|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
355-716 |
2.20e-25 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 110.77 E-value: 2.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 355 RRASLGHTGSVNCIEPFPSSSpclpigTLITGGSDGTIRFWnfngDSEDKKEIANIlcpsllkvifldenpdllvdkrnl 434
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGK------TLASGSADGTVRLW----DLATGKLLRTL------------------------ 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 435 esvgpsndenqSASSSGVLCTRVSHDGRMLIAGTATGMLYIVDLSfsDTPIIDVINAHDHDVTSIDFSDHASTsshdhpi 514
Cdd:COG2319 159 -----------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPDGKL------- 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 515 fLASGGRDRFVHVFRriPYSSQFVHcaVLDGHQSAIKSIKFaSNNGQLhLYTAASDRSLIIWKLSSFSDQHCEFTRVQMI 594
Cdd:COG2319 219 -LASGSADGTVRLWD--LATGKLLR--TLTGHSGSVRSVAF-SPDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGV 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 595 -SVA-SSIGDmnfikhvdLFVVAGHDRMLRQFDIN-GKTVREVKGtdddvaHSGKILKVAIDHSGSYAISVCSDKFVYVT 671
Cdd:COG2319 292 nSVAfSPDGK--------LLASGSDDGTVRLWDLAtGKLLRTLTG------HTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1254046855 672 DLRSGVCLAVLCGFGAPATDATFSDDFKNVIVTTSNGSIFIWQLA 716
Cdd:COG2319 358 DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
355-714 |
2.70e-24 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 104.72 E-value: 2.70e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 355 RRASLGHTGSVNCIEPFPSSspclpiGTLITGGSDGTIRFWNFNGDSedkkeianilCPSLLKVifldenpdllvdkrnl 434
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDG------KLLATGSGDGTIKVWDLETGE----------LLRTLKG---------------- 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 435 esvgpsndenqsaSSSGVLCTRVSHDGRMLIAGTATGMLYIVDLSfsDTPIIDVINAHDHDVTSIDFSDHAStsshdhpi 514
Cdd:cd00200 50 -------------HTGPVRDVAASADGTYLASGSSDKTIRLWDLE--TGECVRTLTGHTSYVSSVAFSPDGR-------- 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 515 FLASGGRDRFVHVFRRIpyssQFVHCAVLDGHQSAIKSIKFASNNGqlHLYTAASDRSLIIWKLSSFSdqhceftrvqmi 594
Cdd:cd00200 107 ILSSSSRDKTIKVWDVE----TGKCLTTLRGHTDWVNSVAFSPDGT--FVASSSQDGTIKLWDLRTGK------------ 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 595 SVASSIGDMNFIKHVDL------FVVAGHDRMLRQFDIN-GKTVREVKGtdddvaHSGKILKVAIDHSGSYAISVCSDKF 667
Cdd:cd00200 169 CVATLTGHTGEVNSVAFspdgekLLSSSSDGTIKLWDLStGKCLGTLRG------HENGVNSVAFSPDGYLLASGSEDGT 242
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1254046855 668 VYVTDLRSGVCLAVLCGFGAPATDATFSDDFKNVIVTTSNGSIFIWQ 714
Cdd:cd00200 243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
10-399 |
9.18e-14 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 75.33 E-value: 9.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 10 RLKNVVGRSGVTVNGIALHHASDTLLQVAGSSII----VSSTASHDRFEGHlisqtKQQFTCVAVTSCGKYAATGETGHq 85
Cdd:COG2319 69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVrlwdLATGLLLRTLTGH-----TGAVRSVAFSPDGKTLASGSADG- 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 86 pAVRLWQLRDaqgnfvGRLVRSMQSHTVSITIVRFTPDDSTLISIGcqHDAQIFTWDWRTGHDLGVGKL-MSPVNALTIS 164
Cdd:COG2319 143 -TVRLWDLAT------GKLLRTLTGHSGAVTSVAFSPDGKLLASGS--DDGTVRLWDLATGKLLRTLTGhTGAVRSVAFS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 165 FDSSMCVTVGS-KSVKYWflplasdgmNKRTGLTSRSaILADKRNVNFVdaAFCDSTNRMVTVTSSGEILEFNGNKKyvK 243
Cdd:COG2319 214 PDGKLLASGSAdGTVRLW---------DLATGKLLRT-LTGHSGSVRSV--AFSPDGRLLASGSADGTVRLWDLATG--E 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 244 CYTWKESGDFKAICIARVPEG--LLVGCSDGLVRLFcligddldflaDLAPPTHLfqdpsnvydpQQLQNHPEDaifpeP 321
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGklLASGSDDGTVRLW-----------DLATGKLL----------RTLTGHTGA-----V 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 322 RCLVASSSSPTFVVGYADRSLiefarenKSWSFRRASL-----GHTGSVNCIEPFPSSSpclpigTLITGGSDGTIRFWN 396
Cdd:COG2319 334 RSVAFSPDGKTLASGSDDGTV-------RLWDLATGELlrtltGHTGAVTSVAFSPDGR------TLASGSADGTVRLWD 400
|
...
