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Conserved domains on  [gi|115533218|ref|NP_001041131|]
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Class II aldolase/adducin N-terminal domain-containing protein [Caenorhabditis elegans]

Protein Classification

class II aldolase/adducin head domain-containing protein( domain architecture ID 842)

class II aldolase/adducin head domain-containing protein involved in catalyzing central steps of carbohydrate metabolism; it promotes carbon-carbon bond cleavage and stabilizes enolate intermediates using divalent cations

Gene Symbol:  ADD3
PubMed:  10581174

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Aldolase_II super family cl00214
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 31-285 7.69e-99

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


The actual alignment was detected with superfamily member PRK07044:

Pssm-ID: 469663  Cd Length: 252  Bit Score: 290.60  E-value: 7.69e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  31 DGYDPEELTQRNKLASLYRLVDLFRWSQGIYNHITVRVSTDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGgsTNFG 110
Cdd:PRK07044   8 ARVSPAEWQARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVDD--SPYP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 111 VNQAGYVLHSAIHNGRPEVKCVVHLHHPSVVAVSAQKCGLLPISQESMIV-GDVGYHEYRGILIDEAERALLVRDLGDRN 189
Cdd:PRK07044  86 VNPAGFTIHSAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGDKP 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 190 VMILRNHGFVVCGESIEHALSLTYHLIIACETQIRTVPGGNTdnVHFPAQSAIKqvyKVASQGgggvnrqnghVNSMQWK 269
Cdd:PRK07044 166 AMLLRNHGLLTVGRTVAEAFLLMYTLERACEIQVAAQAGGGE--LVLPPPEVAE---RTARQS----------LFDPGAG 230

                        250
                 ....*....|....*.
gi 115533218 270 KGELEWQAYMRQLDAQ 285
Cdd:PRK07044 231 AGELAWPALLRKLDRI 246
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 31-285 7.69e-99

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 290.60  E-value: 7.69e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  31 DGYDPEELTQRNKLASLYRLVDLFRWSQGIYNHITVRVSTDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGgsTNFG 110
Cdd:PRK07044   8 ARVSPAEWQARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVDD--SPYP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 111 VNQAGYVLHSAIHNGRPEVKCVVHLHHPSVVAVSAQKCGLLPISQESMIV-GDVGYHEYRGILIDEAERALLVRDLGDRN 189
Cdd:PRK07044  86 VNPAGFTIHSAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGDKP 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 190 VMILRNHGFVVCGESIEHALSLTYHLIIACETQIRTVPGGNTdnVHFPAQSAIKqvyKVASQGgggvnrqnghVNSMQWK 269
Cdd:PRK07044 166 AMLLRNHGLLTVGRTVAEAFLLMYTLERACEIQVAAQAGGGE--LVLPPPEVAE---RTARQS----------LFDPGAG 230

                        250
                 ....*....|....*.
gi 115533218 270 KGELEWQAYMRQLDAQ 285
Cdd:PRK07044 231 AGELAWPALLRKLDRI 246
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 35-225 2.36e-56

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 180.41  E-value: 2.36e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  35 PEELTQRNKLASLYRLVDLFRWSQGIYNHITVRVstDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGGstnfGVNQA 114
Cdd:COG0235    1 MEEEELREELAAAGRRLARRGLVDGTAGNISVRL--DDDRFLITPSGVDFGELTPEDLVVVDLDGNVVEGD----LKPSS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 115 GYVLHSAIHNGRPEVKCVVHLHHPSVVAVSAQKCGLLPISQE--SMIVGDVGYHEYRGIlIDEAERALLVRDLGDRNVMI 192
Cdd:COG0235   75 ETPLHLAIYRARPDVGAVVHTHSPYATALSALGEPLPPLEQTeaAAFLGDVPVVPYAGP-GTEELAEAIAEALGDRPAVL 153

                        170       180       190
                 ....*....|....*....|....*....|...
gi 115533218 193 LRNHGFVVCGESIEHALSLTYHLIIACETQIRT 225
Cdd:COG0235  154 LRNHGVVVWGKDLAEAFDRAEVLEEAARIQLLA 186
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 42-223 1.55e-51

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 167.34  E-value: 1.55e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218   42 NKLASLYRLVDLFRWSQGIYNHITVRVstDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGGstnfGVNQAGYVLHSA 121
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRL--PGDGFLITPSGVDFGELTPEDLVVVDLDGNVVEGG----LKPSSETPLHLA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  122 IHNGRPEVKCVVHLHHPSVVAVSAQKCGLLPISQESMIV--GDVGYHEYRGILIDEAERAlLVRDLG-DRNVMILRNHGF 198
Cdd:pfam00596  75 IYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAADFlgGDIPIIPYYTPGTEELGER-IAEALGgDRKAVLLRNHGL 153

