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Conserved domains on  [gi|45555333|ref|NP_996452|]
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clathrin heavy chain, isoform C [Drosophila melanogaster]

Protein Classification

clathrin heavy chain( domain architecture ID 12019196)

clathrin heavy chain is a component of clathrin, the major protein of the polyhedral coat of coated pits and vesicles

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1275-1417 9.21e-34

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 127.39  E-value: 9.21e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    1275 LHIVVHADELEDLINYYQNRGYFDELIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAE 1354
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45555333    1355 SAHLWSELVFLYDKYEEYDNAVLAMMAHPTEAWReghFKDIITKVANIELYYKAIEFYLDFKP 1417
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEK---AIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
980-1118 1.71e-31

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 120.84  E-value: 1.71e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     980 LSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVfsdHRNLQNLLILTAIKADRTRVMDYI-NRLENYDAPDIAN 1058
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSE---NPALQTKLIELYAKYDPQKEIERLdNKSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    1059 IAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFAERCNEPAVWSQLAKAQLQ 1118
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLD 137
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1429-1562 4.42e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


:

Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 116.97  E-value: 4.42e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333   1429 PRMDHTRAVSYFSKTGYLPLVKPYLRSVQSL---NNKAINEALNGLLIDEEDYQGLRNSIDGFDNFDNIALAQKLEKHEL 1505
Cdd:pfam00637    6 DPIDVSRVVKLFEKAGLLEELISYLESALKEdsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKADL 85

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 45555333   1506 TEFRRiaaYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELLGWFLERD 1562
Cdd:pfam00637   86 YEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
CLH smart00299
Clathrin heavy chain repeat homology;
834-969 8.66e-30

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 115.83  E-value: 8.66e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     834 ILVVKGQFSTDELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNP--ERYLKENQYYDSRVVGRYCE 911
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     912 KRDPH-LACVAYERGLCDRELIAVCNENS-LFKSEARYLVGRRDAELWAEVLSESNPYKR 969
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
687-825 2.94e-29

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 114.29  E-value: 2.94e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     687 ATKYHEQLTNKALIDLFEGFKSYDGLFYFLSSIVNF-SQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLK 765
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45555333     766 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYVQKVNPSRLPVVVGGLLDVDC 825
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1129-1268 3.79e-29

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


:

Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 114.28  E-value: 3.79e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333   1129 YIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARE--SYIESELIYAYARTGRLADLEEFISGPNHADIQKIGNRC 1206
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45555333   1207 FSDGMYDAAKLLYNNVSNFARLAITLVYLKEFQGAVDSARKANSTRTWKEVCFACVDAEEFR 1268
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
542-672 1.17e-27

Clathrin heavy chain repeat homology;


:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 109.67  E-value: 1.17e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     542 EPLADINQIVDIFMEHSMVQQCTAFLLDALKHNrPAEGALQTRLLEMNLMSAPQVADAILGNaMFTHYDRAHIAQLCEKA 621
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 45555333     622 GLLQRALEHYTDLYDIKRAVVHT--HMLNAEWLVSFFGT-LSVEDSLECLKAML 672
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALL 136
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 356-422 2.31e-20

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


:

Pssm-ID: 463995  Cd Length: 66  Bit Score: 86.11  E-value: 2.31e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45555333    356 NLAGAEDLFVRKFNKLFTAGQYAEAAKVAALAPKAILRTPQTIQRFQQVQTPAGsTTPPLLQYFGIL 422
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPG-QLSPILQYFGTL 66
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 3.92e-08

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


:

Pssm-ID: 462732  Cd Length: 24  Bit Score: 50.52  E-value: 3.92e-08
                           10        20
                   ....*....|....*....|....
gi 45555333    331 EEQIIPYINTVLQNPDLALRMAVR 354
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 9.57e-06

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 43.94  E-value: 9.57e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 45555333    256 AQNDFPVAMQVSAKYDTIYLITKYGYIHLYDME 288
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 1.87e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 43.17  E-value: 1.87e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 45555333    198 AASFATFKIDANKEPTTLFCFAVRTATGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 1.29e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.86  E-value: 1.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 45555333    296 NRISADTIFVTAPHEASGGIIGVN--RKGQVLSVTVD 330
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-56 2.40e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.09  E-value: 2.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 45555333     19 GINANSFSFSTLTMESDKFICVReKVNDTAQVVIIDMN 56
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAI-NGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 148-187 2.64e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