gi 1254046855 397 FNG 399
Cdd:COG2319 401 LAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
104-529 |
1.46e-13 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 73.14 E-value: 1.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 104 LVRSMQSHTVSITIVRFTPDDSTLISiGCQhDAQIFTWDWRTGHDLGVGKLMS-PVNALTISFDSSMCVTVGSksvkywf 182
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLAT-GSG-DGTIKVWDLETGELLRTLKGHTgPVRDVAASADGTYLASGSS------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 183 lplasdgmnkrtgltsrsailadkrnvnfvdaafcDSTNRMVTVTSSGEILEFNGNKKYVKCYTWKESGDfkaiciarvp 262
Cdd:cd00200 72 -----------------------------------DKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR---------- 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 263 egLLVGCS-DGLVRLFcligddldflaDLAPPTHLfqdpsnvydpQQLQNHPEDAifpepRCLVASSSSPTFVVGYADRS 341
Cdd:cd00200 107 --ILSSSSrDKTIKVW-----------DVETGKCL----------TTLRGHTDWV-----NSVAFSPDGTFVASSSQDGT 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 342 LIEFarENKSWSFRRASLGHTGSVNCIEPFPSSSPclpigtLITGGSDGTIRFWNFNGDsedkkeianilcpSLLKVIFL 421
Cdd:cd00200 159 IKLW--DLRTGKCVATLTGHTGEVNSVAFSPDGEK------LLSSSSDGTIKLWDLSTG-------------KCLGTLRG 217
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 422 DENPdllvdkrnlesvgpsndenqsasssgVLCTRVSHDGRMLIAGTATGMLYIVDLSFSDtpIIDVINAHDHDVTSIDF 501
Cdd:cd00200 218 HENG--------------------------VNSVAFSPDGYLLASGSEDGTIRVWDLRTGE--CVQTLSGHTNSVTSLAW 269
|
410 420
....*....|....*....|....*...
gi 1254046855 502 SDHAStsshdhpiFLASGGRDRFVHVFR 529
Cdd:cd00200 270 SPDGK--------RLASGSADGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
360-396 |
8.84e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.45 E-value: 8.84e-04
10 20 30
....*....|....*....|....*....|....*..
gi 1254046855 360 GHTGSVNCIEPFPSSSpclpigTLITGGSDGTIRFWN 396
Cdd:smart00320 10 GHTGPVTSVAFSPDGK------YLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
360-396 |
2.33e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 37.32 E-value: 2.33e-03
10 20 30
....*....|....*....|....*....|....*..
