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Conserved domains on  [gi|392900092|ref|NP_001255400|]
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eLRR (extracellular Leucine-Rich Repeat) ONly [Caenorhabditis elegans]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-370 1.39e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 1.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 114 FAGLGQLYSLIVKNAKITDFPREIfAHVPNLMTLDLSGNRLRIEPYSLRSLQNLIHLDVSDNDIGFLTNTLISLTKLKVI 193
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 194 TMNNNKITNI--DFRRFPeNLTDLSIRHNLVSTIHYVPASARNLKRLDLAGNRMEFVGGLTTgavnvLPaELKHVDLSNN 271
Cdd:COG4886  188 DLSNNQITDLpePLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGN-----LT-NLEELDLSNN 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 272 KLTYLHDHAfeHLTNLILLDLKNNSLKEVKSSSFAGSKFQVKLFLSENPLLCHCNHKWLMDSSAKNISIGDLQTIECLNI 351
Cdd:COG4886  261 QLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338

                        250
                 ....*....|....*....
gi 392900092 352 LKPEKKMLLTLAHSRNQLL 370
Cdd:COG4886  339 TLALSLSLLALLTLLLLLN 357
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
450-537 2.16e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 2.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 450 EKLKELSNLRALKITNSKMTSVEmEKLTDLANLTHLEITSSAITSIPETITKLPSLTHLYLSDNPLDQLSStSLNHLDGL 529
Cdd:COG4886  130 EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE-PLGNLTNL 207


                 ....*...
gi 392900092 530 KKIRLGGN 537
Cdd:COG4886  208 EELDLSGN 215
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-370 1.39e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 1.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 114 FAGLGQLYSLIVKNAKITDFPREIfAHVPNLMTLDLSGNRLRIEPYSLRSLQNLIHLDVSDNDIGFLTNTLISLTKLKVI 193
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 194 TMNNNKITNI--DFRRFPeNLTDLSIRHNLVSTIHYVPASARNLKRLDLAGNRMEFVGGLTTgavnvLPaELKHVDLSNN 271
Cdd:COG4886  188 DLSNNQITDLpePLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGN-----LT-NLEELDLSNN 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 272 KLTYLHDHAfeHLTNLILLDLKNNSLKEVKSSSFAGSKFQVKLFLSENPLLCHCNHKWLMDSSAKNISIGDLQTIECLNI 351
Cdd:COG4886  261 QLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338

                        250
                 ....*....|....*....
gi 392900092 352 LKPEKKMLLTLAHSRNQLL 370
Cdd:COG4886  339 TLALSLSLLALLTLLLLLN 357
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
450-537 2.16e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 2.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 450 EKLKELSNLRALKITNSKMTSVEmEKLTDLANLTHLEITSSAITSIPETITKLPSLTHLYLSDNPLDQLSStSLNHLDGL 529
Cdd:COG4886  130 EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE-PLGNLTNL 207


                 ....*...
gi 392900092 530 KKIRLGGN 537
Cdd:COG4886  208 EELDLSGN 215
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 136-366 6.69e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 6.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 136 EIFAHVPNLMTLDLSGNRL-RIEpySLRSLQNLIHLDVSDNDIGFLTNtLISLTKLKVITMNNNKITNIdfrrfpENLTD 214
Cdd:cd21340   18 DNLSLCKNLKVLYLYDNKItKIE--NLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRISVV------EGLEN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 215 LSirhnlvstihyvpasarNLKRLDLAGNRMEFVGGLT--TGAVNVLPAELKHVDLSNNKLTYLHDhaFEHLTNLILLDL 292
Cdd:cd21340   89 LT-----------------NLEELHIENQRLPPGEKLTfdPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDA 149

