNFLLTRL 150
Cdd:cd18349  84 ATLYAAKKYIVPALAKACVNFLETSL 109
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 177-226 6.74e-05

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 41.56  E-value: 6.74e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 25150435 177 DYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLN 226
Cdd:cd18503  27 DYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTE 76
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 52-128 7.27e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 41.73  E-value: 7.27e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25150435  52 DVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSIML 128
Cdd:cd18190   1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSVENVHEVL 77
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 52-146 7.75e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 42.67  E-value: 7.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  52 DVALLVENRKLSAHKVILAATIPYFRGMFT---LDLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSIML 128
Cdd:cd18296  19 DVCFQVEGHRFPCHKAFFCGRSDYFKALLRdhfAESEENNGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLY 98

                        90
                ....*....|....*...
gi 25150435 129 GANFFQMLEVVQHCGNFL 146
Cdd:cd18296  99 VADMYLLPGLKRLCGTVL 116
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 149-251 8.80e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 42.05  E-value: 8.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 149 RLHPSNALSIREFCKMM-CVEEKITEMTddYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWlnc 227
Cdd:cd18469   2 QIDATNCLGICEFGETHgCPEVAAKAWS--FLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRW--- 76

                        90       100       110
                ....*....|....*....|....*....|
gi 25150435 228 dvIRHEQAAKI------LPCVRLPLLSPTY 251
Cdd:cd18469  77 --VGHDPQARAahlpelLSLVHLSLLTDQY 104
EVH1_family cd00837
EVH1 (Drosophila Enabled (Ena)/Vasodilator-stimulated phosphoprotein (VASP) homology 1) domain; ...
 315-383 9.68e-05

EVH1 (Drosophila Enabled (Ena)/Vasodilator-stimulated phosphoprotein (VASP) homology 1) domain; The EVH1 domains are part of the PH domain superfamily. EVH1 subfamilies include Enables/VASP, Homer/Vesl, WASP, and Spred. Ligands are known for three of the EVH1 subfamilies, all of which bind proline-rich sequences: the Enabled/VASP family binds to FPPPP peptides, the Homer/Vesl family binds PPxxF peptides, and the WASP family binds LPPPEP peptides. EVH1 has a PH-like fold, despite having minimal sequence similarity to PH or PTB domains.


Pssm-ID: 269909  Cd Length: 103  Bit Score: 41.68  E-value: 9.68e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25150435 315 SQSKSSVEIYDPTSKKWSPIDGMVTLRTRVgVAVNQRQVYAIGGFNGQDRLDLVEKFDYDTLKWTTLSP 383
Cdd:cd00837   3 FSARAHVMQIDDSNKNWVPAGGKGASRVSY-FKDTTRNSFRIIGVDIKDKKVVINCTITKNLVYNKATQ 70
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-142 9.87e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 42.49  E-value: 9.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVALLVENRKLSAHKVILAATIPYFRgMFTLDLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSIMLG 129
Cdd:cd18956  23 LCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDRPAGGRDTVRLNGDIVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAA 101

                        90
                ....*....|...
gi 25150435 130 ANFFQMLEVVQHC 142
Cdd:cd18956 102 ASYLHMYDIVKVC 114
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 49-155 1.02e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 42.40  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  49 QLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDLMEAnmKEINIEDSDMNYETVDALLSFAYTGELRITTSNVQSIML 128
Cdd:cd18342  21 RFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEES--KKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLA 98

                        90       100
                ....*....|....*....|....*..
gi 25150435 129 GANFFQMLEVVQHCGNFLLTRLHPSNA 155
Cdd:cd18342  99 AADKYALERLKVMCEDALCSNLSVENA 125
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 169-250 1.11e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 41.80  E-value: 1.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435 169 EKITEMTDDYIQKHFMAVSKDEDF-KRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWLNCDVIRHEQAAKILPCVRLPLL 247
Cdd:cd18454  21 EGVREKLDSFLLENFVPLMSRPDFlSYLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHDRRRWRHTDTIIQNIRFCLM 100