gi 1254046855 360 GHTGSVNCIEPFPSSSpclpigTLITGGSDGTIRFWN 396
Cdd:pfam00400 9 GHTGSVTSLAFSPDGK------LLASGSDDGTVKVWD 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
355-716 |
2.20e-25 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 110.77 E-value: 2.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 355 RRASLGHTGSVNCIEPFPSSSpclpigTLITGGSDGTIRFWnfngDSEDKKEIANIlcpsllkvifldenpdllvdkrnl 434
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGK------TLASGSADGTVRLW----DLATGKLLRTL------------------------ 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 435 esvgpsndenqSASSSGVLCTRVSHDGRMLIAGTATGMLYIVDLSfsDTPIIDVINAHDHDVTSIDFSDHASTsshdhpi 514
Cdd:COG2319 159 -----------TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPDGKL------- 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 515 fLASGGRDRFVHVFRriPYSSQFVHcaVLDGHQSAIKSIKFaSNNGQLhLYTAASDRSLIIWKLSSFSDQHCEFTRVQMI 594
Cdd:COG2319 219 -LASGSADGTVRLWD--LATGKLLR--TLTGHSGSVRSVAF-SPDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGV 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 595 -SVA-SSIGDmnfikhvdLFVVAGHDRMLRQFDIN-GKTVREVKGtdddvaHSGKILKVAIDHSGSYAISVCSDKFVYVT 671
Cdd:COG2319 292 nSVAfSPDGK--------LLASGSDDGTVRLWDLAtGKLLRTLTG------HTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1254046855 672 DLRSGVCLAVLCGFGAPATDATFSDDFKNVIVTTSNGSIFIWQLA 716
Cdd:COG2319 358 DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
355-714 |
2.70e-24 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 104.72 E-value: 2.70e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 355 RRASLGHTGSVNCIEPFPSSspclpiGTLITGGSDGTIRFWNFNGDSedkkeianilCPSLLKVifldenpdllvdkrnl 434
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDG------KLLATGSGDGTIKVWDLETGE----------LLRTLKG---------------- 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 435 esvgpsndenqsaSSSGVLCTRVSHDGRMLIAGTATGMLYIVDLSfsDTPIIDVINAHDHDVTSIDFSDHAStsshdhpi 514
Cdd:cd00200 50 -------------HTGPVRDVAASADGTYLASGSSDKTIRLWDLE--TGECVRTLTGHTSYVSSVAFSPDGR-------- 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 515 FLASGGRDRFVHVFRRIpyssQFVHCAVLDGHQSAIKSIKFASNNGqlHLYTAASDRSLIIWKLSSFSdqhceftrvqmi 594
Cdd:cd00200 107 ILSSSSRDKTIKVWDVE----TGKCLTTLRGHTDWVNSVAFSPDGT--FVASSSQDGTIKLWDLRTGK------------ 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 595 SVASSIGDMNFIKHVDL------FVVAGHDRMLRQFDIN-GKTVREVKGtdddvaHSGKILKVAIDHSGSYAISVCSDKF 667
Cdd:cd00200 169 CVATLTGHTGEVNSVAFspdgekLLSSSSDGTIKLWDLStGKCLGTLRG------HENGVNSVAFSPDGYLLASGSEDGT 242
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1254046855 668 VYVTDLRSGVCLAVLCGFGAPATDATFSDDFKNVIVTTSNGSIFIWQ 714
Cdd:cd00200 243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
285-716 |
1.01e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 99.60 E-value: 1.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 285 DFLADLAPPTHLFQDPSNVYDPQQLQNHPEDAIFPEPRCLVASSSSPTFVVGYADRSLIEFARENKSWSFRRASLGHTGS 364
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 365 VNCIEPFPSSspclpiGTLITGGSDGTIRFWNfngdsedkkeIANILCPSLLKvifldenpdllvdkrnlesvgpsnden 444
Cdd:COG2319 81 VLSVAFSPDG------RLLASASADGTVRLWD----------LATGLLLRTLT--------------------------- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 445 qsASSSGVLCTRVSHDGRMLIAGTATGMLYIVDLSfsDTPIIDVINAHDHDVTSIDFSDHASTsshdhpifLASGGRDRF 524
Cdd:COG2319 118 --GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGKL--------LASGSDDGT 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 525 VHVFRriPYSSQFVHcaVLDGHQSAIKSIKFaSNNGQLhLYTAASDRSLIIWKLSSfsdQHCEFTRVqmisvassiGDMN 604
Cdd:COG2319 186 VRLWD--LATGKLLR--TLTGHTGAVRSVAF-SPDGKL-LASGSADGTVRLWDLAT---GKLLRTLT---------GHSG 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 605 FIKHVD------LFVVAGHDRMLRQFDIN-GKTVREVKGtdddvaHSGKILKVAIDHSGSYAISVCSDKFVYVTDLRSGV 677
Cdd:COG2319 248 SVRSVAfspdgrLLASGSADGTVRLWDLAtGELLRTLTG------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321
|
410 420 430
....*....|....*....|....*....|....*....