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392900092 293 KNNSLKEVKSSSFAGSKFQV--KLFLSENPlLCHcNHKWlmdssaKNISIGDLQTIECLN---ILKPEKKMLLTLAHSR 366
Cdd:cd21340  150 SNNQISDLEELLDLLSSWPSlrELDLTGNP-VCK-KPKY------RDKIILASKSLEVLDgkeITDTERQFLKRLKARK 220
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
81-320 8.65e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.94  E-value: 8.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092  81 KVSTPPHSLFQgfrNLDRLELDRCLIDTVPEGLFAGLGQLYsliVKNAKITDFPreifAHVPN-LMTLDLSGNRLRIEPY 159
Cdd:PRK15370 189 GLTTIPACIPE---QITTLILDNNELKSLPENLQGNIKTLY---ANSNQLTSIP----ATLPDtIQEMELSINRITELPE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 160 SLRS-LQNLihlDVSDNDIGFLTNTLISltKLKVITMNNNKITNIDfRRFPENLTDLSIRHNlvsTIHYVPAS-ARNLKR 237
Cdd:PRK15370 259 RLPSaLQSL---DLFHNKISCLPENLPE--ELRYLSVYDNSIRTLP-AHLPSGITHLNVQSN---SLTALPETlPPGLKT 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 238 LDLAGNRMefvggltTGAVNVLPAELKHVDLSNNKLTYLHDHAFEHLTNL-----ILLDLKNN---SLKEVKSSSFAGSK 309
Cdd:PRK15370 330 LEAGENAL-------TSLPASLPPELQVLDVSKNQITVLPETLPPTITTLdvsrnALTNLPENlpaALQIMQASRNNLVR 402

                        250
                 ....*....|...
gi 392900092 310 FQVKL--FLSENP 320
Cdd:PRK15370 403 LPESLphFRGEGP 415
LRR_8 pfam13855
Leucine rich repeat;
262-321 1.14e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092  262 ELKHVDLSNNKLTYLHDHAFEHLTNLILLDLKNNSLKEVKSSSFAGSKFQVKLFLSENPL 321
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
481-537 8.91e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.91e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 392900092  481 NLTHLEITSSAITSI-PETITKLPSLTHLYLSDNPLDQLSSTSLNHLDGLKKIRLGGN 537
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 446-532 2.18e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 2.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 446 IFETEKLKELSN-LRALKITNSKMTSveMEKLTDLANLTHLEITSSAITSIPE---TITKLPSLTHLYLSDNPLDQ---- 517
Cdd:cd21340  109 TFDPRSLAALSNsLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGNPVCKkpky 186

                         90       100
                 ....*....|....*....|
gi 392900092 518 -----LSSTSLNHLDGlKKI 532
Cdd:cd21340  187 rdkiiLASKSLEVLDG-KEI 205
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-370 1.39e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 1.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 114 FAGLGQLYSLIVKNAKITDFPREIfAHVPNLMTLDLSGNRLRIEPYSLRSLQNLIHLDVSDNDIGFLTNTLISLTKLKVI 193
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 194 TMNNNKITNI--DFRRFPeNLTDLSIRHNLVSTIHYVPASARNLKRLDLAGNRMEFVGGLTTgavnvLPaELKHVDLSNN 271
Cdd:COG4886  188 DLSNNQITDLpePLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGN-----LT-NLEELDLSNN 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 272 KLTYLHDHAfeHLTNLILLDLKNNSLKEVKSSSFAGSKFQVKLFLSENPLLCHCNHKWLMDSSAKNISIGDLQTIECLNI 351
Cdd:COG4886  261 QLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338

                        250
                 ....*....|....*....
gi 392900092 352 LKPEKKMLLTLAHSRNQLL 370
Cdd:COG4886  339 TLALSLSLLALLTLLLLLN 357
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-304 4.60e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 4.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092  96 LDRLELDRCLIDTVPEGLFAGLGQLYSLIVKNAKITDFPREIFAHVPNLMTLD-----------------LSGNRLRIEP 158
Cdd:COG4886   50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDlsgneelsnltnlesldLSGNQLTDLP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 159 YSLRSLQNLIHLDVSDNDIGFLTNTLISLTKLKVITMNNNKITNID--FRRFPeNLTDLSIRHNLVSTIHYVPASARNLK 236
Cdd:COG4886  130 EELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPeeLGNLT-NLKELDLSNNQITDLPEPLGNLTNLE 208

