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Conserved domains on  [gi|24657743|ref|NP_611647|]
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F-box protein 42 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 24-61 8.32e-19

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438882  Cd Length: 38  Bit Score: 79.69  E-value: 8.32e-19
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 24657743  24 LNVLPDEILEFIFTYLPPYGDLEHCSLVCKRWHAIVKN 61
Cdd:cd22110   1 INDLPEEILEYILSYLSPYGDLKSAALVCKRWHRIIKG 38
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
101-307 5.44e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.74  E-value: 5.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743 101 AGRFAHSAVRQDNSMYVFGG---GSSSDTTFNDLWRFDLTHMRWARpvaTGTYPSPKGSASMVAWRNQLILFGGWRYPSl 177
Cdd:COG3055  59 PPRHHAAAVAQDGKLYVFGGftgANPSSTPLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGG- 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743 178 hppYQPWclFDElhyYDLGKNRWllrSSLSSPP-PMAGHSATVHGD-RMVVFGGYQIKDDFNVNSNdtwVLDLPEQRWWQ 255
Cdd:COG3055 135 ---NVAW--VEV---YDPATGTW---TQLAPLPtPRDHLAAAVLPDgKILVIGGRNGSGFSNTWTT---LAPLPTARAGH 200

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 24657743 256 PLFVGNtrpspryGQIQVelgrnhllivggCGGANRVYTDAWLLDMTRDVWS 307
Cdd:COG3055 201 AAAVLG-------GKILV------------FGGESGFSDEVEAYDPATNTWT 233
 
Name Accession Description Interval E-value
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 24-61 8.32e-19

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 79.69  E-value: 8.32e-19
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 24657743  24 LNVLPDEILEFIFTYLPPYGDLEHCSLVCKRWHAIVKN 61
Cdd:cd22110   1 INDLPEEILEYILSYLSPYGDLKSAALVCKRWHRIIKG 38
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
101-307 5.44e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.74  E-value: 5.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743 101 AGRFAHSAVRQDNSMYVFGG---GSSSDTTFNDLWRFDLTHMRWARpvaTGTYPSPKGSASMVAWRNQLILFGGWRYPSl 177
Cdd:COG3055  59 PPRHHAAAVAQDGKLYVFGGftgANPSSTPLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGG- 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743 178 hppYQPWclFDElhyYDLGKNRWllrSSLSSPP-PMAGHSATVHGD-RMVVFGGYQIKDDFNVNSNdtwVLDLPEQRWWQ 255
Cdd:COG3055 135 ---NVAW--VEV---YDPATGTW---TQLAPLPtPRDHLAAAVLPDgKILVIGGRNGSGFSNTWTT---LAPLPTARAGH 200

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 24657743 256 PLFVGNtrpspryGQIQVelgrnhllivggCGGANRVYTDAWLLDMTRDVWS 307
Cdd:COG3055 201 AAAVLG-------GKILV------------FGGESGFSDEVEAYDPATNTWT 233
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 24-59 3.60e-09

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 52.49  E-value: 3.60e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 24657743    24 LNVLPDEILEFIFTYLPPYgDLEHCSLVCKRWHAIV 59
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPK-DLLRLALVCRRWRELA 35
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 209-249 2.53e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 44.48  E-value: 2.53e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 24657743   209 PPPMAGHSATVHGDRMVVFGGYqiKDDFNVNSNDTWVLDLP 249
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGY--TGGEGQPSDDVYVLSLP 39
PRK14131 PRK14131
N-acetylneuraminate epimerase;
91-230 2.57e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 50.01  E-value: 2.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743   91 GGAGALLsfiagrfahsavrqDNSMYVfgGGSSSDTTFndlWRFDL--THMRWaRPVATgtYPSPKGS-ASMVAWRNQLI 167
Cdd:PRK14131  31 NGTGAID--------------NNTVYV--GLGSAGTSW---YKLDLnaPSKGW-TKIAA--FPGGPREqAVAAFIDGKLY 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24657743  168 LFGGWRYPSLHPPYQpwcLFDELHYYDLGKNRWllrSSLSSPPP--MAGHSATV-HGDRMVVFGGY 230
Cdd:PRK14131  89 VFGGIGKTNSEGSPQ---VFDDVYKYDPKTNSW---QKLDTRSPvgLAGHVAVSlHNGKAYITGGV 148
FBOX smart00256
A Receptor for Ubiquitination Targets;
27-61 8.90e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 42.81  E-value: 8.90e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 24657743     27 LPDEILEFIFTYLPPYgDLEHCSLVCKRWHAIVKN 61
Cdd:smart00256   1 LPDEILEEILSKLDPK-DLLRLRKVSRKWRSLIDS 34
 
