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POLY polyprotein;protein F [ Hepatitis C virus genotype 1 ]

Gene ID: 951475, updated on 18-Aug-2023

Summary

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Gene symbol
POLY
Gene description
polyprotein;protein F
Locus tag
HCVgp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Hepatitis C virus genotype 1 (serotype: 1a, isolate: H77)
Lineage
Viruses; Riboviria; Flaviviridae; Hepacivirus
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Genomic context

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Sequence:
NC_004102.1 (342..9377)

NC_004102.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004102.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hepatitis C virus RNA replication is regulated by Ras-Erk signalling. Gretton S, et al. J Gen Virol, 2010 Mar. PMID 19889932
  2. A conserved proline between domains II and III of hepatitis C virus NS5A influences both RNA replication and virus assembly. Hughes M, et al. J Virol, 2009 Oct. PMID 19656877, Free PMC Article
  3. Identification of in vivo interaction between Hepatitis C Virus core protein and 5' and 3' UTR RNA. Yu KL, et al. Virus Res, 2009 Nov. PMID 19665505
  4. Hepatitis C virus NS2/3 protease regulates HCV IRES-dependent translation and NS5B RdRp activity. She Y, et al. Arch Virol, 2009. PMID 19688585
  5. An amphipathic alpha-helix at the C terminus of hepatitis C virus nonstructural protein 4B mediates membrane association. Gouttenoire J, et al. J Virol, 2009 Nov. PMID 19692468, Free PMC Article

See all (656) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Hepatitis C virus NS5A and core proteins exert antagonistic effects on HAMP gene expression: the hidden interplay with the MTF-1/MRE pathway.
    Title: The Hepatitis C virus NS5A and core proteins exert antagonistic effects on HAMP gene expression: the hidden interplay with the MTF-1/MRE pathway.
  2. Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b.
    Title: Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b.
  3. Adenosylhomocysteinase like 1 interacts with nonstructural 5A and regulates hepatitis C virus propagation.
    Title: Adenosylhomocysteinase like 1 interacts with nonstructural 5A and regulates hepatitis C virus propagation.
  4. Domain I of hepatitis C virus NS5A associates with ACBD3 in a genotype-dependent manner.
    Title: Domain I of hepatitis C virus NS5A associates with ACBD3 in a genotype-dependent manner.
  5. A Novel Approach To Display Structural Proteins of Hepatitis C Virus Quasispecies in Patients Reveals a Key Role of E2 HVR1 in Viral Evolution.
    Title: A Novel Approach To Display Structural Proteins of Hepatitis C Virus Quasispecies in Patients Reveals a Key Role of E2 HVR1 in Viral Evolution.
  6. Genotypic Regulation of Type I Interferon Induction Pathways by Frameshift (F) Proteins of Hepatitis C Virus.
    Title: Genotypic Regulation of Type I Interferon Induction Pathways by Frameshift (F) Proteins of Hepatitis C Virus.
  7. OCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease.
    Title: OCIAD1 is a host mitochondrial substrate of the hepatitis C virus NS3-4A protease.
  8. Analysis of drug-resistance-associated mutations and genetic barriers in hepatitis C virus NS5B sequences in China.
    Title: Analysis of drug-resistance-associated mutations and genetic barriers in hepatitis C virus NS5B sequences in China.
  9. Baseline resistance-associated substitutions in NS5A and NS5B were frequently observed in HCV-1-infected patients from Buenos Aires, Argentina but not related to treatment outcome.
    Title: Hepatitis C virus genotype 1 infection: Prevalence of NS5A and NS5B resistance-associated substitutions in naïve patients from Argentina.
  10. Two mutations of NS3 protein, hepatitis C virus (HCV) (NS3) are associated with HCV resistance: D168N and L153I. The L153I substitution decreases the S139 deprotonation susceptibility, and impairs the covalent binding between the residue S139 from NS3 and the electrophilic trap on boceprevir. Substitution D168N causes destabilization of hydrogen bonds of NS3/boceprevir.
    Title: A novel molecular mechanism to explain mutations of the HCV protease associated with resistance against covalently bound inhibitors.
Submit: New GeneRIF Correction See all GeneRIFs (555)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
polyprotein;protein F
Names
core protein
envelope protein E1
envelope protein E2
protein p7
nonstructural protein NS2
protease/helicase protein NS3
nonstructural protein NS4A
nonstructural protein NS4B
nonstructural protein NS5A
RNA-dependent RNA polymerase NS5B
NP_803170.1
  • -2/+1 frameshift; although the exact location of the frameshift is unknown, it was mapped to codons 9 to 11 of the core protein coding sequence.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004102.1 Reference assembly