:

Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.01  E-value: 2.64e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 45555333    148 LNGCQIINYRCNASQQWLLLVGISalpSRVAGAMQLYSVE 187
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1275-1417 9.21e-34

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 127.39  E-value: 9.21e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    1275 LHIVVHADELEDLINYYQNRGYFDELIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAE 1354
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45555333    1355 SAHLWSELVFLYDKYEEYDNAVLAMMAHPTEAWReghFKDIITKVANIELYYKAIEFYLDFKP 1417
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEK---AIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
980-1118 1.71e-31

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 120.84  E-value: 1.71e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     980 LSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVfsdHRNLQNLLILTAIKADRTRVMDYI-NRLENYDAPDIAN 1058
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSE---NPALQTKLIELYAKYDPQKEIERLdNKSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    1059 IAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFAERCNEPAVWSQLAKAQLQ 1118
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLD 137
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1429-1562 4.42e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 116.97  E-value: 4.42e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333   1429 PRMDHTRAVSYFSKTGYLPLVKPYLRSVQSL---NNKAINEALNGLLIDEEDYQGLRNSIDGFDNFDNIALAQKLEKHEL 1505
Cdd:pfam00637    6 DPIDVSRVVKLFEKAGLLEELISYLESALKEdsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKADL 85

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 45555333   1506 TEFRRiaaYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELLGWFLERD 1562
Cdd:pfam00637   86 YEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
CLH smart00299
Clathrin heavy chain repeat homology;
834-969 8.66e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 115.83  E-value: 8.66e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     834 ILVVKGQFSTDELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNP--ERYLKENQYYDSRVVGRYCE 911
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     912 KRDPH-LACVAYERGLCDRELIAVCNENS-LFKSEARYLVGRRDAELWAEVLSESNPYKR 969
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 980-1120 1.44e-29

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 115.43  E-value: 1.44e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    980 LSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSvfSDHRNLQNLLILTAIKADR-TRVMDYINRLENYDAPDIAN 1058
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45555333   1059 IAISNQLYEEAFAIFKKFDVNTSAIqVLIDQVNNLERANEFAERCNEPAVWSQLAKAQLQQG 1120
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
CLH smart00299
Clathrin heavy chain repeat homology;
687-825 2.94e-29

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 114.29  E-value: 2.94e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     687 ATKYHEQLTNKALIDLFEGFKSYDGLFYFLSSIVNF-SQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLK 765
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45555333     766 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYVQKVNPSRLPVVVGGLLDVDC 825
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1129-1268 3.79e-29

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 114.28  E-value: 3.79e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333   1129 YIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARE--SYIESELIYAYARTGRLADLEEFISGPNHADIQKIGNRC 1206
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45555333   1207 FSDGMYDAAKLLYNNVSNFARLAITLVYLKEFQGAVDSARKANSTRTWKEVCFACVDAEEFR 1268
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
542-672 1.17e-27

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 109.67  E-value: 1.17e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     542 EPLADINQIVDIFMEHSMVQQCTAFLLDALKHNrPAEGALQTRLLEMNLMSAPQVADAILGNaMFTHYDRAHIAQLCEKA 621
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 45555333     622 GLLQRALEHYTDLYDIKRAVVHT--HMLNAEWLVSFFGT-LSVEDSLECLKAML 672
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALL 136
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 844-971 3.25e-26

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 105.80  E-value: 3.25e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    844 DELVEEVEKRNRLKLLLPWLESRVHEGCVE-PATHNALAKIYIDSN--NNPERYLKENQYYDSRVVGRYCEKRDPH-LAC 919
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESALKEDSREnPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 45555333    920 VAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQL 971
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1275-1417 3.98e-26

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 105.42  E-value: 3.98e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333   1275 LHIVVHADELEDLINYYQNRGYFDELIALLESALGL-ERAHMGMFTELAILYSKF-KPSKMREHLELFWSrVNIPKVLRA 1352
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45555333   1353 AESAHLWSELVFLYDKYEEYDNAVlaMMAHPTEAWREGHfkDIITKVANIELYYKAIEFYLDFKP 1417
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
CLH smart00299
Clathrin heavy chain repeat homology;
1129-1266 2.20e-25