Name Accession Description Interval E-value
F-box_FBXO42 cd22110
F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called ...
 24-61 8.32e-19

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438882  Cd Length: 38  Bit Score: 79.69  E-value: 8.32e-19
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 24657743  24 LNVLPDEILEFIFTYLPPYGDLEHCSLVCKRWHAIVKN 61
Cdd:cd22110   1 INDLPEEILEYILSYLSPYGDLKSAALVCKRWHRIIKG 38
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
101-307 5.44e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.74  E-value: 5.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743 101 AGRFAHSAVRQDNSMYVFGG---GSSSDTTFNDLWRFDLTHMRWARpvaTGTYPSPKGSASMVAWRNQLILFGGWRYPSl 177
Cdd:COG3055  59 PPRHHAAAVAQDGKLYVFGGftgANPSSTPLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGG- 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743 178 hppYQPWclFDElhyYDLGKNRWllrSSLSSPP-PMAGHSATVHGD-RMVVFGGYQIKDDFNVNSNdtwVLDLPEQRWWQ 255
Cdd:COG3055 135 ---NVAW--VEV---YDPATGTW---TQLAPLPtPRDHLAAAVLPDgKILVIGGRNGSGFSNTWTT---LAPLPTARAGH 200

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 24657743 256 PLFVGNtrpspryGQIQVelgrnhllivggCGGANRVYTDAWLLDMTRDVWS 307
Cdd:COG3055 201 AAAVLG-------GKILV------------FGGESGFSDEVEAYDPATNTWT 233
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
146-307 1.28e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 62.48  E-value: 1.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743 146 ATGTYPSPKGSASMVAWRNQLILFGGWRYPSLHppyqpwclfDELHYYDLGKNRWllrSSLSSPP-PMAGHSATV-HGDR 223
Cdd:COG3055   5 SLPDLPTPRSEAAAALLDGKVYVAGGLSGGSAS---------NSFEVYDPATNTW---SELAPLPgPPRHHAAAVaQDGK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743 224 MVVFGGYQIKDDFNVNSNDTWVLDlPEQRWWQPLfvgNTRPSPRYGQIQVELGrNHLLIVGGCGGANRVyTDAWLLDMTR 303
Cdd:COG3055  73 LYVFGGFTGANPSSTPLNDVYVYD-PATNTWTKL---APMPTPRGGATALLLD-GKIYVVGGWDDGGNV-AWVEVYDPAT 146


                ....
gi 24657743 304 DVWS 307
Cdd:COG3055 147 GTWT 150
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 27-60 7.41e-10

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 54.37  E-value: 7.41e-10
                        10        20        30
                ....*....|....*....|....*....|....
gi 24657743  27 LPDEILEFIFTYLPPYgDLEHCSLVCKRWHAIVK 60
Cdd:cd09917   3 LPDEILLKILSYLDPR-DLLRLSLVCKRWRELAS 35
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 24-59 3.60e-09

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 52.49  E-value: 3.60e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 24657743    24 LNVLPDEILEFIFTYLPPYgDLEHCSLVCKRWHAIV 59
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPK-DLLRLALVCRRWRELA 35
F-box_AtTIR1-like cd22159
F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), ...
 24-67 1.18e-08

