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Conserved domains on  [gi|45552709|ref|NP_995879|]
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semaphorin 1b, isoform B [Drosophila melanogaster]

Protein Classification

semaphorin-3; sugar porter family MFS transporter( domain architecture ID 10181268)

semaphorin-3 is a class III semaphorin that is secreted and contains a Sema domain, an Ig domain, and a short basic domain; may function as an axonal guidance cue and may have a role in the regulation of the cardiovascular, immune, and respiratory systems| sugar porter family major facilitator superfamily (MFS) transporter belonging to the SLC2A13 subfamily functions as a myo-inositol/H+ symporter or inositol/H+ symporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sema_1A cd11237
The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a ...
55-511 0e+00

The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a transmembrane protein. It has been shown to mediate the defasciculation of motor axon bundles at specific choice points. Sema1A binds to its receptor plexin A (PlexA), which in turn triggers downstream signaling events involving the receptor tyrosine kinase Otk, the evolutionarily conserved flavoprotein monooxygenase molecule interacting with CasL (MICAL), and the A kinase anchoring protein Nervy, leading to repulsive growth-cone response. Sema1A has also been shown to be involved in synaptic formation. It is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


:

Pssm-ID: 200498 [Multi-domain]  Cd Length: 446  Bit Score: 809.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  55 GNSTDYFKILDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEVLLCG 134
Cdd:cd11237   1 ETHSDHFKLLDQDGNSLLVGARNAVYNISLSDLTENQRIEWPSSDAHREMCLLKGKSEDDCQNYIRVLAKKSAGRLLVCG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 135 TNSYKPRCRHYTPVEVSseeagsaghahamrYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYREN 214
Cdd:cd11237  81 TNAYKPLCREYTVKDGG--------------YRVEREFDGQGLCPYDPKHNSTAVYADGQLYSATVADFSGADPLIYREP 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 215 LRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPG 294
Cdd:cd11237 147 LRTERYDLKQLNAPNFVSSFAYGDYVYFFFRETAVEYINCGKAIYSRVARVCKNDKGGPHPFRDRWTSFLKARLNCSVPG 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 295 EFPFYFDEIQAISPIVESG----SKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPK 370
Cdd:cd11237 227 EYPFYFNEIQSTSDIVEGGyggkSAKLIYGVFTTPVNSISGSAVCAFSLQDILEVFDGSFKEQQDINSNWLPVPSNKVPE 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 371 PRPGQCVEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTK 450
Cdd:cd11237 307 PRPGQCVNDSRTLPDVTVNFIKSHPLMDEAVPSFFGRPILVRTSLQYRFTQIAVDPQVKALDGKYYDVLFIGTDDGKVLK 386
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45552709 451 FINILSTHpnsTVDRLKTVVISEMQVLPLGTPIRELVISTSK--NSLVVVSDGSLVSVPLHHC 511
Cdd:cd11237 387 AVNIASAD---TVDKVSPVVIEETQVFPRGVPIRNLLIVRGKddGRLVVVSDDEIVSIPLHRC 446
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
510-537 2.13e-04

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 39.45  E-value: 2.13e-04
                           10        20
                   ....*....|....*....|....*...
gi 45552709    510 HCSHIVDCLGCLSLQDPICAWDLQTHEC 537
Cdd:smart00423   1 RCSKYTSCSECLLARDPYCAWCSSQGRC 28
 
Name Accession Description Interval E-value
Sema_1A cd11237
The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a ...
55-511 0e+00

The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a transmembrane protein. It has been shown to mediate the defasciculation of motor axon bundles at specific choice points. Sema1A binds to its receptor plexin A (PlexA), which in turn triggers downstream signaling events involving the receptor tyrosine kinase Otk, the evolutionarily conserved flavoprotein monooxygenase molecule interacting with CasL (MICAL), and the A kinase anchoring protein Nervy, leading to repulsive growth-cone response. Sema1A has also been shown to be involved in synaptic formation. It is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200498 [Multi-domain]  Cd Length: 446  Bit Score: 809.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  55 GNSTDYFKILDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEVLLCG 134
Cdd:cd11237   1 ETHSDHFKLLDQDGNSLLVGARNAVYNISLSDLTENQRIEWPSSDAHREMCLLKGKSEDDCQNYIRVLAKKSAGRLLVCG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 135 TNSYKPRCRHYTPVEVSseeagsaghahamrYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYREN 214
Cdd:cd11237  81 TNAYKPLCREYTVKDGG--------------YRVEREFDGQGLCPYDPKHNSTAVYADGQLYSATVADFSGADPLIYREP 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 215 LRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPG 294
Cdd:cd11237 147 LRTERYDLKQLNAPNFVSSFAYGDYVYFFFRETAVEYINCGKAIYSRVARVCKNDKGGPHPFRDRWTSFLKARLNCSVPG 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 295 EFPFYFDEIQAISPIVESG----SKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPK 370
Cdd:cd11237 227 EYPFYFNEIQSTSDIVEGGyggkSAKLIYGVFTTPVNSISGSAVCAFSLQDILEVFDGSFKEQQDINSNWLPVPSNKVPE 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 371 PRPGQCVEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTK 450
Cdd:cd11237 307 PRPGQCVNDSRTLPDVTVNFIKSHPLMDEAVPSFFGRPILVRTSLQYRFTQIAVDPQVKALDGKYYDVLFIGTDDGKVLK 386
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45552709 451 FINILSTHpnsTVDRLKTVVISEMQVLPLGTPIRELVISTSK--NSLVVVSDGSLVSVPLHHC 511
Cdd:cd11237 387 AVNIASAD---TVDKVSPVVIEETQVFPRGVPIRNLLIVRGKddGRLVVVSDDEIVSIPLHRC 446
Sema smart00630
semaphorin domain;
61-484 3.98e-140

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 417.92  E-value: 3.98e-140
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709     61 FKILDHNDEFVLVGAKDVIYNVSLNGLKEI-ARLEWHSTDADRELCALKGKHEW-DCHNYLRVYALRPNGEVLLCGTNSY 138
Cdd:smart00630   3 HLLLDEDNGTLYVGARNRLYQLSLNLILEAeLKTGPVLSSPDCEECVSKGKDPPtDCVNYIRLLLDYNEDRLLVCGTNAF 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709    139 KPRCRHytpvevsseeagsaghahamryevsrdveaqglcpyspaHNStyafadGHLYSATVADFSGGDPLIYREN---- 214
Cdd:smart00630  83 QPVCRL---------------------------------------RNL------GELYVGTVADFSGSDPAIPRSLsvrr 117
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709    215 --------LRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKA 286
Cdd:smart00630 118 lkgtsgvsLRTVLYDSKWLNEPNFVYAFESGDFVYFFFRETAVEDDNCGKAVHSRVARVCKNDVGGPRSLDKKWTSFLKA 197
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709    287 RLNCSVPGEFPFYFDEIQAISPIVE-SGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVER 365
Cdd:smart00630 198 RLECSVPGEDPFYFNELQAAFLLPPgSESDDVLYGVFSTSSNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQWLPYSR 277
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709    366 EQVPKPRPGQCVE---DSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSgayYDVIYSG 442
Cdd:smart00630 278 GKVPYPRPGTCPNkppSSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKTDSNYLLTSIAVDRVATDGN---YTVLFLG 354
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|..
gi 45552709    443 TDDGKVTKFINILSTHPNstvdrlKTVVISEMQVLPLGTPIR 484
Cdd:smart00630 355 TSDGRILKVVLSESSSSS------ESVVLEEISVFPDGSPIS 390
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
303-489 2.45e-56

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 190.56  E-value: 2.45e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709   303 IQAIS---PIVESGSKSLIYAVFTTS-VNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREqVPKPRPGQCVE 378
Cdd:pfam01403   1 LQDVFvlkPGAGDALDTVLYGVFTTQwSNSIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPYTGK-VPYPRPGTCIN 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709   379 DSR--TLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNlhHRLTAIAVHpQVKSLSGAyYDVIYSGTDDGKVTKFINILS 456
Cdd:pfam01403  80 DPLrlDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTG--VRLTSIAVD-RVQALDGN-YTVLFLGTDDGRLHKVVLVGS 155
                         170       180       190
                  ....*....|....*....|....*....|...
gi 45552709   457 THPnstvdrlktVVISEMQVLPLGTPIRELVIS 489
Cdd:pfam01403 156 EES---------HIIEEIQVFPEPQPVLNLLLS 179
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
510-537 2.13e-04

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 39.45  E-value: 2.13e-04
                           10        20
                   ....*....|....*....|....*...
gi 45552709    510 HCSHIVDCLGCLSLQDPICAWDLQTHEC 537
Cdd:smart00423   1 RCSKYTSCSECLLARDPYCAWCSSQGRC 28
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
510-537 3.38e-04

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 39.23  E-value: 3.38e-04
                          10        20
                  ....*....|....*....|....*...
gi 45552709   510 HCSHIVDCLGCLSLQDPICAWDLQTHEC 537
Cdd:pfam01437   1 RCSQYTSCSSCLAARDPYCGWCSSEGRC 28
 
Name Accession Description Interval E-value
Sema_1A cd11237
The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a ...
55-511 0e+00

The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a transmembrane protein. It has been shown to mediate the defasciculation of motor axon bundles at specific choice points. Sema1A binds to its receptor plexin A (PlexA), which in turn triggers downstream signaling events involving the receptor tyrosine kinase Otk, the evolutionarily conserved flavoprotein monooxygenase molecule interacting with CasL (MICAL), and the A kinase anchoring protein Nervy, leading to repulsive growth-cone response. Sema1A has also been shown to be involved in synaptic formation. It is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200498 [Multi-domain]  Cd Length: 446  Bit Score: 809.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  55 GNSTDYFKILDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEVLLCG 134
Cdd:cd11237   1 ETHSDHFKLLDQDGNSLLVGARNAVYNISLSDLTENQRIEWPSSDAHREMCLLKGKSEDDCQNYIRVLAKKSAGRLLVCG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 135 TNSYKPRCRHYTPVEVSseeagsaghahamrYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYREN 214
Cdd:cd11237  81 TNAYKPLCREYTVKDGG--------------YRVEREFDGQGLCPYDPKHNSTAVYADGQLYSATVADFSGADPLIYREP 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 215 LRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPG 294
Cdd:cd11237 147 LRTERYDLKQLNAPNFVSSFAYGDYVYFFFRETAVEYINCGKAIYSRVARVCKNDKGGPHPFRDRWTSFLKARLNCSVPG 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 295 EFPFYFDEIQAISPIVESG----SKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPK 370
Cdd:cd11237 227 EYPFYFNEIQSTSDIVEGGyggkSAKLIYGVFTTPVNSISGSAVCAFSLQDILEVFDGSFKEQQDINSNWLPVPSNKVPE 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 371 PRPGQCVEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAYYDVIYSGTDDGKVTK 450
Cdd:cd11237 307 PRPGQCVNDSRTLPDVTVNFIKSHPLMDEAVPSFFGRPILVRTSLQYRFTQIAVDPQVKALDGKYYDVLFIGTDDGKVLK 386
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45552709 451 FINILSTHpnsTVDRLKTVVISEMQVLPLGTPIRELVISTSK--NSLVVVSDGSLVSVPLHHC 511
Cdd:cd11237 387 AVNIASAD---TVDKVSPVVIEETQVFPRGVPIRNLLIVRGKddGRLVVVSDDEIVSIPLHRC 446
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
61-509 3.45e-167