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392900092 237 RLDLAGNRM----EFVGGLTtgavnvlpaELKHVDLSNNKLTYLHDhaFEHLTNLILLDLKNNSLKEVKSSS 304
Cdd:COG4886  209 ELDLSGNQLtdlpEPLANLT---------NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
450-537 2.16e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 2.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 450 EKLKELSNLRALKITNSKMTSVEmEKLTDLANLTHLEITSSAITSIPETITKLPSLTHLYLSDNPLDQLSStSLNHLDGL 529
Cdd:COG4886  130 EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE-PLGNLTNL 207


                 ....*...
gi 392900092 530 KKIRLGGN 537
Cdd:COG4886  208 EELDLSGN 215
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 136-366 6.69e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 6.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 136 EIFAHVPNLMTLDLSGNRL-RIEpySLRSLQNLIHLDVSDNDIGFLTNtLISLTKLKVITMNNNKITNIdfrrfpENLTD 214
Cdd:cd21340   18 DNLSLCKNLKVLYLYDNKItKIE--NLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRISVV------EGLEN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 215 LSirhnlvstihyvpasarNLKRLDLAGNRMEFVGGLT--TGAVNVLPAELKHVDLSNNKLTYLHDhaFEHLTNLILLDL 292
Cdd:cd21340   89 LT-----------------NLEELHIENQRLPPGEKLTfdPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDA 149

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392900092 293 KNNSLKEVKSSSFAGSKFQV--KLFLSENPlLCHcNHKWlmdssaKNISIGDLQTIECLN---ILKPEKKMLLTLAHSR 366
Cdd:cd21340  150 SNNQISDLEELLDLLSSWPSlrELDLTGNP-VCK-KPKY------RDKIILASKSLEVLDgkeITDTERQFLKRLKARK 220
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
452-537 1.10e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 452 LKELSNLRALKITNSKMTSVEMEkLTDLANLTHLEITSSAITSIPETITKLPSLTHLYLSDNPLDQLSstSLNHLDGLKK 531
Cdd:COG4886  178 LGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEE 254


                 ....*.
gi 392900092 532 IRLGGN 537
Cdd:COG4886  255 LDLSNN 260
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
81-320 8.65e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.94  E-value: 8.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092  81 KVSTPPHSLFQgfrNLDRLELDRCLIDTVPEGLFAGLGQLYsliVKNAKITDFPreifAHVPN-LMTLDLSGNRLRIEPY 159
Cdd:PRK15370 189 GLTTIPACIPE---QITTLILDNNELKSLPENLQGNIKTLY---ANSNQLTSIP----ATLPDtIQEMELSINRITELPE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 160 SLRS-LQNLihlDVSDNDIGFLTNTLISltKLKVITMNNNKITNIDfRRFPENLTDLSIRHNlvsTIHYVPAS-ARNLKR 237
Cdd:PRK15370 259 RLPSaLQSL---DLFHNKISCLPENLPE--ELRYLSVYDNSIRTLP-AHLPSGITHLNVQSN---SLTALPETlPPGLKT 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 238 LDLAGNRMefvggltTGAVNVLPAELKHVDLSNNKLTYLHDHAFEHLTNL-----ILLDLKNN---SLKEVKSSSFAGSK 309
Cdd:PRK15370 330 LEAGENAL-------TSLPASLPPELQVLDVSKNQITVLPETLPPTITTLdvsrnALTNLPENlpaALQIMQASRNNLVR 402

                        250
                 ....*....|...
gi 392900092 310 FQVKL--FLSENP 320
Cdd:PRK15370 403 LPESLphFRGEGP 415
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
440-537 1.70e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 440 NQTDWKIFETEKLKELSNLRALKITNSkmtsvemEKLTDLANLTHLEITSSAITSIPETITKLPSLTHLYLSDNPLDQLS 519
Cdd:COG4886   80 LLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP 152