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438930  Cd Length: 40  Bit Score: 50.93  E-value: 1.18e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 24657743  24 LNVLPDEILEFIFTYLPPYGDLEHCSLVCKRWHaivkNLVRRSR 67
Cdd:cd22159   1 IDLLPDEILELIFSYLSDPWDRNSCSLVCKRWY----RLERATR 40
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 27-62 7.83e-08

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 48.69  E-value: 7.83e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 24657743    27 LPDEILEFIFTYLPPYgDLEHCSLVCKRWHAIVKNL 62
Cdd:pfam00646   4 LPDDLLLEILSRLDPK-DLLRLSLVSKRWRSLVDSL 38
F-box_FBXO18 cd22095
F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called ...
 27-60 3.42e-07

F-box domain found in F-box only protein 18 (FBXO18) and similar proteins; FBXO18, also called FBX18, or F-box DNA helicase 1 (FBH1), is a 3'-5' DNA helicase and the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438867  Cd Length: 48  Bit Score: 47.27  E-value: 3.42e-07
                        10        20        30
                ....*....|....*....|....*....|....
gi 24657743  27 LPDEILEFIFTYLPPYGDLEHCSLVCKRWHAIVK 60
Cdd:cd22095   5 LPEELLRNIFAFLPAEDLYQNISLVCRHWRDIVS 38
F-box_FBXO45 cd22111
F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called ...
 27-56 4.38e-07

F-box domain found in F-box only protein 45 (FBXO45) and similar proteins; FBXO45, also called FBX45, or F-box/SPRY domain-containing protein 1, functions as the substrate-recognition component of E3 ubiquitin ligase complexes. It is critical for synaptogenesis, neuronal migration, and synaptic transmission. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438883  Cd Length: 36  Bit Score: 46.51  E-value: 4.38e-07
                        10        20        30
                ....*....|....*....|....*....|
gi 24657743  27 LPDEILEFIFTYLPpYGDLEHCSLVCKRWH 56
Cdd:cd22111   4 LPSRVLEVIFSYLD-LPDLRNCSLVCKSWY 32
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 209-249 2.53e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 44.48  E-value: 2.53e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 24657743   209 PPPMAGHSATVHGDRMVVFGGYqiKDDFNVNSNDTWVLDLP 249
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGY--TGGEGQPSDDVYVLSLP 39
PRK14131 PRK14131
N-acetylneuraminate epimerase;
91-230 2.57e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 50.01  E-value: 2.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743   91 GGAGALLsfiagrfahsavrqDNSMYVfgGGSSSDTTFndlWRFDL--THMRWaRPVATgtYPSPKGS-ASMVAWRNQLI 167
Cdd:PRK14131  31 NGTGAID--------------NNTVYV--GLGSAGTSW---YKLDLnaPSKGW-TKIAA--FPGGPREqAVAAFIDGKLY 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24657743  168 LFGGWRYPSLHPPYQpwcLFDELHYYDLGKNRWllrSSLSSPPP--MAGHSATV-HGDRMVVFGGY 230
Cdd:PRK14131  89 VFGGIGKTNSEGSPQ---VFDDVYKYDPKTNSW---QKLDTRSPvgLAGHVAVSlHNGKAYITGGV 148
FBOX smart00256
A Receptor for Ubiquitination Targets;
27-61 8.90e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 42.81  E-value: 8.90e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 24657743     27 LPDEILEFIFTYLPPYgDLEHCSLVCKRWHAIVKN 61
Cdd:smart00256   1 LPDEILEEILSKLDPK-DLLRLRKVSRKWRSLIDS 34
PLN02193 PLN02193
nitrile-specifier protein
 113-285 1.98e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 47.64  E-value: 1.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743  113 NSMYVFGGGSSSdTTFNDLWRFDLTHMRWA--RPVATGtyPSPKGSASMVAWRNQLILFGGwrypslhppYQPWCLFDEL 190
Cdd:PLN02193 229 STLYVFGGRDAS-RQYNGFYSFDTTTNEWKllTPVEEG--PTPRSFHSMAADEENVYVFGG---------VSATARLKTL 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743  191 HYYDLGKNRWLlrsSLSSPppmaGHSATVHGDR--MVVFGGYQIKDDFN-VNSNDTWVLDLPEQRWWQPLFVGnTRPSPR 267
Cdd:PLN02193 297 DSYNIVDKKWF---HCSTP----GDSFSIRGGAglEVVQGKVWVVYGFNgCEVDDVHYYDPVQDKWTQVETFG-VRPSER 368

