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    APOE apolipoprotein E [ Homo sapiens (human) ]

    Gene ID: 348, updated on 4-Jan-2025

    Summary

    Official Symbol
    APOEprovided by HGNC
    Official Full Name
    apolipoprotein Eprovided by HGNC
    Primary source
    HGNC:HGNC:613
    See related
    Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AD2; LPG; APO-E; ApoE4; LDLCQ5
    Summary
    The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
    Expression
    Biased expression in liver (RPKM 1021.7), kidney (RPKM 648.1) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See APOE in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44905796..44909393)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (47730492..47734089)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45409053..45412650)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45351264-45352246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45353716-45354627 Neighboring gene nectin cell adhesion molecule 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45382143-45382992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45382993-45383842 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45383843-45384692 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45388007-45388506 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45388826-45389326 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45393067-45393568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10744 Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45408370-45409172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45409975-45410777 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45415901-45416660 Neighboring gene APOC1 promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45418179-45418936 Neighboring gene apolipoprotein C1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45430599-45431491 Neighboring gene apolipoprotein C1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (22 hits/1282 screens)

    Associated conditions

    Description Tests
    Age related macular degeneration 1
    MedGen: C1864205 OMIM: 603075 GeneReviews: Not available
    Compare labs
    Alzheimer disease 2
    MedGen: C1863051 OMIM: 104310 GeneReviews: Not available
    Compare labs
    Alzheimer disease 3
    MedGen: C1843013 OMIM: 607822 GeneReviews: Alzheimer Disease Overview
    Compare labs
    Alzheimer disease 4
    MedGen: C1847200 OMIM: 606889 GeneReviews: Alzheimer Disease Overview
    Compare labs
    Familial type 3 hyperlipoproteinemia
    MedGen: C0020479 OMIM: 617347 GeneReviews: Not available
    Compare labs
    Lipoprotein glomerulopathy
    MedGen: C2673196 OMIM: 611771 GeneReviews: Not available
    Compare labs
    Sea-blue histiocyte syndrome
    MedGen: C0036489 OMIM: 269600 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Items 1 - 10 of 54
    Description
    A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.
    EBI GWAS Catalog
    A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
    EBI GWAS Catalog
    A genome-wide scan for common variants affecting the rate of age-related cognitive decline.
    EBI GWAS Catalog
    A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.
    EBI GWAS Catalog
    ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
    EBI GWAS Catalog
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog
    APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
    EBI GWAS Catalog
    Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
    EBI GWAS Catalog
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.
    EBI GWAS Catalog
    Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.
    EBI GWAS Catalog
    Common variants at 30 loci contribute to polygenic dyslipidemia.
    EBI GWAS Catalog
    Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Examination of the current top candidate genes for AD in a genome-wide association study.
    EBI GWAS Catalog
    Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.
    EBI GWAS Catalog
    Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
    EBI GWAS Catalog
    Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
    EBI GWAS Catalog
    Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
    EBI GWAS Catalog
    Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study.
    EBI GWAS Catalog
    Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
    EBI GWAS Catalog
    Genome-wide analysis of genetic loci associated with Alzheimer disease.
    EBI GWAS Catalog
    Genome-wide association analysis of age-at-onset in Alzheimer's disease.
    EBI GWAS Catalog
    Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.
    EBI GWAS Catalog
    Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
    EBI GWAS Catalog
    Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
    EBI GWAS Catalog
    Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
    EBI GWAS Catalog
    Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
    EBI GWAS Catalog
    Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
    EBI GWAS Catalog
    Genome-wide association study of Alzheimer's disease with psychotic symptoms.
    EBI GWAS Catalog
    Genome-wide association study of Alzheimer's disease.
    EBI GWAS Catalog
    Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
    EBI GWAS Catalog
    Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
    EBI GWAS Catalog
    Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
    EBI GWAS Catalog
    Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
    EBI GWAS Catalog
    GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
    EBI GWAS Catalog
    High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE.
    EBI GWAS Catalog
    Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
    EBI GWAS Catalog
    Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
    EBI GWAS Catalog
    Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
    EBI GWAS Catalog
    Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
    EBI GWAS Catalog
    Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.
    EBI GWAS Catalog
    Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
    EBI GWAS Catalog
    Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
    EBI GWAS Catalog
    Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
    EBI GWAS Catalog
    Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.
    EBI GWAS Catalog
    Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
    EBI GWAS Catalog
    Seven new loci associated with age-related macular degeneration.
    EBI GWAS Catalog
    Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
    EBI GWAS Catalog
    Sorl1 as an Alzheimer's disease predisposition gene?
    EBI GWAS Catalog
    SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
    EBI GWAS Catalog
    SUCLG2 identified as both a determinator of CSF Aß1-42-levels and an attenuator of cognitive decline in Alzheimer's disease.
    EBI GWAS Catalog
    The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.
    EBI GWAS Catalog
    Items 1 - 10 of 54