                ...
gi 25150435 248 SPT 250
Cdd:cd18454 101 TPT 103
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-150 1.13e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 41.61  E-value: 1.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSkcqlcDVALLV----ENRKLSAHKVILAATIPYFRGMFTLDLMEaNMKEINIedSDMNYETVDALLSFAYTGELR 117
Cdd:cd18282   4 NELMA-----DVHFIVgppgGTQRIPAHKYVLATGSSVFYAMFYGGLAE-NKNEIEI--PDVEPAAFLNLLRYLYCDEID 75

                        90       100       110
                ....*....|....*....|....*....|...
gi 25150435 118 ITTSNVQSIMLGANFFQMLEVVQHCGNFLLTRL 150
Cdd:cd18282  76 LEPDTVLATLYAAKKYLVPHLARACVQFLETSL 108
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 42-135 1.21e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 41.80  E-value: 1.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVAL-LVENRKLSAHKVILAATIPYFRgmfTLDLMEANMKEINIEDSDMNYETVDALLSFAYTGELRITT 120
Cdd:cd18311   6 QNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYFN---VLEQTCEIVDDTLIMPNELQADAVVPVINFMYTGQLEFEE 82

                        90
                ....*....|....*
gi 25150435 121 SNVQSIMLGANFFQM 135
Cdd:cd18311  83 KSYGKLLRTAKELNM 97
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 52-114 1.38e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 41.12  E-value: 1.38e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25150435  52 DVALLVENRKLSAHKVILAATIPYFRGMFTLDLME----ANMKEINIEdsDMNYETVDALLSFAYTG 114
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTsedaVGCDVVHIE--KVPPEIFEQLLQFIYTD 84
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-154 2.36e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 41.58  E-value: 2.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  60 RKLSAHKVILAATIPYFRGMFTLDLMEANMKeinIEDSDMNYETVDALLSFAYTGELRITTSNVQSIMLGANFFQMLEVV 139
Cdd:cd18346  42 QRIPAHRFVLAAGSAVFDAMFNGGMATTSAE---IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALE 118

                        90
                ....*....|....*
gi 25150435 140 QHCGNFLLTRLHPSN 154
Cdd:cd18346 119 AHCVEFLTKHLRADN 133
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 50-154 2.62e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 41.21  E-value: 2.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVALLV----ENRKLSAHKVILAATIPYFRGMFTLDLMEANMKeinIEDSDMNYETVDALLSFAYTGELRITTSNVQS 125
Cdd:cd18347  22 LSDVHFLVgkglGSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE---IELPDVEPAAFLALLKFLYSDEVQIGPETVMT 98

                        90       100
                ....*....|....*....|....*....
gi 25150435 126 IMLGANFFQMLEVVQHCGNFLLTRLHPSN 154
Cdd:cd18347  99 TLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-142 4.54e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 40.02  E-value: 4.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  42 NELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMF-------TLDLMEAnmkeiniedsdmnyETVDALLSFAYTG 114
Cdd:cd18205  10 NQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFhrnsqhyTLDFLSP--------------KTFQQILEYAYTA 75

                        90       100
                ....*....|....*....|....*...
gi 25150435 115 ELRITTSNVQSIMLGANFFQMLEVVQHC 142
Cdd:cd18205  76 TLQAKVEDLDDLLYAAEILEIEYLEEQC 103
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 388-431 6.14e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 37.70  E-value: 6.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 25150435   388 RSALAAAFVTNRLYVCGGYDGL--HSLSSIEIYDINRNVWEAGPPM 431
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLgdLSSSDVLVYDPETNVWTEVPRL 47
PRK14131 PRK14131
N-acetylneuraminate epimerase;
392-500 6.38e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 42.31  E-value: 6.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  392 AAAFVTNRLYVcggydGLHSLSSiEIYDINRNV----WEA-----GPPmenmRSAAGVTVIDKHIYICGG-----HDG-M 456
Cdd:PRK14131  33 TGAIDNNTVYV-----GLGSAGT-SWYKLDLNApskgWTKiaafpGGP----REQAVAAFIDGKLYVFGGigktnSEGsP 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 25150435  457 QIFASVERLDTENQQWERIPSmIQQRCRFGAATFK---GKIYVAGGY 500
Cdd:PRK14131 103 QVFDDVYKYDPKTNSWQKLDT-RSPVGLAGHVAVSlhnGKAYITGGV 148
Kelch_6 pfam13964
Kelch motif;
300-337 1.11e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.31  E-value: 1.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 25150435   300 IVPGLIVAIGGLMHQSQSKSSVEIYDPTSKKWSPIDGM 337
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPL 46
Kelch_4 pfam13418
Galactose oxidase, central domain;
484-525 2.05e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.44  E-value: 2.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 25150435   484 RFGAATF---KGKIYVAGGYDG-TSFLKSVEVYDPVEKKWSPVSPM 525
Cdd:pfam13418   2 RAYHTSTsipDDTIYLFGGEGEdGTLLSDLWVFDLSTNEWTRLGSL 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
491-530 2.23e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.11  E-value: 2.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 25150435   491 KGKIYVAGGYD--GTSFLKSVEVYDPVEKKWSPVSPMNMRRS 530
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRS 42
PLN02153 PLN02153
epithiospecifier protein
 482-578 2.45e-03