                         90
                 ....*....|....*...
gi 392900092 520 StSLNHLDGLKKIRLGGN 537
Cdd:COG4886  153 E-PLGNLTNLKSLDLSNN 169
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
422-537 2.03e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 2.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 422 LRWDKLGKFPSP------LTQLHMNQTDWKIFETEkLKELSNLRALKITNSKMTSVEMEkLTDLANLTHLEITSSAITSI 495
Cdd:COG4886  166 LSNNQLTDLPEElgnltnLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL 243

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 392900092 496 PEtITKLPSLTHLYLSDNPLDQLSstSLNHLDGLKKIRLGGN 537
Cdd:COG4886  244 PE-LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNN 282
LRR_8 pfam13855
Leucine rich repeat;
262-321 1.14e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 1.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092  262 ELKHVDLSNNKLTYLHDHAFEHLTNLILLDLKNNSLKEVKSSSFAGSKFQVKLFLSENPL 321
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-203 1.30e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.87  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092  90 FQGFRNLDRLELDRCLIdTVPEGLfAGLGQLYSLIVKN------AKITDFPREIFAHVPNLMTLDLSGNRLRiEPYSLRS 163
Cdd:cd21340   64 LENLVNLKKLYLGGNRI-SVVEGL-ENLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNID-SLEPLAP 140

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 392900092 164 LQNLIHLDVSDN---DIGFLTNTLISLTKLKVITMNNNKITNI 203
Cdd:cd21340  141 LRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPVCKK 183
LRR_8 pfam13855
Leucine rich repeat;
233-297 1.98e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392900092  233 RNLKRLDLAGNRMEFVGGlttGAVNVLPAeLKHVDLSNNKLTYLHDHAFEHLTNLILLDLKNNSL 297
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD---GAFKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-537 2.58e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 2.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 120 LYSLIVKNAKITDFPREIFAHVPNLMTLDLSGNRLRIEPYSLRSLQNLIHLDVSDNDIGFLTNTLISLTKLKVITMNNNK 199
Cdd:COG4886    6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 200 ITNIDFRRFPENLTDLSIRHNLVStihyvpASARNLKRLDLAGNRM----EFVGGLTtgavnvlpaELKHVDLSNNKLTY 275
Cdd:COG4886   86 LLGLTDLGDLTNLTELDLSGNEEL------SNLTNLESLDLSGNQLtdlpEELANLT---------NLKELDLSNNQLTD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 276 LHDhAFEHLTNLILLDLKNNSLKEVkSSSFAGSKFQVKLFLSENPLlchcnhkwlmdsSAKNISIGDLQTIECLNIlkpe 355
Cdd:COG4886  151 LPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI------------TDLPEPLGNLTNLEELDL---- 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 356 kkmlltlahSRNQLlckysnmceadceccqkkececrfecpptckclrsadvsivrtsqnimvcdklrwdklGKFPSPLT 435
Cdd:COG4886  213 ---------SGNQL----------------------------------------------------------TDLPEPLA 225

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 436 QLhmnqtdwkifeteklkelSNLRALKITNSKMTSVEmeKLTDLANLTHLEITSSAITSIPEtITKLPSLTHLYLSDNPL 515
Cdd:COG4886  226 NL------------------TNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQL 284