                        170
                 ....*....|....*...
gi 24657743  268 YGQIQVELGRnHLLIVGG 285
Cdd:PLN02193 369 SVFASAAVGK-HIVIFGG 385
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 25-61 2.35e-05

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 41.92  E-value: 2.35e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 24657743  25 NVLPDEILEFIFTYLPPYgDLEHCSLVCKRWHAIVKN 61
Cdd:cd22151   1 RKLPDDLLQEIFKRLDPK-SLARAACVCRRWRAAARS 36
F-box_FBA cd22083
F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box ...
 24-59 3.23e-05

F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438855  Cd Length: 37  Bit Score: 41.22  E-value: 3.23e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 24657743  24 LNVLPDEILEFIFTYLPPYGDLEHCSLVCKRWHAIV 59
Cdd:cd22083   1 LNEIPEELLLEILTHVPATSLITNCRLVCTLWRDII 36
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 24-60 3.41e-05

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 41.17  E-value: 3.41e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 24657743  24 LNVLPDEILEFIFTYLPPYgDLEHCSLVCKRWHAIVK 60
Cdd:cd22118   1 ISSLPPEIMLKIFSYLNPQ-DLCRCAQVCTKWSQLAR 36
F-box_AtSKIP5-like cd22163
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar ...
 24-59 5.32e-05

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 5 (AtSKIP5) and similar proteins; AtSKIP5, also called F-box protein SKIP5, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438934  Cd Length: 46  Bit Score: 40.79  E-value: 5.32e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 24657743  24 LNVLPDEILEFIFTYLPPYGDLEHCSLVCKRWHAIV 59
Cdd:cd22163   1 INDLDDDCLMHIFSFLTPLPDRFNAARVCKRWRALA 36
Kelch_3 pfam13415
Galactose oxidase, central domain;
112-161 7.59e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 40.74  E-value: 7.59e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 24657743   112 DNSMYVFGG-GSSSDTTFNDLWRFDLTHMRWARpvaTGTYPSPKGSASMVA 161
Cdd:pfam13415   1 GDKLYIFGGlGFDGQTRLNDLYVYDLDTNTWTQ---IGDLPPPRSGHSATY 48
PLN02193 PLN02193
nitrile-specifier protein
 103-255 7.92e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.72  E-value: 7.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743  103 RFAHSAVRQDNSMYVFGGGSSSDTTFND-LWRFDLTHMRWARPVATGTYPSPKG-SASMVAWRNQLILFGGwRYPSLHpp 180
Cdd:PLN02193 166 RCSHGIAQVGNKIYSFGGEFTPNQPIDKhLYVFDLETRTWSISPATGDVPHLSClGVRMVSIGSTLYVFGG-RDASRQ-- 242

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24657743  181 yqpwclFDELHYYDLGKNRW-LLRSSLSSPPPMAGHSATVHGDRMVVFGGYQIKDdfNVNSNDTWvlDLPEQRWWQ 255
Cdd:PLN02193 243 ------YNGFYSFDTTTNEWkLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATA--RLKTLDSY--NIVDKKWFH 308
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 24-62 9.44e-05

