Sema1b Semaphorin 1b [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sema1bprovided by FlyBase
Official Full Name: Semaphorin 1bprovided by FlyBase
Primary source: FLYBASE:FBgn0016059
Locus tag: Dmel_CG6446
See related: AllianceGenome:FB:FBgn0016059
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH03186; CG6446; D-semaIII; Dmel\CG6446; Sema 1b; Sema III; Sema-1b; sema-III; sema1b
Summary: Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in embryonic development via the syncytial blastoderm. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; ectoderm; follicle cell; and lamina. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Orthologous to several human genes including SEMA6A (semaphorin 6A); SEMA6B (semaphorin 6B); and SEMA6C (semaphorin 6C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (17672839..17683499, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (13560344..13571004, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Structural basis of semaphorin-plexin cis interaction.
Title: Structural basis of semaphorin-plexin cis interaction.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chemorepellent activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic development via the syncytial blastoderm	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: CG6446-PA; CG6446-PB; CG6446-PC; Sema-1b; Sema1b-PA; Sema1b-PB; Sema1b-PC; semaphorin; semaphorin-I; semaphorin-III; semaphorin-like; semiphorin

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The following sections contain reference sequences that belong to a specific genome build. Explain