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 489.23  E-value: 3.45e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  61 FKILDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEVLLCGTNSYKP 140
Cdd:cd11235   5 TKLLHEDRSTLYVGARDRVYLVDLDSLYTEQKVAWPSSPDDVDTCYLKGKSKDDCRNFIKVLEKNSDDSLLVCGTNAFNP 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 141 RCRHY---TPVEVSSEEAGsaghahamryevsrdveaQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR----- 212
Cdd:cd11235  85 SCRNYnveTFELVGKEESG------------------RGKCPYDPDHNSTALFADGELYSGTSADFLGTDPVIYRtlghn 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 213 ENLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSV 292
Cdd:cd11235 147 PPLRTEYHDSKWLNEPQFVGAFDIGDYVYFFFREIAVEYINCGKAVYSRVARVCKNDQGGSRSLEKKWTTFLKARLNCSV 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 293 PGEFPFYFDEIQAISPIVESGSK-SLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKP 371
Cdd:cd11235 227 PGEFPFYFNELQDVFDLPSPSNKeKIFYAVFTTPYNSIPGSAVCAYSLSDIEAVFNGPFKEQHSSNSAWLPVPDERVPEP 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 372 RPGQCVEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSGAyYDVIYSGTDDGKVTKF 451
Cdd:cd11235 307 RPGTCVDDSSPLPDDTLNFIKSHPLMDEAVTPILNRPLFIKTDVNYRFTKIAVDRVQAKLGQT-YDVLFVGTDRGIILKV 385
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 45552709 452 InilstHPNSTvDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPLH 509
Cdd:cd11235 386 V-----SLPEQ-GLQASNILEEMPVGPPPEPIQTMQLSRKRRSLYVGSETGVLQVPLA 437
Sema smart00630
semaphorin domain;
61-484 3.98e-140

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 417.92  E-value: 3.98e-140
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709     61 FKILDHNDEFVLVGAKDVIYNVSLNGLKEI-ARLEWHSTDADRELCALKGKHEW-DCHNYLRVYALRPNGEVLLCGTNSY 138
Cdd:smart00630   3 HLLLDEDNGTLYVGARNRLYQLSLNLILEAeLKTGPVLSSPDCEECVSKGKDPPtDCVNYIRLLLDYNEDRLLVCGTNAF 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709    139 KPRCRHytpvevsseeagsaghahamryevsrdveaqglcpyspaHNStyafadGHLYSATVADFSGGDPLIYREN---- 214
Cdd:smart00630  83 QPVCRL---------------------------------------RNL------GELYVGTVADFSGSDPAIPRSLsvrr 117
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709    215 --------LRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKA 286
Cdd:smart00630 118 lkgtsgvsLRTVLYDSKWLNEPNFVYAFESGDFVYFFFRETAVEDDNCGKAVHSRVARVCKNDVGGPRSLDKKWTSFLKA 197
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709    287 RLNCSVPGEFPFYFDEIQAISPIVE-SGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVER 365
Cdd:smart00630 198 RLECSVPGEDPFYFNELQAAFLLPPgSESDDVLYGVFSTSSNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQWLPYSR 277
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709    366 EQVPKPRPGQCVE---DSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLSgayYDVIYSG 442
Cdd:smart00630 278 GKVPYPRPGTCPNkppSSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKTDSNYLLTSIAVDRVATDGN---YTVLFLG 354
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|..
gi 45552709    443 TDDGKVTKFINILSTHPNstvdrlKTVVISEMQVLPLGTPIR 484
Cdd:smart00630 355 TSDGRILKVVLSESSSSS------ESVVLEEISVFPDGSPIS 390
Sema_6 cd11242
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ...
59-508 8.39e-134

The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200503 [Multi-domain]  Cd Length: 465  Bit Score: 404.59  E-value: 8.39e-134
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  59 DYFKILDHNDEfVLVGAKDVIYNVSLN-----GLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEVLLC 133
Cdd:cd11242  10 DFQRMLRINRT-LYIAARDHVYTVDLDashteEIVPSKKLTWRSRQADVENCRMKGKHKDECHNFIKVLVPRNDETLFVC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 134 GTNSYKPRCRHYtpvEVSSEEagsaghahamryEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYRE 213
Cdd:cd11242  89 GTNAFNPVCRNY---RIDTLE------------QDGEEISGMARCPFDAKQANVALFADGKLYSATVTDFLASDAVIYRS 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 214 -----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGG-PYSHGKSWTSFLKAR 287
Cdd:cd11242 154 lgdspTLRTVKYDSKWLKEPHFVHAVEYGDYVYFFFREIAVEYNTLGKVVFSRVARVCKNDMGGsPRVLEKQWTSFLKAR 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 288 LNCSVPGEFPFYFDEIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQ 367
Cdd:cd11242 234 LNCSVPGDSHFYFDVLQAVTDVIRINGRPVVLGVFTTQYNSIPGSAVCAFDMDDIEKVFEGRFKEQKSPDSAWTPVPEDR 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 368 VPKPRPGQCVED--------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAvhpqVKSLSGAY--YD 437
Cdd:cd11242 314 VPKPRPGCCAGSgsaekyktSNDFPDDTLNFIKTHPLMDEAVPSIINRPWFTRTMVRYRLTQIA----VDNAAGPYqnYT 389
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 438 VIYSGTDDGKVTKFinILSTHPNSTVDrlkTVVISEMQVL---------PLGTPIRELVISTSKNSLVVVSDGSLVSVPL 508
Cdd:cd11242 390 VVFLGSEAGTVLKF--LARIGPSGSNG---SVFLEEIDVYnpakcsydgEEDRRIIGLELDRASHALFVAFSGCVIRVPL 464
Sema_6D cd11269
The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed ...
55-476 3.24e-118

The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed predominantly in the nervous system during embryogenesis and it uses Plexin-A1 as a receptor. It displays repellent activity for dorsal root ganglion axons. Sema6D also acts as a regulator of late phase primary immune responses. In addition, Sema6D is overexpressed in gastric carcinoma, indicating that it may have an important role in the occurrence and development of the cancer. Sema6D is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200530 [Multi-domain]  Cd Length: 465  Bit Score: 364.35  E-value: 3.24e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  55 GNSTDY---FKILDHNDEFVLVGAKDVIYNVSLNGL--KEIA---RLEWHSTDADRELCALKGKHEWDCHNYLRVYALRP 126
Cdd:cd11269   2 GNESQHrldFQLMLKIRDTLYIAGRDQVYTVNLNEVpkTEVTpsrKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 127 NGEVLLCGTNSYKPRCRHY--TPVEVSSEEagsaghahamryevsrdVEAQGLCPYSPAHNSTYAFADGHLYSATVADFS 204
Cdd:cd11269  82 DEMVFVCGTNAFNPMCRYYrlSTLEYDGEE-----------------ISGLARCPFDARQTNVALFADGKLYSATVADFL 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 205 GGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYS-HGK 278
Cdd:cd11269 145 ASDAVIYRSmgdgsALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRvLEK 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 279 SWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQS 358
Cdd:cd11269 225 HWTSFLKARLNCSVPGDSFFYFDVLQSITDIIEINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDS 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 359 HWLPVEREQVPKPRPGQCV-----EDSRTLTSI---AVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAvhpqVKS 430
Cdd:cd11269 305 VWTAVPEDKVPKPRPGCCAkhglaEAYKTSIDFpdeTLSFIKSHPLMDSAVPSIIEEPWFTKTRVRYRLTAIA----VDH 380
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*...
gi 45552709 431 LSGAY--YDVIYSGTDDGKVTKFinILSTHPNSTVDrlkTVVISEMQV 476
Cdd:cd11269 381 AAGPHqnYTVIFVGSEAGVVLKI--LAKTSPFSLND---SVLLEEIEA 423
Sema_6B cd11267
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as ...
73-508 2.49e-111

The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as repellents for axon growth; this repulsive activity is mediated by its receptor Plexin A4. Sema6B is expressed in CA3, and repels mossy fibers in a Plexin A4 dependent manner. In human, it was shown that peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. Sema6B is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200528 [Multi-domain]  Cd Length: 466  Bit Score: 346.43  E-value: 2.49e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  73 VGAKDVIYNVSLNG-----LKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEVLLCGTNSYKPRCRHYTp 147
Cdd:cd11267  23 IGDRDNLYRVELDPtagteMRYHKKLTWRSNKNDINVCRMKGKHEGECRNFIKVLLLRDYGTLFVCGTNAFNPVCANYS- 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 148 veVSSEEagsaghahamryEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYRE-----NLRTEQYDL 222
Cdd:cd11267 102 --IDTLE------------PVGDNISGMARCPYDPKHANVALFADGMLFTATVTDFLAIDAVIYRSlgdspALRTVKHDS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 223 KQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGG-PYSHGKSWTSFLKARLNCSVPGEFPFYFD 301
Cdd:cd11267 168 KWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDMGGsQRVLEKQWTSFLKARLNCSVPGDSHFYFN 247
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 302 EIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCV---- 377
Cdd:cd11267 248 VLQAVSDILNLGGRPVVLAVFSTPTNSIPGSAVCAFDMTQVAAVFEGRFREQKSPESIWTPVPEELVPRPRPGCCAapgm 327
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 378 --EDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQvkslSGAY--YDVIYSGTDDGKVTKFIn 453
Cdd:cd11267 328 ryNSSSTLPDEVLNFVKTHPLMDEAVPSLGHAPWIVRTMTRYQLTHMVVDTE----AGPHgnHTVVFLGSTRGTVLKFL- 402
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45552709 454 ilsTHPNSTVDRL--KTVVISEMQVLPLG-------TPIRELVISTSKNS--LVVVSDGSLVSVPL 508
Cdd:cd11267 403 ---IIPNASSSEIsnQSVFLEELETYNPErcgwdspQAQKLLSLELDKGSggLLLAFPSCVVRVPV 465
Sema_5C cd11265
The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, ...
63-507 4.03e-109

The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, Sema5C was identified as an early development gene, which is expressed in stage 2 embryos with a striped pattern emerging at later stages. Sema5c may play a role in odor-guided behavior and in tumorigenesis. Sema5C belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200526 [Multi-domain]  Cd Length: 433  Bit Score: 339.45  E-value: 4.03e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  63 ILDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVyaLRPNGEVLL-CGTNSYKPR 141
Cdd:cd11265  13 LFDVARNQVIVGARDNLYRLSLDGLELLERASWPAAESKVALCQNKGQSEEDCHNYVKV--LLSYGKQLFaCGTNAFSPR 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 142 CRhYTPVEVSSEeagsaghahamryeVSRDVEAQGLCPYSPAHNSTYAFA-DGHLYSATVADFSGGDPLIYR-------E 213
Cdd:cd11265  91 CS-WREMENLTS--------------VTEWDSGVAKCPYSPHANITALLSsSGQLFVGSPTDFSGSDSAIYRtlgtsnkS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 214 NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGK-SWTSFLKARLNCSV 292
Cdd:cd11265 156 FLRTKQYNSKWLNEPQFVGSFETGNFVYFLFRESAVEYMNCGKVIYSRIARVCKNDVGGGTMLLKdNWTTFLKARLNCSL 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 293 PGEFPFYFDEIQAISPIVESGsksLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPV------ERE 366
Cdd:cd11265 236 PGEYPFYFDEIQGMTYLPDEG---ILYATFTTPENSIAGSAVCAFNLSSINAAFDGPFKHQESSGAAWERVnvnhrdHFN 312
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 367 QVPKPRPGQCVEDSRtltsiavnfiknHPLMEEAVPAVHGRPlltkvnLHH----RLTAIAV-------HPQVKslsgay 435
Cdd:cd11265 313 QCSSSSSSHLLESSR------------YQLMDEAVQPITLEP------LHHakleRFSHIAVdviptkiHQSVH------ 368
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45552709 436 ydVIYSGTDDGKVTKfiniLSTHPNSTvdrlKTVVISEMQVLPLG-TPIRELVISTSKNSLVVVSDGSLVSVP 507
Cdd:cd11265 369 --VLYVATTGGLIKK----ISVLPRTQ----ETCLVEIWQPLPTPdSPIKTMQYLKVTDSLYVGTELALMRIP 431
Sema_2A cd11238
The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted ...
64-500 2.73e-107