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 40.32  E-value: 9.44e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24657743  24 LNVLPDEILEFIFTYLPpYGDLEHCSLVCKRWHAIVKNL 62
Cdd:cd22084   1 LDDLPSDPLLNILSFLD-YRDLISCSQVCRRLNQLCSHD 38
Kelch_4 pfam13418
Galactose oxidase, central domain;
102-143 1.01e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 40.29  E-value: 1.01e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 24657743   102 GRFAHSAVR-QDNSMYVFGGGSSSDTTFNDLWRFDLTHMRWAR 143
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEWTR 43
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 27-59 1.11e-04

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 39.92  E-value: 1.11e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 24657743  27 LPDEILEFIFTYLPPYgDLEHCSLVCKRWHAIV 59
Cdd:cd22139   4 LPDELWLHIFSFLSPK-DLCQVALVCRRFNRLA 35
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
 27-56 1.79e-04

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 39.32  E-value: 1.79e-04
                        10        20        30
                ....*....|....*....|....*....|
gi 24657743  27 LPDEILEFIFTYLPpYGDLEHCSLVCKRWH 56
Cdd:cd22114   4 LPDELLLGIFSCLC-LPDLLKVSQVCKRWY 32
PLN02153 PLN02153
epithiospecifier protein
 40-285 1.81e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 44.21  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743   40 PPYGDLEHCSLVCKRWHAIVKNLVRRSRHNLEKGLIDFRL------RWEVFSQQTVNGGAGAllsfiagRFAHSAVRQDN 113
Cdd:PLN02153  66 PANGDVPRISCLGVRMVAVGTKLYIFGGRDEKREFSDFYSydtvknEWTFLTKLDEEGGPEA-------RTFHSMASDEN 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743  114 SMYVFGGGS-----SSDTTFNDLWRFDLTHMRWARPVATGTYPSPKGSASMVAWRNQLILFGGWRYPSLhPPYQPWCLFD 188
Cdd:PLN02153 139 HVYVFGGVSkgglmKTPERFRTIEAYNIADGKWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFATSIL-PGGKSDYESN 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743  189 ELHYYDLGKNRWL-LRSSLSSPPPMAGHSATVHGDRMVVFGGyQIKDDFNVN------SNDTWVLDlPEQRWWQPLFVGN 261
Cdd:PLN02153 218 AVQFFDPASGKWTeVETTGAKPSARSVFAHAVVGKYIIIFGG-EVWPDLKGHlgpgtlSNEGYALD-TETLVWEKLGECG 295

                        250       260
                 ....*....|....*....|....*...
gi 24657743  262 TRPSPR----YGQIQVElGRNHLLIVGG 285
Cdd:PLN02153 296 EPAMPRgwtaYTTATVY-GKNGLLMHGG 322
F-box_FBXO6-like cd22168
F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily ...
 22-59 1.82e-04

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438939 [Multi-domain]  Cd Length: 82  Bit Score: 40.34  E-value: 1.82e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 24657743  22 VNLNVLPDEILEFIFTYLPPYGDLEHCSLVCKRWHAIV 59
Cdd:cd22168   2 LTISDLPEDVLLEILSLVPARDLILSCRLVCSRWRDLV 39
F-box_FBXO17-like cd22169
F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and ...
 24-59 2.06e-04

F-box domain found in F-box only protein 17 (FBXO17), F-box only protein 27 (FBXO27) and similar proteins; This subfamily includes FBXO17 and FBXO27. FBXO17 is also called FBX17, F-box only protein 26 (FBX26/FBXO26), or FBG4, while FBXO27 is also called FBX27, or F-box/G-domain protein 5. FBXO17 and FBXO27 are the substrate-recognition components of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. They can recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. FBXO17 also recognizes sulfated glycans but does not bind high-mannose glycoproteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438940  Cd Length: 48  Bit Score: 39.33  E-value: 2.06e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 24657743  24 LNVLPDEILEFIFTYLPPYGDLEHCSLVCKRWHAIV 59
Cdd:cd22169   1 LSLLPEELLLLVLSHVPARTLVTRCRLVCRDWRDLV 36
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
 24-67 3.27e-04