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 103.12  E-value: 2.20e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    1129 YIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARE-SYIESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCF 1207
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    1208 SDGMYDAAKLLYNNVSNFARLAITLVY-LKEFQGAVDSARKANSTRTWKEVCFACVDAEE 1266
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEhLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 687-827 3.11e-24

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 100.02  E-value: 3.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    687 ATKYHEQLTNKALIDLFEGFKSYDGLFYFLSSIVNFS--QDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFL 764
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45555333    765 KEAKLTDQLPLIIVCdrFDFVHDLV-LYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSE 827
Cdd:pfam00637   81 EKADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 540-679 6.44e-24

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 99.25  E-value: 6.44e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    540 EEEPLADINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGALQTRLLEMNLMSAP-QVADAILGnaMFTHYDRAHIAQLC 618
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFLK--KNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45555333    619 EKAGLLQRALEHYTDLYDIKRAVVHTHMLNA-EWLVSFFGTLSVEDSLECLKAMLTANLRQN 679
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDyKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1428-1579 1.75e-21

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 91.95  E-value: 1.75e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    1428 APRMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKaiNEALNGLLIDEEDYQGLRNSIDGFDNFdnialaqklekHELTE 1507
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLNSE--NPALQTKLIELYAKYDPQKEIERLDNK-----------SNHYD 71

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45555333    1508 FRRIAAYLYKGNNrWKQSVELCKKDKLYKDAMEYAAESCKqdIAEELLGWFLERDAYDCFAACLYQCYDLLR 1579
Cdd:smart00299   72 IEKVGKLCEKAKL-YEEAVELYKKDGNFKDAIVTLIEHLG--NYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 356-422 2.31e-20

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 86.11  E-value: 2.31e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45555333    356 NLAGAEDLFVRKFNKLFTAGQYAEAAKVAALAPKAILRTPQTIQRFQQVQTPAGsTTPPLLQYFGIL 422
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPG-QLSPILQYFGTL 66
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 3.92e-08

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 50.52  E-value: 3.92e-08
                           10        20
                   ....*....|....*....|....
gi 45555333    331 EEQIIPYINTVLQNPDLALRMAVR 354
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 9.57e-06

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 43.94  E-value: 9.57e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 45555333    256 AQNDFPVAMQVSAKYDTIYLITKYGYIHLYDME 288
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 1.87e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 43.17  E-value: 1.87e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 45555333    198 AASFATFKIDANKEPTTLFCFAVRTATGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1057-1248 6.21e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.65  E-value: 6.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333 1057 ANIAISNQLYEEAFAIFKK-FDVNTSAIQVLIDQVNNLERANEF--AERC---------NEPAVWSQLAKAQLQQGLVKE 1124
Cdd:COG2956   15 GLNYLLNGQPDKAIDLLEEaLELDPETVEAHLALGNLYRRRGEYdrAIRIhqkllerdpDRAEALLELAQDYLKAGLLDR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333 1125 AIDSYIKA-----DDPSAYVDVVDVASKVESWDDLVRYLQMARKKARES-YIESELIYAYARTGRLAD----LEEFISG- 1193
Cdd:COG2956   95 AEELLEKLleldpDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEaieaLEKALKLd 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333 1194 PNHADIQ-KIGNRCFSDGMYDAAKLLYNNV----SNFARLAITLVYLKEFQGAVDSARKA 1248
Cdd:COG2956  175 PDCARALlLLAELYLEQGDYEEAIAALERAleqdPDYLPALPRLAELYEKLGDPEEALEL 234
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 1.29e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.86  E-value: 1.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 45555333    296 NRISADTIFVTAPHEASGGIIGVN--RKGQVLSVTVD 330
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-56 2.40e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.09  E-value: 2.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 45555333     19 GINANSFSFSTLTMESDKFICVReKVNDTAQVVIIDMN 56
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAI-NGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 148-187 2.64e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.01  E-value: 2.64e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 45555333    148 LNGCQIINYRCNASQQWLLLVGISalpSRVAGAMQLYSVE 187
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1055-1187 5.00e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.52  E-value: 5.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333 1055 DIANIAISNQLYEEAFAIFKKF-DVNTSAIQVLIDQVNNLERANEFAE-----------RCNEPAVWSQLAKAQLQQGLV 1122
Cdd:COG3914  117 NLGNLLLALGRLEEALAALRRAlALNPDFAEAYLNLGEALRRLGRLEEaiaalrralelDPDNAEALNNLGNALQDLGRL 196

