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Conserved domains on  [gi|193205037|ref|NP_495302|]
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Degenerin-like protein del-10 [Caenorhabditis elegans]

Protein Classification

amiloride-sensitive sodium channel family protein( domain architecture ID 10467616)

amiloride-sensitive sodium channel family protein such as mammalian acid-sensing ion channel 5, Drosophila melanogaster sodium channel protein Nach, and Caenorhabditis elegans degenerin-like protein del-10

CATH:  1.10.3590.10|2.60.470.10|1.10.287.770|1.10.287.820
Gene Ontology:  GO:0005272|GO:0006814|GO:0016020
PubMed:  7929098|8181670|8905643
SCOP:  4006059
TCDB:  1.A.6

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ASC pfam00858
Amiloride-sensitive sodium channel;
83-419 7.98e-36

Amiloride-sensitive sodium channel;


:

Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 141.92  E-value: 7.98e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037    83 VHHLNAASPV-TRGLWCMIIIAFVILVLVQCYSQIKLYISEPVATNIE-AEYPSKISFPTVAICNNNQFRLTYLTGGRI- 159
Cdd:pfam00858   10 VRYIKSKDGFlRRLFWLLLFLASLIFLIYLISLLFEKYLSYPVITVIEeILYVWNVPFPAVTICNLNPFRYSALKELSLf 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   160 ----------MNRRSKSISGSLLSTGHDVESVFDTVLRKSWDMDAV--KFLRSAAHWKSRMILGCTWPNGTSCKLSDFKA 227
Cdd:pfam00858   90 ydnlsfllylKFKFLEKILKSLTSNTEELEDELKLLLDFTNELLNSlsGYILNLGLRCEDLIVSCSFGGEKEDCSANFTP 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   228 VWTTTGLCWAIN----TDPHNPYEVTGSGEGHGLRLLLNVESYERVDACTKHFRtktlpGLKILIYNQTDIPDSSMNGVN 303
Cdd:pfam00858  170 ILTEYGNCYTFNskdnGSKLYPRRLKGAGSGRGLSLILNIQQSETYSPLDYQAA-----GFKVSIHSPGEPPDVDKRGFS 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   304 VPSGYSMDIPFKMQ--HRSKLTGVHCIEENDEqieasTDFNNPENIRTCTLRRYMTEVENSCHCTL----RRAYTSNSTD 377
Cdd:pfam00858  245 VPPGTETSVGIQPTeiTTLKRPYGNCTFDDEK-----LLYFKSYSQSNCLLECRQNYILKLCGCVPffypLPPGTKTGAD 319

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 193205037   378 VKmkaCNVDqyfgcAQKAMQRIREEGTASTCLPPCKSIDYTA 419
Cdd:pfam00858  320 IP---CLLN-----YEDHLLEVNEGLSCQDCLPPCNETEYET 353
ASC pfam00858
Amiloride-sensitive sodium channel;
759-849 8.47e-12

Amiloride-sensitive sodium channel;


:

Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 68.73  E-value: 8.47e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   759 SSFKKSYRELQAAYGKLFKEELPDYLENFQFGNKFVGDNFAMVNIFLHRMNLEVWSQDRTYGFWSLACDIGGALGLFLGA 838
Cdd:pfam00858  349 TEYETEISYSTWPSLSSQLFLLYYELSTYNNSSSTIRENLAKLNIYFKELNYETYRRSPAYTWTDLLSSIGGQLGLFLGA 428

                           90
                   ....*....|.
gi 193205037   839 SLLTIIEIVYL 849
Cdd:pfam00858  429 SVLSLVEIVYF 439
 
Name Accession Description Interval E-value
ASC pfam00858
Amiloride-sensitive sodium channel;
83-419 7.98e-36

