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Conserved domains on  [gi|17534141|ref|NP_495877|]
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WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
82-405 1.00e-30

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.33  E-value: 1.00e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141  82 WNVS------VLKGHKKEVTDVAFASDGKKFVSISGDRSVILWDVRDfenkeHKCIRQTVEY-DTPTRVVFAPDCKSVVf 154
Cdd:COG2319 105 WDLAtglllrTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-----GKLLRTLTGHsGAVTSVAFSPDGKLLA- 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 155 SVKRENKICVYKLVKKTEgsgshhfvhIDNLefeRVHQVDIQNIGIAGNAKYLMSAALDNKICLYDLR-GQLLQSIDAKV 233
Cdd:COG2319 179 SGSDDGTVRLWDLATGKL---------LRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHS 246

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 234 SSLYDCRLSPDGRFIIVSGFTPDVFVFEPiftrdgtfQSAKKVFSLSGHQSGVLAAAFNNSSTRAVTVSRDGKWRIFDTD 313
Cdd:COG2319 247 GSVRSVAFSPDGRLLASGSADGTVRLWDL--------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 314 iryeagqDSKILREgswapLHAATSEHVRLEMSPSGDSFAVsfktdlkvfASEDET------KDYPELKDI--CSTTISS 385
Cdd:COG2319 319 -------TGKLLRT-----LTGHTGAVRSVAFSPDGKTLAS---------GSDDGTvrlwdlATGELLRTLtgHTGAVTS 377

                       330       340
                ....*....|....*....|.
gi 17534141 386 IAYSSDGKYIATCG-DKYVRV 405
Cdd:COG2319 378 VAFSPDGRTLASGSaDGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
82-405 1.00e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.33  E-value: 1.00e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141  82 WNVS------VLKGHKKEVTDVAFASDGKKFVSISGDRSVILWDVRDfenkeHKCIRQTVEY-DTPTRVVFAPDCKSVVf 154
Cdd:COG2319 105 WDLAtglllrTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-----GKLLRTLTGHsGAVTSVAFSPDGKLLA- 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 155 SVKRENKICVYKLVKKTEgsgshhfvhIDNLefeRVHQVDIQNIGIAGNAKYLMSAALDNKICLYDLR-GQLLQSIDAKV 233
Cdd:COG2319 179 SGSDDGTVRLWDLATGKL---------LRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHS 246

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 234 SSLYDCRLSPDGRFIIVSGFTPDVFVFEPiftrdgtfQSAKKVFSLSGHQSGVLAAAFNNSSTRAVTVSRDGKWRIFDTD 313
Cdd:COG2319 247 GSVRSVAFSPDGRLLASGSADGTVRLWDL--------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 314 iryeagqDSKILREgswapLHAATSEHVRLEMSPSGDSFAVsfktdlkvfASEDET------KDYPELKDI--CSTTISS 385
Cdd:COG2319 319 -------TGKLLRT-----LTGHTGAVRSVAFSPDGKTLAS---------GSDDGTvrlwdlATGELLRTLtgHTGAVTS 377

                       330       340
                ....*....|....*....|.
gi 17534141 386 IAYSSDGKYIATCG-DKYVRV 405
Cdd:COG2319 378 VAFSPDGRTLASGSaDGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-405 6.27e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 6.27e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141  83 NVSVLKGHKKEVTDVAFASDGKKFVSISGDRSVILWDVRDFEnkehKCIRQTVEYDTPTRVVFAPDCKSvVFSVKRENKI 162
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE----LLRTLKGHTGPVRDVAASADGTY-LASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 163 CVYKLVKKTEgsgSHHFVHidnlefervHQVDIQNIGIAGNAKYLMSAALDNKICLYDLR-GQLLQSIDAKVSSLYDCRL 241
Cdd:cd00200  76 RLWDLETGEC---VRTLTG---------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRGHTDWVNSVAF 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 242 SPDGRFIIVSGftpdvfvfepiftRDGT-----FQSAKKVFSLSGHQSGVLAAAFNNSSTRAVTVSRDGKWRIFDTDiry 316
Cdd:cd00200 144 SPDGTFVASSS-------------QDGTiklwdLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS--- 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 317 eAGQDSKILReGSWAPLHAAtsehvrlemspsgdsfAVSFKTDLKVFASEDET-KDYPELKDICSTTIS-------SIAY 388
Cdd:cd00200 208 -TGKCLGTLR-GHENGVNSV----------------AFSPDGYLLASGSEDGTiRVWDLRTGECVQTLSghtnsvtSLAW 269