The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted semaphorin, signals through its receptor plexin B (PlexB) to regulate central and peripheral axon pathfinding. In the Drosophila embryo, Sema2A secreted by oenocytes interacts with PlexB to guide sensory axons. Sema2A is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200499 [Multi-domain]  Cd Length: 452  Bit Score: 335.55  E-value: 2.73e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  64 LDHNDEFVLVGAKDVI-----YNVSLNGLKeIARLEWHSTDADRELCALKGKHE-WDCHNYLRVYALRPNGEVLL-CGTN 136
Cdd:cd11238   8 LDEKRNALYVGAMDRVfrlnlYNINDTGNN-CARDELTLSPSDVSECVSKGKDEeYECRNHVRVIQPMGDGQTLYvCSTN 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 137 SYKPRCRhytpvEVSSeeagSAGHAHAMRYEVSRDVeaqGLCPYSPAHNSTYAFAD-GH------LYSATVADFSGGDPL 209
Cdd:cd11238  87 AMNPKDR-----VLDA----NLLHLPEYVPGPGNGI---GKCPYDPDDNSTAVWVEwGNpgdlpaLYSGTRTEFTKANTV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 210 IYRENL------------RTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHG 277
Cdd:cd11238 155 IYRPPLynntkgrhesfmRTLKYDSKWLDEPNFVGSFDIGDYVYFFFRETAVEYINCGKVVYSRVARVCKKDTGGKNVLR 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 278 KSWTSFLKARLNCSVPGEFPFYFDEIQAISPiVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFD-GEFKSQKDS 356
Cdd:cd11238 235 QNWTTFLKARLNCSISGEFPFYFNEIQSVYK-VPGRDDTLFYATFTTSENGFTGSAVCVFTLSDINAAFDtGKFKEQASS 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 357 QSHWLPVEREQVPKPRPGQCVEDSRTLTSIAVNFIKNHPLMEEAVPavHGRPLLTKVNlhHRLTAIAVhpQVKSLSGAYY 436
Cdd:cd11238 314 SSAWLPVLSSEVPEPRPGTCVNDSATLSDTVLHFARTHPLMDDAVS--HGPPLLYLRD--VVFTHLVV--DKLRIDDQEY 387
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45552709 437 DVIYSGTDDGKVTKfinILSTHPNSTVdrlKTVVISEMQVLPlGTPIRELVISTSKnSLVVVSD 500
Cdd:cd11238 388 VVFYAGSNDGKVYK---IVHWKDAGES---KSNLLDVFELTP-GEPIRAMELLPGE-FLYVASD 443
Sema_6A cd11266
The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, ...
73-452 1.16e-106

The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, Sema6A-plexin A2 signaling modulates granule cell migration by controlling centrosome positioning. Besides plexin A2, plexin A4 is also found to be a receptor of Sema6A. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. It is required for the clustering of boundary cap cells at the PNS/CNS interface and thus, prevents motoneurons from streaming out of the ventral spinal cord. At the dorsal root entry site, it organizes the segregation of dorsal roots. Sema6A may also be involved in axonal pathfinding processes in the periinfarct and homotopic contralateral cortex. Sema6A is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200527 [Multi-domain]  Cd Length: 466  Bit Score: 334.31  E-value: 1.16e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  73 VGAKDVIYNVSLNG--LKEI---ARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEVLLCGTNSYKPRCRHYT- 146
Cdd:cd11266  23 IAARDHIYTVDIDTshTEEIyfsKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKRNDDTLFVCGTNAFNPSCRNYKm 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 147 -PVEVSSEEagsaghahamryevsrdVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYRE-----NLRTEQY 220
Cdd:cd11266 103 dTLEFFGDE-----------------FSGMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSlgdspTLRTVKH 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 221 DLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYS-HGKSWTSFLKARLNCSVPGEFPFY 299
Cdd:cd11266 166 DSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNSMGKVVFPRVAQVCKNDMGGSQRvLEKQWTSFLKARLNCSVPGDSHFY 245
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 300 FDEIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCVeD 379
Cdd:cd11266 246 FNILQAVTDVIHINGRDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCA-G 324
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 380 SRTLTSIA---------VNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAvhpqVKSLSGAY--YDVIYSGTDDGKV 448
Cdd:cd11266 325 SSSLEKYAtsnefpddtLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLTKIA----VDNAAGPYqnHTVVFLGSEKGII 400

                ....
gi 45552709 449 TKFI 452
Cdd:cd11266 401 LKFL 404
Sema_5 cd11241
The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins ...
54-508 2.05e-104

The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. There are three subfamilies in class 5 semaphorins, namely 5A, 5B and 5C. Sema5A and Sema5B function as guidance cues for optic and corticofugal nerve development, respectively. Sema5A-induced cell migration requires Met signaling. Sema5C is an early development gene and may play a role in odor-guided behavior. Sema5A is also implicated in cancer. In a screening model for metastasis, the Drosophila Sema5A ortholog, Dsema-5C, has been found to be required in tumorigenicity and metastasis. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200502 [Multi-domain]  Cd Length: 438  Bit Score: 327.59  E-value: 2.05e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  54 IGNSTDYFKI-LDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALrpNGEVLL 132
Cdd:cd11241   3 IEYVSDFSRLvLDPTHDQLIVGARNYLFRLRLQSLSLLQAVPWNSDEDTKRQCQSKGKSVEECQNYVRVLLV--VGKNLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 133 -CGTNSYKPRCrhytpvevSSEEAGSAghahamrYEVSRDVEAQGLCPYSPAHNSTYAF-ADGHLYSATVADFSGGDPLI 210
Cdd:cd11241  81 tCGTYAFSPVC--------TIRKLSNL-------TQILDTISGVARCPYSPAHNSTALIsASGELYAGTVYDFSGRDPAI 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 211 YRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLK 285
Cdd:cd11241 146 YRSlggkpPLRTAQYNSKWLNEPNFVGSYEIGNHTYFFFRENAVEHQDCGKTVYSRIARVCKNDIGGRFLLEDTWTTFMK 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 286 ARLNCSVPGEFPFYFDEIQAISPIVESGsksLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPver 365
Cdd:cd11241 226 ARLNCSLPGEFPFYYNEIQGTFYLPETD---LIYAVFTTNVNGIAGSAICAFNLSAINQAFNGPFKYQENNGSAWLP--- 299
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 366 eqVPKPRPGQCVEDSR------TLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLhhRLTAIAVHpQVKSLSGAYYDVI 439
Cdd:cd11241 300 --TPNPHPNFQCTTSIdrgqpaNTTERDLQDAQKYQLMAEVVQPVTKIPLVTMDDV--RFSKLAVD-VVQGRGTQLVHIF 374
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45552709 440 YSGTDDGKVTKfinILSTHpnstvDRLKTVVISEMQVLP--LGTPIRELVISTSKNSLVVVSDGSLVSVPL 508
Cdd:cd11241 375 YVGTDYGTILK---MYQPH-----RSQKSCTLEEIKILPamKGEPITSLQFLKSEKSLFVGLETGVLRIPL 437
Sema_3 cd11239
The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins ...
52-511 2.45e-104

The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins (Sema3s) are secreted regulator molecules involved in the development of the nervous system, vasculogenesis, angiogenesis,and tumorigenesis. There are 7 distinct subfamilies named Sema3A to 3G. Sema3s function as repellent signals during axon guidance by repelling neurons away from the source of Sema3s. However, Sema3s that are secreted by tumor cells play an inhibitory role in tumor growth and angiogenesis (specifically Sema3B and Sema3F). Sema3s functions by forming complexes with neuropilins and A-type plexins, where neuropilins serve as the ligand binding moiety and the plexins function as signal transduction component. Sema3s primarily inhibit the cell motility and migration of tumor and endothelial cells by inducing collapse of the actin cytoskeleton via neuropilins and plexins. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200500 [Multi-domain]  Cd Length: 471  Bit Score: 328.55  E-value: 2.45e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  52 HFIGNSTDYFKIL-DHNDEFVLVGAKDVIYNVSLNGLKEIAR-LEWHSTDADRELCALKGKH-EWDCHNYLRVYALRPNG 128
Cdd:cd11239   2 LGSMNSLDYRSLLlDEDRDRLYVGGKDHILSLSLDNINQDPKkIYWPASPERIEECKMAGKDpNTECANFVRVLQPYNRT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 129 EVLLCGTNSYKPRCRhYTPVEVSSEEAGsaghahamRYEVSRDVEA-QGLCPYSPAHNSTYAFADGHLYSATVADFSGGD 207
Cdd:cd11239  82 HLYACGTGAFHPICA-FINVGRRLEDPI--------FKLDDSSLESgRGKCPFDPNQPFASVLIDGELYSGTAIDFMGRD 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 208 PLIYR-----ENLRTEQYDLKQLNQPDFVGAI-------ERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYS 275
Cdd:cd11239 153 AAIFRslghrHYIRTEQYDSRWLNEPKFVGAYlipdsdnPDDDKVYFFFREKAVEAEGSGKAIYSRVGRICKNDVGGQRS 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 276 HGKSWTSFLKARLNCSVPGE--FPFYFDEIQAISPIVESGSKS-LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKS 352
Cdd:cd11239 233 LVNKWSTFLKARLVCSVPGPdgIDTYFDELEDVFLLPTRDPKNpLIYGVFTTSSNVFKGSAVCVYSMADIRAAFNGPFAH 312
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 353 QKDSQSHWLPVErEQVPKPRPGQCveDSRTLTSI----------AVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAI 422
Cdd:cd11239 313 KEGPNYQWVEYQ-GKVPYPRPGTC--PSKTYGPLykstkdfpddVISFARSHPLMYNPVYPLHGRPLLIRTNVPYRLTQI 389
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 423 AVHpQVKSLSGaYYDVIYSGTDDGKVTKFINIlsthPNSTVDrLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGS 502
Cdd:cd11239 390 AVD-RVEAEDG-QYDVLFIGTDSGTVLKVVSL----PKENWE-MEEVILEELQVFKHPSPITSMEISSKRQQLYVGSAEG 462

                ....*....
gi 45552709 503 LVSVPLHHC 511
Cdd:cd11239 463 VVQLPLHRC 471
Sema_4 cd11240
The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 ...
55-508 6.48e-101

The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 semaphorins (Sema4s) are transmembrane regulator molecules involved in the development of the nervous system, immune response, cytoskeletal organization, angiogenesis, and cell-cell interactions. There are 7 distinct subfamilies in class 4 semaphorins, named 4A to 4G. Several class 4 subfamilies play important roles in the immune system and are called "immune semaphorins". Sema4A plays critical roles in T cell-DC interactions in the immune response. Sema4D/CD100, expressed by lymphocytes, promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. It is required for normal activation of B and T lymphocytes. Sema4B negatively regulates basophil functions through T cell-basophil contacts and significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. Sema4s not only influence the activation state of cells but also modulate their migration and survival. The effects of Sema4s on nonlymphoid cells are mediated by plexin D1 and plexin Bs. The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex and are involved in neural tube closure and development of cerebellar granules cells through receptor plexin B2. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200501 [Multi-domain]  Cd Length: 456  Bit Score: 318.97  E-value: 6.48e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  55 GNSTDYFKILDHNDEFVL-VGAKDVIYNVSLNGLKEI--ARLEWHSTDADRELCALKGKH-EWDCHNYLRVYALRPNGEV 130
Cdd:cd11240   4 EGIQNYSTLLLSEDEGTLyVGAREALFALNVSDISTElkDKIKWEASEDKKKECANKGKDnQTDCFNFIRILQFYNSTHL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 131 LLCGTNSYKPRCRHytpVEVSSeeaGSAGHAHAMryevsrdvEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLI 210
Cdd:cd11240  84 YVCGTFAFSPRCTY---INLSD---FSLSSIKFE--------DGKGRCPFDPAQRYTAIMVDGELYSATVNNFLGSEPVI 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 211 YR-----ENLRTEqYDLKQLNQPDFVGA----------IERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYS 275
Cdd:cd11240 150 SRnhsegNVLKTE-NTLRWLNEPAFVGSahiresidspDGDDDKIYFFFTETAVEYDFYEKVTVSRVARVCKGDLGGQRT 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 276 HGKSWTSFLKARLNCSVPGEfPFYFDEIQAIspIVESGS---KSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKS 352
Cdd:cd11240 229 LQKKWTTFLKAQLVCSQPDS-GLPFNVLRDV--FVLSPDswdATIFYGVFTSQWNVSGLSAVCAYSLEDIKKVFSGKYKE 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 353 QKDSQSHWLPvEREQVPKPRPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVhGRPLLTKVNLhhRLTAIA 423
Cdd:cd11240 306 FNRETSKWSR-YTGPVPDPRPGACITNsarsqgitsSLNLPDNVLTFVKDHPLMDEQVHPI-NRPLLVKSGV--NYTRIA 381
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 424 VHpQVKSLSGAYYDVIYSGTDDGKVTKFINIlsthpNSTVdrlktVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSL 503
Cdd:cd11240 382 VH-RVQALDGQTYTVLFLGTEDGFLHKAVSL-----DGGM-----HIIEEIQLFDQPQPVKNLLLSSSKGVLYVGSSSGV 450

