del-10 Degenerin-like protein del-10 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: del-10
Official Full Name: Degenerin-like protein del-10
Primary source: WormBase:WBGene00020897
Locus tag: CELE_T28D9.7
See related: AllianceGenome:WB:WBGene00020897
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See del-10 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 18

Sequence:: Chromosome: II; NC_003280.10 (6474338..6482125, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data document the first example of synergistically toxic intersubunit interactions in the DEG/ENaC channel class and provide evidence that Ca(2+) current levels may be decisive factors in tipping the balance between neuronal survival and necrosis.
Title: Intersubunit interactions between mutant DEG/ENaCs induce synthetic neurotoxicity.

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Pathways from PubChem

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General gene information

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Markers

T28D9.4 (e-PCR)
- UniSTS:311060

T28D9.7 (e-PCR)
- UniSTS:306300

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Degenerin-like protein del-10

NP_495302.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6474338..6482125 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062901.6 → NP_495302.3 Degenerin-like protein del-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495302.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q10025

Conserved Domains (1) summary

pfam00858
Location:83 → 419

ASC; Amiloride-sensitive sodium channel