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 causes increased neurotoxicity in human neuronal cultures with the ApoE4 allele PubMed
    Tat tat Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake and degradation of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid beta-protein PubMed
    tat The antioxidant properties of human lipidated apoE3 protects neurons from Tat-induced toxicity PubMed
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates expression of six genes, APOE, CCL5, DGKK, GPX5, NOS2, and PXDNL PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC1571

    Gene Ontology Provided by GOA

    Items 1 - 25 of 29
    Function Evidence Code Pubs
    enables amyloid-beta binding PubMed 
    enables amyloid-beta binding PubMed 
    enables antioxidant activity PubMed 
    enables cholesterol transfer activity  
    enables enzyme binding PubMed 
    enables heparan sulfate proteoglycan binding PubMed 
    enables heparin binding PubMed 
    enables identical protein binding PubMed 
    enables lipid binding PubMed 
    enables lipid transporter activity PubMed 
    enables lipoprotein particle binding  
    enables low-density lipoprotein particle receptor binding PubMed 
    enables low-density lipoprotein particle receptor binding PubMed 
    enables low-density lipoprotein particle receptor binding PubMed 
    enables metal chelating activity PubMed 
    enables phosphatidylcholine-sterol O-acyltransferase activator activity  
    enables phosphatidylcholine-sterol O-acyltransferase activator activity PubMed 
    enables phospholipid binding  
    enables phospholipid binding PubMed 
    enables protein binding PubMed 
    enables protein dimerization activity PubMed 
    enables protein homodimerization activity PubMed 
    enables protein-containing complex binding PubMed 
    enables receptor ligand activity PubMed 
    enables signaling receptor binding PubMed 
    enables structural molecule activity PubMed 
    enables tau protein binding PubMed 
    enables very-low-density lipoprotein particle receptor binding PubMed 
    enables very-low-density lipoprotein particle receptor binding PubMed 
    Items 1 - 25 of 29
    Items 1 - 25 of 124
    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect AMPA glutamate receptor clustering PubMed 
    involved_in G protein-coupled receptor signaling pathway PubMed 
    acts_upstream_of_or_within_positive_effect NMDA glutamate receptor clustering PubMed 
    involved_in acylglycerol homeostasis  
    involved_in amyloid precursor protein metabolic process PubMed 
    involved_in artery morphogenesis  
    involved_in cellular oxidant detoxification  
    involved_in cellular response to lipoprotein particle stimulus PubMed 
    involved_in cholesterol catabolic process  
    involved_in cholesterol efflux  
    involved_in cholesterol efflux PubMed 
    involved_in cholesterol homeostasis PubMed 
    involved_in cholesterol homeostasis PubMed 
    involved_in cholesterol metabolic process  
    involved_in cholesterol metabolic process PubMed 
    involved_in cholesterol metabolic process PubMed 
    involved_in chylomicron remnant clearance PubMed 
    involved_in chylomicron remnant clearance PubMed 
    involved_in cytoskeleton organization PubMed 
    involved_in fatty acid homeostasis PubMed 
    involved_in gene expression  
    involved_in high-density lipoprotein particle assembly PubMed 
    involved_in high-density lipoprotein particle clearance PubMed 
    involved_in high-density lipoprotein particle remodeling PubMed 
    involved_in intermediate-density lipoprotein particle clearance PubMed 
    involved_in intracellular calcium ion homeostasis  
    involved_in intracellular transport PubMed 
    involved_in lipid transport involved in lipid storage  
    involved_in lipoprotein biosynthetic process PubMed 
    involved_in lipoprotein catabolic process  
    involved_in locomotory exploration behavior PubMed 
    involved_in long-chain fatty acid transport PubMed 
    involved_in long-term memory PubMed 
    involved_in low-density lipoprotein particle remodeling  
    involved_in maintenance of location in cell  
    involved_in melanosome organization PubMed 
    involved_in negative regulation of MAP kinase activity PubMed 
    involved_in negative regulation of amyloid fibril formation  
    involved_in negative regulation of amyloid-beta formation PubMed 
    involved_in negative regulation of blood coagulation PubMed 
    involved_in negative regulation of blood vessel endothelial cell migration PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of cholesterol biosynthetic process PubMed 
    involved_in negative regulation of cholesterol efflux PubMed 
    acts_upstream_of_or_within negative regulation of dendritic spine development PubMed 
    acts_upstream_of_or_within negative regulation of dendritic spine maintenance PubMed 
    involved_in negative regulation of endothelial cell migration PubMed 
    involved_in negative regulation of endothelial cell proliferation PubMed 
    involved_in negative regulation of gene expression  
    involved_in negative regulation of inflammatory response PubMed 
    involved_in negative regulation of lipid biosynthetic process PubMed 
    involved_in negative regulation of lipid transport across blood-brain barrier PubMed 
    involved_in negative regulation of long-term synaptic potentiation PubMed 
    involved_in negative regulation of neuron projection development PubMed 
    involved_in negative regulation of phospholipid efflux PubMed 
    involved_in negative regulation of platelet activation PubMed 
    involved_in negative regulation of postsynaptic membrane organization PubMed 
    involved_in negative regulation of protein metabolic process PubMed 
    involved_in negative regulation of protein secretion PubMed 
