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    rga-8 Rho-GAP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180799, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rga-8
    Official Full Name
    Rho-GAP domain-containing protein
    Primary source
    WormBase:WBGene00021324
    Locus tag
    CELE_Y34B4A.8
    See related
    AllianceGenome:WB:WBGene00021324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction; regulation of Rac protein signal transduction; and regulation of actin cytoskeleton organization. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and skin melanoma. Orthologous to human ARHGAP17 (Rho GTPase activating protein 17); ARHGAP44 (Rho GTPase activating protein 44); and SH3BP1 (SH3 domain binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rga-8 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    16
    Sequence:
    Chromosome: X; NC_003284.9 (5271710..5279774, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Rap guanine nucleotide exchange factor 1;Ras-GEF domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Heparan-sulfate 6-O-sulfotransferase Neighboring gene UV radiation resistance-associated gene protein-like Neighboring gene tRNA Neighboring gene Vacuolar protein sorting-associated protein 41 homolog Neighboring gene Activator of G protein signaling;TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 28 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RhoGAP RGA-8 supports morphogenesis in C. elegans by polarizing epithelia. Raduwan H, et al. Biol Open, 2020 Nov 26. PMID 33243762, Free PMC Article
    2. Actin and CDC-42 contribute to nuclear migration through constricted spaces in C. elegans. Ho J, et al. Development, 2023 Oct 1. PMID 37756590, Free PMC Article
    3. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article
    4. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rho-GAP domain-containing protein
    NP_001257018.1
    • Confirmed by transcript evidence
    NP_001257019.1
    • Confirmed by transcript evidence
    NP_001348821.1
    • Partially confirmed by transcript evidence
    NP_001348822.1
    • Confirmed by transcript evidence
    NP_001348823.1
    • Partially confirmed by transcript evidence
    NP_001348824.1
    • Partially confirmed by transcript evidence
    NP_001348825.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5271710..5279774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001361808.3 → NP_001348822.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2K5AU25
      Conserved Domains (2) summary
      cd04386
      Location:235 → 428
      RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
      cl12013
      Location:58 → 246
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_001270089.4 → NP_001257018.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5NU64
      Conserved Domains (2) summary
      cd04386
      Location:235 → 428
      RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
      cl12013
      Location:58 → 246
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. NM_001270090.4 → NP_001257019.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257019.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZX8
      Conserved Domains (2) summary
      cd04386
      Location:235 → 428
      RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
      cl12013
      Location:58 → 246
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. NM_001361805.4 → NP_001348821.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2K5AU23
      Conserved Domains (2) summary
      cd04386
      Location:286 → 479
      RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
      cl12013
      Location:109 → 297
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. NM_001361804.3 → NP_001348823.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2K5AU29
      Conserved Domains (2) summary
      cd04386
      Location:286 → 479
      RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
      cl12013
      Location:109 → 297
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. NM_001361806.3 → NP_001348825.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2K5AU32
      Conserved Domains (2) summary
      cd04386
      Location:243 → 436
      RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
      cl12013
      Location:66 → 254
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. NM_001361807.3 → NP_001348824.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2K5AU28
      Conserved Domains (2) summary
      cd04386
      Location:243 → 436
      RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
      cl12013
      Location:66 → 254
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
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