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    DppIII Dipeptidyl aminopeptidase III [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DppIIIprovided by FlyBase
    Official Full Name
    Dipeptidyl aminopeptidase IIIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037580
    Locus tag
    Dmel_CG7415
    See related
    AllianceGenome:FB:FBgn0037580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7415; Dmel\CG7415; DPP; DPP III
    Summary
    Enables dipeptidyl-peptidase activity. Involved in proteolysis. Located in cytosol and membrane. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; embryonic/larval midgut primordium; and larval ventral nerve cord. Orthologous to human DPP3 (dipeptidyl peptidase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DppIII in Genome Data Viewer
    Location:
    84F13-84F13; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8344400..8347465)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4170122..4173187)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor-like 2 Neighboring gene Polynucleotide kinase 3'-phosphatase Neighboring gene Cytochrome c oxidase subunit 7A-like Neighboring gene uncharacterized protein Neighboring gene mir-9380 stem loop Neighboring gene Autophagy-related 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification, partial sequencing and characterization of an insect membrane dipeptidyl aminopeptidase that degrades the insect neuropeptide proctolin. Mazzocco C, et al. Eur J Biochem, 2001 Sep. PMID 11559363
    2. Characterization of a functionally expressed dipeptidyl aminopeptidase III from Drosophila melanogaster. Mazzocco C, et al. Eur J Biochem, 2003 Jul. PMID 12846841
    3. SR proteins control a complex network of RNA-processing events. Bradley T, et al. RNA, 2015 Jan. PMID 25414008, Free PMC Article
    4. Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase. Chen CL, et al. Proc Natl Acad Sci U S A, 2015 Sep 29. PMID 26362788, Free PMC Article
    5. Evolutionary expressed sequence tag analysis of Drosophila female reproductive tracts identifies genes subjected to positive selection. Swanson WJ, et al. Genetics, 2004 Nov. PMID 15579698, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptidyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloexopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dipeptidyl aminopeptidase III
    Names
    CG7415-PB
    CG7415-PC
    Dipeptidyl-peptidase III
    DppIII-PB
    DppIII-PC
    dipeptidyl aminopeptidase
    NP_731237.1
    NP_731238.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8344400..8347465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169217.3 → NP_731237.1  dipeptidyl aminopeptidase III, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731237.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IHE9, Q961F1, Q9VHR8
      UniProtKB/TrEMBL
      Q6BCZ0
      Related
      FBpp0081331
      Conserved Domains (1) summary
      pfam03571
      Location:211 → 760
      Peptidase_M49; Peptidase family M49

    2. NM_169218.3 → NP_731238.1  dipeptidyl aminopeptidase III, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731238.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6BCZ0
      Related
      FBpp0081330
      Conserved Domains (1) summary
      pfam03571
      Location:148 → 697
      Peptidase_M49; Peptidase family M49
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHR8.2 Q9VHR8

    Gene LinkOut

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    Other Literature Sources
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