                ....*
gi 45552709 504 VSVPL 508
Cdd:cd11240 451 VQVPL 455
Sema_5B cd11264
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed ...
64-508 1.15e-96

The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed in regions of the basal telencephalon in rat. Sema5B is an inhibitory cue for corticofugal axons and acts as a source of repulsion for the appropriate guidance of cortical axons away from structures such as the ventricular zone as they navigate toward and within subcortical regions. In addition to its role as a guidance cue, Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons. In addition, the sema domain of Sema5B can be cleaved of the whole protein and exerts its function in regulation of synapse morphology. Sema5B belongs to the class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200525 [Multi-domain]  Cd Length: 437  Bit Score: 307.29  E-value: 1.15e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  64 LDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVyaLRPNG-EVLLCGTNSYKPRC 142
Cdd:cd11264  14 LDLNRNQLIVGARNYLFRLSLHNVSLIQATEWGSDEDTRRSCQSKGKTEEECQNYVRV--LIVYGkKVFTCGTNAFSPVC 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 143 rhytpvevSSEEAGSAGhahamryEVSRDVEAQGLCPYSPAHNSTYAFAD-GHLYSATVADFSGGDPLIYRE-----NLR 216
Cdd:cd11264  92 --------TSRQVGNLS-------KVIERINGVARCPYDPRHNSTAVITSrGELYAATVIDFSGRDPAIYRSlgsvpPLR 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 217 TEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEvMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEF 296
Cdd:cd11264 157 TAQYNSKWLNEPNFIAAYDIGLFTYFFFRENAVE-HDCGKTVYSRVARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEI 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 297 PFYFDEIQAISPIVEsgsKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPvereqVPKPRPG-Q 375
Cdd:cd11264 236 PFYYNELQSTFYLPE---QDLIYGVFTTNVNSIAASAVCAFNLSAITQAFNGPFRYQENPRSAWLP-----TANPIPNfQ 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 376 C---VEDS--RTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLhhRLTAIAVhpQVKSLSGAYYDVIYSGTDDGKVTK 450
Cdd:cd11264 308 CgtlSDDSpnENLTERSLQDAQRLFLMNDVVQPVTVDPLVTQDSV--RFSKLVV--DIVQGKDTLYHVMYIGTEYGTILK 383
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 451 finILSTHPNStvdrLKTVVISEMQVLPLG--TPIRELVISTSKNSLVVVSDGSLVSVPL 508
Cdd:cd11264 384 ---ALSTTNRS----LRSCYLEEMQILPPGqrEPIRSLQILHSDRSLFVGLNNGVLKIPL 436
Sema_6E cd11270
The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed ...
59-508 7.54e-96

The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed predominantly in the nervous system during embryogenesis. It binds Plexin A1 and might utilize it as a receptor to repel axons of specific types during development. Sema6E acts as a repellent to dorsal root ganglion axons as well as sympathetic axons. Sema6E is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200531 [Multi-domain]  Cd Length: 462  Bit Score: 305.88  E-value: 7.54e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  59 DYFKILDHNdEFVLVGAKDVIYNVSLNGLKEI----ARLEWHSTDAdrELCALKGKHEWDCHNYLRVYALRPNGEVLLCG 134
Cdd:cd11270  10 DFQRMLRIN-HMVYIAARDHVFAINLSASLERivpqQKLTWKTKDV--EKCTVRGKNSDECYNYIKVLVPRNDETLFACG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 135 TNSYKPRCRHYTPVEVSSEeagsaghahamryevSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYRE- 213
Cdd:cd11270  87 TNAFNPTCRNYKMSSLEQD---------------GEEVIGQARCPFESRQSNVGLFAGGDFYSATMTDFLASDAVIYRSl 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 214 -----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGG-PYSHGKSWTSFLKAR 287
Cdd:cd11270 152 gesspVLRTVKYDSKWLREPHFLHAIEYGNYVYFFLSEIAVEYTTLGKVVFSRVARVCKNDNGGsPRVLERYWTSFLKAR 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 288 LNCSVPGEFPFYFDEIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQ 367
Cdd:cd11270 232 LNCSVPGDSFFYFDVLQSLTNVMQINHRPAVLGVFTTQANSITGSAVCAFYMDDIEKVFNGKFKEQRNSESAWTPVPDEA 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 368 VPKPRPGQCV--------EDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTaiavHPQVKSLSGAY--YD 437
Cdd:cd11270 312 VPKPRPGSCAgdgpaagyKSSTNFPDETLTFIKSYPLMDEAVPSVNNRPCFTRTTSRFKLT----QIAVDTAAGPYknYT 387
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45552709 438 VIYSGTDDGKVTKFINilSTHPNSTVDrlkTVVISEMQVL-PLGTPIRE-------LVISTSKNSLVVVSDGSLVSVPL 508
Cdd:cd11270 388 VVFLGSENGHVLKVLA--SMHPNSSYS---TQVLEDIDVYnPNKCNVRGedrrilgLELDKDHHALFVAFTGCVIRVPL 461
Sema_6C cd11268
The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called ...
59-452 7.49e-92

The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called semaphorin Y); Sema6C is highly expressed in adult brain and skeletal muscle and it shows growth cone collapsing activity. It may play a role in the maintenance and remodelling of neuronal connections. In adult skeletal muscle, this role includes prevention of motor neuron sprouting and uncontrolled motor neuron growth. The expression of Sema6C in adult skeletal muscle is down-regulated following denervation. Sema6C is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200529 [Multi-domain]  Cd Length: 465  Bit Score: 295.46  E-value: 7.49e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  59 DYFKILDHNdEFVLVGAKDVIYNVSLN------GLKEIARLEWHSTDAdrELCALKGKHEWDCHNYLRVYALRPNGEVLL 132
Cdd:cd11268  10 DFQRFLTLN-RTLLVAARDHVFSFDLQaeeegeGLVPNKYLTWRSQDV--ENCAVRGKLTDECYNYIRVLVPWDSQTLLA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 133 CGTNSYKPRCRHYTPVEVSSEeagsaghahamryevSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR 212
Cdd:cd11268  87 CGTNSFSPVCRSYGITSLQQE---------------GEELSGQARCPFDATQSNVAIFAEGSLYSATAADFQASDAVVYR 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 213 E-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGG-PYSHGKSWTSFLKA 286
Cdd:cd11268 152 SlgpqpPLRSAKYDSKWLREPHFVQALEHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGsPRALDRHWTSFLKL 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 287 RLNCSVPGEFPFYFDEIQAISPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVERE 366
Cdd:cd11268 232 RLNCSVPGDSTFYFDVLQALTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPVSED 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 367 QVPKPRPGQCV--------EDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTkvnlhhrLTAIAVHPQ--VKSLSGAYY 436
Cdd:cd11268 312 RVPSPRPGSCAgvggaalfSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLT-------LTSRALLTQvaVDGMAGPHS 384
                       410
                ....*....|....*...
gi 45552709 437 D--VIYSGTDDGKVTKFI 452
Cdd:cd11268 385 NitVMFLGSNDGTVLKVL 402
Sema_5A cd11263
The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse ...
56-508 2.11e-89

The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse Sema5A was identified as a protein that induces inhibitory responses during optic nerve development. Recent studies show that Sema5A controls innate immunity in mice. It also has been identified as a candidate gene for causing idiopathic autism in humans. Plexin B3 functions as a binding partner and receptor for Sema5A. Furthermore, Sema5A is also implicated in cancer. The role of the Drosophila Sema5A ortholog, Dsema-5C, in tumorigenicity and metastasis has been reported. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Sema5A belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200524 [Multi-domain]  Cd Length: 436  Bit Score: 288.08  E-value: 2.11e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  56 NSTDYFKI-LDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVyaLRPNGEVLL-C 133
Cdd:cd11263   5 NAVDFSQLtFDPGQKELIVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRV--LLVGGDRLFtC 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 134 GTNSYKPRCRHYTPVEVSseeagsaghahamryEVSRDVEAQGLCPYSPAHNSTYAF-ADGHLYSATVADFSGGDPLIYR 212
Cdd:cd11263  83 GTNAFTPICTNRTLNNLT---------------EIHDQISGMARCPYSPQHNSTALLtSSGELYAATAMDFPGRDPAIYR 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 213 E-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSMEvMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKAR 287
Cdd:cd11263 148 SlgilpPLRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVE-HDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKAR 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 288 LNCSVPGEFPFYFDEIQAISPIVEsgsKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPvereq 367
Cdd:cd11263 227 LNCSRPGEIPFYYNELQSTFFLPE---LDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLP----- 298
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 368 VPKPRPG-QC-VEDSR---TLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLhhRLTAIAVhpQVKSLSGAYYDVIYSG 442
Cdd:cd11263 299 YPNPNPNfQCgTMDQGlyvNLTERNLQDAQKFILMHEVVQPVTPVPYFMEDNS--RFSHVAV--DVVQGKDMLFHIIYLA 374
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45552709 443 TDDGKVTKFINILSTHPNStvdrlktVVISEMQVLP--LGTPIRELVISTSKNSLVVVSDGSLVSVPL 508
Cdd:cd11263 375 TDYGTIKKVLAPLNQSSSS-------CLLEEIELFPkrQREPIRSLQILHSQSVLFVGLQEHVIKIPL 435
Sema_3F cd11254
The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is ...
53-511 3.72e-87