gi 1254046855 678 CLAVLCGFGAPATDATFSDDFKNVIVTTSNGSIFIWQLA 716
Cdd:COG2319 322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
486-717 |
1.63e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 96.64 E-value: 1.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 486 IDVINAHDHDVTSIDFSDHAStsshdhpiFLASGGRDRFVHVFRripySSQFVHCAVLDGHQSAIKSIKFASNNGQLhlY 565
Cdd:cd00200 2 RRTLKGHTGGVTCVAFSPDGK--------LLATGSGDGTIKVWD----LETGELLRTLKGHTGPVRDVAASADGTYL--A 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 566 TAASDRSLIIWKLSSfsdQHCEFTrvqMISVASSIGDMNFIKHVDLFVVAGHDRMLRQFDI-NGKTVREVKGTDDDVAHs 644
Cdd:cd00200 68 SGSSDKTIRLWDLET---GECVRT---LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNS- 140
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1254046855 645 gkilkVAIDHSGSYAISVCSDKFVYVTDLRSGVCLAVLCGFGAPATDATFSDDFKNVIVTTSNGSIFIWQLAK 717
Cdd:cd00200 141 -----VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
322-670 |
1.90e-20 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 93.55 E-value: 1.90e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 322 RCLVASSSSPTFVVGYADRSLIEFARENKSWSFRRAslGHTGSVNCIEPFPSSSpclpigTLITGGSDGTIRFWNFNgds 401
Cdd:cd00200 13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASADGT------YLASGSSDKTIRLWDLE--- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 402 edKKEIANILcpsllkvifldenpdllvdkrnlesvgpsndenqSASSSGVLCTRVSHDGRMLIAGTATGMLYIVDlsFS 481
Cdd:cd00200 82 --TGECVRTL----------------------------------TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD--VE 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 482 DTPIIDVINAHDHDVTSIDFsdhastssHDHPIFLASGGRDRFVHVFRripySSQFVHCAVLDGHQSAIKSIKFaSNNGQ 561
Cdd:cd00200 124 TGKCLTTLRGHTDWVNSVAF--------SPDGTFVASSSQDGTIKLWD----LRTGKCVATLTGHTGEVNSVAF-SPDGE 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 562 lHLYTAASDRSLIIWKLSSFsDQHCEFTRVQMISVAssigdMNFIKHVDLFVVAGHDRMLRQFDI-NGKTVREVKGtddd 640
Cdd:cd00200 191 -KLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNS-----VAFSPDGYLLASGSEDGTIRVWDLrTGECVQTLSG---- 259
|
330 340 350
....*....|....*....|....*....|
gi 1254046855 641 vaHSGKILKVAIDHSGSYAISVCSDKFVYV 670
Cdd:cd00200 260 --HTNSVTSLAWSPDGKRLASGSADGTIRI 287
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
449-726 |
8.42e-20 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 91.63 E-value: 8.42e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 449 SSGVLCTRVSHDGRMLIAGTATGMLYIVDLSFSDTPIIDVinAHDHDVTSIDFSDHAStsshdhpiFLASGGRDRFVhvf 528
Cdd:cd00200 9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASADGT--------YLASGSSDKTI--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 529 rRIpYSSQFVHCA-VLDGHQSAIKSIKFaSNNGQLhLYTAASDRSLIIWKLSSFsdqhceftrvQMISVASSIGDmnFIK 607
Cdd:cd00200 76 -RL-WDLETGECVrTLTGHTSYVSSVAF-SPDGRI-LSSSSRDKTIKVWDVETG----------KCLTTLRGHTD--WVN 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 608 HV-----DLFVVAGH-DRMLRQFDI-NGKTVREVKGtdddvaHSGKILKVAIDHSGSYAISVCSDKFVYVTDLRSGVCLA 680
Cdd:cd00200 140 SVafspdGTFVASSSqDGTIKLWDLrTGKCVATLTG------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG 213
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1254046855 681 VLCGFGAPATDATFSDDFKNVIVTTSNGSIFIWQLAKNLTERMISA 726
Cdd:cd00200 214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
255-577 |
