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    nfya-2 Nuclear transcription factor Y subunit nfya-2 [ Caenorhabditis elegans ]

    Gene ID: 3565955, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nfya-2
    Official Full Name
    Nuclear transcription factor Y subunit nfya-2
    Primary source
    WormBase:WBGene00043056
    Locus tag
    CELE_Y53H1A.5
    See related
    AllianceGenome:WB:WBGene00043056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription repressor activity. Involved in tissue development. Located in nucleus. Is expressed in excretory cell; gonad; head neurons; intestine; and oocyte. Orthologous to human NFYA (nuclear transcription factor Y subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nfya-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (11224836..11233332)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Arginine/serine-rich protein PNISR Neighboring gene C2H2-type domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the CCAAT-binding factor NF-Y in Caenorhabditis elegans. Franchini A, et al. J Mol Histol, 2005 Feb. PMID 15704008
    2. The CCAAT-box transcription factor, NF-Y complex, mediates the specification of the IL1 neurons in C. elegans. Heo W, et al. BMB Rep, 2023 Mar. PMID 36330709, Free PMC Article
    3. NF-Y and the transcriptional activation of CCAAT promoters. Dolfini D, et al. Crit Rev Biochem Mol Biol, 2012 Jan-Feb. PMID 22050321
    4. Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5. Deng H, et al. Dev Biol, 2007 Aug 15. PMID 17574230
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear transcription factor Y subunit nfya-2
    NP_001251586.1
    • Confirmed by transcript evidence
    NP_001251587.1
    • Confirmed by transcript evidence
    NP_001251588.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11224836..11233332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001264657.2 → NP_001251586.1  Nuclear transcription factor Y subunit nfya-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251586.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F3Y5S2, F3Y5S3, Q5ZEP9
      Conserved Domains (1) summary
      pfam02045
      Location:147 → 201
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

    2. NM_001264658.3 → NP_001251587.1  Nuclear transcription factor Y subunit nfya-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3Y5S2
      Conserved Domains (1) summary
      smart00521
      Location:135 → 193
      CBF; CCAAT-Binding transcription Factor

    3. NM_001264659.3 → NP_001251588.1  Nuclear transcription factor Y subunit nfya-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251588.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3Y5S3
      Conserved Domains (1) summary
      cl02165
      Location:1 → 53
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ZEP9.2

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