    Range
    342..9377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_671491.1 polyprotein [Hepatitis C virus genotype 1]

    See identical proteins and their annotated locations for NP_671491.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9ELS8
    Conserved Domains (16) summary
    pfam01001
    Location:1728 → 1921
    HCV_NS4b; Hepatitis C virus non-structural protein NS4b
    pfam01539
    Location:193 → 382
    HCV_env; Hepatitis C virus envelope glycoprotein E1
    pfam01560
    Location:386 → 729
    HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
    pfam02907
    Location:1056 → 1204
    Peptidase_S29; Hepatitis C virus NS3 protease
    pfam01543
    Location:2 → 115
    HCV_capsid; Hepatitis C virus capsid protein
    pfam08301
    Location:2068 → 2168
    HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
    pfam01538
    Location:811 → 1005
    HCV_NS2; Hepatitis C virus non-structural protein NS2
    smart00487
    Location:1228 → 1355
    DEXDc; DEAD-like helicases superfamily
    cd00046
    Location:1224 → 1351
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:1378 → 1455
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00998
    Location:2423 → 2934
    RdRP_3; Viral RNA dependent RNA polymerase
    pfam01006
    Location:1658 → 1711
    HCV_NS4a; Hepatitis C virus non-structural protein NS4a
    pfam01506
    Location:1974 → 1996
    HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
    pfam01542
    Location:116 → 190
    HCV_core; Hepatitis C virus core protein
    pfam08300
    Location:2006 → 2067
    HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
    pfam12941
    Location:2179 → 2420
    HCV_NS5a_C; HCV NS5a protein C-terminal region

  2. NP_751919.1 core protein

    UniProtKB/TrEMBL
    A0A075C2Z9, A0A075C392, A0A075C3A1, A0A075C3F8, A0A075C549, A0A075C551, A0A075C673, A0A077CW64, A0A077CW68, A0A077CW83, A0A077CW92, A0A077CW98, A0A077CWX7, A0A077CWY1, A0A077CWY6, A0A077CWZ4, A0A077CX03, A0A077CX08, A0A077CX16, A0A077CYR9, A0A077CYS6, A0A077CYU1, A0A077CYU8, A0A077CYW6, A0A077D125, A0A077D131, A0A077D140, A0A077D156, A0A077D1I0, A0A077D1I6, A0A077D1J1, A0A077D1J4, A0A077D1K6, A0A0A0YPR1, A0A221C814, B8Y460, C8CP42, D2E5C6, D2E5D5, D2E5D6, D2E5D7, D2E5D8, D2E5D9, D2E5E0, E2ICK2, G3FEN7, G3FEN8, L7Z1C8, L7Z1D2, L7Z1F6, L7Z1G2, L7Z5V0, L7Z5V3, L7Z5X5, L7Z6V5, L7Z6Y6, L7Z7D6, L7Z951, Q68113, Q68123, Q68124, Q68139, Q68149, Q6QY91, Q6QY92, Q6QY99, Q6QYA1, Q6QYA2, Q6QYA6, Q6QYA7, Q6QYB1, Q6QYB2, Q6QYB4, Q6QYB6, Q6QYB7, Q6QYB8, Q6QYB9, Q6QYC1, Q6QYC2, Q6QYC3, Q6QYE5, Q6QYE6, Q6QYE7, Q6QYE8, Q6QYE9, Q6QYF0, Q6QYF1, Q6QYF2, Q6QYF6, Q6QYF7, Q6QYF9, Q6QYG0, Q6QYG5, Q6QYJ7, Q6QYJ9, Q6QYK0, Q6QYK2, Q6QYK3, Q6QYK6, Q6QYK7, Q6QYK8, Q6QYK9, Q6QYL0, Q6QYL1, Q6QYL2, Q6QYL4, Q6QYL5, Q6QYM0, Q6QYN0, Q6QYQ9, Q6QYR0, Q6QYR1, Q6QYR2, Q6QYR3, Q6QYR4, Q6QYR5, Q6QYR6, Q6QYR7, Q6QYT2, Q6QYT4, Q6QYT5, Q6QYT6, Q6QYT7, Q6QYT8, Q6QYT9, Q6QYU0, Q6QYU1, Q6QYU2, Q6QYU3, Q6QZ00, Q6QZ04, Q6QZ15, Q6QZ18, Q6QZ19, Q6QZ20, Q6QZ21, Q6QZ22, Q6QZ25, Q6QZ26, Q6QZ27, Q6QZ28, Q6QZ29, Q6QZ31, Q6QZ32, Q6QZ56, Q6QZ58, Q6QZ60, Q6QZ61, Q6QZ62, Q6QZ63, Q6QZ64, Q6QZ67, Q6QZ80, Q6QZ81, Q6QZ82, Q6QZ83, Q6QZ84, Q6QZ85, Q6QZ87, Q6QZ88, Q6QZ91, Q6QZ99, Q6QZA0, Q6QZA1, Q6QZA2, Q6QZA3, Q6QZA4, Q6QZA5, Q6QZA6, Q6QZA7, Q6QZA9, Q6QZD2, Q6QZD3, Q6QZD8, Q6QZE2, Q6QZE3, Q6QZE5, Q6QZE7, Q6QZE8, Q6QZE9, Q6QZF1, Q6QZF2, Q6QZG0, Q6QZG4, Q6QZG5, Q6QZG6, Q6QZG7, Q6QZG8, Q6QZG9, Q6QZH0, Q6QZH1, Q6QZH2, Q6QZH3, Q6UNT8, Q8BES1
    Conserved Domains (2) summary
    pfam01543
    Location:2 → 115
    HCV_capsid; Hepatitis C virus capsid protein
    pfam01542
    Location:116 → 190
    HCV_core; Hepatitis C virus core protein