3.55e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 87.01 E-value: 3.55e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 255 AICIARVPEGLLVGCSDGLVRLFCLIGDDLdfladlappthlfqdpsnvydPQQLQNHPEdaifpEPRCLVASSSSPTFV 334
Cdd:cd00200 14 CVAFSPDGKLLATGSGDGTIKVWDLETGEL---------------------LRTLKGHTG-----PVRDVAASADGTYLA 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 335 VGYADRSLiefarenKSWSFRRASL-----GHTGSVNCIepfpSSSPCLPIgtLITGGSDGTIRFWNFngdsEDKKEIAN 409
Cdd:cd00200 68 SGSSDKTI-------RLWDLETGECvrtltGHTSYVSSV----AFSPDGRI--LSSSSRDKTIKVWDV----ETGKCLTT 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 410 ILC-PSLLKVIFLDENPDLLV-----------DKRNLESVgpsndENQSASSSGVLCTRVSHDGRMLIAGTATGMLYIVD 477
Cdd:cd00200 131 LRGhTDWVNSVAFSPDGTFVAsssqdgtiklwDLRTGKCV-----ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 478 LSFSDTpiIDVINAHDHDVTSIDFSDHAStsshdhpiFLASGGRDRFVHVFRripySSQFVHCAVLDGHQSAIKSIKFaS 557
Cdd:cd00200 206 LSTGKC--LGTLRGHENGVNSVAFSPDGY--------LLASGSEDGTIRVWD----LRTGECVQTLSGHTNSVTSLAW-S 270
|
330 340
....*....|....*....|
gi 1254046855 558 NNGQLhLYTAASDRSLIIWK 577
Cdd:cd00200 271 PDGKR-LASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
360-675 |
2.06e-16 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 83.42 E-value: 2.06e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 360 GHTGSVNCIEPFPSSSpclpigTLITGGSDGTIRFWnfngDSEDKKEIANIlcpsllkvifldenpdllvdkrnlesvgp 439
Cdd:COG2319 160 GHSGAVTSVAFSPDGK------LLASGSDDGTVRLW----DLATGKLLRTL----------------------------- 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 440 sndenqSASSSGVLCTRVSHDGRMLIAGTATGMLYIVDLSfsDTPIIDVINAHDHDVTSIDFSDHASTsshdhpifLASG 519
Cdd:COG2319 201 ------TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRL--------LASG 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 520 GRDRFVHVFRriPYSSQFVHcaVLDGHQSAIKSIKFaSNNGQlHLYTAASDRSLIIWKLSS------FSDQHCEFTrvqm 593
Cdd:COG2319 265 SADGTVRLWD--LATGELLR--TLTGHSGGVNSVAF-SPDGK-LLASGSDDGTVRLWDLATgkllrtLTGHTGAVR---- 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 594 iSVA-SSIGDMnfikhvdlFVVAGHDRMLRQFDIN-GKTVREVKGtdddvaHSGKILKVAIDHSGSYAISVCSDKFVYVT 671
Cdd:COG2319 335 -SVAfSPDGKT--------LASGSDDGTVRLWDLAtGELLRTLTG------HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
|
....
gi 1254046855 672 DLRS 675
Cdd:COG2319 400 DLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
124-580 |
3.83e-14 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 76.49 E-value: 3.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 124 DSTLISIGCQHDAQIFTWDWRTGHDLGVGKLMSPVNALTISFDSSMCVTVGSKSVKYWFLPLASDGMNKRTGLTSRSAIL 203
Cdd:COG2319 5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 204 ADKRNVNFVDAAFCDSTNRMVTVTSSGEILEFNGNKKYVKCytwkesgdfkaicIARVPEG--LLVGCSDGLVRLFclig 281
Cdd:COG2319 85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRS-------------VAFSPDGktLASGSADGTVRLW---- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 282 ddldflaDLAPPTHLfqdpsnvydpQQLQNHPEdaifpEPRCLVASSSSPTFVVGYADRSLiefarenKSWSFRRASL-- 359
Cdd:COG2319 148 -------DLATGKLL----------RTLTGHSG-----AVTSVAFSPDGKLLASGSDDGTV-------RLWDLATGKLlr 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 360 ---GHTGSVNCIEPFPSSSpclpigTLITGGSDGTIRFWnfngDSEDKKEIANILCPSLLkVIFLDENPD--LLV----D 430