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438915  Cd Length: 44  Bit Score: 38.75  E-value: 3.27e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 24657743  24 LNVLPDEILEFIFTYLPPyGDLEHCSLVCKRWHAIVKNLVRRSR 67
Cdd:cd22143   2 FDSLPDEILSIIFSHLPQ-SDLYNLLFVNKHFYSLALPELWRSI 44
F-box_FBXO10 cd22090
F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called ...
 23-62 3.46e-04

F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called FBX10, or PRMT11, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an anti-apoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. It also associates with the receptor for advanced glycation end products (RAGE) to mediate its ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438862  Cd Length: 50  Bit Score: 38.87  E-value: 3.46e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 24657743  23 NLNVLPDEILEFIFTYLPpYGDLEHCSLVCKRWHAIVKNL 62
Cdd:cd22090   1 EVTGLPLELWRLILAYLP-VRDLCRCCQVCRAWYELILSL 39
PHA03098 PHA03098
kelch-like protein; Provisional
 103-247 4.74e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.22  E-value: 4.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743  103 RFAHSAVRQDNSMYVFGGGSSSDTTFNDLWRFDLTHMRWaRPVATGTYPSPKGSAsmVAWRNQLILFGGWRYPSLHPPYq 182
Cdd:PHA03098 380 RYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKW-SKGSPLPISHYGGCA--IYHDGKIYVIGGISYIDNIKVY- 455

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24657743  183 pwclfDELHYYDLGKNRWLLRSSLSSPPPMAghSATVHGDRMVVFGGYqiKDDFNVN-------SNDTWVLD 247
Cdd:PHA03098 456 -----NIVESYNPVTNKWTELSSLNFPRINA--SLCIFNNKIYVVGGD--KYEYYINeievyddKTNTWTLF 518
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
 25-55 6.17e-04

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 38.01  E-value: 6.17e-04
                        10        20        30
                ....*....|....*....|....*....|.
gi 24657743  25 NVLPDEILEFIFTYLPPyGDLEHCSLVCKRW 55
Cdd:cd22104   2 ANLPSVVLVHIFSYLPP-RDRLRASSTCRRW 31
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 101-137 6.79e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.54  E-value: 6.79e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24657743   101 AGRFAHSAVRQDNSMYVFGGGSSSDT-TFNDLWRFDLT 137
Cdd:pfam13854   2 VPRYGHCAVTVGDYIYLYGGYTGGEGqPSDDVYVLSLP 39
Kelch_6 pfam13964
Kelch motif;
103-141 7.69e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.70  E-value: 7.69e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 24657743   103 RFAHSAVRQDNSMYVFGGGSSSDTTFNDLWRFDLTHMRW 141
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSW 40
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
 27-58 7.97e-04

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 37.79  E-value: 7.97e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 24657743  27 LPDEILEFIFTYLPPYgDLEHCSLVCKRWHAI 58
Cdd:cd22091   4 LPDEVLLKIFSYLLEQ-DLCRAAQVCKRFNTL 34
F-box_FBXO28 cd22100
F-box domain found in F-box only protein 28 (FBXO28) and similar proteins; FBXO28, also called ...
 24-62 1.08e-03

F-box domain found in F-box only protein 28 (FBXO28) and similar proteins; FBXO28, also called FBX28, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It promotes mitotic progression and regulates topoisomerase IIalpha-dependent DNA decatenation. FBXO28 plays a crucial role in the pathogenesis of the 1q41q42 microdeletion syndrome. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438872  Cd Length: 45  Bit Score: 37.14  E-value: 1.08e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 24657743  24 LNVLPDEILEFIFTYLpPYGDLEHCSLVCKRWHAIVKNL 62
Cdd:cd22100   1 LLELPDEIIEKILSYL-SYDEISKLRLVCRRFNEVCQRI 38
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 27-58 1.23e-03

