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    wdr-62 Cep57 centrosome microtubule-binding domain-containing protein;Protein kinase domain-containing protein;WD Repeat protein;WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179326, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wdr-62
    Official Full Name
    Cep57 centrosome microtubule-binding domain-containing protein;Protein kinase domain-containing protein;WD Repeat protein;WD_REPEATS_REGION domain-containing protein
    Primary source
    WormBase:WBGene00019237
    Locus tag
    CELE_H24G06.1
    See related
    AllianceGenome:WB:WBGene00019237
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable kinase activity. Predicted to be involved in centriole replication. Predicted to be active in mitotic spindle. Is expressed in intestine. Human ortholog(s) of this gene implicated in intellectual disability; nephronophthisis 20; polymicrogyria; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to several human genes including WDR62 (WD repeat domain 62). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See wdr-62 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    25
    Sequence:
    Chromosome: V; NC_003283.11 (9444048..9460669)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RRM domain-containing protein Neighboring gene QQDSEVEREMM Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proximity labeling reveals non-centrosomal microtubule-organizing center components required for microtubule growth and localization. Sanchez AD, et al. Curr Biol, 2021 Aug 23. PMID 34242576, Free PMC Article
    2. Dose-dependent functions of SWI/SNF BAF in permitting and inhibiting cell proliferation in vivo. van der Vaart A, et al. Sci Adv, 2020 May. PMID 32494730, Free PMC Article
    3. Roles of MAP kinase cascades in Caenorhabditis elegans. Sakaguchi A, et al. J Biochem, 2004 Jul. PMID 15269234
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cep57 centrosome microtubule-binding domain-containing protein;Protein kinase domain-containing protein;WD Repeat protein;WD_REPEATS_REGION domain-containing protein
    NP_001343681.1
    • Confirmed by transcript evidence
    NP_001343682.1
    • Confirmed by transcript evidence
    NP_001343683.1
    • Confirmed by transcript evidence
    NP_001343684.1
    • Confirmed by transcript evidence
    NP_001343852.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class wdr
    NP_741593.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9444048..9460669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356730.3 → NP_001343682.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WSM1
      Conserved Domains (3) summary
      COG2319
      Location:17 → 257
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:496 → 545
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:355 → 714
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001356729.2 → NP_001343681.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0C5
      Conserved Domains (3) summary
      COG2319
      Location:17 → 257
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:496 → 545
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:355 → 714
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_171508.4 → NP_741593.2  Cep57 centrosome microtubule-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C3D0

    4. NM_001356731.3 → NP_001343683.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5TKA5
      Conserved Domains (1) summary
      pfam11244
      Location:17 → 88
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing

    5. NM_001356732.3 → NP_001343684.1  Cep57 centrosome microtubule-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0C6

    6. NM_001356733.3 → NP_001343852.1  WD Repeat protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C3E2
    Nucleotide Protein
    Heading Accession and Version

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