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333 1123 KEAIDSYIKA-----DDPSAYVDVVDVASKVESWDDLVRYLQMARKKARESYIESELIYAYARTGRLADL 1187
Cdd:COG3914  197 EEAIAAYRRAleldpDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAEL 266
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1065-1134 7.52e-03

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 40.91  E-value: 7.52e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45555333 1065 LYEEAFAIF----KKFDVntsAIQVlidqvNNLERANEFAERCNEPAVWSQLAKAQLQQGLVKEAIDSYIKADD 1134
Cdd:cd22947  327 LKELALEVStdpdHKFEL---ALQL-----GDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGD 392
 
Name Accession Description Interval E-value
CLH smart00299
Clathrin heavy chain repeat homology;
1275-1417 9.21e-34

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 127.39  E-value: 9.21e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    1275 LHIVVHADELEDLINYYQNRGYFDELIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAE 1354
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45555333    1355 SAHLWSELVFLYDKYEEYDNAVLAMMAHPTEAWReghFKDIITKVANIELYYKAIEFYLDFKP 1417
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEK---AIEYFVKQNNPELWAEVLKALLDKPR 140
CLH smart00299
Clathrin heavy chain repeat homology;
980-1118 1.71e-31

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 120.84  E-value: 1.71e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     980 LSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVfsdHRNLQNLLILTAIKADRTRVMDYI-NRLENYDAPDIAN 1058
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSE---NPALQTKLIELYAKYDPQKEIERLdNKSNHYDIEKVGK 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    1059 IAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFAERCNEPAVWSQLAKAQLQ 1118
Cdd:smart00299   78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLD 137
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1429-1562 4.42e-30

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 116.97  E-value: 4.42e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333   1429 PRMDHTRAVSYFSKTGYLPLVKPYLRSVQSL---NNKAINEALNGLLIDEEDYQGLRNSIDGFDNFDNIALAQKLEKHEL 1505
Cdd:pfam00637    6 DPIDVSRVVKLFEKAGLLEELISYLESALKEdsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKADL 85

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 45555333   1506 TEFRRiaaYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELLGWFLERD 1562
Cdd:pfam00637   86 YEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
CLH smart00299
Clathrin heavy chain repeat homology;
834-969 8.66e-30

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 115.83  E-value: 8.66e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     834 ILVVKGQFSTDELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNP--ERYLKENQYYDSRVVGRYCE 911
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     912 KRDPH-LACVAYERGLCDRELIAVCNENS-LFKSEARYLVGRRDAELWAEVLSESNPYKR 969
Cdd:smart00299   81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 980-1120 1.44e-29

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 115.43  E-value: 1.44e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    980 LSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSvfSDHRNLQNLLILTAIKADR-TRVMDYINRLENYDAPDIAN 1058
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45555333   1059 IAISNQLYEEAFAIFKKFDVNTSAIqVLIDQVNNLERANEFAERCNEPAVWSQLAKAQLQQG 1120
Cdd:pfam00637   79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
CLH smart00299
Clathrin heavy chain repeat homology;
687-825 2.94e-29

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 114.29  E-value: 2.94e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     687 ATKYHEQLTNKALIDLFEGFKSYDGLFYFLSSIVNF-SQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLK 765
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45555333     766 EAKLTDQLPLIIVCDrFDFVHDLVLYLYR-NNLQKYIEIYVQKVNPSRLPVVVGGLLDVDC 825
Cdd:smart00299   81 KAKLYEEAVELYKKD-GNFKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1129-1268 3.79e-29

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 114.28  E-value: 3.79e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333   1129 YIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARE--SYIESELIYAYARTGRLADLEEFISGPNHADIQKIGNRC 1206
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45555333   1207 FSDGMYDAAKLLYNNVSNFARLAITLVYLKEFQGAVDSARKANSTRTWKEVCFACVDAEEFR 1268
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
542-672 1.17e-27

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 109.67  E-value: 1.17e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333     542 EPLADINQIVDIFMEHSMVQQCTAFLLDALKHNrPAEGALQTRLLEMNLMSAPQVADAILGNaMFTHYDRAHIAQLCEKA 621
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN-SENPALQTKLIELYAKYDPQKEIERLDN-KSNHYDIEKVGKLCEKA 82