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 141.92  E-value: 7.98e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037    83 VHHLNAASPV-TRGLWCMIIIAFVILVLVQCYSQIKLYISEPVATNIE-AEYPSKISFPTVAICNNNQFRLTYLTGGRI- 159
Cdd:pfam00858   10 VRYIKSKDGFlRRLFWLLLFLASLIFLIYLISLLFEKYLSYPVITVIEeILYVWNVPFPAVTICNLNPFRYSALKELSLf 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   160 ----------MNRRSKSISGSLLSTGHDVESVFDTVLRKSWDMDAV--KFLRSAAHWKSRMILGCTWPNGTSCKLSDFKA 227
Cdd:pfam00858   90 ydnlsfllylKFKFLEKILKSLTSNTEELEDELKLLLDFTNELLNSlsGYILNLGLRCEDLIVSCSFGGEKEDCSANFTP 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   228 VWTTTGLCWAIN----TDPHNPYEVTGSGEGHGLRLLLNVESYERVDACTKHFRtktlpGLKILIYNQTDIPDSSMNGVN 303
Cdd:pfam00858  170 ILTEYGNCYTFNskdnGSKLYPRRLKGAGSGRGLSLILNIQQSETYSPLDYQAA-----GFKVSIHSPGEPPDVDKRGFS 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   304 VPSGYSMDIPFKMQ--HRSKLTGVHCIEENDEqieasTDFNNPENIRTCTLRRYMTEVENSCHCTL----RRAYTSNSTD 377
Cdd:pfam00858  245 VPPGTETSVGIQPTeiTTLKRPYGNCTFDDEK-----LLYFKSYSQSNCLLECRQNYILKLCGCVPffypLPPGTKTGAD 319

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 193205037   378 VKmkaCNVDqyfgcAQKAMQRIREEGTASTCLPPCKSIDYTA 419
Cdd:pfam00858  320 IP---CLLN-----YEDHLLEVNEGLSCQDCLPPCNETEYET 353
ASC pfam00858
Amiloride-sensitive sodium channel;
759-849 8.47e-12

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 68.73  E-value: 8.47e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   759 SSFKKSYRELQAAYGKLFKEELPDYLENFQFGNKFVGDNFAMVNIFLHRMNLEVWSQDRTYGFWSLACDIGGALGLFLGA 838
Cdd:pfam00858  349 TEYETEISYSTWPSLSSQLFLLYYELSTYNNSSSTIRENLAKLNIYFKELNYETYRRSPAYTWTDLLSSIGGQLGLFLGA 428

                           90
                   ....*....|.
gi 193205037   839 SLLTIIEIVYL 849
Cdd:pfam00858  429 SVLSLVEIVYF 439
deg-1 TIGR00867
degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of ...
 791-849 1.00e-08

degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the invertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273309 [Multi-domain]  Cd Length: 600  Bit Score: 59.09  E-value: 1.00e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 193205037   791 NKFVGDNFAMVNIFLHRMNLEVWSQDRTYGFWSLACDIGGALGLFLGASLLTIIEIVYL 849
Cdd:TIGR00867  542 NEYYRENAAMIEVFYEQLNYELLTESEAYTLVNLIADFGGQLGLWLGASVITVCEFVFL 600
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
 94-427 1.13e-06

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 52.81  E-value: 1.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037    94 RGLWCMIIIAFVILVLVQCYSQIKLYISEPVATNIEAEYpSKISFPTVAICNNNQFR----------LTYLTGGRIMN-- 161
Cdd:TIGR00859   31 RALWALLTLLALALLLWQCGLLVRYYLSYPVSVSLSVNS-DKLTFPAVTLCNLNPYRyskvkhlleeLDLETAQTLLSly 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   162 --RRSKSISGSLLSTGHDVESVFD-----------------------------TVLRKSWDM------------------ 192
Cdd:TIGR00859  110 gyNSSLARSARSNNRNRIPLVVLDetlprhpvprdlftrqvhnklisnrsnspQVNASDWKVgfklcnnngsdcfyrtyt 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   193 ---DAVK----------FLRSAAHWKSRM-------ILGCTWpNGTSCKLSDFKAVWTTT-GLCWAINTDPHNPYEVTG- 250
Cdd:TIGR00859  190 sgvQAVRewyrfhyiniFAQVPAEDKDRMgyqledfILTCRF-DGESCDARNFTHFHHPMyGNCYTFNSGENSNLLTSSm 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   251 SGEGHGLRLLLNVESYERVDActkhfrTKTLPGLKILIYNQTDIPDSSMNGVNVPSGYSMDIPFKMQHRSKLTG--VHCi 328
Cdd:TIGR00859  269 PGAENGLKLVLDIEQDEYLPL------LSTEAGARVMVHSQDEPPFIDDLGFGVRPGTETSISMQEDELQRLGGpyGDC- 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   329 EENDEQIEASTDFNNPENIRTCTL---RRYMTEvenSCHCtlrrAYTSNSTDVKMKACNVDQYFG---CAQKAMQR--IR 400
Cdd:TIGR00859  342 TENGSDVPVENLYNSSYSIQACLRscfQRYMVE---NCGC----AYYHYPLPGGAEYCNYEQHPDwayCYYKLYAEfdQE 414