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.23e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 24657743  27 LPDEILEFIFTYLPPyGDLEHCSLVCKRWHAI 58
Cdd:cd22132   4 LPDSLLLHIFSYLSP-KDLLAAGQVCKQWYRV 34
F-box_5 pfam18511
F-box; Jasmonates are a family of plant hormones that regulate plant growth, development and ...
 28-58 1.27e-03

F-box; Jasmonates are a family of plant hormones that regulate plant growth, development and responses to stress. COI1 is an F-box protein that functions as the substrate-recruiting module of the Skp1-Cul1-F-box protein (SCF) ubiquitin E3 ligase complex. The role of COI1-mediated JAZ degradation in jasmonate (JA) signaling is analogous to auxin signaling through the receptor F-box protein transport inhibitor response 1 (TIR1), which promotes hormone-dependent turnover of the AUX/IAA transcriptional repressors. The crystal structure of COI1 reveals a TIR1-like overall architecture, with an N-terminal tri-helical F-box motif bound to ASK1 and a C-terminal horseshoe-shaped solenoid domain formed by 18 tandem leucine-rich repeats. This entry represents the N-terminal F-box domain which is also found in other auxin signaling f-box proteins such as AFB1, AFB2 and AFB3.


Pssm-ID: 436553  Cd Length: 42  Bit Score: 36.78  E-value: 1.27e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 24657743    28 PDEILEFIFTYLPPYGDLEHCSLVCKRWHAI 58
Cdd:pfam18511   5 PDEVLECVLPYITSPRDRNAVSLVCKRWYRI 35
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 27-62 1.51e-03

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 36.54  E-value: 1.51e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 24657743  27 LPDEILEFIFTYLPPyGDLEHCSLVCKRWHAIVKNL 62
Cdd:cd22131   6 LPLELSFYLLSFLDP-ESLLTCCLVSKQWNKVISSC 40
PLN02193 PLN02193
nitrile-specifier protein
 103-229 1.60e-03

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 41.48  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657743  103 RFAHSAVRQDNSMYVFGGGSSSDtTFNDLWRFDLTHMRWARPVATGTYPSPKGSASMVAWRNQLILFGGWRypslhppyq 182
Cdd:PLN02193 269 RSFHSMAADEENVYVFGGVSATA-RLKTLDSYNIVDKKWFHCSTPGDSFSIRGGAGLEVVQGKVWVVYGFN--------- 338

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 24657743  183 pWCLFDELHYYDLGKNRWLLRSSLS-SPPPMAGHSATVHGDRMVVFGG 229
Cdd:PLN02193 339 -GCEVDDVHYYDPVQDKWTQVETFGvRPSERSVFASAAVGKHIVIFGG 385
F-box_FBXL7 cd22120
F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also ...
 27-59 4.14e-03

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438892  Cd Length: 44  Bit Score: 35.44  E-value: 4.14e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 24657743  27 LPDEILEFIFTYLPPyGDLEHCSLVCKRWHAIV 59
Cdd:cd22120   4 LPDDVILQIFSHLPT-NQLCRCARVCRRWYNLA 35
F-box_FBXO9 cd22089
F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called ...
 24-54 4.77e-03

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438861  Cd Length: 53  Bit Score: 35.67  E-value: 4.77e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 24657743  24 LNVLPDEILEFIFTYLPPYGD---LEHCSLVCKR 54
Cdd:cd22089   3 ISALPSEILLYILRWVVSDLDlrsLEQLSLVCRK 36
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 25-61 5.80e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 35.13  E-value: 5.80e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 24657743  25 NVLPDEILEFIFTYLPPyGDLEHCSLVCKRWHAIVKN 61
Cdd:cd22157   1 SSLPDDLVEEILSRLPA-KSLLRFRCVCKQWNSLISS 36
Kelch_4 pfam13418
Galactose oxidase, central domain;
213-255 6.16e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 6.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 24657743   213 AGHSATVHGDRMV-VFGGYQIKDDFnvnSNDTWVLDLPEQRWWQ 255
Cdd:pfam13418   3 AYHTSTSIPDDTIyLFGGEGEDGTL---LSDLWVFDLSTNEWTR 43
F-box_FBXO13 cd22092
F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called ...
 23-56 6.70e-03