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 45555333     622 GLLQRALEHYTDLYDIKRAVVHT--HMLNAEWLVSFFGT-LSVEDSLECLKAML 672
Cdd:smart00299   83 KLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALL 136
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 844-971 3.25e-26

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 105.80  E-value: 3.25e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    844 DELVEEVEKRNRLKLLLPWLESRVHEGCVE-PATHNALAKIYIDSN--NNPERYLKENQYYDSRVVGRYCEKRDPH-LAC 919
Cdd:pfam00637   11 SRVVKLFEKAGLLEELISYLESALKEDSREnPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 45555333    920 VAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQL 971
Cdd:pfam00637   91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 1275-1417 3.98e-26

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 105.42  E-value: 3.98e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333   1275 LHIVVHADELEDLINYYQNRGYFDELIALLESALGL-ERAHMGMFTELAILYSKF-KPSKMREHLELFWSrVNIPKVLRA 1352
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEdSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45555333   1353 AESAHLWSELVFLYDKYEEYDNAVlaMMAHPTEAWREGHfkDIITKVANIELYYKAIEFYLDFKP 1417
Cdd:pfam00637   80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
CLH smart00299
Clathrin heavy chain repeat homology;
1129-1266 2.20e-25

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 103.12  E-value: 2.20e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    1129 YIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARE-SYIESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCF 1207
Cdd:smart00299    1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    1208 SDGMYDAAKLLYNNVSNFARLAITLVY-LKEFQGAVDSARKANSTRTWKEVCFACVDAEE 1266
Cdd:smart00299   81 KAKLYEEAVELYKKDGNFKDAIVTLIEhLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 687-827 3.11e-24

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 100.02  E-value: 3.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    687 ATKYHEQLTNKALIDLFEGFKSYDGLFYFLSSIVNFS--QDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFL 764
Cdd:pfam00637    1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45555333    765 KEAKLTDQLPLIIVCdrFDFVHDLV-LYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSE 827
Cdd:pfam00637   81 EKADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 540-679 6.44e-24

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 99.25  E-value: 6.44e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    540 EEEPLADINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGALQTRLLEMNLMSAP-QVADAILGnaMFTHYDRAHIAQLC 618
Cdd:pfam00637    3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRENPALQTALIELYAKYDDpEELEEFLK--KNNNYDLEKVAKLC 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45555333    619 EKAGLLQRALEHYTDLYDIKRAVVHTHMLNA-EWLVSFFGTLSVEDSLECLKAMLTANLRQN 679
Cdd:pfam00637   81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDyKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
CLH smart00299
Clathrin heavy chain repeat homology;
1428-1579 1.75e-21

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 91.95  E-value: 1.75e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333    1428 APRMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKaiNEALNGLLIDEEDYQGLRNSIDGFDNFdnialaqklekHELTE 1507
Cdd:smart00299    5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLNSE--NPALQTKLIELYAKYDPQKEIERLDNK-----------SNHYD 71

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45555333    1508 FRRIAAYLYKGNNrWKQSVELCKKDKLYKDAMEYAAESCKqdIAEELLGWFLERDAYDCFAACLYQCYDLLR 1579
Cdd:smart00299   72 IEKVGKLCEKAKL-YEEAVELYKKDGNFKDAIVTLIEHLG--NYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
Clathrin_H_link pfam13838
Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins ...
 356-422 2.31e-20

Clathrin-H-link; This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain pfam09268.


Pssm-ID: 463995  Cd Length: 66  Bit Score: 86.11  E-value: 2.31e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45555333    356 NLAGAEDLFVRKFNKLFTAGQYAEAAKVAALAPKAILRTPQTIQRFQQVQTPAGsTTPPLLQYFGIL 422
Cdd:pfam13838    1 GLPGADDLYFQQFNQLLNQGDYAEAAKVAANSPRGALRTPETIQRFKQLPAQPG-QLSPILQYFGTL 66
Clathrin-link pfam09268
Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of ...
 331-354 3.92e-08

Clathrin, heavy-chain linker; Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain.