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 40.35  E-value: 2.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  482 RCRFGAATFKGKIYVAGG--YDGTSFLKSVEVYDPVEKKWSpVSPMNMRRSRVS-----LVSTNEGLFAVAGFDGENNLC 554
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGelKPNEHIDKDLYVFDFNTHTWS-IAPANGDVPRISclgvrMVAVGTKLYIFGGRDEKREFS 101

                         90       100
                 ....*....|....*....|....
gi 25150435  555 SMEQYDDVTDSWTIATALTcHEGG 578
Cdd:PLN02153 102 DFYSYDTVKNEWTFLTKLD-EEGG 124
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 50-172 2.66e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 37.73  E-value: 2.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  50 LCDVALLVENRK-LSAHKVILAATIPYFRGMFTLDLMEAN-MKEINIEDSDmnyETVDALLSFAYTGElritTSNVQSim 127
Cdd:cd18302   5 LYDVTIVSEDGKeFPCHKCVLVARLEYFHSMLSSSWIEASsCSALTMPIPS---DILEIILDYLYTDE----ASAVKE-- 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 25150435 128 lGANFFQMLEVVQHCGNFLLTRLhpsnalsiREFCKMMCVeEKIT 172
Cdd:cd18302  76 -SQNVEFLCNVLVIADQLLITRL--------KEICEVALV-ELLS 110
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 60-155 5.05e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 37.69  E-value: 5.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  60 RKLSAHKVILAATIPYFRGMFTLDLMEaNMKEINIedSDMNYETVDALLSFAYTGELRITTSNVQSIMLGANFFQMLEVV 139
Cdd:cd18348  35 QRLPGHKYVLAVGSSVFHAMFYGELAE-DKDEIRI--PDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLA 111

                        90
                ....*....|....*.
gi 25150435 140 QHCGNFLLTRLHPSNA 155
Cdd:cd18348 112 RACVNFLETSLSAKNA 127
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 153-225 6.34e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 35.63  E-value: 6.34e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25150435 153 SNALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWL 225
Cdd:cd18493   3 NHAVSWLQYAKMCGHKE-LAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 150-225 7.68e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 36.09  E-value: 7.68e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25150435 150 LHPSNALSIREFCKMMCVEEkITEMTDDYIQKHFMAVSKDEDFKRLSLEDAIELLRNDHLYVDSEEQVYVAAMEWL 225
Cdd:cd18451   1 LNLSNCVAIHSLAHMYSLDQ-LALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWV 75
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 41-146 8.28e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 36.94  E-value: 8.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25150435  41 FNELRSKCQLCDVALLVENRKLSAHKVILAATIPYFRGMFTLDlmeanmkeiNIEDSDMNYETVDALLSFAYTGELRITT 120
Cdd:cd18243  23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSIN---------NLVLQGCSSIGLRLVLEYLYTANVTLSL 93

                        90       100
                ....*....|....*....|....*.
gi 25150435 121 SNVQSIMLGANFFQMLEVVQHCGNFL 146
Cdd:cd18243  94 DTVEEVLSVSKILHIPQVTKLCVQFL 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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