    acts_upstream_of negative regulation of smooth muscle cell proliferation  
    involved_in negative regulation of triglyceride metabolic process  
    involved_in neuron projection development PubMed 
    involved_in nitric oxide-cGMP-mediated signaling PubMed 
    involved_in phospholipid efflux  
    involved_in phospholipid efflux PubMed 
    involved_in positive regulation by host of viral process PubMed 
    involved_in positive regulation of CoA-transferase activity PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of amyloid fibril formation PubMed 
    involved_in positive regulation of amyloid-beta clearance  
    involved_in positive regulation of amyloid-beta formation PubMed 
    involved_in positive regulation of cholesterol efflux PubMed 
    involved_in positive regulation of cholesterol efflux PubMed 
    involved_in positive regulation of cholesterol metabolic process PubMed 
    acts_upstream_of_or_within positive regulation of dendritic spine development PubMed 
    acts_upstream_of_or_within positive regulation of dendritic spine maintenance PubMed 
    involved_in positive regulation of endocytosis PubMed 
    involved_in positive regulation of lipid biosynthetic process PubMed 
    involved_in positive regulation of lipid transport across blood-brain barrier PubMed 
    involved_in positive regulation of lipoprotein transport PubMed 
    involved_in positive regulation of low-density lipoprotein particle receptor catabolic process PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis PubMed 
    involved_in positive regulation of neurofibrillary tangle assembly PubMed 
    involved_in positive regulation of neuron projection development PubMed 
    involved_in positive regulation of neuron projection development  
    involved_in positive regulation of nitric oxide biosynthetic process PubMed 
    involved_in positive regulation of phospholipid efflux PubMed 
    involved_in positive regulation of presynaptic membrane organization PubMed 
    involved_in protein import PubMed 
    involved_in receptor-mediated endocytosis PubMed 
    involved_in receptor-mediated endocytosis PubMed 
    involved_in regulation of Cdc42 protein signal transduction PubMed 
    involved_in regulation of amyloid fibril formation PubMed 
    involved_in regulation of amyloid precursor protein catabolic process PubMed 
    involved_in regulation of amyloid-beta clearance PubMed 
    involved_in regulation of apoptotic process  
    involved_in regulation of axon extension PubMed 
    involved_in regulation of behavioral fear response PubMed 
    involved_in regulation of cellular response to very-low-density lipoprotein particle stimulus PubMed 
    involved_in regulation of cholesterol metabolic process PubMed 
    involved_in regulation of innate immune response  
    involved_in regulation of neuronal synaptic plasticity PubMed 
    involved_in regulation of proteasomal protein catabolic process PubMed 
    involved_in regulation of protein metabolic process PubMed 
    involved_in regulation of protein-containing complex assembly PubMed 
    involved_in response to caloric restriction PubMed 
    involved_in response to dietary excess  
    involved_in response to reactive oxygen species PubMed 
    involved_in reverse cholesterol transport PubMed 
    involved_in synaptic transmission, cholinergic PubMed 
    involved_in triglyceride homeostasis  
    involved_in triglyceride metabolic process PubMed 
    involved_in triglyceride metabolic process PubMed 
    involved_in triglyceride-rich lipoprotein particle clearance PubMed 
    involved_in vasodilation  
    involved_in very-low-density lipoprotein particle clearance PubMed 
    involved_in very-low-density lipoprotein particle clearance PubMed 
    involved_in very-low-density lipoprotein particle remodeling PubMed 
    involved_in very-low-density lipoprotein particle remodeling PubMed 
    involved_in virion assembly PubMed 
    Items 1 - 25 of 124
    Items 1 - 20 of 43
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in blood microparticle PubMed 
    part_of chylomicron  
    part_of chylomicron PubMed 
    part_of chylomicron remnant PubMed 
    located_in clathrin-coated endocytic vesicle membrane  
    located_in collagen-containing extracellular matrix PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in dendrite PubMed 
    part_of discoidal high-density lipoprotein particle PubMed 
    located_in early endosome  
    located_in endocytic vesicle lumen  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum lumen  
    located_in extracellular exosome PubMed 
    located_in extracellular exosome PubMed 
    located_in extracellular matrix PubMed 
    located_in extracellular region PubMed 
    located_in extracellular region PubMed 
    located_in extracellular region  
    located_in extracellular space PubMed 
    is_active_in extracellular space PubMed 
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in extracellular vesicle PubMed 
    is_active_in extracellular vesicle  
    is_active_in glutamatergic synapse PubMed 
    part_of high-density lipoprotein particle  
    part_of high-density lipoprotein particle PubMed 
    part_of intermediate-density lipoprotein particle PubMed 
    part_of lipoprotein particle PubMed 
    part_of low-density lipoprotein particle  
    part_of low-density lipoprotein particle PubMed 
    located_in melanosome PubMed 
    located_in membrane PubMed 
    located_in multivesicular body, internal vesicle PubMed 
    located_in neuronal cell body PubMed 
    located_in nucleus PubMed 
    located_in plasma membrane  
    is_active_in synaptic cleft PubMed 
    part_of very-low-density lipoprotein particle  
    part_of very-low-density lipoprotein particle PubMed 
    Items 1 - 20 of 43

