add-2 Adducin-related protein 2;Class II aldolase/adducin N-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: add-2
Official Full Name: Adducin-related protein 2;Class II aldolase/adducin N-terminal domain-containing protein
Primary source: WormBase:WBGene00000073
Locus tag: CELE_F57F5.4
See related: AllianceGenome:WB:WBGene00000073
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin filament binding activity. Predicted to be located in cytoplasm. Predicted to be active in cytoskeleton; plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; gastroschisis; and spastic quadriplegic cerebral palsy 3. Orthologous to human ADD1 (adducin 1); ADD2 (adducin 2); and ADD3 (adducin 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See add-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (12009540..12013406, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F57F5.4 (e-PCR)
- UniSTS:314516

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Adducin-related protein 2;Class II aldolase/adducin N-terminal domain-containing protein

NP_001041130.1

Confirmed by transcript evidence

NP_001041131.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

12009540..12013406 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047665.4 → NP_001041130.1 Adducin-related protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041130.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20952

Conserved Domains (1) summary

cl00214
Location:348 → 604

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001047666.5 → NP_001041131.1 Class II aldolase/adducin N-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041131.1

Status: REVIEWED

UniProtKB/TrEMBL

Q1ZXU2

Conserved Domains (1) summary

cl00214
Location:31 → 285

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...