The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is coexpressed with semaphorin3B. Both Sema3B and Sema3F proteins are candidate tumor suppressors that are down-regulated in highly metastatic tumors. Two receptor families, the neuropilins and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3F is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200515 [Multi-domain]  Cd Length: 470  Bit Score: 283.25  E-value: 3.72e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  53 FIGNSTDYfKIL--DHNDEFVLVGAKDVIYNVSLNGL-KEIARLEWHSTDADRELCALKGKHEWD-CHNYLRVYALRPNG 128
Cdd:cd11254   3 FLLNTSDY-RILlkDEDHDRMYVGSKDYVLSLDLHDInREPLIIHWPASPQRIEECILSGKGSNGeCGNFIRLIQPWNRT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 129 EVLLCGTNSYKPRCRHYTpvevsseeAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDP 208
Cdd:cd11254  82 HLYVCGTGAYNPVCAYIN--------RGRRAEDYMFRLEPDKLESGKGKCPYDPKQDSVSALINGELYAGVYIDFMGTDA 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 209 LIYRE-----NLRTEQYDLKQLNQPDFVGAI------ERNGYVL-FFFRELSMEvMNFGKAVYSRVARVCKNDRGGPYSH 276
Cdd:cd11254 154 AIFRTmgkqpAMRTDQYNSRWLNDPAFVHAHlipdssEKNDDKLyFFFREKSLE-APQSPAVLSRIGRVCLNDDGGHCCL 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 277 GKSWTSFLKARLNCSVPGE--FPFYFDEIQA--ISPiVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKS 352
Cdd:cd11254 233 VNKWSTFLKARLVCSVPGAdgIETHFDELRDvfIQP-TQDTKNPVIYAVFSTSGSVFKGSAVCVYSMADIRMVFNGPFAH 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 353 QKDSQSHWLPVErEQVPKPRPGQC--------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAV 424
Cdd:cd11254 312 KEGPNYQWMPYT-GKIPYPRPGTCpggtftpsMKSTKDYPDEVINFMRTHPLMYNAVYPVHRRPLVVRTNVNYRFTTIAV 390
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 425 HpQVKSLSGAyYDVIYSGTDDGKVTKFInILsthPNSTVDrLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLV 504
Cdd:cd11254 391 D-QVDAADGR-YEVLFLGTDRGTVQKVI-VL---PKDDLE-TEELTLEEVEVFKVPAPIKTMKISSKRQQLYVSSAVGVT 463

                ....*..
gi 45552709 505 SVPLHHC 511
Cdd:cd11254 464 HLSLHRC 470
Sema_3E cd11253
The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted ...
60-511 7.90e-84

The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. It is also highly expressed in metastatic cancer cells. Sema3E signaling, through its high affinity functional receptor Plexin D1, drives cancer cell invasiveness and metastatic spreading. Sema3E is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200514 [Multi-domain]  Cd Length: 471  Bit Score: 274.42  E-value: 7.90e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  60 YFKILDHNDEFVLVGAKDVIYNVSL----NGLKEIarlEWHSTDADRELCALKGKHEWDCHNYLRVYALRPNGEVLLCGT 135
Cdd:cd11253  11 HTMLLDEYQERLFVGGRDLLYSLSLerisANYKEI---HWPSTQLQVEDCIMKGRDKPECANYIRVLHHYNRTHLLACGT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 136 NSYKPRCRhYTPVEVSSEEagsaghaHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR--- 212
Cdd:cd11253  88 GAFDPVCA-FIRVGRGSED-------HLFQLESDKFERGRGRCPFDPNSSFISTLIGGELFVGLYSDYWGRDAAIFRtmn 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 213 --ENLRTEQYDLKQLNQPDFVGA--IERN-----GYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSF 283
Cdd:cd11253 160 hlAHIRTEHDDERLLKEPKFVGSymIPDNedpddNKVYFFFTEKALEAEGGNHAIYTRVGRVCANDQGGQRMLVNKWSTF 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 284 LKARLNCSVPGE--FPFYFDEIQAISPIVESGSKS-LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHW 360
Cdd:cd11253 240 LKTRLICSVPGPngIDTHFDELEDVFLLRTRDNKNpEIFGLFSTTSNIFKGYAICVYHMASIRAAFNGPFAHKEGPEYHW 319
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 361 lPVEREQVPKPRPGQCVED--------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHpQVKSLS 432
Cdd:cd11253 320 -SVYEGKVPYPRPGSCASKvngghygtTKDYPDEALRFARSHPLMYQAVKPVHKRPILVKTDGKYNLKQIAVD-RVEAED 397
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45552709 433 GaYYDVIYSGTDDGKVTKFINILsthpNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPLHHC 511
Cdd:cd11253 398 G-QYDVLFIGTDNGIVLKVITIY----NQETETMEEVILEELQVFKVPVPIISMEISSKRQQLYIGSESGVAQIRFHQC 471
Sema_3B cd11250
The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is ...
63-511 4.57e-83

The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is coexpressed with semaphorin 3F and both proteins are candidate tumor suppressors. Both Sema3B and Sema3F show high levels of expression in normal tissues and low-grade tumors but are down-regulated in highly metastatic tumors in the lung, melanoma cells, bladder carcinoma cells and prostate carcinoma. They are upregulated by estrogen and inhibit cell motility and invasiveness through decreased FAK phosphorylation and inhibition of MMP-2 and MMP-9 expression. Two receptor families, the neuropilins (NP) and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3B is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200511 [Multi-domain]  Cd Length: 471  Bit Score: 272.56  E-value: 4.57e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  63 ILDHNDEFVLVGAKDVIYNVSLNGL-KEIARLEWHSTDADRELCALKGKH-EWDCHNYLRVYALRPNGEVLLCGTNSYKP 140
Cdd:cd11250  14 LLDEERGRLFVGAKNYLASLSLDNIsKQEKKIYWPAPVEWREECNWAGKDiNTDCMNYVKILHHYNRTHLYACGTGAFHP 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 141 RCRHytpVEVsseeaGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYRE-----NL 215
Cdd:cd11250  94 TCAF---VEV-----GQRMEDHVFRLDPSRVEDGKGKSPYDPRHTAASVLVGDELYSGVATDLMGRDFTIFRSlgqrpSL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 216 RTEQYDLKQLNQPDFVGAI-------ERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARL 288
Cdd:cd11250 166 RTEQHDSRWLNEPKFVKVFwipesenPDDDKIYFFFRETAVEAAGLGKQSYSRIGQICRNDMGGQRSLVNKWTTFLKARL 245
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 289 NCSVPGE--FPFYFDEIQAISPIVESGSKS-LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEr 365
Cdd:cd11250 246 VCSVPGNegGDTHFDELRDVFLLQTRDKRNpLIYAVFSTSSSVFQGSAVCVYTMNDVRRAFLGPFAHKEGPNYQWVSYQ- 324
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 366 EQVPKPRPGQC-------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHpQVKSLSGaYYDV 438
Cdd:cd11250 325 GKVPYPRPGMCpsktfgsFESTKDFPDDVIQFARNHPLMFNPVLPLGGRPLFLRTGIPYTFTQIAVD-RVAAADG-HYDV 402
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45552709 439 IYSGTDDGKVTKFINIlsthPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPLHHC 511
Cdd:cd11250 403 MFIGTDVGSVLKVISV----PKGSWPSNEELLLEELHVFKDSSPITSMQISSKRQQLYVGSRSGVSQLPLHRC 471
Sema_3A cd11249
The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been ...
54-511 1.30e-82

The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been reported to inhibit the growth of certain experimental tumors and to regulate endothelial cell migration and apoptosis in vitro, as well as arteriogenesis in the muscle, skin vessel permeability, and tumor angiogenesis in vivo. The function of Sema3A is mediated through receptors neuropilin-1 (NP1) and plexins, although little is known about the requirement of specific plexins in its receptor complex. It is known however that Plexin-A4 is the receptor for Sema3A in the Toll-like receptor- and sepsis-induced cytokine storm during immune response. Sema3A is a member of the Class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200510 [Multi-domain]  Cd Length: 493  Bit Score: 271.87  E-value: 1.30e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  54 IGNSTDYFK-ILDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKH-EWDCHNYLRVYALRPNGEVL 131
Cdd:cd11249  26 LANSSSYHTfLLDEERGRLYVGAKDHIFSFNLVNIKDFQKIVWPVSPSRRDECKWAGKDiLKECANFIKVLKAYNQTHLY 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 132 LCGTNSYKPRCRHYtpvevsseEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIY 211
Cdd:cd11249 106 ACGTGAFHPVCTYI--------EVGHHPEDNIFRLEDSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIF 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 212 R-----ENLRTEQYDLKQLNQPDFVGAI-------ERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKS 279
Cdd:cd11249 178 RtlghhHPIRTEQHDSRWLNDPRFISAHlipesdnPEDDKIYFFFRENAIDGEHTGKATHARIGQLCKNDFGGHRSLVNK 257
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 280 WTSFLKARLNCSVPGE--FPFYFDEIQAISPIVESGSKS-LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDS 356
Cdd:cd11249 258 WTTFLKARLICSVPGPngIDTHFDELQDVFLMNSKDPKNpIVYAVFTTSSNIFKGSAVCMYSMTDIRRVFLGPYAHRDGP 337
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 357 QSHWLPVErEQVPKPRPGQC-------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHpQVK 429
Cdd:cd11249 338 NYQWVPFQ-GRVPYPRPGTCpsktfggFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIIIKTDVDYQFTQIVVD-RVE 415
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 430 SLSGAyYDVIYSGTDDGKVTKFINIlsthPNSTVDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPLH 509
Cdd:cd11249 416 AEDGQ-YDVMFIGTDMGTVLKVVSI----PKETWHDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSAIGVSQLPLH 490

                ..
gi 45552709 510 HC 511
Cdd:cd11249 491 RC 492
Sema_4G cd11262
The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and ...
52-508 4.80e-79

The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex. Sema4G and Sema4C proteins specifically bind to Plexin B2 expressed in the cerebellar granule cells. Sema4G and Sema4C are involved in neural tube closure and cerebellar granule cell development through Plexin B2.Sema4G belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200523 [Multi-domain]  Cd Length: 457  Bit Score: 261.24  E-value: 4.80e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  52 HFIGNSTDYFKILDHNDEFVL-VGAKDVIY-----NVSLNGLKEIarlEWHSTDADRELCALKGK-HEWDCHNYLRvYAL 124
Cdd:cd11262   2 RFRGPAQNYSTLLLEDESGRLyVGARGAIFslnasDISDSSALTI---DWEASPEQKHQCLKKGKnNQTECFNHVR-FLQ 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 125 RPNGEVL-LCGTNSYKPRCRhYTPVE---VSSeeagsaghahamRYEVSRDVeaqglCPYSPAHNSTYAFADGHLYSATV 200
Cdd:cd11262  78 RFNSTHLyTCGTHAFRPLCA-YIDAErftLSS------------QFEEGKEK-----CPYDPAKGYTGLIVDGQLYTASQ 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 201 ADFSGgDPLIYRE----NLRTEQYDLKQLNQPDFVGAI----ERNGYV------LFFFRELSME-VMNFGKAVYSRVARV 265
Cdd:cd11262 140 YEFRS-FPDIRRNspqpTLRTEEAPTRWLNDADFVGSVlvreSMNSSVgdddkiYFFFTERSQEeTAYFSQSRVARVARV 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 266 CKNDRGGPYSHGKSWTSFLKARLNCSVPgEFPFYFDEIQaiSPIVESGSK---SLIYAVFTTSVNAIPGSAVCAFNVDDI 342
Cdd:cd11262 219 CKGDRGGKKTLQRKWTSFLKARLVCYIP-EYEFLFNVLR--SVFVLWGSTpqdTVFYGIFGLEWKNVKASAICRYSLSDI 295
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 343 LAAFDGEFKSQKDSQSHWLPVEREqVPKPRPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKV 413
Cdd:cd11262 296 QTAFEGPYMEYQDSSSKWSRYTGK-VPEPRPGSCITDehrsqginsSQDLPDNVLDFVRRHPLMAEQVLPVEGRPLLFKR 374
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 414 NLHHrlTAIAVHPqVKSLSGAYYDVIYSGTDDGKVTKFINILSTHPnstvdrlktvVISEMQVLPLGTPIRELVISTSKN 493
Cdd:cd11262 375 NVIY--TKIAVQT-VRGLDGRVYDVLFLGTDEGWLHKAVVIGSAVH----------IIEELQVFREPQPVENLVISKKQN 441
                       490
                ....*....|....*
gi 45552709 494 SLVVVSDGSLVSVPL 508
Cdd:cd11262 442 SLYVGARSGVVQVPL 456
Sema_3G cd11255
The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is ...
64-511 1.30e-78