Cdd:COG2319 199 tltGHTGAVRSVAFSPDGK------LLASGSADGTVRLW----DLATGKLLRTLTGHSGS-VRSVAFSPDgrLLAsgsaD 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 431 KR----NLEsvGPSNDENQSASSSGVLCTRVSHDGRMLIAGTATGMLYIVDLsfSDTPIIDVINAHDHDVTSIDFSDHAS 506
Cdd:COG2319 268 GTvrlwDLA--TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGK 343
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1254046855 507 TsshdhpifLASGGRDRFVHVFRRipysSQFVHCAVLDGHQSAIKSIKFaSNNGQLhLYTAASDRSLIIWKLSS 580
Cdd:COG2319 344 T--------LASGSDDGTVRLWDL----ATGELLRTLTGHTGAVTSVAF-SPDGRT-LASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
10-399 |
9.18e-14 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 75.33 E-value: 9.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 10 RLKNVVGRSGVTVNGIALHHASDTLLQVAGSSII----VSSTASHDRFEGHlisqtKQQFTCVAVTSCGKYAATGETGHq 85
Cdd:COG2319 69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVrlwdLATGLLLRTLTGH-----TGAVRSVAFSPDGKTLASGSADG- 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 86 pAVRLWQLRDaqgnfvGRLVRSMQSHTVSITIVRFTPDDSTLISIGcqHDAQIFTWDWRTGHDLGVGKL-MSPVNALTIS 164
Cdd:COG2319 143 -TVRLWDLAT------GKLLRTLTGHSGAVTSVAFSPDGKLLASGS--DDGTVRLWDLATGKLLRTLTGhTGAVRSVAFS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 165 FDSSMCVTVGS-KSVKYWflplasdgmNKRTGLTSRSaILADKRNVNFVdaAFCDSTNRMVTVTSSGEILEFNGNKKyvK 243
Cdd:COG2319 214 PDGKLLASGSAdGTVRLW---------DLATGKLLRT-LTGHSGSVRSV--AFSPDGRLLASGSADGTVRLWDLATG--E 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 244 CYTWKESGDFKAICIARVPEG--LLVGCSDGLVRLFcligddldflaDLAPPTHLfqdpsnvydpQQLQNHPEDaifpeP 321
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGklLASGSDDGTVRLW-----------DLATGKLL----------RTLTGHTGA-----V 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 322 RCLVASSSSPTFVVGYADRSLiefarenKSWSFRRASL-----GHTGSVNCIEPFPSSSpclpigTLITGGSDGTIRFWN 396
Cdd:COG2319 334 RSVAFSPDGKTLASGSDDGTV-------RLWDLATGELlrtltGHTGAVTSVAFSPDGR------TLASGSADGTVRLWD 400
|
...
gi 1254046855 397 FNG 399
Cdd:COG2319 401 LAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
104-529 |
1.46e-13 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 73.14 E-value: 1.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 104 LVRSMQSHTVSITIVRFTPDDSTLISiGCQhDAQIFTWDWRTGHDLGVGKLMS-PVNALTISFDSSMCVTVGSksvkywf 182
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLAT-GSG-DGTIKVWDLETGELLRTLKGHTgPVRDVAASADGTYLASGSS------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 183 lplasdgmnkrtgltsrsailadkrnvnfvdaafcDSTNRMVTVTSSGEILEFNGNKKYVKCYTWKESGDfkaiciarvp 262
Cdd:cd00200 72 -----------------------------------DKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR---------- 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 263 egLLVGCS-DGLVRLFcligddldflaDLAPPTHLfqdpsnvydpQQLQNHPEDAifpepRCLVASSSSPTFVVGYADRS 341
Cdd:cd00200 107 --ILSSSSrDKTIKVW-----------DVETGKCL----------TTLRGHTDWV-----NSVAFSPDGTFVASSSQDGT 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 342 LIEFarENKSWSFRRASLGHTGSVNCIEPFPSSSPclpigtLITGGSDGTIRFWNFNGDsedkkeianilcpSLLKVIFL 421
Cdd:cd00200 159 IKLW--DLRTGKCVATLTGHTGEVNSVAFSPDGEK------LLSSSSDGTIKLWDLSTG-------------KCLGTLRG 217
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 422 DENPdllvdkrnlesvgpsndenqsasssgVLCTRVSHDGRMLIAGTATGMLYIVDLSFSDtpIIDVINAHDHDVTSIDF 501
Cdd:cd00200 218 HENG--------------------------VNSVAFSPDGYLLASGSEDGTIRVWDLRTGE--CVQTLSGHTNSVTSLAW 269
|
410 420
....*....|....*....|....*...