                          410       420
                   ....*....|....*....|....*..
gi 193205037   401 EEGTASTCLPPCKSIDYTAWQDMNRLP 427
Cdd:TIGR00859  415 ELGCFSVCREPCNFTEYKLTLSMARWP 441
 
Name Accession Description Interval E-value
ASC pfam00858
Amiloride-sensitive sodium channel;
83-419 7.98e-36

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 141.92  E-value: 7.98e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037    83 VHHLNAASPV-TRGLWCMIIIAFVILVLVQCYSQIKLYISEPVATNIE-AEYPSKISFPTVAICNNNQFRLTYLTGGRI- 159
Cdd:pfam00858   10 VRYIKSKDGFlRRLFWLLLFLASLIFLIYLISLLFEKYLSYPVITVIEeILYVWNVPFPAVTICNLNPFRYSALKELSLf 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   160 ----------MNRRSKSISGSLLSTGHDVESVFDTVLRKSWDMDAV--KFLRSAAHWKSRMILGCTWPNGTSCKLSDFKA 227
Cdd:pfam00858   90 ydnlsfllylKFKFLEKILKSLTSNTEELEDELKLLLDFTNELLNSlsGYILNLGLRCEDLIVSCSFGGEKEDCSANFTP 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   228 VWTTTGLCWAIN----TDPHNPYEVTGSGEGHGLRLLLNVESYERVDACTKHFRtktlpGLKILIYNQTDIPDSSMNGVN 303
Cdd:pfam00858  170 ILTEYGNCYTFNskdnGSKLYPRRLKGAGSGRGLSLILNIQQSETYSPLDYQAA-----GFKVSIHSPGEPPDVDKRGFS 244

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   304 VPSGYSMDIPFKMQ--HRSKLTGVHCIEENDEqieasTDFNNPENIRTCTLRRYMTEVENSCHCTL----RRAYTSNSTD 377
Cdd:pfam00858  245 VPPGTETSVGIQPTeiTTLKRPYGNCTFDDEK-----LLYFKSYSQSNCLLECRQNYILKLCGCVPffypLPPGTKTGAD 319

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 193205037   378 VKmkaCNVDqyfgcAQKAMQRIREEGTASTCLPPCKSIDYTA 419
Cdd:pfam00858  320 IP---CLLN-----YEDHLLEVNEGLSCQDCLPPCNETEYET 353
ASC pfam00858
Amiloride-sensitive sodium channel;
759-849 8.47e-12

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 68.73  E-value: 8.47e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   759 SSFKKSYRELQAAYGKLFKEELPDYLENFQFGNKFVGDNFAMVNIFLHRMNLEVWSQDRTYGFWSLACDIGGALGLFLGA 838
Cdd:pfam00858  349 TEYETEISYSTWPSLSSQLFLLYYELSTYNNSSSTIRENLAKLNIYFKELNYETYRRSPAYTWTDLLSSIGGQLGLFLGA 428

                           90
                   ....*....|.
gi 193205037   839 SLLTIIEIVYL 849
Cdd:pfam00858  429 SVLSLVEIVYF 439
deg-1 TIGR00867
degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of ...
 791-849 1.00e-08

degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the invertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273309 [Multi-domain]  Cd Length: 600  Bit Score: 59.09  E-value: 1.00e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 193205037   791 NKFVGDNFAMVNIFLHRMNLEVWSQDRTYGFWSLACDIGGALGLFLGASLLTIIEIVYL 849
Cdd:TIGR00867  542 NEYYRENAAMIEVFYEQLNYELLTESEAYTLVNLIADFGGQLGLWLGASVITVCEFVFL 600
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
 94-427 1.13e-06

