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    pld-1 Phospholipase [ Caenorhabditis elegans ]

    Gene ID: 173876, updated on 4-Jan-2025

    Summary

    Official Symbol
    pld-1
    Official Full Name
    Phospholipase
    Primary source
    WormBase:WBGene00004040
    Locus tag
    CELE_C04G6.3
    See related
    AllianceGenome:WB:WBGene00004040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phospholipase D activity. Predicted to be involved in phospholipid catabolic process and regulation of vesicle-mediated transport. Predicted to be active in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including intestine; nervous system; pharyngeal-intestinal valve; rectal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to several human genes including PLD1 (phospholipase D1). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See pld-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    18
    Sequence:
    Chromosome: II; NC_003280.10 (5083848..5091690, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DiSHevelled related Neighboring gene Protein TIC Neighboring gene UPF0057 membrane protein C04G6.5 Neighboring gene ncRNA Neighboring gene DUF281 domain-containing protein Neighboring gene C6 domain-containing protein

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity  
    enables catalytic activity  
    enables hydrolase activity  
    enables phosphatidylinositol binding  
    enables phospholipase D activity  
    enables phospholipase D activity  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction  
    involved_in lipid catabolic process  
    involved_in phosphatidic acid biosynthetic process  
    involved_in phospholipid catabolic process  
    involved_in regulation of vesicle-mediated transport  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    Phospholipase
    NP_494939.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5083848..5091690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062538.7 → NP_494939.1  Phospholipase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494939.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDU3
      Conserved Domains (5) summary
      cd09138
      Location:528 → 674
      PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      cd09141
      Location:1101 → 1278
      PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins
      PLN02866
      Location:988 → 1426
      PLN02866; phospholipase D
      cd01254
      Location:372 → 502
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
      cl02563
      Location:153 → 384
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
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