                         170       180
                  ....*....|....*....|....*
gi 115533218  199 VVCGESIEHALSLTYHLIIACETQI 223
Cdd:pfam00596 154 LVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 44-223 8.74e-50

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 162.81  E-value: 8.74e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218    44 LASLYRLVDLFRWSQGIYNHITVRVStDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGGSTnfGVNQAGYVLHSAIH 123
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARVG-EEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGGG--PKPSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218   124 NGRPEVKCVVHLHHPSVVAVSAQ--KCGLLPISQESMIVG-DVGYHEYRGILIDEAER-----ALLVRDLGDRNVMILRN 195
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALgkPLPLLPTEQAAAFLGgEIPYAPYAGPGTELAEEgaelaEALAEALPDRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 115533218   196 HGFVVCGESIEHALSLTYHLIIACETQI 223
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 42-229 1.61e-37

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 132.10  E-value: 1.61e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  42 NKLASLYRLVDLFRWSQGIYNHITVRvstDPDE--ILINAFGQLYSEVSASSLIKVDLDGTVIDG--GSTNFGvnqagyv 117
Cdd:cd00398    5 RKIIAACLLLDLYGWVTGTGGNVSAR---DRDRgyFLITPSGVDYEEMTASDLVVVDAQGKVVEGkkPSSETP------- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 118 LHSAIHNGRPEVKCVVHLHHPSVVAVSAQKCGLLPISQESMIV---GDVGYHEYRGILiDEAERALLVRDLGDRN--VMI 192
Cdd:cd00398   75 LHLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGHTACAVyftGDIPCTPYMTPE-TGEDEIGTQRALGFPNskAVL 153

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 115533218 193 LRNHGFVVCGESIEHALSLTYHLIIACETQIRTVPGG 229
Cdd:cd00398  154 LRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMG 190
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 31-285 7.69e-99

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 290.60  E-value: 7.69e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  31 DGYDPEELTQRNKLASLYRLVDLFRWSQGIYNHITVRVSTDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGgsTNFG 110
Cdd:PRK07044   8 ARVSPAEWQARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVDD--SPYP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 111 VNQAGYVLHSAIHNGRPEVKCVVHLHHPSVVAVSAQKCGLLPISQESMIV-GDVGYHEYRGILIDEAERALLVRDLGDRN 189
Cdd:PRK07044  86 VNPAGFTIHSAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGDKP 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 190 VMILRNHGFVVCGESIEHALSLTYHLIIACETQIRTVPGGNTdnVHFPAQSAIKqvyKVASQGgggvnrqnghVNSMQWK 269
Cdd:PRK07044 166 AMLLRNHGLLTVGRTVAEAFLLMYTLERACEIQVAAQAGGGE--LVLPPPEVAE---RTARQS----------LFDPGAG 230

                        250
                 ....*....|....*.
gi 115533218 270 KGELEWQAYMRQLDAQ 285
Cdd:PRK07044 231 AGELAWPALLRKLDRI 246
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 35-225 2.36e-56

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 180.41  E-value: 2.36e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  35 PEELTQRNKLASLYRLVDLFRWSQGIYNHITVRVstDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGGstnfGVNQA 114
Cdd:COG0235    1 MEEEELREELAAAGRRLARRGLVDGTAGNISVRL--DDDRFLITPSGVDFGELTPEDLVVVDLDGNVVEGD----LKPSS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 115 GYVLHSAIHNGRPEVKCVVHLHHPSVVAVSAQKCGLLPISQE--SMIVGDVGYHEYRGIlIDEAERALLVRDLGDRNVMI 192
Cdd:COG0235   75 ETPLHLAIYRARPDVGAVVHTHSPYATALSALGEPLPPLEQTeaAAFLGDVPVVPYAGP-GTEELAEAIAEALGDRPAVL 153

                        170       180       190
                 ....*....|....*....|....*....|...
gi 115533218 193 LRNHGFVVCGESIEHALSLTYHLIIACETQIRT 225
Cdd:COG0235  154 LRNHGVVVWGKDLAEAFDRAEVLEEAARIQLLA 186
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 42-223 1.55e-51