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 52.81  E-value: 1.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037    94 RGLWCMIIIAFVILVLVQCYSQIKLYISEPVATNIEAEYpSKISFPTVAICNNNQFR----------LTYLTGGRIMN-- 161
Cdd:TIGR00859   31 RALWALLTLLALALLLWQCGLLVRYYLSYPVSVSLSVNS-DKLTFPAVTLCNLNPYRyskvkhlleeLDLETAQTLLSly 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   162 --RRSKSISGSLLSTGHDVESVFD-----------------------------TVLRKSWDM------------------ 192
Cdd:TIGR00859  110 gyNSSLARSARSNNRNRIPLVVLDetlprhpvprdlftrqvhnklisnrsnspQVNASDWKVgfklcnnngsdcfyrtyt 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   193 ---DAVK----------FLRSAAHWKSRM-------ILGCTWpNGTSCKLSDFKAVWTTT-GLCWAINTDPHNPYEVTG- 250
Cdd:TIGR00859  190 sgvQAVRewyrfhyiniFAQVPAEDKDRMgyqledfILTCRF-DGESCDARNFTHFHHPMyGNCYTFNSGENSNLLTSSm 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   251 SGEGHGLRLLLNVESYERVDActkhfrTKTLPGLKILIYNQTDIPDSSMNGVNVPSGYSMDIPFKMQHRSKLTG--VHCi 328
Cdd:TIGR00859  269 PGAENGLKLVLDIEQDEYLPL------LSTEAGARVMVHSQDEPPFIDDLGFGVRPGTETSISMQEDELQRLGGpyGDC- 341

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   329 EENDEQIEASTDFNNPENIRTCTL---RRYMTEvenSCHCtlrrAYTSNSTDVKMKACNVDQYFG---CAQKAMQR--IR 400
Cdd:TIGR00859  342 TENGSDVPVENLYNSSYSIQACLRscfQRYMVE---NCGC----AYYHYPLPGGAEYCNYEQHPDwayCYYKLYAEfdQE 414

                          410       420
                   ....*....|....*....|....*..
gi 193205037   401 EEGTASTCLPPCKSIDYTAWQDMNRLP 427
Cdd:TIGR00859  415 ELGCFSVCREPCNFTEYKLTLSMARWP 441
deg-1 TIGR00867
degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of ...
 199-418 4.99e-06

degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the invertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273309 [Multi-domain]  Cd Length: 600  Bit Score: 50.61  E-value: 4.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   199 RSAAHWKSRMILGCTWpNGTSCKL-SDFKAVWTTT-GLCWAINTDPHNPYEVTGSGEGHGLRLLLNVESyervdacTKHF 276
Cdd:TIGR00867  299 EALSYTKHELILKCSF-NGKPCDIdRDFTLHIDPVfGNCYTFNYNRSVNLSSSRAGPMYGLRLLLFVNQ-------SDYL 370

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205037   277 RTKTLPGLKILIYNQTDIPDSSMNGVNVPSGY--SMDIPFKMQHRSKLTGVHCIEENDEQIEASTDFN-NPENI-RTCTL 352
Cdd:TIGR00867  371 PTTEAAGVRLTIHDKDEFPFPDTFGYSAPTGYisSFGVRLKQMSRLPAPYGNCVDTGKDSSYIYKGYIySPEGChRSCFQ 450

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193205037   353 RRYMTEvensCHCTLRRaYTSNSTDVKMKACNVDQyFGCAQKAMQRIRE---EGTASTCLPPCKSIDYT 418
Cdd:TIGR00867  451 RLIIAK----CGCADPR-FPVPEGTRHCQAFNKTD-RECLETLTGDLGElhhSIFKCRCQQPCQESIYT 513
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
 792-861 1.45e-05

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 48.96  E-value: 1.45e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193205037   792 KFVGDNFAMVNIFLHRMNLEVWSQDRTYGFWSLACDIGGALGLFLGASLLTIIEI---VYLCIQYGLCGKRAR 861
Cdd:TIGR00859  462 TLIRNGIAKLNIFFEELNYRTIEESPAYNVVTLLSNLGGQMGLWMGASVLCVLELlelIIDLIFITLLRLLWR 534
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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