The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is identified as a primarily endothelial cell- expressed class 3 semaphorin that controls endothelial and smooth muscle cell functions in autocrine and paracrine manners, respectively. It is mainly expressed in the lung and kidney, and a little in the brain. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200516 [Multi-domain]  Cd Length: 474  Bit Score: 260.61  E-value: 1.30e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  64 LDHNDEFVLVGAKDVIYNVSLNGLKEIAR-LEWHSTDADRELCALKGKH-EWDCHNYLRVYALRPNGEVLLCGTNSYKPR 141
Cdd:cd11255  15 LDEYRDRLFLGGKDVLYSLRLDQTHPDAKeIHWPPLPGQREECIRKGKDpETECANFVRVLQPFNRTHLLACGTGAFQPV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 142 CRHYTpvevsseeAGSAGHaHAMRYEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR-----ENLR 216
Cdd:cd11255  95 CALIN--------VGHRGE-HVFSLDPTTVESGRGRCPHEPKRPFASTFTGGELYTGLTADFLGRDSVIFRgfgtrSPLR 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 217 TEQyDLKQLNQPDFVGAI-------ERNGYVLFFFRELSMEV-MNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARL 288
Cdd:cd11255 166 TET-DQRLLHEPRFVAAHlipdnadRDNDKVYFFFTERATETaEDDDGAIHSRVGRLCANDAGGQRVLVNKWSTFIKARL 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 289 NCSVPGE--FPFYFDEIQAISPIVESGSKSL-IYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEr 365
Cdd:cd11255 245 VCSVPGPhgIQTHFDQLEDVFLLRTKDGKSPeIYALFSTISNVFQGFAVCVYSMADIWEVFNGPFAHKDGPDHQWGPYE- 323
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 366 EQVPKPRPGQC-----VEDSRTLTSI------AVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHpQVKSLSGa 434
Cdd:cd11255 324 GKVPYPRPGVCpskitAQPGRAFRSTkdypdeVLQFARAHPLMWRPVYPSHRRPVLVKTGLPYRLTQIVVD-RVEAEDG- 401
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45552709 435 YYDVIYSGTDDGKVTKFINIlsTHPNSTVDrlKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPLHHC 511
Cdd:cd11255 402 YYDVMFIGTDSGSVLKVIVL--QKGNSAAG--EEVTLEELQVFKVPTPITEMEISVKRQMLYVGSRTGVAQVPLHRC 474
Sema_3D cd11252
The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted ...
63-511 1.43e-78

The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted semaphorin expressed during the development of the nervous system. In zebrafish, Sema3D is expressed in the ventral tectum. It guides retinal axons along the dorsoventral axis of the tectum and guides the laterality of retinal ganglion cell (RGC) projections. Both Sema3D knockdown or its ubiquitous overexpression induced aberrant ipsilateral projections. Proper balance of Sema3D is needed at the midline for the progression of RGC axons from the chiasm midline into the contralateral optic tract. Sema3D is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200513 [Multi-domain]  Cd Length: 474  Bit Score: 260.61  E-value: 1.43e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  63 ILDHNDEFVLVGAKDVIYNVSLNGL-KEIARLEWHSTDADRELCALKGKH-EWDCHNYLRVYALRPNGEVLLCGTNSYKP 140
Cdd:cd11252  14 LLDEERGRLLLGAKDHIYLLDLVDLnKNPKKIYWPAAKERVELCKLAGKDaNTECANFIRVLHPYNRTHVYVCGTGAFHP 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 141 RCrHYTPVEVSSEEAGSAGHAHAMryevsrdvEAQGL-CPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR------- 212
Cdd:cd11252  94 TC-GYIELGTHKEDRIFLLDTQNL--------ESGRLkCPFDPQQPFASVMTDEYLYAGTASDFLGKDTTFTRslgptpd 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 213 -ENLRTEQYDLKQLNQPDFVGAI-------ERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFL 284
Cdd:cd11252 165 hHYIRTDISEHYWLNGAKFIGTFpipdtynPDDDKIYFFFREASQDGSTSDKSVLSRVGRVCKNDVGGQRSLINKWTTFL 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 285 KARLNCSVPGE--FPFYFDEIQAISPIVESGSKS-LIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWL 361
Cdd:cd11252 245 KARLVCSIPGPdgADTHFDELQDIFLLPTRDERNpVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESPDHRWV 324
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 362 PVErEQVPKPRPGQC--------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHpQVKSLSG 433
Cdd:cd11252 325 QYE-GRIPYPRPGTCpsktydplIKSTKDFPDEVISFIKRHPLMYKSVYPLTGGPVFTRINVDYRLTQIVVD-HVAAEDG 402
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45552709 434 AyYDVIYSGTDDGKVTKFINIlsTHPNSTVDRlktVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPLHHC 511
Cdd:cd11252 403 Q-YDVMFLGTDIGTVLKVVSI--TKEKWTMEE---VVLEELQIFKHPSPILNMELSLKQQQLYIGSRDGLVQLSLHRC 474
Sema_4B cd11257
The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in ...
63-508 7.26e-74

The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in T and B cells, is an immune semaphorin. It functions as a negative regulatory of basophils through T cell-basophil contacts and it significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. In addition, T cell-derived Sema4B suppresses basophil-mediated Th2 skewing and humoral memory responses. Sema4B may be also involved in lung cancer cell mobility by inducing the degradation of CLCP1 (CUB, LCCL-homology, coagulation factor V/VIII homology domains protein). Sema4B is characterized by a PDZ-binding motif at the carboxy-terminus, which mediates interaction with the post-synaptic density protein PSD-95/SAP90, which is thought to play a central role during synaptogenesis and in the structure and function of post-synaptic specializations of excitatory synapses. Sema4B belongs to class 4 transmembrane semaphorin family proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200518 [Multi-domain]  Cd Length: 464  Bit Score: 247.85  E-value: 7.26e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  63 ILDHNDEFVLVGAKDVIYNVSLNGL---KEIARLEWHSTDADRELCALKGKH-EWDCHNYLRVYaLRPNGEVL-LCGTNS 137
Cdd:cd11257  14 LLSKDGNMLYVGARETLFALSSNDIsptGEQQELTWSADEEKKQECSFKGKDpQRDCQNYIKIL-LRLNSTHLfTCGTYA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 138 YKPRCRhYTPVEVSSEEAGSAGHAhamryeVSRDveAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYREN--- 214
Cdd:cd11257  93 FSPICT-YIVMTNFSLERDEKGEP------LLED--GKGRCPFDPEYKSTAIMVDGELYTGTVSNFQGNDPIIYRSLgsg 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 215 --LRTEQyDLKQLNQPDFVG----------AIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTS 282
Cdd:cd11257 164 tpLKTEN-SLNWLQDPAFVGsayiqeslpkLVGDDDKIYFFFSETGKEFDFFENTIVSRIARVCKGDEGGERVLQKRWTT 242
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 283 FLKARLNCSVPGE-FPF-YFDEIQAISPIVESGSKSLIYAVFTTSVN--AIPGSAVCAFNVDDILAAFDGEFKSQKDSQS 358
Cdd:cd11257 243 FLKAQLLCSLPDDgFPFnVLQDVFVLTPSPEDWKDTLFYGVFTSQWHkgTAGSSAVCVFTMDQVQRAFNGLYKEVNRETQ 322
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 359 HWLPVErEQVPKPRPGQCVEDSRTLTSI---------AVNFIKNHPLMEEavpAVHGRPLLTKVNLHHrlTAIAVHpQVK 429
Cdd:cd11257 323 QWYTYT-HPVPEPRPGACITNSARERKInsslhmpdrVLNFVKDHFLMDG---QVRSQPLLLQPQVRY--TQIAVH-RVK 395
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45552709 430 SLSGAyYDVIYSGTDDGKVTKFINILSthpnstvdrlKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPL 508
Cdd:cd11257 396 GLHKT-YDVLFLGTDDGRLHKAVSVGP----------MVHIIEELQIFSEGQPVQNLLLDTHKGLLYASSHSGVVQVPV 463
Sema_4D cd11259
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); ...
50-508 7.80e-72

The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); Sema4D/CD100 is expressed in immune cells and plays critical roles in immune response; it is thus termed an "immune semaphorin". It is expressed by lymphocytes and promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. Sema4D/CD100 knock-out mice demonstrate that Sema4D is required for normal activation of B and T lymphocytes. Sema4D increases B-cell and DC function using either Plexin B1 or CD72 as receptors. The function of Sema4D in immune response implicates its role in infectious and noninfectious diseases. Sema4D belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200520 [Multi-domain]  Cd Length: 471  Bit Score: 242.45  E-value: 7.80e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  50 LAHF-IGNSTDYFKILDHNDEFVL-VGAKDVIYNVS-LNGLKEIARLEWHSTDADRELCALKGKHEW-DCHNYLRVYALR 125
Cdd:cd11259   9 LVHFhEPDVSNYSTLLLSEDKDVLyVGAREAVFALNaLNISEKQHELYWKVSEDKRTKCAVKGKSKQtECRNYIRVLQPL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 126 PNGEVLLCGTNSYKPRCRHYTPVEVSSEEagsaghahamryevsRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSG 205
Cdd:cd11259  89 NDTFLYVCGTNAFQPTCDYLNLTSFRLLG---------------KNEDGKGRCPFDPAQSYTSVMVDGELYSGTSYNFLG 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 206 GDPLIYREN----LRTEqYDLKQLNQPDFVGA-IERNG---------YVLFFFRELSMEVMNFGKAVYSRVARVCKNDRG 271
Cdd:cd11259 154 SEPIISRNSsqspLRTE-YAIPWLNEPSFVFAdVIRADpdspdgeddKIYFFFTEVSVEYEFVGKLLIPRIARVCKGDQG 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 272 GPYSHGKSWTSFLKARLNCSVPgEFPFYFDEIQAISPIVESGSK-SLIYAVFTTSVNAIPGSAVCAFNVDDILAAFD-GE 349
Cdd:cd11259 233 GLRTLQKKWTSFLKARLICSIP-DKNLVFNVVNDVFILKSPTLKePVIYGVFTPQLNNVGLSAVCAYNLSTVEEVFSkGK 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 350 F-KSQKDSQSH--WLPVEREqVPKPRPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHH 417
Cdd:cd11259 312 YmQSATVEQSHtkWVRYNGE-VPKPRPGACINNearaanytsSLNLPDKTLQFVKDHPLMDDSVTPIGNRPRLIKKDVNY 390
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 418 rlTAIAVHpQVKSLSGAYYDVIYSGTDDGKVTKFINILSthpnstvdrlKTVVISEMQVLPLGTPIRELVIST--SKNSL 495
Cdd:cd11259 391 --TQIVVD-RVQALDGTIYDVMFISTDRGALHKAISLEN----------EVHIIEETQLFPDFEPVQTLLLSSkkGRRFL 457
                       490
                ....*....|...
gi 45552709 496 VVVSDGSLVSVPL 508
Cdd:cd11259 458 YAGSNSGVVQSPL 470
Sema_4F cd11261
The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in ...
50-507 2.38e-71

