FSD1 Fe superoxide dismutase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FSD1
Official Full Name: Fe superoxide dismutase 1
Primary source: TAIR:AT4G25100
Locus tag: AT4G25100
See related: Araport:AT4G25100
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS FE SUPEROXIDE DISMUTASE 1; ATFSD1; F24A6.1; Fe superoxide dismutase 1
Summary: Fe-superoxide dismutase
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Genomic context

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See FSD1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 9

Sequence:: Chromosome: 4; NC_003075.7 (12884300..12887011, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vivo light-sheet microscopy resolves localisation patterns of FSD1, a superoxide dismutase with function in root development and osmoprotection.
Title: In vivo light-sheet microscopy resolves localisation patterns of FSD1, a superoxide dismutase with function in root development and osmoprotection.
The expression of SPL7 and its targets COPT2 and FSD1 was differently regulated in various light signalling mutants. Under copper deficiency, the expression of both targets decreased drastically in continuous darkness.
Title: Modulation of copper deficiency responses by diurnal and circadian rhythms in Arabidopsis thaliana.
Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments. Another kinase, MPK6, was also involved in the MKK5-mediated iron superoxide dismutase (FSD) signalling pathway in salt stress.
Title: Mitogen-activated protein kinase kinase 5 (MKK5)-mediated signalling cascade regulates expression of iron superoxide dismutase gene in Arabidopsis under salinity stress.
Data indicate that cadmium (Cd) elicits SPL7-dependent copper (Cu) deficiency responses by altering expression of COPT1, COPT2, COPT6, CSD1, CSD2, miRNA398 b/c precursors and FSD1.
Title: The CTR/COPT-dependent copper uptake and SPL7-dependent copper deficiency responses are required for basal cadmium tolerance in A. thaliana.
Data suggest that iron superoxide dismutase gene FSD1 and SPL7 transcriptional regulator SPL7 may associate withi copper homeostasis.
Title: Comparison of global responses to mild deficiency and excess copper levels in Arabidopsis seedlings.
CPN20 silencing decreases iron superoxide dismutases activity in chloroplast.
Title: CHAPERONIN 20 mediates iron superoxide dismutase (FeSOD) activity independent of its co-chaperonin role in Arabidopsis chloroplasts.
While for roots, based on an increase in FSD1 gene expression, oxidative stress was suggested to be superoxide induced...
Title: Study of oxidative stress related responses induced in Arabidopsis thaliana following mixed exposure to uranium and cadmium.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001036633.2

Supported by ESTs:

NM_001203905.1

Supported by ESTs:

NM_118642.2

Supported by ESTs:

NM_179109.3

Supported by ESTs:

NM_179110.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables copper ion binding	HDA more info	PubMed
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info
enables superoxide dismutase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within removal of superoxide radicals	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light intensity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ozone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast	NAS Non-traceable Author Statement more info	PubMed
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plasma membrane	HDA more info	PubMed
located_in thylakoid	HDA more info	PubMed

General protein information

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Preferred Names: Fe superoxide dismutase 1

NP_001031710.1

Fe superoxide dismutase 1 (FSD1); FUNCTIONS IN: superoxide dismutase activity, copper ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, removal of superoxide radicals, response to copper ion, circadian rhythm; LOCATED IN: mitochondrion, chloroplast, plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Fe superoxide dismutase 2 (TAIR:AT5G51100.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_001190834.1

Fe superoxide dismutase 1 (FSD1); CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Fe superoxide dismutase 2 (TAIR:AT5G51100.1).

NP_194240.1

Fe superoxide dismutase 1 (FSD1); FUNCTIONS IN: superoxide dismutase activity, copper ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, removal of superoxide radicals, response to copper ion, circadian rhythm; LOCATED IN: in 6 components; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Fe superoxide dismutase 2 (TAIR:AT5G51100.1); Has 11570 Blast hits to 11569 proteins in 3359 species: Archae - 194; Bacteria - 8166; Metazoa - 431; Fungi - 784; Plants - 398; Viruses - 1; Other Eukaryotes - 1596 (source: NCBI BLink).

NP_849440.1

Fe superoxide dismutase 1 (FSD1); FUNCTIONS IN: superoxide dismutase activity, copper ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, removal of superoxide radicals, response to copper ion, circadian rhythm; LOCATED IN: thylakoid, mitochondrion, plasma membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Fe superoxide dismutase 2 (TAIR:AT5G51100.1); Has 11570 Blast hits to 11569 proteins in 3359 species: Archae - 194; Bacteria - 8166; Metazoa - 431; Fungi - 784; Plants - 398; Viruses - 1; Other Eukaryotes - 1596 (source: NCBI BLink).

NP_849441.1

Fe superoxide dismutase 1 (FSD1); FUNCTIONS IN: superoxide dismutase activity, copper ion binding; INVOLVED IN: response to oxidative stress, response to cadmium ion, removal of superoxide radicals, response to copper ion, circadian rhythm; LOCATED IN: thylakoid, mitochondrion, plasma membrane, chloroplast, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Fe superoxide dismutase 2 (TAIR:AT5G51100.1); Has 11570 Blast hits to 11569 proteins in 3359 species: Archae - 194; Bacteria - 8166; Metazoa - 431; Fungi - 784; Plants - 398; Viruses - 1; Other Eukaryotes - 1596 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

12884300..12887011 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_179109.3 → NP_849440.1 Fe superoxide dismutase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849440.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P21276, Q9FE21, Q9SW16

UniProtKB/TrEMBL

A0A5S9XVM4, A0A654FSM5

Conserved Domains (1) summary

PLN02184
Location:1 → 212

PLN02184; superoxide dismutase [Fe]
NM_001036633.2 → NP_001031710.1 Fe superoxide dismutase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031710.1

Status: REVIEWED

UniProtKB/TrEMBL

F4JRV2

Conserved Domains (3) summary

COG0605
Location:1 → 184

SodA; Superoxide dismutase [Inorganic ion transport and metabolism]

pfam00081
Location:1 → 68

Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain

pfam02777
Location:79 → 177

Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain
NM_179110.2 → NP_849441.1 Fe superoxide dismutase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849441.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P21276, Q9FE21, Q9SW16

UniProtKB/TrEMBL

A0A5S9XVM4, A0A654FSM5

Conserved Domains (1) summary

PLN02184
Location:1 → 212

PLN02184; superoxide dismutase [Fe]
NM_118642.2 → NP_194240.1 Fe superoxide dismutase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194240.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P21276, Q9FE21, Q9SW16

UniProtKB/TrEMBL

A0A5S9XVM4, A0A654FSM5

Conserved Domains (1) summary

PLN02184
Location:1 → 212

PLN02184; superoxide dismutase [Fe]
NM_001203905.1 → NP_001190834.1 Fe superoxide dismutase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190834.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P21276, Q9FE21, Q9SW16

UniProtKB/TrEMBL

A0A5S9XVM4, A0A654FSM5

Conserved Domains (1) summary

PLN02184
Location:1 → 212

PLN02184; superoxide dismutase [Fe]