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 167.34  E-value: 1.55e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218   42 NKLASLYRLVDLFRWSQGIYNHITVRVstDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGGstnfGVNQAGYVLHSA 121
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRL--PGDGFLITPSGVDFGELTPEDLVVVDLDGNVVEGG----LKPSSETPLHLA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  122 IHNGRPEVKCVVHLHHPSVVAVSAQKCGLLPISQESMIV--GDVGYHEYRGILIDEAERAlLVRDLG-DRNVMILRNHGF 198
Cdd:pfam00596  75 IYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAADFlgGDIPIIPYYTPGTEELGER-IAEALGgDRKAVLLRNHGL 153

                         170       180
                  ....*....|....*....|....*
gi 115533218  199 VVCGESIEHALSLTYHLIIACETQI 223
Cdd:pfam00596 154 LVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 44-223 8.74e-50

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 162.81  E-value: 8.74e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218    44 LASLYRLVDLFRWSQGIYNHITVRVStDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGGSTnfGVNQAGYVLHSAIH 123
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARVG-EEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGGG--PKPSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218   124 NGRPEVKCVVHLHHPSVVAVSAQ--KCGLLPISQESMIVG-DVGYHEYRGILIDEAER-----ALLVRDLGDRNVMILRN 195
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALgkPLPLLPTEQAAAFLGgEIPYAPYAGPGTELAEEgaelaEALAEALPDRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 115533218   196 HGFVVCGESIEHALSLTYHLIIACETQI 223
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
PRK06661 PRK06661
hypothetical protein; Provisional
 44-280 1.47e-49

hypothetical protein; Provisional


Pssm-ID: 168637  Cd Length: 231  Bit Score: 163.85  E-value: 1.47e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  44 LASLYRLVDLFRWSQGIYNHITVRvSTDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGGSTNFgvNQAGYVLHSAIH 123
Cdd:PRK06661   7 LAAAYRIMAYLSLDDHTYTHLSAR-PKNADFYYIYPFGLRFEEVTTENLLKVSLDGQILEGEEYQY--NKTGYFIHGSIY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 124 NGRPEVKCVVHLHHPSVVAVSAQKCGLLPISQESM-IVGDVGYHEYRGILIDEA-ERALLVRDLGDRNVMILRNHGFVVC 201
Cdd:PRK06661  84 KTRPDISAIFHYHTPASIAVSALKCGLLPISQWALhFYDRISYHNYNSLALDADkQSSRLVNDLKQNYVMLLRNHGAITC 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115533218 202 GESIEHALSLTYHLIIACETQIRTVpggntdnvhfpaqSAIKQVYKVASQGGGGVNRQNghVNSMQWKKGELEWQAYMR 280
Cdd:PRK06661 164 GKTIHEAMFYTYHLEQACKTQCLLN-------------STKKQELIIPSVEICKKTVKD--LLSFEEDLGKRDWAAWLR 227
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 42-229 1.61e-37

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 132.10  E-value: 1.61e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  42 NKLASLYRLVDLFRWSQGIYNHITVRvstDPDE--ILINAFGQLYSEVSASSLIKVDLDGTVIDG--GSTNFGvnqagyv 117
Cdd:cd00398    5 RKIIAACLLLDLYGWVTGTGGNVSAR---DRDRgyFLITPSGVDYEEMTASDLVVVDAQGKVVEGkkPSSETP------- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 118 LHSAIHNGRPEVKCVVHLHHPSVVAVSAQKCGLLPISQESMIV---GDVGYHEYRGILiDEAERALLVRDLGDRN--VMI 192
Cdd:cd00398   75 LHLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGHTACAVyftGDIPCTPYMTPE-TGEDEIGTQRALGFPNskAVL 153

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 115533218 193 LRNHGFVVCGESIEHALSLTYHLIIACETQIRTVPGG 229
Cdd:cd00398  154 LRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMG 190
PRK06208 PRK06208
class II aldolase/adducin family protein;
9-223 5.57e-35

class II aldolase/adducin family protein;


Pssm-ID: 235743  Cd Length: 274  Bit Score: 127.41  E-value: 5.57e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218   9 TATVPAPMFHPHITPIADLKDDDGYDP----------EELTQRNKLASLYRLVDLFRWSQGIYNHITVRVSTDPDEILIN 78
Cdd:PRK06208   2 SAVLSRAADTAAALSIPQPPREGLWFPrpppfatvaeERLHRKQRLAAAFRLFARFGFDEGLAGHITARDPELPDHFWVN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  79 AFGQLYSEVSASSLIKVDLDGTVIDGgstNFGVNQAGYVLHSAIHNGRPEVKCVVHLHHPSVVAVSAQKCGLLPISQES- 157
Cdd:PRK06208  82 PLGVHFSQIKVSDLLLVDHDGEVVEG---DRPLNRAAFAIHSAIHEARPDVVAAAHTHSTYGKAWSTLGRPLDPITQDAc 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115533218 158 MIVGDVG-YHEYRGILIDEAERALLVRDLGDRNVMILRNHGFVVCGESIEHALSLTYHLIIACETQI 223
Cdd:PRK06208 159 AFYEDHAlFDDFTGVVVDTSEGRRIAAALGTHKAVILQNHGLLTVGPSVDAAAWWFIALERACQTQL 225
PRK06486 PRK06486
aldolase;
30-286 1.68e-32

aldolase;