                        410       420
                 ....*....|....*....|..
gi 392900092 516 DQLSSTSLNHLDGLKKIRLGGN 537
Cdd:COG4886  285 TDLKLKELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
119-177 2.82e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.82e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092  119 QLYSLIVKNAKITDFPREIFAHVPNLMTLDLSGNRLR-IEPYSLRSLQNLIHLDVSDNDI 177
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTtLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
142-200 6.43e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 6.43e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392900092  142 PNLMTLDLSGNRL-RIEPYSLRSLQNLIHLDVSDNDIGFL-TNTLISLTKLKVITMNNNKI 200
Cdd:pfam13855   1 PNLRSLDLSNNRLtSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 142-389 3.76e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.66  E-value: 3.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 142 PNLMTLDLSGNRLRIEPYSLRSL-------QNLIHLDVSDNDIGFLT-NTLISLTK---LKVITMNNNKITNIDFRRFPE 210
Cdd:cd00116   51 PSLKELCLSLNETGRIPRGLQSLlqgltkgCGLQELDLSDNALGPDGcGVLESLLRsssLQELKLNNNGLGDRGLRLLAK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 211 NLTDLSIRhnlvstihyvpasarnLKRLDLAGNRMEfvGGLTTGAVNVLPA--ELKHVDLSNNKL-----TYLHdHAFEH 283
Cdd:cd00116  131 GLKDLPPA----------------LEKLVLGRNRLE--GASCEALAKALRAnrDLKELNLANNGIgdagiRALA-EGLKA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 284 LTNLILLDLKNNSLKEVKSSSFAGSkfqvklfLSENPLLCHCNhkwLMDSsakniSIGDLQTIECLNILKPEKKMLLTLA 363
Cdd:cd00116  192 NCNLEVLDLNNNGLTDEGASALAET-------LASLKSLEVLN---LGDN-----NLTDAGAAALASALLSPNISLLTLS 256

                        250       260
                 ....*....|....*....|....*.
gi 392900092 364 HSRNQLLCKysnMCEADCECCQKKEC 389
Cdd:cd00116  257 LSCNDITDD---GAKDLAEVLAEKES 279
LRR_8 pfam13855
Leucine rich repeat;
94-154 8.07e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.07e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392900092   94 RNLDRLELDRCLIDTVPEGLFAGLGQLYSLIVKNAKITDFPREIFAHVPNLMTLDLSGNRL 154
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
481-537 8.91e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.91e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 392900092  481 NLTHLEITSSAITSI-PETITKLPSLTHLYLSDNPLDQLSSTSLNHLDGLKKIRLGGN 537
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-321 1.11e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092  81 KVSTP-PHSLFqGFRNLDRLEL-DRCLIDTVPEgLFAGLGQLYSLIVKNAKITDFPREIFAHVPNLMTLDLSGNRLRIE- 157
Cdd:PLN00113 271 KLSGPiPPSIF-SLQKLISLDLsDNSLSGEIPE-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEi 348

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 158 PYSLRSLQNLIHLDVSDNDI-GFLTNTLIS---LTKL---------------------KVITMNNNKITN---IDFRRFP 209
Cdd:PLN00113 349 PKNLGKHNNLTVLDLSTNNLtGEIPEGLCSsgnLFKLilfsnslegeipkslgacrslRRVRLQDNSFSGelpSEFTKLP 428

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 210 -ENLTDLSiRHNLVSTIHYVPASARNLKRLDLAGNRmeFVGGL--TTGAVNvlpaeLKHVDLSNNKLTYLHDHAFEHLTN 286
Cdd:PLN00113 429 lVYFLDIS-NNNLQGRINSRKWDMPSLQMLSLARNK--FFGGLpdSFGSKR-----LENLDLSRNQFSGAVPRKLGSLSE 500

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 392900092 287 LILLDLKNNSLKEVKSSSFAGSKFQVKLFLSENPL 321
Cdd:PLN00113 501 LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 109-297 2.09e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 109 VPEGLFAGLGQLYSLIVKNAKIT-DFPReifAHVPNLMTLDLSGNRLRIE-PYSLRSLQNLIHLDVSDND-IGFLTNTLI 185
Cdd:PLN00113 109 IPDDIFTTSSSLRYLNLSNNNFTgSIPR---GSIPNLETLDLSNNMLSGEiPNDIGSFSSLKVLDLGGNVlVGKIPNSLT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 186 SLTKLKVITMNNNKITNidfrRFPENLTDL-SIR------HNLVSTIHYVPASARNLKRLDLAGNRMefVGGLTTGAVNV 258
Cdd:PLN00113 186 NLTSLEFLTLASNQLVG----QIPRELGQMkSLKwiylgyNNLSGEIPYEIGGLTSLNHLDLVYNNL--TGPIPSSLGNL 259