                       330
                ....*....|....*...
gi 17534141 389 SSDGKYIATCG-DKYVRV 405
Cdd:cd00200 270 SPDGKRLASGSaDGTIRI 287
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 84-119 1.50e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.50e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 17534141     84 VSVLKGHKKEVTDVAFASDGKKFVSISGDRSVILWD 119
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
84-119 3.51e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.51e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 17534141    84 VSVLKGHKKEVTDVAFASDGKKFVSISGDRSVILWD 119
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
82-405 1.00e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.33  E-value: 1.00e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141  82 WNVS------VLKGHKKEVTDVAFASDGKKFVSISGDRSVILWDVRDfenkeHKCIRQTVEY-DTPTRVVFAPDCKSVVf 154
Cdd:COG2319 105 WDLAtglllrTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-----GKLLRTLTGHsGAVTSVAFSPDGKLLA- 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 155 SVKRENKICVYKLVKKTEgsgshhfvhIDNLefeRVHQVDIQNIGIAGNAKYLMSAALDNKICLYDLR-GQLLQSIDAKV 233
Cdd:COG2319 179 SGSDDGTVRLWDLATGKL---------LRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHS 246

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 234 SSLYDCRLSPDGRFIIVSGFTPDVFVFEPiftrdgtfQSAKKVFSLSGHQSGVLAAAFNNSSTRAVTVSRDGKWRIFDTD 313
Cdd:COG2319 247 GSVRSVAFSPDGRLLASGSADGTVRLWDL--------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 314 iryeagqDSKILREgswapLHAATSEHVRLEMSPSGDSFAVsfktdlkvfASEDET------KDYPELKDI--CSTTISS 385
Cdd:COG2319 319 -------TGKLLRT-----LTGHTGAVRSVAFSPDGKTLAS---------GSDDGTvrlwdlATGELLRTLtgHTGAVTS 377

                       330       340
                ....*....|....*....|.
gi 17534141 386 IAYSSDGKYIATCG-DKYVRV 405
Cdd:COG2319 378 VAFSPDGRTLASGSaDGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
86-405 1.08e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 1.08e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141  86 VLKGHKKEVTDVAFASDGKKFVSISGDRSVILWDVRDfenkeHKCIRQTVEY-DTPTRVVFAPDCKSVVfSVKRENKICV 164
Cdd:COG2319  73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-----GLLLRTLTGHtGAVRSVAFSPDGKTLA-SGSADGTVRL 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 165 YKLVKKTEgsgshhfvhIDNLefeRVHQVDIQNIGIAGNAKYLMSAALDNKICLYDLR-GQLLQSIDAKVSSLYDCRLSP 243
Cdd:COG2319 147 WDLATGKL---------LRTL---TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSP 214

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 244 DGRFIIVSGFTPDVFVFEPiftrdgtfQSAKKVFSLSGHQSGVLAAAFNNSSTRAVTVSRDGKWRIFDTDiryeAGQDSK 323
Cdd:COG2319 215 DGKLLASGSADGTVRLWDL--------ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA----TGELLR 282

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 324 ILREGSWAPLHAAtsehvrleMSPSGDSFAVsfktdlkvfASEDET------KDYPELKDIC--STTISSIAYSSDGKYI 395
Cdd:COG2319 283 TLTGHSGGVNSVA--------FSPDGKLLAS---------GSDDGTvrlwdlATGKLLRTLTghTGAVRSVAFSPDGKTL 345

                       330
                ....*....|.
gi 17534141 396 ATCG-DKYVRV 405
Cdd:COG2319 346 ASGSdDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
82-313 6.01e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 6.01e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141  82 WNVS------VLKGHKKEVTDVAFASDGKKFVSISGDRSVILWDVRDFEnkehkcIRQTVEYDTP--TRVVFAPDCKSVV 153
Cdd:COG2319 189 WDLAtgkllrTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK------LLRTLTGHSGsvRSVAFSPDGRLLA 262

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 154 fSVKRENKICVYKLvkkTEGSGSHHFVHidnlefervHQVDIQNIGIAGNAKYLMSAALDNKICLYDLR-GQLLQSIDAK 232
Cdd:COG2319 263 -SGSADGTVRLWDL---ATGELLRTLTG---------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGH 329

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 233 VSSLYDCRLSPDGRFIIVSGftpdvfvfepiftRDGT-----FQSAKKVFSLSGHQSGVLAAAFNNSSTRAVTVSRDGKW 307
Cdd:COG2319 330 TGAVRSVAFSPDGKTLASGS-------------DDGTvrlwdLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTV 396