The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in heterotypic cell-cell contacts and controls cell proliferation and suppresses tumorigenesis. In neurofibromatosis type 1 (NF1) patients, reduced Sema4F level disrupts Schwann cell/axonal interactions. Experiments using a yeast two-hybrid system show that the extreme C-terminus of Sema4F interacts with the PDZ domains of post-synaptic density protein SAP90/PSD-95, indicating possible functional involvement of Semas4F at glutamatergic synapses. Recent work also suggests a role for Sema4F in the injury response of intramedullary axotomized motoneuron. Sema4F belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulator molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200522 [Multi-domain]  Cd Length: 460  Bit Score: 240.94  E-value: 2.38e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  50 LAHFIGNSTDYFKIL--DHNDEFVLVGAKDVIYNVSLNGLKEIA-RLEWHSTDADRELCALKGKHEWDCHNYLRVYALRP 126
Cdd:cd11261   3 LTRFSAPHTYNYSVLlvDPASHTLYVGARDAIFALTLPFSGERPrRIDWMVPEAHRQNCRKKGKKEAECHNFIRILAIAN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 127 NGEVLLCGTNSYKPRCRHytpVEVSSEEagsaghahamryEVSRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGG 206
Cdd:cd11261  83 ASHLLTCGTFAFDPKCGV---IDVSSFQ------------QVERLESGRGKCPFEPAQRSAAIMAGGVLYAATVKNFLGT 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 207 DPLIYRENLRTEQY-----DLKQLNQPDFVGAI----------ERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRG 271
Cdd:cd11261 148 EPIISRAVGRAEEWirtetLPSWLNAPAFVAAVflspaewgdeDGDDEIYFFFTETAREYDSYERIKVPRVARVCAGDLG 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 272 GPYSHGKSWTSFLKARLNCSVP--GEFPFYFDEIQAISPIVESGSkSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGE 349
Cdd:cd11261 228 GRKTLQQRWTTFLKADLLCPGPehGRASSILQDVTTLRPLPGAGT-PIFYGIFSSQWEGASISAVCAFRPQDIRRVMNGP 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 350 FKSQKDSQSHWLPVEREQVPKPRPGQCVEDSRTLTSIA---------VNFIKNHPLMEEAVPAVHGRPLLTKVN-LHHRL 419
Cdd:cd11261 307 FREFKHDCNRGLPVMDSDVPQPRPGECITNNMKLLGFGsslslpdrvLTFVRDHPLMDRPVFPADGHPLLVTTDtAYLRV 386
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 420 taiAVHpQVKSLSGAYYDVIYSGTDDGKVTKFINILSthpnstvdrlKTVVISEMQVLPLGTPIRELVIstSKNSLVVVS 499
Cdd:cd11261 387 ---AAH-RVTSLSGKEYDVLYLGTEDGHLHRAVRIGA----------QLSVLEDLALFPEPQPVENLQL--HHNWLLVGS 450

                ....*...
gi 45552709 500 DGSLVSVP 507
Cdd:cd11261 451 DTEVTQIN 458
Sema_3C cd11251
The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted ...
56-511 4.97e-68

The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted semaphorin expressed in and adjacent to cardiac neural crest cells, and causes impaired migration of neural crest cells to the developing cardiac outflow tract, resulting in the interruption of the aortic arch and persistent truncus arteriosus. It has been proposed that Sema3C acts as a guidance molecule, regulating migration of neural crest cells that express semaphorin receptors such as plexin A2. Sema3C may also participate in tumor progression. The cleavage of Sema3C induced by ADAMTS1 promotes the migration of breast cancer cells. Sema3C is a member of the class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200512 [Multi-domain]  Cd Length: 470  Bit Score: 232.09  E-value: 4.97e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  56 NSTDYfKIL--DHNDEFVLVGAKDVIYNVSLNGLKEIA-RLEWHSTDADRELCALKGKH-EWDCHNYLRVYALRPNGEVL 131
Cdd:cd11251   6 RPLDY-RILfmDEDQDRIYVGSKDHILSLNINNISQDAlSIFWPASASKVEECKMAGKDpTHGCGNFVRVIQPYNRTHLY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 132 LCGTNSYKPRCRHYTPVEVSSEEAgsaghahamrYEVSRDVEA-QGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLI 210
Cdd:cd11251  85 VCGSGAFSPVCVYVNRGRRSEEQV----------FHIDSKAESgKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAI 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 211 YRE-----NLRTEQYDLKQLNQPDFV-------GAIERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGK 278
Cdd:cd11251 155 FRSltkrnAVRTDQHNSKWLSEPIFVdahlipdGTDPNDAKLYFFLKERLTDNSGSTKQIHSMIARVCPNDTGGQRSLVN 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 279 SWTSFLKARLNCSVPGE--FPFYFDEIQAISPI-VESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKD 355
Cdd:cd11251 235 KWTTFLKARLVCSVMDEdgTETHFDELEDVFLLeTDNPRTTLVYGIFTTSSSVFKGSAVCVYHMSDIQTVFNGPFAHKEG 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 356 SQSHWLPVErEQVPKPRPGQC--------VEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHpQ 427
Cdd:cd11251 315 PNHQLIAYQ-GRIPYPRPGTCpggaftpnMQSTKEFPDDVVTFIRNHPLMFNPIYPIGRRPLLVRTGTDYKYTKIAVD-R 392
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 428 VKSLSGAYYdVIYSGTDDGKVTKFInILSThpNSTVDrlKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVP 507
Cdd:cd11251 393 VNAADGRYH-VLFLGTDKGTVQKVV-VLPT--NGSLS--GELILEELEVFKNHAPITNMKISSKKQQLYVSSEEGISQVS 466

                ....
gi 45552709 508 LHHC 511
Cdd:cd11251 467 LHRC 470
Sema_4E cd11260
The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed ...
59-508 2.57e-67

The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed in the epithelial cells that line the pharyngeal arches in zebrafish. It may act as a guidance molecule to restrict the branchiomotor axons to the mesenchymal cells. Gain-of-function and loss-of-function studies demonstrate that Sema4E is essential for the guidance of facial axons from the hindbrain into their pharyngeal arch targets and is sufficient for guidance of gill motor axons. Sema4E guides facial motor axons by a repulsive action. Sema4E belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200521 [Multi-domain]  Cd Length: 456  Bit Score: 229.79  E-value: 2.57e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  59 DYFKILDHNDEFVLV-GAKDVIYNVSLNGLK-EIARLEWHSTDADRELCALKGKH-EWDCHNYLRVYALRPNGEVLLCGT 135
Cdd:cd11260   8 NYSTMLLREDLGLLVlGAREAVFALDLNDISvKRAKVLWEVTEEKQKDCTNKGKHaDIDCHNYIRILHKMNDSRMYVCGT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 136 NSYKPRCRHYTPVEvsseeagsaghaHAMRYEVSRDvEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR--- 212
Cdd:cd11260  88 NAFSPTCDYISYDD------------GQLTLEGKQE-DGKGKCPFDPFQRYSSVMVDQDLYSATSMNFLGSEPVIMRssp 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 213 ENLRTEqYDLKQLNQPDFV-------GAIERNG---YVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTS 282
Cdd:cd11260 155 ITIRTE-FKSSWLNEPNFIymaavpeSEDSPEGdddKIYLFFSETAVEYDFYNKLVVSRVARVCKGDLGGQRTLQKKWTS 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 283 FLKARLNCSVP-GEFPFYFDEIQAISPivESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAF-DGEFKSQ---KDSQ 357
Cdd:cd11260 234 FLKARLDCSVPePSLPYVIQDVFHVCH--QDWRKCVFYAVFTSQSDSSQSSAVCAYNVTDISNVFsRGKFKTPvavETSF 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 358 SHWLPVEREqVPKPRPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNlhHRLTAIAVHpQV 428
Cdd:cd11260 312 VKWVMYSGE-LPVPRPGACINNaartsgikkSLNLPDKTLQFVKDKPLMDQAVHPITGKPLLVKRG--ALFTRIVVD-MV 387
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 429 KSLSGAYYDVIYSGTDDGKVTKFINILSthpnstvdrlKTVVISEMQVLPLGTPIRelVISTSKNSLVVVSDGSLVSVPL 508
Cdd:cd11260 388 TAADGQSYPVMFIGTANGYVLKAVNYDG----------EMHIIEEVQLFEPEEPID--ILRLSQNQLYAGSASGVVQMPV 455
Sema_4A cd11256
The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed ...
63-508 4.53e-64

The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed in immune cells and is thus termed an "immune semaphorin". It plays critical roles in T cell-DC interactions in the immune response. It has been reported to enhance activation and differentiation of T cells in vitro and generation of antigen-specific T cells in vivo. The function of Sema4A in the immune response implicates its role in infectious and noninfectious diseases. Sema4A exerts its function through three receptors, namely Plexin B, Plexin D1, and Tim-2. Sema4A belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. TThe Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200517 [Multi-domain]  Cd Length: 447  Bit Score: 220.94  E-value: 4.53e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  63 ILDHNDEFVLVGAKDVIYNVSLNG---LKEIARLEWHSTDADRELCALKGK-HEWDCHNYLRVYALRPNGEVLLCGTNSY 138
Cdd:cd11256  14 LLSPDETTLYVGARDNILALGIRTpgpIRLKHQIPWPANDSKISECAFKKKsNETECFNFIRVLVPVNGTHLYTCGTYAF 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 139 KPRC-----RHYTPVEVSSEEagsaghahamryevsRDVEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYRE 213
Cdd:cd11256  94 SPACtyielDHFSLPPPNGTI---------------ITMDGKGQSPFDPQHNYTAILVDGELYTGTMNNFRGNEPIIFRN 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 214 -----NLRTEQYdLKQLN-QPDFVGAIERNGY--VLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLK 285
Cdd:cd11256 159 lgtkvSLKTDGF-LRWLNaDAVFVASFNPQGDskVYFFFEETAREFDFFEKLTVARVARVCKNDVGGEKLLQKKWTTFLK 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 286 ARLNCSVPGEFPFYFDEIQAISPiVESGSKSLIYAVFTT--SVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWlPV 363
Cdd:cd11256 238 AQLTCSQQGHFPFNVIHHVALLN-QPDPNNSVFYAVFTSqwQLGGRRSSAVCAYKLNDIEKVFNGKYKELNKESSRW-TR 315
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 364 EREQVPKPRPGQCVEDSRTLTsiAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHrlTAIAVHpQVKSLSGAYYDVIYSGT 443
Cdd:cd11256 316 YMGPVSDPRPGSCSGGKSSDK--ALNFMKDHFLMDEVVLPGAGRPLLVKSNVQY--TRIAVD-SVQGVSGHNYTVMFLGT 390
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45552709 444 DDGKVTKFI--NILSTHpnstvdrlktvVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPL 508
Cdd:cd11256 391 DKGFLHKAVlmGGSESH-----------IIEEIELLTPPEPVENLLLAANEGVVYIGYSAGVWRVPL 446
Sema_4C cd11258
The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a ...
64-508 5.09e-62

The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a Plexin B2 ligand to regulate the development of cerebellar granule cells and to modulate ureteric branching in the developing kidney. The binding of Sema4C to Plexin B2 results the phosphorylation of downstream regulator ErbB-2 and the plexin protein itself. The cytoplasmic region of Sema4C binds a neurite-outgrowth-related protein SFAP75, suggesting that Sema4C may also play a role in neural function. Sema4C belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200519 [Multi-domain]  Cd Length: 458  Bit Score: 215.44  E-value: 5.09e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  64 LDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGK-HEWDCHNYLRVYALRPNGEVLLCGTNSYKPRC 142
Cdd:cd11258  17 LAEHRGLLYVGAREAIFALSLSNIELQPPISWEAPAEKKTECAQKGKsNQTECFNYIRFLQPYNQSHLYTCGTYAFQPKC 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 143 RhYTPVEVSSEEAGSaghahamrYEvsrdvEAQGLCPYSPAHNSTYAFADGHLYSATVADFSGGDPLIYR----ENLRTE 218
Cdd:cd11258  97 A-YINMLTFTLDRAE--------FE-----DGKGKCPYDPAKGHTGLIVDGELYSATLNNFLGTEPVILRnlgqHYSMKT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 219 QYDLKQLNQPDFVGA----------IERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARL 288
Cdd:cd11258 163 EYLAFWLNEPHFVGSafvpesvgsfTGDDDKIYFFFSERAVEYDCDSEQVVARVARVCKGDLGGARTLQKKWTTFLKARL 242
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 289 NCSVPgEFPFYFDEIQAISPI-VESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWlPVEREQ 367
Cdd:cd11258 243 LCSIP-EWQLYFNQLKAVFTLeGASWRNTTFFAVFQARWGDMDVSAVCEYQLGEIQQVFEGPYKEYSEQAQKW-GRYTDP 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 368 VPKPRPGQCVED---------SRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNlHHRLTAIAVhpQVKSLSGAYYDV 438
Cdd:cd11258 321 VPSPRPGSCINNwhrdhgytsSLELPDNTLNFVKKHPLMEDRVKPRLGRPLLVPCN-SNFTHVVWT--RVLGLDGETYSV 397
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 439 IYSGTDDGKVTKFInilSTHPNSTvdrlktvVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPL 508
Cdd:cd11258 398 LFIGTLDGWLIKAV---SLGSWVH-------MIEELQVFDQEPPESLVVSQSSKKLLFAGSRSELLQLPW 457
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
303-489 2.45e-56