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 392900092 259 lpAELKHVDLSNNKLTYLHDHAFEHLTNLILLDLKNNSL 297
Cdd:PLN00113 260 --KNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSL 296
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 446-532 2.18e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 2.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 446 IFETEKLKELSN-LRALKITNSKMTSveMEKLTDLANLTHLEITSSAITSIPE---TITKLPSLTHLYLSDNPLDQ---- 517
Cdd:cd21340  109 TFDPRSLAALSNsLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGNPVCKkpky 186

                         90       100
                 ....*....|....*....|
gi 392900092 518 -----LSSTSLNHLDGlKKI 532
Cdd:cd21340  187 rdkiiLASKSLEVLDG-KEI 205
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
106-276 3.87e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.00  E-value: 3.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 106 IDTVPEGLFAglgQLYSLIVKNAKITDFPreifAHVPNLMTLDLSGNRLRIEPY-------------------------- 159
Cdd:PRK15387 213 LTTLPDCLPA---HITTLVIPDNNLTSLP----ALPPELRTLEVSGNQLTSLPVlppgllelsifsnplthlpalpsglc 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 160 -------SLRSLQ----NLIHLDVSDNDIGFLTNTLISLTKLKVItmnNNKITNIDfrRFPENLTDLSIRHNLVSTI--- 225
Cdd:PRK15387 286 klwifgnQLTSLPvlppGLQELSVSDNQLASLPALPSELCKLWAY---NNQLTSLP--TLPSGLQELSVSDNQLASLptl 360

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392900092 226 --------------HYVPASARNLKRLDLAGNRMEfvgglttgAVNVLPAELKHVDLSNNKLTYL 276
Cdd:PRK15387 361 pselyklwaynnrlTSLPALPSGLKELIVSGNRLT--------SLPVLPSELKELMVSGNRLTSL 417
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 143-321 6.25e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 6.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 143 NLMTLDLSGNRLRIE-PYSLRSLQNLIHLDVSDNDI-GFLTNTLISLTKLKVITMNNNKIT-NIDFRRFP-ENLTDLSIR 218
Cdd:PLN00113 381 NLFKLILFSNSLEGEiPKSLGACRSLRRVRLQDNSFsGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDmPSLQMLSLA 460

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 219 HNlvSTIHYVPASAR--NLKRLDLAGNRMEFVGGLTTGAVnvlpAELKHVDLSNNKLTYLHDHAFEHLTNLILLDLKNNS 296
Cdd:PLN00113 461 RN--KFFGGLPDSFGskRLENLDLSRNQFSGAVPRKLGSL----SELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQ 534

                        170       180
                 ....*....|....*....|....*..
gi 392900092 297 LKEVKSSSFagSKFQV--KLFLSENPL 321
Cdd:PLN00113 535 LSGQIPASF--SEMPVlsQLDLSQNQL 559
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 136-322 9.81e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 9.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 136 EIFAHVPNLMTLDLSGNRL--RIEPYSLRSLQNLIH----LDVSDNDIGF-----LTNTLISLTKLKVITMNNNKITNID 204
Cdd:cd00116  102 ESLLRSSSLQELKLNNNGLgdRGLRLLAKGLKDLPPalekLVLGRNRLEGasceaLAKALRANRDLKELNLANNGIGDAG 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 205 FRRFPENLTDLSirhnlvstihyvpasarNLKRLDLAGNRMEFVGGLTTGAVNVLPAELKHVDLSNNKLT-----YLHDH 279
Cdd:cd00116  182 IRALAEGLKANC-----------------NLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTdagaaALASA 244

