Chc Clathrin heavy chain [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Chcprovided by FlyBase
Official Full Name: Clathrin heavy chainprovided by FlyBase
Primary source: FLYBASE:FBgn0000319
Locus tag: Dmel_CG9012
See related: AllianceGenome:FB:FBgn0000319
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9012; chc; CHC; chc1; Cla; Clh; CLH; D-Chc; dCHC; Dmel\CG9012; l(1)13Fb; l(1)G0438; l(1)VI
Summary: Predicted to enable clathrin light chain binding activity. Involved in several processes, including compound eye retinal cell programmed cell death; germ cell development; and open tracheal system development. Located in several cellular components, including clathrin-coated pit; cytoplasmic vesicle; and trans-Golgi network. Is expressed in several structures, including adult head; epidermis; gland; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain) and CLTCL1 (clathrin heavy chain like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 13F5-13F7; 1-52 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15827986..15835490, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15722019..15729523, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bic-D is also required to transport Chc mRNA into the oocyte and for transport and proper localization of Chc protein to the oocyte cortex.
Title: Clathrin heavy chain plays multiple roles in polarizing the Drosophila oocyte downstream of Bic-D.
Results report a Drosophila disabled (DAB)mutant revealing a novel role for DAB proteins in chemical synaptic transmission, and support a role for clathrin-mediated endocytosis in rapid clearance of neurotransmitter release sites.
Title: The DISABLED protein functions in CLATHRIN-mediated synaptic vesicle endocytosis and exoendocytic coupling at the active zone.
Bicaudal-D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling.
Title: Bicaudal-D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling.
chc mRNA and protein are highly expressed from early stages of embryogenesis onwards, consistent with genetic studies predicting a maternal contribution of the gene function
Title: Expression and localization of clathrin heavy chain in Drosophila melanogaster.
Chc is critical for synaptic vesicle recycling and in the absence of the protein, bulk retrieval mediates massive synaptic membrane internalization.
Title: Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables clathrin light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin light chain binding	IEA Inferred from Electronic Annotation more info
enables clathrin light chain binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in liquid clearance, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte microtubule cytoskeleton polarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secretory granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
part_of clathrin coat of coated pit	IEA Inferred from Electronic Annotation more info
part_of clathrin coat of trans-Golgi network vesicle	IEA Inferred from Electronic Annotation more info
part_of clathrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of clathrin complex	IEA Inferred from Electronic Annotation more info
part_of clathrin complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in clathrin-coated endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: clathrin heavy chain

Names: CG9012-PA; CG9012-PB; CG9012-PC; CG9012-PD; CG9012-PE; CG9012-PF; CG9012-PG; Chc-PA; Chc-PB; Chc-PC; Chc-PD; Chc-PE; Chc-PF; Chc-PG; clathrin; clathrin hc; clathrin heavy-chain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

15827986..15835490 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001103524.2 → NP_001096994.1 clathrin heavy chain, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096994.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29742, Q540W2, Q9VXN6

UniProtKB/TrEMBL

X2JC31

Conserved Domains (5) summary

smart00299
Location:1275 → 1417

CLH; Clathrin heavy chain repeat homology

pfam00637
Location:984 → 1120

Clathrin; Region in Clathrin and VPS

pfam01394
Location:256 → 288

Clathrin_propel; Clathrin propeller repeat

pfam09268
Location:331 → 353

Clathrin-link; Clathrin, heavy-chain linker

pfam13838
Location:364 → 422

Clathrin_H_link; Clathrin-H-link
NM_001103523.2 → NP_001096993.1 clathrin heavy chain, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096993.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29742, Q540W2, Q9VXN6

UniProtKB/TrEMBL

X2JC31

Conserved Domains (5) summary

smart00299
Location:1275 → 1417

CLH; Clathrin heavy chain repeat homology

pfam00637
Location:984 → 1120

Clathrin; Region in Clathrin and VPS

pfam01394
Location:256 → 288

Clathrin_propel; Clathrin propeller repeat

pfam09268
Location:331 → 353

Clathrin-link; Clathrin, heavy-chain linker

pfam13838
Location:364 → 422

Clathrin_H_link; Clathrin-H-link
NM_057694.3 → NP_477042.1 clathrin heavy chain, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477042.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29742, Q540W2, Q9VXN6

UniProtKB/TrEMBL

X2JC31

Related

FBpp0073966

Conserved Domains (5) summary

smart00299
Location:1275 → 1417

CLH; Clathrin heavy chain repeat homology

pfam00637
Location:984 → 1120

Clathrin; Region in Clathrin and VPS

pfam01394
Location:256 → 288

Clathrin_propel; Clathrin propeller repeat

pfam09268
Location:331 → 353

Clathrin-link; Clathrin, heavy-chain linker

pfam13838
Location:364 → 422

Clathrin_H_link; Clathrin-H-link
NM_001298371.1 → NP_001285300.1 clathrin heavy chain, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285300.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29742, Q540W2, Q9VXN6

UniProtKB/TrEMBL

X2JC31

Conserved Domains (5) summary

smart00299
Location:1275 → 1417

CLH; Clathrin heavy chain repeat homology

pfam00637
Location:984 → 1120

Clathrin; Region in Clathrin and VPS

pfam01394
Location:256 → 288

Clathrin_propel; Clathrin propeller repeat

pfam09268
Location:331 → 353

Clathrin-link; Clathrin, heavy-chain linker

pfam13838
Location:364 → 422

Clathrin_H_link; Clathrin-H-link
NM_206729.2 → NP_996452.1 clathrin heavy chain, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996452.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29742, Q540W2, Q9VXN6

UniProtKB/TrEMBL

X2JC31

Conserved Domains (5) summary

smart00299
Location:1275 → 1417

CLH; Clathrin heavy chain repeat homology

pfam00637
Location:984 → 1120

Clathrin; Region in Clathrin and VPS

pfam01394
Location:256 → 288

Clathrin_propel; Clathrin propeller repeat

pfam09268
Location:331 → 353

Clathrin-link; Clathrin, heavy-chain linker

pfam13838
Location:364 → 422

Clathrin_H_link; Clathrin-H-link
NM_206728.2 → NP_996451.1 clathrin heavy chain, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996451.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29742, Q540W2, Q9VXN6

UniProtKB/TrEMBL

X2JC31

Conserved Domains (5) summary

smart00299
Location:1275 → 1417

CLH; Clathrin heavy chain repeat homology

pfam00637
Location:984 → 1120

Clathrin; Region in Clathrin and VPS

pfam01394
Location:256 → 288

Clathrin_propel; Clathrin propeller repeat

pfam09268
Location:331 → 353

Clathrin-link; Clathrin, heavy-chain linker

pfam13838
Location:364 → 422

Clathrin_H_link; Clathrin-H-link
NM_167466.2 → NP_727901.1 clathrin heavy chain, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727901.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29742, Q540W2, Q9VXN6

UniProtKB/TrEMBL

X2JC31

Related

FBpp0073967

Conserved Domains (5) summary

smart00299
Location:1275 → 1417

CLH; Clathrin heavy chain repeat homology

pfam00637
Location:984 → 1120

Clathrin; Region in Clathrin and VPS

pfam01394
Location:256 → 288

Clathrin_propel; Clathrin propeller repeat

pfam09268
Location:331 → 353

Clathrin-link; Clathrin, heavy-chain linker

pfam13838
Location:364 → 422

Clathrin_H_link; Clathrin-H-link