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 190.56  E-value: 2.45e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709   303 IQAIS---PIVESGSKSLIYAVFTTS-VNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREqVPKPRPGQCVE 378
Cdd:pfam01403   1 LQDVFvlkPGAGDALDTVLYGVFTTQwSNSIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPYTGK-VPYPRPGTCIN 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709   379 DSR--TLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNlhHRLTAIAVHpQVKSLSGAyYDVIYSGTDDGKVTKFINILS 456
Cdd:pfam01403  80 DPLrlDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTG--VRLTSIAVD-RVQALDGN-YTVLFLGTDDGRLHKVVLVGS 155
                         170       180       190
                  ....*....|....*....|....*....|...
gi 45552709   457 THPnstvdrlktVVISEMQVLPLGTPIRELVIS 489
Cdd:pfam01403 156 EES---------HIIEEIQVFPEPQPVLNLLLS 179
Sema cd09295
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
59-508 4.74e-53

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


Pssm-ID: 200495 [Multi-domain]  Cd Length: 392  Bit Score: 188.95  E-value: 4.74e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  59 DYFKILDHNDEF-VLVGAKDVIYNVSLNGLKE-----IARLEWHSTDADRELCALKGKHEWDCHNYLRVyaLRPNGE--- 129
Cdd:cd09295   1 DDDKILVSFRKDtIYVGAIARIYKVDGGGTRLllsciSPELNFGFNEDQKAFCPLRRGKWTECINYIKV--LQQKGDldi 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 130 VLLCGTNSYKPRCRHY--TPVEVSSEEAGSAGHahamryevsrdveaqGLCPYSPAHNSTYAFADGHLYSATVADFSGGD 207
Cdd:cd09295  79 LAVCGSNAAQPSCGSYrlDVLVELGKVRWPSGR---------------PRCPIDNKHSNMGVNVDSKLYSATDHDFKDGD 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 208 -PLIYRE-----NLRTEQYDLKQLNQPDFVGAI---ERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGK 278
Cdd:cd09295 144 rPALSRRssnvhYLRIVVDSSTGLDEITFVYAFvsgDDDDEVYFFFRQEPVEYLKKGMVYVPRIARVCKLDVGGCHRLKK 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 279 SWTSFLKARLNCSVPG---EFPFYFDEIQAISPIVEsgskSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDgefksqkd 355
Cdd:cd09295 224 KLTSFLKADLNCSRPQsgfAFNLLQDATGDTKNLIQ----DVKFAIFSSCLNKSVESAVCAYLFTDINNVFD-------- 291
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 356 sqshwlpvereqvpkprpgqcvedsrtltsiavnfiknhplmeEAVPAVHGRPLLTKVNLHHRLTAIAVHpqVKSLSGAY 435
Cdd:cd09295 292 -------------------------------------------DPVEAINNRPLYAHQNQRSRLTSIAVD--ATKQKSVG 326
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45552709 436 YDVIYSGTDDGKVTKFinILSTHPNstvdrlKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPL 508
Cdd:cd09295 327 YQVVFLGLKLGSLGKA--LAFFFLY------KGHIIEEWKVFKDSSRITNLDLSRPPLYLYVGSESGVLGVPV 391
Sema_7A cd11243
The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); ...
58-508 2.08e-45

The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); Sema7A plays regulatory roles in both immune and nervous systems. Unlike other semaphorins, which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Sema7A also plays a critical role in the negative regulation of T cell activation and function. Sema7A is a membrane-anchored member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200504 [Multi-domain]  Cd Length: 414  Bit Score: 168.10  E-value: 2.08e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709  58 TDYFKILDH--NDEFVLVGAKDVIYNVSLNGLKEIARLewhSTDADRELCALKGKHEWDCHNYLRVYALRPNGeVLLCGT 135
Cdd:cd11243   1 KESYPVFFHeaGSSSVYVGGQGALYLLDFTGSAVIVKK---IPDEKTEKDCKKRATLDDCENYITLIKKLDYR-LLVCGT 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 136 NSYKPRCRHYTPVEVSSEEAGsaghahamryevsrdveaQGLCPYSPAHNSTYAFADGHLYSAT--------VADFSGGD 207
Cdd:cd11243  77 NAGSPKCWFLVNQTLVTLSAD------------------RGVAPFLPDENSLVLIEGNNVYSTIsgkkgnipRFRRYGGK 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 208 PLIYRENlrteqydlKQLNQPDFVGAI------ERNGYVLFFFRELSMEVMNFGKAVYSRVARVCKNDRGG-PYSHGKSW 280
Cdd:cd11243 139 KELYTSD--------TVMQKPQFVKATllpedeQYQDKIYYFFREDNEDKGPEAEPNISRVARLCKEDQGGtSSLSTSKW 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 281 TSFLKARLNCSVPGEfPFYFDEIQAISPI-VESGSKSLIYAVFTTSVNAipgSAVCAFNVDDIlaafDGEFKSQKDSQSH 359
Cdd:cd11243 211 STFLKARLVCGDPAT-PMNFNRLQDVFLLpKEEWREAVVYGVFSNTWGS---SAVCSYSLGDI----DKVFRTSSLKGYS 282
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 360 wlpverEQVPKPRPGQCVEDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHrLTAIAVHpQVKSLSGAYYDVI 439
Cdd:cd11243 283 ------GSLPNPRPGTCVPPEQTHPSETFSFADEHPELDDRIEPDEPRKLPVFQNKDH-YQKVVVD-EVRASDGVSYDVL 354
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45552709 440 YSGTDDGKVTKFINilsthpnstvDRLKTVVISEMQVLPLGTPIRELVISTSKNSLVVVSDGSLVSVPL 508
Cdd:cd11243 355 YLATDKGKIHKVVE----------SKGQTHNIMEIQPFKEQEPIQSMILDAERSHLYVGTKAEVTRLPL 413
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
260-537 8.44e-10

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 61.87  E-value: 8.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 260 SRVARVCKNDrggPYSHgkswtSFLKARLNCsVPGEFPFYFDEIQAISPIVESGSKSL--------IYAVFTTSVNAI-- 329
Cdd:cd11272 241 SRIVRLCKDD---PKFH-----SYVSLPFGC-VRGGVEYRLLQAAYLSKPGEVLARSLnitaqedvLFAIFSKGQKQYhh 311
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 330 --PGSAVCAFNVDDILAAFDGEFKS----QKDSQSHWLPvereqvpkprpGQCVEDSRTLTSIAVNFIK---NHPLmEEA 400
Cdd:cd11272 312 ppDDSALCAFPIRAINAQIKERLQScyqgEGNLELNWLL-----------GKDVQCTKAPVPIDDNFCGldiNQPL-GGS 379
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 401 VPaVHGRPLLTKVnlHHRLTAIAvhpqvkslSGAY--YDVIYSGTDDGKVTKfinILSTHPNSTVDRLKTVvisemQVLP 478
Cdd:cd11272 380 TP-VEGVTLYTSS--RDRLTSVA--------SYVYngYSVVFVGTKSGKLKK---IRADGPPHGGVQYEMV-----SVFK 440
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 479 LGTPI-RELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHEC 537
Cdd:cd11272 441 DGSPIlRDMAFSIDHKYLYVMSERQVSRVPVESCEQYTTCGECLSSGDPHCGWCALHNMC 500
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
229-507 7.09e-07

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 52.47  E-value: 7.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 229 DFVGAIERNGYVLFFF-RELSMEVMNFgkavySRVARVCKNDrggpyshgKSWTSFLKARLNCSVPGEfpfYFDEIQAI- 306
Cdd:cd11276 191 QFRYAFEDNNYVYFLFnQQLGHPDKNR-----TLIARLCEND--------HHYYSYTEMDLNCRDGAN---AYNKCQAAy 254
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 307 ----------SPIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAF----DGEFKSQKDsqshwlpvEREQVPKP- 371
Cdd:cd11276 255 vstpgkelaqNYGNSILSDKVLFAVFSRDEKDSGESALCMFPLKSINAKMeanrEACYTGTID--------DRDVFYKPf 326
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 372 ---RPGQCVedsrtltSIAVNFIKNHPLMEEAVPAVHG--------RPLLTKVNLHhrLTAIAVHPQVKslsgayYDVIY 440
Cdd:cd11276 327 hsqKDIICG-------SHQQKNSKSFPCGSEHLPYPLGsrdelaltAPVLQRGGLN--LTAVTVAVENG------HTVAF 391
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45552709 441 SGTDDGKVTKfinilsTHPNSTVDRLKTVVISemqvlpLGTPI-RELVISTSKNSLVVVSDGSLVSVP 507
Cdd:cd11276 392 LGTSDGRILK------VHLSPDPEEYNSILIE------KNKPVnKDLVLDKTLEHLYIMTEDKVFRLP 447
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
211-508 2.22e-06

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 50.70  E-value: 2.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 211 YRENLRTEQYDLKQLNQpDFVGAIERNGYVLFFFR----ELSMEVMNFgkavysrVARVCKNDrggpyshgKSWTSFLKA 286
Cdd:cd11245 168 NEVEAKLVVGSASRYHH-DFVYAFADNGYIYFLFSrrpgTADSTKRTY-------ISRLCEND--------HHYYSYVEL 231
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 287 RLNCSVPGEFPFYFDEIQAISPIVESGSKSLIYAVFTTSVNAIPG----SAVCAFNVDDILAAFD--------GEFKSQK 354
Cdd:cd11245 232 PLNCTVNQENTYNLVQAAYLAKPGKVLNGKVLFGVFSADEASTAApdgrSALCMYPLSSVDARFErtrescytGEGLEDD 311
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 355 DSQSHWLPVEREQVPKPRPGQCVE-----DSRTLTSIAvnfiKNHPLMEEavpavhgrPLLTKVNLhhrLTAIAVHPQvk 429
Cdd:cd11245 312 KPETAYIEYNVKSICKTLPDKNVKaypcgAEHTPSPLA----SRYPLAAK--------PILTRNDM---LTAVAVAVE-- 374
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45552709 430 slsgAYYDVIYSGTDDGKVTK-FINILSTHPNSTvdrlktvvISEMQvlplGTPI-RELVISTSKNSLVVVSDGSLVSVP 507
Cdd:cd11245 375 ----NGHTIAFLGDSGGQLHKvYLDPNHTDFYST--------IPGDQ----DSAVnKDLLFDSTLNHLYVMTGKKISKVP 438

                .
gi 45552709 508 L 508
Cdd:cd11245 439 V 439
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
510-537 2.13e-04

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 39.45  E-value: 2.13e-04
                           10        20
                   ....*....|....*....|....*...
gi 45552709    510 HCSHIVDCLGCLSLQDPICAWDLQTHEC 537
Cdd:smart00423   1 RCSKYTSCSECLLARDPYCAWCSSQGRC 28
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
510-537 3.38e-04

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 39.23  E-value: 3.38e-04
                          10        20
                  ....*....|....*....|....*...
gi 45552709   510 HCSHIVDCLGCLSLQDPICAWDLQTHEC 537
Cdd:pfam01437   1 RCSQYTSCSSCLAARDPYCGWCSSEGRC 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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