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    lron-14 eLRR (extracellular Leucine-Rich Repeat) ONly [ Caenorhabditis elegans ]

    Gene ID: 188075, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lron-14
    Official Full Name
    eLRR (extracellular Leucine-Rich Repeat) ONly
    Primary source
    WormBase:WBGene00011454
    Locus tag
    CELE_T05A1.3
    See related
    AllianceGenome:WB:WBGene00011454
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in head neurons and ventral nerve cord. Orthologous to human CHADL (chondroadherin like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lron-14 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    15
    Sequence:
    Chromosome: IV; NC_003282.8 (9560782..9566605, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Fibulin-1 Neighboring gene ncRNA Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eLRR (extracellular Leucine-Rich Repeat) ONly
    NP_001255400.1
    • Product from WormBase gene class lron;
      Confirmed by transcript evidence
    NP_001255401.1
    • Product from WormBase gene class lron;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9560782..9566605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268471.2 → NP_001255400.1  eLRR (extracellular Leucine-Rich Repeat) ONly [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255400.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22187
      Conserved Domains (4) summary
      cd00116
      Location:142 → 389
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:98 → 119
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:481 → 520
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:456 → 515
      LRR_8; Leucine rich repeat

    2. NM_001268472.3 → NP_001255401.1  eLRR (extracellular Leucine-Rich Repeat) ONly [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255401.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L281
      Conserved Domains (4) summary
      cd00116
      Location:58 → 170
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:42 → 65
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:65 → 104
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:40 → 99
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version

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