  3. NP_751920.1 envelope protein E1

    Conserved Domains (1) summary
    pfam01539
    Location:2 → 191
    HCV_env; Hepatitis C virus envelope glycoprotein E1

  4. NP_751921.1 envelope protein E2

    Conserved Domains (1) summary
    pfam01560
    Location:3 → 346
    HCV_NS1; Hepatitis C virus non-structural protein E2/NS1

  5. NP_751922.1 protein p7

  6. NP_751923.1 nonstructural protein NS2

    Conserved Domains (1) summary
    pfam01538
    Location:2 → 196
    HCV_NS2; Hepatitis C virus non-structural protein NS2

  7. NP_803144.1 protease/helicase protein NS3

    Conserved Domains (4) summary
    pfam02907
    Location:30 → 178
    Peptidase_S29; Hepatitis C virus NS3 protease
    smart00487
    Location:202 → 329
    DEXDc; DEAD-like helicases superfamily
    cd00046
    Location:198 → 325
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:352 → 429
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

  8. NP_751925.1 nonstructural protein NS4A

    UniProtKB/TrEMBL
    C9WU76, C9WUC9, C9WUD6, C9WUE1
    Conserved Domains (1) summary
    pfam01006
    Location:1 → 54
    HCV_NS4a; Hepatitis C virus non-structural protein NS4a

  9. NP_751926.1 nonstructural protein NS4B

  10. NP_751927.1 nonstructural protein NS5A

    Conserved Domains (4) summary
    pfam08301
    Location:96 → 196
    HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
    pfam12941
    Location:207 → 448
    HCV_NS5a_C; HCV NS5a protein C-terminal region
    pfam01506
    Location:2 → 24
    HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
    pfam08300
    Location:34 → 95
    HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain

  11. NP_751928.1 RNA-dependent RNA polymerase NS5B

    Conserved Domains (1) summary
    pfam00998
    Location:3 → 514
    RdRP_3; Viral RNA dependent RNA polymerase

  12. NP_803170.1 protein F [Hepatitis C virus genotype 1]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0C045
    Conserved Domains (1) summary
    pfam01543
    Location:66 → 127
    HCV_capsid; Hepatitis C virus capsid protein
Protein Accession Links
GenPept Link UniProtKB Link
AAB66324.1

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