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    Fbxo42 F-box protein 42 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37532, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxo42provided by FlyBase
    Official Full Name
    F-box protein 42provided by FlyBase
    Primary source
    FLYBASE:FBgn0034704
    Locus tag
    Dmel_CG6758
    See related
    AllianceGenome:FB:FBgn0034704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6758; Dmel\CG6758; FBXO6
    Summary
    Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of synaptonemal complex assembly. Part of SCF ubiquitin ligase complex. Orthologous to human FBXO42 (F-box protein 42). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fbxo42 in Genome Data Viewer
    Location:
    58C5-58C5; 2-98 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22174922..22177428)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18062427..18064933)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene arc Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45151 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FipoQ/FBXO33, a Cullin-1-based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein. Chen ZS, et al. J Neurochem, 2019 Jun. PMID 30685895
    2. SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56. Barbosa P, et al. J Cell Biol, 2021 Feb 1. PMID 33382409, Free PMC Article
    3. A conserved F-box gene with unusual transcript localization. Das T, et al. Dev Genes Evol, 2002 Apr. PMID 11976951
    4. F-box proteins: the key to protein degradation. Ho MS, et al. J Biomed Sci, 2006 Mar. PMID 16463014
    5. A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila. Dui W, et al. J Genet Genomics, 2012 Aug 20. PMID 22884096

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    involved_in positive regulation of synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    F-box protein 42
    Names
    CG6758-PA
    Fbxo42-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22174922..22177428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137803.3 → NP_611647.1  F-box protein 42 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611647.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W281
      Related
      FBpp0071681
      Conserved Domains (4) summary
      sd00038
      Location:103 → 148
      Kelch; KELCH repeat [structural motif]
      pfam12937
      Location:24 → 59
      F-box-like; F-box-like
      pfam13415
      Location:112 → 162
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:209 → 249
      Kelch_5; Kelch motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W281 Q9W281

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