Pssm-ID: 235814  Cd Length: 262  Bit Score: 120.59  E-value: 1.68e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  30 DDGYDPEELTQ-RNKLASLYRLVDLFRWSQGIYNHITVRVSTDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGGSTn 108
Cdd:PRK06486  16 RPLLDSDAVAQaRVDLAACFRAAARHGLEEGICNHFSAVLPGHDDLFLVNPYGYAFSEITASDLLICDFDGNVLAGRGE- 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 109 fgVNQAGYVLHSAIHNGRPEVKCVVHLHHPSVVAVS-AQKCGLLPISQESM-----IVGDvgyHEYRGILIDEAERALLV 182
Cdd:PRK06486  95 --PEATAFFIHARIHRAIPRAKAAFHTHMPYATALSlTEGRPLTTLGQTALkfygrTAVD---EDYNGLALDAAEGDRIA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 183 RDLGDRNVMILRNHGFVVCGESIEHALSLTYHLIIACETQirtVPGGNTDNVHFPAQSAIKQvyKVASQGGGGVNRQngh 262
Cdd:PRK06486 170 RAMGDADIVFLKNHGVMVCGPRIAEAWDDLYYLERACEVQ---VLAMSTGRPLVPVDPAIAA--AVARQMREGDRES--- 241

                        250       260
                 ....*....|....*....|....
gi 115533218 263 vnsmqwkkGELEWQAYMRQLDAQG 286
Cdd:PRK06486 242 --------ARLHLEALRRTLDREE 257
PRK07490 PRK07490
hypothetical protein; Provisional
 36-224 1.63e-23

hypothetical protein; Provisional


Pssm-ID: 236031 [Multi-domain]  Cd Length: 245  Bit Score: 96.33  E-value: 1.63e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  36 EELTQRNKLASLYRLVDLFRWSQGIYNHITVRVSTDPDEILINAFGQLYSEVSASSLIKVDLDgtviDGGSTNFG--VNQ 113
Cdd:PRK07490   7 DEEQIRVDLAAAFRWIARLGMHEAVANHFSAAVSADGKQFLLNPKWKHFSRIRASDLLLLDAD----DPSTAERPdvPDA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 114 AGYVLHSAIHNGRPEVKCVVHLHHPSVVAVSAQKCG-LLPISQESMIV-GDVGYHEYRGILIDEAERALLVRDLGDRNVM 191
Cdd:PRK07490  83 TAWAIHGQIHRRLPHARCVMHVHSVYATALACLADPtLPPIDQNTARFfNRVAVDTLYGGMALEEEGERLAGLLGDKRRL 162

                        170       180       190
                 ....*....|....*....|....*....|...
gi 115533218 192 ILRNHGFVVCGESIEHALSLTYHLIIACETQIR 224
Cdd:PRK07490 163 LMGNHGVLVTGDTVAEAFDDLYYFERACQTYIT 195
PRK07090 PRK07090
class II aldolase/adducin domain protein; Provisional
 38-211 1.30e-16

class II aldolase/adducin domain protein; Provisional


Pssm-ID: 180832  Cd Length: 260  Bit Score: 77.75  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  38 LTQRNKLASLYRLVDLFRWSQGIYNHITVRvSTDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDGGSTNFGVNQagyv 117
Cdd:PRK07090  29 WTLRQKLALTCRILFDAGHDSGLAGQITAR-AEAPGTYYTQRLGLGFDEITASNLLLVDEDLNVLDGEGMPNPANR---- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 118 LHSAIHNGRPEVKCVVHLHHPSVVAVSAQKCGLLpISQESMIV--GDVGY-HEYRGILIDEAERALLVRDLGDRNVMILR 194
Cdd:PRK07090 104 FHSWIYRARPDVNCIIHTHPPHVAALSMLEVPLV-VSHMDTCPlyDDCAFlKDWPGVPVGNEEGEIISAALGDKRAILLS 182