    General protein information

    Preferred Names
    apolipoprotein E
    Names
    apolipoprotein E3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007084.2 RefSeqGene

      Range
      5015..8612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000041.4 → NP_000032.1  apolipoprotein E isoform b precursor

      See identical proteins and their annotated locations for NP_000032.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.
      Source sequence(s)
      BC003557, HY056112
      Consensus CDS
      CCDS12647.1
      UniProtKB/Swiss-Prot
      B2RC15, C0JYY5, P02649, Q9P2S4
      UniProtKB/TrEMBL
      A0A0S2Z3D5
      Related
      ENSP00000252486.3, ENST00000252486.9
      Conserved Domains (1) summary
      pfam01442
      Location:86 → 266
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    2. NM_001302688.2 → NP_001289617.1  apolipoprotein E isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC003557, BM042032, HY056112
      UniProtKB/Swiss-Prot
      P02649
      Conserved Domains (1) summary
      pfam01442
      Location:112 → 292
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    3. NM_001302689.2 → NP_001289618.1  apolipoprotein E isoform b precursor

      See identical proteins and their annotated locations for NP_001289618.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.
      Source sequence(s)
      BC003557, DB486513, HY074384
      Consensus CDS
      CCDS12647.1
      UniProtKB/Swiss-Prot
      B2RC15, C0JYY5, P02649, Q9P2S4
      UniProtKB/TrEMBL
      A0A0S2Z3D5
      Conserved Domains (1) summary
      pfam01442
      Location:86 → 266
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    4. NM_001302690.2 → NP_001289619.1  apolipoprotein E isoform b precursor

      See identical proteins and their annotated locations for NP_001289619.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.
      Source sequence(s)
      BC003557, CA771535, HY074888
      Consensus CDS
      CCDS12647.1
      UniProtKB/Swiss-Prot
      B2RC15, C0JYY5, P02649, Q9P2S4
      UniProtKB/TrEMBL
      A0A0S2Z3D5
      Conserved Domains (1) summary
      pfam01442
      Location:86 → 266
      Apolipoprotein; Apolipoprotein A1/A4/E domain
    5. NM_001302691.2 → NP_001289620.1  apolipoprotein E isoform b precursor

      See identical proteins and their annotated locations for NP_001289620.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' terminal exon and uses an alternate splice site in another 5' exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 4 and 5 all encode isoform b.
      Source sequence(s)
      BC003557, BI550631
      Consensus CDS
      CCDS12647.1
      UniProtKB/Swiss-Prot
      B2RC15, C0JYY5, P02649, Q9P2S4
      UniProtKB/TrEMBL
      A0A0S2Z3D5
      Conserved Domains (1) summary
      pfam01442
      Location:86 → 266
      Apolipoprotein; Apolipoprotein A1/A4/E domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      44905796..44909393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      47730492..47734089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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