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 392900092 280 AFEHLTNLILLDLKNNSLKEVKSSSFAG----SKFQVKLFLSENPLL 322
Cdd:cd00116  245 LLSPNISLLTLSLSCNDITDDGAKDLAEvlaeKESLLELDLRGNKFG 291
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 119-299 1.08e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.08  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 119 QLYSLIVKNAKITDFPREIFA----HVPNLMTLDLSGNRLRIEPY-----SLRSLQNLIHLDVSDNDIG-----FLTNTL 184
Cdd:COG5238  209 TVTTLWLKRNPIGDEGAEILAealkGNKSLTTLDLSNNQIGDEGVialaeALKNNTTVETLYLSGNQIGaegaiALAKAL 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 185 ISLTKLKVITMNNNKITNIDFRRFPENL------TDLSIRHNLVSTIHYVP-ASA----RNLKRLDLAGNRMEFVGGLTT 253
Cdd:COG5238  289 QGNTTLTSLDLSVNRIGDEGAIALAEGLqgnktlHTLNLAYNGIGAQGAIAlAKAlqenTTLHSLDLSDNQIGDEGAIAL 368

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 392900092 254 GAVNVLPAELKHVDLSNNKLT-----YLHDHAFEhlTNLILLDLKNNSLKE 299
Cdd:COG5238  369 AKYLEGNTTLRELNLGKNNIGkqgaeALIDALQT--NRLHTLILDGNLIGA 417
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 117-537 2.59e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 2.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 117 LGQLYSL----IVKNAKITDFPREiFAHVPNLMTLDLSGNRLRIE-PYSLRSLQNLIHLDVSDNDI-GFLTNTLISLTKL 190
Cdd:PLN00113 232 IGGLTSLnhldLVYNNLTGPIPSS-LGNLKNLQYLFLYQNKLSGPiPPSIFSLQKLISLDLSDNSLsGEIPELVIQLQNL 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 191 KVITMNNNKITNidfrRFPENLTDLSirhnlvstihyvpasarNLKRLDLAGNRmeFVGGlttgavnvLPAEL-KH---- 265
Cdd:PLN00113 311 EILHLFSNNFTG----KIPVALTSLP-----------------RLQVLQLWSNK--FSGE--------IPKNLgKHnnlt 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 266 -VDLSNNKLT-----YLHDHAfeHLTNLILLdlkNNSLKEVKSSSFAGSKFQVKLFLSENPLlchcnhkwlmdSSAKNIS 339
Cdd:PLN00113 360 vLDLSTNNLTgeipeGLCSSG--NLFKLILF---SNSLEGEIPKSLGACRSLRRVRLQDNSF-----------SGELPSE 423

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 340 IGDLQTIECLNIlkpekkmlltlahSRNQLLCKYSNMceadceccqkkececRFECPPtckcLRSADVSIVRTSQNIMvc 419
Cdd:PLN00113 424 FTKLPLVYFLDI-------------SNNNLQGRINSR---------------KWDMPS----LQMLSLARNKFFGGLP-- 469

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 420 DKLRWDKLGKFpspltQLHMNQTDWKIfeTEKLKELSNLRALKITNSKMTSVEMEKLTDLANLTHLEITSSAIT-SIPET 498
Cdd:PLN00113 470 DSFGSKRLENL-----DLSRNQFSGAV--PRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPAS 542

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 392900092 499 ITKLPSLTHLYLSDNPLDQLSSTSLNHLDGLKKIRLGGN 537
Cdd:PLN00113 543 FSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHN 581
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 462-537 3.53e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 3.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392900092 462 KITNSKMTSVEMEKLTDLA---NLTHLEITSSAITSIpETITKLPSLTHLYLSDNpldQLSS-TSLNHLDGLKKIRLGGN 537
Cdd:cd21340    3 RITHLYLNDKNITKIDNLSlckNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNN---QIEKiENLENLVNLKKLYLGGN 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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