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    THADA THADA [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33001, updated on 9-Dec-2024

    Summary

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    Official Symbol
    THADAprovided by FlyBase
    Official Full Name
    THADAprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031077
    Locus tag
    Dmel_CG15618
    See related
    AllianceGenome:FB:FBgn0031077
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15618; Dmel\CG15618
    Summary
    Enables calcium channel inhibitor activity. Involved in adaptive thermogenesis and negative regulation of endoplasmic reticulum calcium ion concentration. Is active in cytoplasmic side of endoplasmic reticulum membrane. Is expressed in spermatozoon. Used to study obesity. Orthologous to human THADA (THADA armadillo repeat containing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See THADA in Genome Data Viewer
    Location:
    18F4-18F4; 1-64 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19859743..19865524, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19753776..19759557, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pico Neighboring gene Nucleoporin 205kD Neighboring gene Histone gene-specific Epigenetic Repressor in late S phase Neighboring gene amnesiac Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. THADA Regulates the Organismal Balance between Energy Storage and Heat Production. Moraru A, et al. Dev Cell, 2017 Apr 10. PMID 28399403, Free PMC Article
    2. Larval density can be used to predict genetic modifiers of glucagon signaling in Drosophila melanogaster. Nicol A, et al. PLoS One, 2024. PMID 39196987, Free PMC Article
    3. tRNA 2'-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila. Angelova MT, et al. Nucleic Acids Res, 2020 Feb 28. PMID 31943105, Free PMC Article
    4. Drosophila as a model to study obesity and metabolic disease. Musselman LP, et al. J Exp Biol, 2018 Mar 7. PMID 29514880
    5. Bilberry (Vaccinium myrtillus L.) Extracts Comparative Analysis Regarding Their Phytonutrient Profiles, Antioxidant Capacity along with the In Vivo Rescue Effects Tested on a Drosophila melanogaster High-Sugar Diet Model. Neamtu AA, et al. Antioxidants (Basel), 2020 Oct 30. PMID 33143302, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adaptive thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of endoplasmic reticulum calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of negative regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA nucleoside ribose methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic side of endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    THADA
    Names
    CG15618-PB
    CG15618-PC
    THADA-PB
    THADA-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19859743..19865524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134517.3 → NP_608361.3  THADA, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608361.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MQL6, Q9VWB9
      Conserved Domains (1) summary
      pfam10350
      Location:863 → 1112
      DUF2428; Putative death-receptor fusion protein (DUF2428)

    2. NM_001258841.1 → NP_001245770.1  THADA, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245770.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFG3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NFG3 M9NFG3
    Q9VWB9.3 Q9VWB9

    Gene LinkOut

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