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    F46C5.9 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F46C5.9
    Official Full Name
    WD_REPEATS_REGION domain-containing protein
    Primary source
    WormBase:WBGene00009784
    Locus tag
    CELE_F46C5.9
    See related
    AllianceGenome:WB:WBGene00009784
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human TBL2 (transducin beta like 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F46C5.9 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (8808636..8810729, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene intestinal acid PHOsphatase Neighboring gene Decapping nuclease Neighboring gene Protein RER1 homolog Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    acts_upstream_of_or_within IRE1-mediated unfolded protein response HEP PubMed 
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WD_REPEATS_REGION domain-containing protein
    NP_495877.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8808636..8810729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063476.6 → NP_495877.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495877.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFD7
      Conserved Domains (2) summary
      sd00039
      Location:94 → 133
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:83 → 405
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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