F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called FBX13, F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438864  Cd Length: 49  Bit Score: 35.09  E-value: 6.70e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 24657743  23 NLNVLPDEILEFIFTYLPPYGDLEHCSLVCKRWH 56
Cdd:cd22092   1 NINQLPDSILLKIFSYLSLQERCLSASLVCKYWR 34
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
 29-60 6.93e-03

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 35.00  E-value: 6.93e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 24657743  29 DEILEFIFTYLPPYgDLEHCSLVCKRWHAIVK 60
Cdd:cd22109   8 RDALFCVFSYLDTK-SLLRCAEVCREWRDVSR 38
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 211-253 7.32e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.00  E-value: 7.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 24657743   211 PMAGHSATVHGDRMVVFGGYqiKDDFNVNSNDTWVLDLPEQRW 253
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGS--DGLGDLSSSDVLVYDPETNVW 41
F-box_FBXL8 cd22121
F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also ...
 25-59 8.80e-03

F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also called F-box and leucine-rich repeat protein 8, or F-box protein FBL8, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438893  Cd Length: 35  Bit Score: 34.26  E-value: 8.80e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 24657743  25 NVLPDEILEFIFTYLpPYGDLEHCSLVCKRWHAIV 59
Cdd:cd22121   1 NALPEEILVHIFRHL-SLRDRYAAAQVCKHWREAA 34
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
 27-56 9.16e-03

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 34.66  E-value: 9.16e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 24657743  27 LPDEILEFIFTYLPPYgDLEHCSLVCKRWH 56
Cdd:cd22149   4 LSDEIILSIFKWLPKK-TLARCARVCRRWK 32
F-box_JHDM cd22122
F-box domain found in the JmjC domain-containing histone demethylation protein (JHDM) family; ...
 25-56 9.52e-03

F-box domain found in the JmjC domain-containing histone demethylation protein (JHDM) family; The JHDM family includes F-box/LRR-repeat proteins FBXL10, FBXL11 and FBXL19. FBXL10 is also called lysine-specific demethylase 2B (KDM2B), CXXC-type zinc finger protein 2 (CXXC2), F-box and leucine-rich repeat protein 10 (FBL10), JmjC domain-containing histone demethylation protein 1B (JHDM1B), Jumonji domain-containing EMSY-interactor methyltransferase motif protein, protein JEMMA, protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, or NDY1. It is a histone demethylase that catalyzes the demethylation of H3K4me3 and H3K36me2, thereby playing a central role in the histone code. It preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. FBXL10 may also serve as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXL11, also called KDM2A, CXXC8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, JmjC domain-containing histone demethylation protein 1A (JHDM1A), or [Histone-H3]-lysine-36 demethylase 1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates epithelial mesenchymal transition (EMT) and the metastasis of ovarian cancer. It plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival. FBXL11 may also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. It is required to sustain centromeric integrity and genomic stability, particularly during mitosis. FBXL19, also called F-box and leucine-rich repeat protein 19, is the substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It acts as a CpG island-binding protein in mouse embryonic stem (ES) cells and has been shown to associate with the CDK-Mediator complex. It promotes H2Bub1 at the promoters of CpG island-containing genes by interacting with RNF20. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438894  Cd Length: 43  Bit Score: 34.56  E-value: 9.52e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 24657743  25 NVLPDEILEFIFTYLPPYgDLEHCSLVCKRWH 56
Cdd:cd22122   2 HVLPREVWLPVFQYLSPK-DLCVCMRVCKTWN 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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