Tomm70 translocase of outer mitochondrial membrane 70 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tomm70provided by RGD
Official Full Name: translocase of outer mitochondrial membrane 70provided by RGD
Primary source: RGD:1303049
See related: EnsemblRapid:ENSRNOG00000001640 AllianceGenome:RGD:1303049
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TOM70; Tomm70a
Summary: Predicted to enable mitochondrion targeting sequence binding activity and molecular adaptor activity. Predicted to contribute to protein transmembrane transporter activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; positive regulation of protein targeting to mitochondrion; and response to thyroxine. Located in mitochondrial outer membrane. Used to study congestive heart failure. Biomarker of hypothyroidism. Orthologous to human TOMM70 (translocase of outer mitochondrial membrane 70). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 219.0), Liver (RPKM 153.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (56847837..56886302, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (43378719..43417166, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (45477053..45511409, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

adenosine-induced translocation of PKCepsilon to mitochondria is mediated by a caveolin-3-dependent mechanism and this process is age-related, possibly in part, through regulation of HSP90 and TOM70 expression
Title: Regulation of protein kinase C-epsilon and its age-dependence.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125842 (e-PCR)
- UniSTS:142095

BF410432 (e-PCR)
- UniSTS:246824

Tomm70a (e-PCR), detects polymorphism
- UniSTS:507285

AI029154 (e-PCR)
- UniSTS:245991

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mitochondrion targeting sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to virus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interferon-beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to thyroxine	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial import receptor subunit TOM70

Names: mitochondrial precursor proteins import receptor; translocase of outer membrane 70 kDa subunit; translocase of outer mitochondrial membrane protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212519.2 → NP_997684.1 mitochondrial import receptor subunit TOM70

See identical proteins and their annotated locations for NP_997684.1

Status: PROVISIONAL

Source sequence(s)

BC098640

UniProtKB/Swiss-Prot

Q75Q39

UniProtKB/TrEMBL

A6IQN3

Related

ENSRNOP00000002238.6, ENSRNOT00000002238.8

Conserved Domains (2) summary

TIGR00990
Location:116 → 603

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:116 → 144

TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

56847837..56886302 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008768645.4 → XP_008766867.1 mitochondrial import receptor subunit TOM70 isoform X1

Conserved Domains (3) summary

sd00006
Location:116 → 144

TPR; TPR repeat [structural motif]

pfam00515
Location:116 → 148

TPR_1; Tetratricopeptide repeat

pfam13414
Location:115 → 186

TPR_11; TPR repeat