Pssm-ID: 462732  Cd Length: 24  Bit Score: 50.52  E-value: 3.92e-08
                           10        20
                   ....*....|....*....|....
gi 45555333    331 EEQIIPYINTVLQNPDLALRMAVR 354
Cdd:pfam09268    1 EDNIIPYILNTLQNPDLALRLASR 24
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 256-288 9.57e-06

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 43.94  E-value: 9.57e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 45555333    256 AQNDFPVAMQVSAKYDTIYLITKYGYIHLYDME 288
Cdd:pfam01394    5 AIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 198-234 1.87e-05

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 43.17  E-value: 1.87e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 45555333    198 AASFATFKIDANKEPTTLFCFAVRTATGGKLHIIEVG 234
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINGTKKGQVQIVDVE 37
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1057-1248 6.21e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.65  E-value: 6.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333 1057 ANIAISNQLYEEAFAIFKK-FDVNTSAIQVLIDQVNNLERANEF--AERC---------NEPAVWSQLAKAQLQQGLVKE 1124
Cdd:COG2956   15 GLNYLLNGQPDKAIDLLEEaLELDPETVEAHLALGNLYRRRGEYdrAIRIhqkllerdpDRAEALLELAQDYLKAGLLDR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333 1125 AIDSYIKA-----DDPSAYVDVVDVASKVESWDDLVRYLQMARKKARES-YIESELIYAYARTGRLAD----LEEFISG- 1193
Cdd:COG2956   95 AEELLEKLleldpDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEaieaLEKALKLd 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333 1194 PNHADIQ-KIGNRCFSDGMYDAAKLLYNNV----SNFARLAITLVYLKEFQGAVDSARKA 1248
Cdd:COG2956  175 PDCARALlLLAELYLEQGDYEEAIAALERAleqdPDYLPALPRLAELYEKLGDPEEALEL 234
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 296-330 1.29e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.86  E-value: 1.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 45555333    296 NRISADTIFVTAPHEASGGIIGVN--RKGQVLSVTVD 330
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAINgtKKGQVQIVDVE 37
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 19-56 2.40e-04

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 40.09  E-value: 2.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 45555333     19 GINANSFSFSTLTMESDKFICVReKVNDTAQVVIIDMN 56
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAI-NGTKKGQVQIVDVE 37
Coatomer_WDAD pfam04053
Coatomer WD associated region; This region is composed of WD40 repeats.
 1074-1134 6.96e-04

Coatomer WD associated region; This region is composed of WD40 repeats.


Pssm-ID: 427679  Cd Length: 439  Bit Score: 44.15  E-value: 6.96e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45555333   1074 KKFDVntsAIQVlidqvNNLERANEFAERCNEPAVWSQLAKAQLQQGLVKEAIDSYIKADD 1134
Cdd:pfam04053  319 TRFDL---ALEL-----GNLDVALEIAKELDDPAKWKRLGDAALSQGNIKLAEEAYQKAKD 371
Clathrin_propel pfam01394
Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that ...
 148-187 2.64e-03

Clathrin propeller repeat; Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles. The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure. Each leg contains one heavy and one light chain. The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller.


Pssm-ID: 460192  Cd Length: 37  Bit Score: 37.01  E-value: 2.64e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 45555333    148 LNGCQIINYRCNASQQWLLLVGISalpSRVAGAMQLYSVE 187
Cdd:pfam01394    1 NAISAIIIFPTATMESWLFIIAIN---GTKKGQVQIVDVE 37
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1055-1187 5.00e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.52  E-value: 5.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333 1055 DIANIAISNQLYEEAFAIFKKF-DVNTSAIQVLIDQVNNLERANEFAE-----------RCNEPAVWSQLAKAQLQQGLV 1122
Cdd:COG3914  117 NLGNLLLALGRLEEALAALRRAlALNPDFAEAYLNLGEALRRLGRLEEaiaalrralelDPDNAEALNNLGNALQDLGRL 196

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45555333 1123 KEAIDSYIKA-----DDPSAYVDVVDVASKVESWDDLVRYLQMARKKARESYIESELIYAYARTGRLADL 1187
Cdd:COG3914  197 EEAIAAYRRAleldpDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAEL 266
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 1065-1134 7.52e-03

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 40.91  E-value: 7.52e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45555333 1065 LYEEAFAIF----KKFDVntsAIQVlidqvNNLERANEFAERCNEPAVWSQLAKAQLQQGLVKEAIDSYIKADD 1134
Cdd:cd22947  327 LKELALEVStdpdHKFEL---ALQL-----GDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGD 392
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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