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    tre-4 Trehalase [ Caenorhabditis elegans ]

    Gene ID: 184505, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tre-4
    Official Full Name
    Trehalase
    Primary source
    WormBase:WBGene00006610
    Locus tag
    CELE_F15A2.2
    See related
    AllianceGenome:WB:WBGene00006610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable alpha,alpha-trehalase activity. Predicted to be involved in trehalose catabolic process. Predicted to be located in membrane. Is expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and reproductive system. Orthologous to human TREH (trehalase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tre-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (13472155..13475926)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Ephrin RBD domain-containing protein Neighboring gene Serpentine receptor class delta-50 Neighboring gene Serpentine receptor class delta-51 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes. Pellerone FI, et al. Int J Parasitol, 2003 Sep 30. PMID 13678635
    2. C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens. Ju S, et al. Commun Biol, 2022 Jun 30. PMID 35773333, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables alpha,alpha-trehalase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha,alpha-trehalase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trehalose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Trehalase
    NP_510249.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13472155..13475926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077848.9 → NP_510249.2  Trehalase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510249.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDP3
      Conserved Domains (1) summary
      cl17346
      Location:80 → 557
      Trehalase; Trehalase
    Nucleotide Protein
    Heading Accession and Version

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