                        170
                 ....*....|....*..
gi 115533218 195 NHGFVVCGESIEHALSL 211
Cdd:PRK07090 183 HHGQLVAGKSIEEACVL 199
PRK08130 PRK08130
putative aldolase; Validated
 89-208 4.12e-10

putative aldolase; Validated


Pssm-ID: 181241 [Multi-domain]  Cd Length: 213  Bit Score: 58.35  E-value: 4.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  89 ASSLIKVDLDGTVIDGGSTNFGVnqagyVLHSAIHNGRPEVKCVVHLHHPSVVAVSaqkcgLLPISQES----------- 157
Cdd:PRK08130  53 PARLSKVDADGNWLSGDKPSKEV-----PLHRAIYRNNPECGAVVHLHSTHLTALS-----CLGGLDPTnvlppftpyyv 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 115533218 158 MIVGDV---GYheYR-GilidEAERALLVRDL-GDRNVMILRNHGFVVCGESIEHA 208
Cdd:PRK08130 123 MRVGHVpliPY--YRpG----DPAIAEALAGLaARYRAVLLANHGPVVWGSSLEAA 172
PRK08333 PRK08333
aldolase;
63-208 2.53e-08

aldolase;


Pssm-ID: 181393 [Multi-domain]  Cd Length: 184  Bit Score: 52.90  E-value: 2.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  63 HITVRVStdpDEILINAFGQLYSEVSASSLIKVDLDGTVIDGGSTNfgvnqAGYVLHSAIHNGRPEVKCVVHLHHPSVVA 142
Cdd:PRK08333  27 NLSIRVG---NLVFIKATGSVMDELTREQVAVIDLNGNQLSSVRPS-----SEYRLHLAVYRNRPDVRAIAHLHPPYSIV 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115533218 143 VSAQKCGLLPI--SQESMIVGDVGYHEYRGILIDEAERAlLVRDLGDRNVMILRNHGFVVCGESIEHA 208
Cdd:PRK08333  99 ASTLLEEELPIitPEAELYLKKIPILPFRPAGSVELAEQ-VAEAMKEYDAVIMERHGIVTVGRSLREA 165
PRK06557 PRK06557
L-ribulose-5-phosphate 4-epimerase; Validated
 48-209 3.62e-07

L-ribulose-5-phosphate 4-epimerase; Validated


Pssm-ID: 235829 [Multi-domain]  Cd Length: 221  Bit Score: 50.01  E-value: 3.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  48 YRLVdlfRWSQGiynHITVRVStDPDEILINAFGQLYSEVSASSLIKVDLDGTVIDgGSTNFGVNQAGyvlHSAIHNGRP 127
Cdd:PRK06557  25 YGLV---VWTSG---NVSARDP-GTDLVVIKPSGVSYDDLTPEDMVVVDLDGNVVE-GDLKPSSDTAS---HLYVYRHMP 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 128 EVKCVVHLHHPSVVAVSAQ----KCGLLPISQEsmIVGDVGYHEYRGILIDEAERALLVRDLGDRNVMIL-RNHGFVVCG 202
Cdd:PRK06557  94 DVGGVVHTHSTYATAWAARgepiPCVLTAMADE--FGGPIPVGPFALIGDEAIGKGIVETLKGGRSPAVLmQNHGVFTIG 171


                 ....*..
gi 115533218 203 ESIEHAL 209
Cdd:PRK06557 172 KDAEDAV 178
PRK08660 PRK08660
aldolase;
64-219 5.85e-04

aldolase;


Pssm-ID: 181527 [Multi-domain]  Cd Length: 181  Bit Score: 39.94  E-value: 5.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218  64 ITVRVStdpDEILINAFGQLYSEVSASSLIKVDLDGT--VIDGGSTNFGVnqagyvlHSAIHNgRPEVKCVVHLHHPSVV 141
Cdd:PRK08660  25 ISVRTG---DGLLITRTGSMLDEITEGDVIEVGIDDDgsVDPLASSETPV-------HRAIYR-RTSAKAIVHAHPPYAV 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533218 142 AVSAQKCGLLPISQE--------SMIVGDVGYHEyrgiLIDEAERALlvrdlGDRNVMILRNHGFVVCGESIEHALSLTY 213
Cdd:PRK08660  94 ALSLLEDEIVPLDSEglyflgtiPVVGGDIGSGE----LAENVARAL-----SEHKGVVVRGHGTFAIGKTLEEAYIYTS 164


                 ....*.
gi 115533218 214 HLIIAC 219
Cdd:PRK08660 165 QLEHSC 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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