                ....*.
gi 17534141 308 RIFDTD 313
Cdd:COG2319 397 RLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-405 6.27e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 6.27e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141  83 NVSVLKGHKKEVTDVAFASDGKKFVSISGDRSVILWDVRDFEnkehKCIRQTVEYDTPTRVVFAPDCKSvVFSVKRENKI 162
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE----LLRTLKGHTGPVRDVAASADGTY-LASGSSDKTI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 163 CVYKLVKKTEgsgSHHFVHidnlefervHQVDIQNIGIAGNAKYLMSAALDNKICLYDLR-GQLLQSIDAKVSSLYDCRL 241
Cdd:cd00200  76 RLWDLETGEC---VRTLTG---------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRGHTDWVNSVAF 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 242 SPDGRFIIVSGftpdvfvfepiftRDGT-----FQSAKKVFSLSGHQSGVLAAAFNNSSTRAVTVSRDGKWRIFDTDiry 316
Cdd:cd00200 144 SPDGTFVASSS-------------QDGTiklwdLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS--- 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 317 eAGQDSKILReGSWAPLHAAtsehvrlemspsgdsfAVSFKTDLKVFASEDET-KDYPELKDICSTTIS-------SIAY 388
Cdd:cd00200 208 -TGKCLGTLR-GHENGVNSV----------------AFSPDGYLLASGSEDGTiRVWDLRTGECVQTLSghtnsvtSLAW 269

                       330
                ....*....|....*...
gi 17534141 389 SSDGKYIATCG-DKYVRV 405
Cdd:cd00200 270 SPDGKRLASGSaDGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-311 2.09e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 2.09e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141  84 VSVLKGHKKEVTDVAFASDGKKFVSISGDRSVILWDVRDFENKehkcirQTVEY--DTPTRVVFAPDcKSVVFSVKRENK 161
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL------TTLRGhtDWVNSVAFSPD-GTFVASSSQDGT 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 162 ICVYKLvkkTEGSGSHHFVHidnlefervHQVDIQNIGIAGNAKYLMSAALDNKICLYDLR-GQLLQSIDAKVSSLYDCR 240
Cdd:cd00200 159 IKLWDL---RTGKCVATLTG---------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVA 226

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17534141 241 LSPDGRFIIVSGftpdvfvfepiftRDGTF-----QSAKKVFSLSGHQSGVLAAAFNNSSTRAVTVSRDGKWRIFD 311
Cdd:cd00200 227 FSPDGYLLASGS-------------EDGTIrvwdlRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
82-223 9.58e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 9.58e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141  82 WNVS------VLKGHKKEVTDVAFASDGKKFVSISGDRSVILWDVRDfenkeHKCIRQ-TVEYDTPTRVVFAPDCKSVVf 154
Cdd:COG2319 273 WDLAtgellrTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-----GKLLRTlTGHTGAVRSVAFSPDGKTLA- 346

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17534141 155 SVKRENKICVYKLVKKTEgsgshhfvhidnLEFERVHQVDIQNIGIAGNAKYLMSAALDNKICLYDLRG 223
Cdd:COG2319 347 SGSDDGTVRLWDLATGEL------------LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 84-119 1.50e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.50e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 17534141     84 VSVLKGHKKEVTDVAFASDGKKFVSISGDRSVILWD 119
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
84-119 3.51e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.51e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 17534141    84 VSVLKGHKKEVTDVAFASDGKKFVSISGDRSVILWD 119
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
265-405 6.69e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 6.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534141 265 TRDGTFQSAKKVFSLSGHQSGVLAAAFNNSSTRAVTVSRDGKWRIFDTDiryeagqdskilrEGSWAPLHAATSEHVR-L 343
Cdd:COG2319  60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA-------------TGLLLRTLTGHTGAVRsV 126

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17534141 344 EMSPSGDSFAVsfktdlkvfASEDET------KDYPELKDIC--STTISSIAYSSDGKYIATCG-DKYVRV 405
Cdd:COG2319 127 AFSPDGKTLAS---------GSADGTvrlwdlATGKLLRTLTghSGAVTSVAFSPDGKLLASGSdDGTVRL 188
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 272-311 1.38e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17534141    272 SAKKVFSLSGHQSGVLAAAFNNSSTRAVTVSRDGKWRIFD 311
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
274-311 4.63e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.63e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 17534141   274 KKVFSLSGHQSGVLAAAFNNSSTRAVTVSRDGKWRIFD 311
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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