gi 1254046855 502 SDHAStsshdhpiFLASGGRDRFVHVFR 529
Cdd:cd00200 270 SPDGK--------RLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
66-396 |
3.18e-13 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 71.98 E-value: 3.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 66 TCVAVTSCGKYAATGETGHQpaVRLWQLRDaqgnfvGRLVRSMQSHTVSITIVRFTPDDSTLISIGCqhDAQIFTWDWRT 145
Cdd:cd00200 13 TCVAFSPDGKLLATGSGDGT--IKVWDLET------GELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRLWDLET 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 146 --------GHDlgvgklmSPVNALTISFDSSMCVTVGS-KSVKYWflplasdGMNKRTGLTSRSAILADKRNV------N 210
Cdd:cd00200 83 gecvrtltGHT-------SYVSSVAFSPDGRILSSSSRdKTIKVW-------DVETGKCLTTLRGHTDWVNSVafspdgT 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 211 FVDAAFCDSTNRMVTVTSSGEILEFNGNKKYVKCYTWKESGdfkaiciarvpEGLLVGCSDGLVRLFcligddldflaDL 290
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG-----------EKLLSSSSDGTIKLW-----------DL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 291 APPTHLfqdpsnvydpQQLQNHpEDAIfpepRCLVASSSSPTFVVGYADRSLiefarenKSWSFRRASL-----GHTGSV 365
Cdd:cd00200 207 STGKCL----------GTLRGH-ENGV----NSVAFSPDGYLLASGSEDGTI-------RVWDLRTGECvqtlsGHTNSV 264
|
330 340 350
....*....|....*....|....*....|.
gi 1254046855 366 NCIEPFPSSSpclpigTLITGGSDGTIRFWN 396
Cdd:cd00200 265 TSLAWSPDGK------RLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
26-529 |
1.27e-12 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 71.87 E-value: 1.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 26 ALHHASDTLLQVAGSSIIVSSTASHDRFEGHLISQTKQQFTCVAVTSCGKYAATGetGHQPAVRLWQLRDaqgnfvGRLV 105
Cdd:COG2319 42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLAT------GLLL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 106 RSMQSHTVSITIVRFTPDDSTLISIGcqHDAQIFTWDWRTGHDLGVGKLMS-PVNALTISFDSSMCVTVGS-KSVKYWfl 183
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGS--ADGTVRLWDLATGKLLRTLTGHSgAVTSVAFSPDGKLLASGSDdGTVRLW-- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 184 plasdgmnkrtgltsrsailadkrnvnfvdaafcdstnrmvTVTSSGEILEFNGNKKYVKCYTWKESGDFkaiciarvpe 263
Cdd:COG2319 190 -----------------------------------------DLATGKLLRTLTGHTGAVRSVAFSPDGKL---------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 264 gLLVGCSDGLVRLFcligddldfladlappthlfqdpsNVYDPQQLQ--NHPEDAIfpepRCLVASSSSPTFVVGYADRS 341
Cdd:COG2319 219 -LASGSADGTVRLW------------------------DLATGKLLRtlTGHSGSV----RSVAFSPDGRLLASGSADGT 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 342 LiefarenKSWSFRRASL-----GHTGSVNCIEPFPSSSpclpigTLITGGSDGTIRFWnfngDSEDKKEIANIlcpsll 416
Cdd:COG2319 270 V-------RLWDLATGELlrtltGHSGGVNSVAFSPDGK------LLASGSDDGTVRLW----DLATGKLLRTL------ 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254046855 417 kvifldenpdllvdkrnlesvgpsndenqSASSSGVLCTRVSHDGRMLIAGTATGMLYIVDLsfSDTPIIDVINAHDHDV 496
Cdd:COG2319 327 -----------------------------TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAV 375
|
490 500 510
....*....|....*....|....*....|...
gi 1254046855 497 TSIDFSDHASTsshdhpifLASGGRDRFVHVFR 529
Cdd:COG2319 376 TSVAFSPDGRT--------LASGSADGTVRLWD 400
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
643-718 |
1.27e-04 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 45.79 E-value: 1.27e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1254046855 643 HSGKILKVAIDHSGSYAISVCSDKFVYVTDLRSGVCLAVLCGFGAPATDATFSDDFKNVIVTTSNGSIFIWQLAKN 718
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
360-396 |
8.84e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.45 E-value: 8.84e-04
10 20 30
....*....|....*....|....*....|....*..
gi 1254046855 360 GHTGSVNCIEPFPSSSpclpigTLITGGSDGTIRFWN 396
Cdd:smart00320 10 GHTGPVTSVAFSPDGK------YLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
360-396 |
2.33e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 37.32 E-value: 2.33e-03
10 20 30
....*....|....*....|....*....|....*..
gi 1254046855 360 GHTGSVNCIEPFPSSSpclpigTLITGGSDGTIRFWN 396
Cdd:pfam00400 9 GHTGSVTSLAFSPDGK------LLASGSDDGTVKVWD 39
|
|
| |
